CoATherm. AK Series. APRO KOREA Inc. Radio Frequency Thermal Ablation System

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1 CoATherm Radio Frequency Thermal Ablation System MINIMAL INVASIVE SURGERY FOR TUMORS AK Series APRO KOREA Inc.

2 Ⅰ. RFA Ⅰ RFA Minimal Invasive Surgery? g y Alternating current through the tissue creates coagulation necrosis of benign and malignant tumors with Ultrasonograph or Endoscope guiding, not ventrotomy. CoATherm is used to ablate the border tissue for preventing metastasis after resection of Cancer. CoATherm is based on the frictional heat principle that 480kHz currents make polarity change 480 thousands times from negative pole to positive one or from negative pole to positive one through active tip, not bring about thermal energy from of needle. Applications -. Thyroid/Breast Benign Nodule -. Liver/Lung/Kidney Cancer -. Myoma Mass -. Pancreas/Gallbladder mass through EUS -. Etc.,

3 Ⅱ. CoATherm AK-F200, F150 Ⅱ-1 Output power : Max 200W under 100Ω Output wave : 480kHz±10% sine wave Dimension : 341(W) 394(L) 160(H) mm Classification : Protective Class 1, CF Type RF Electrodes for Tumor Ablation Minimal Invasive Surgery Temperature Monitoring Applied Cold water circulation(with or not) Using for 20/18/17 gauge diameters 90/100/150/200/350mm length 3/5/7/10/20/30mm Tip exposures Ordering Number S20/S17/I18 series Application : Thyroid/Breast Benign Tumor Lung/Liver/Kidney Malignant Tumor Myoma, Adenomyoma etc., RF Electrodes for Endo-surgery Temperature Monitoring Applied Cold water circulation(with or not) Using the Endoscope with working channel under 7French diameters 0.5/1/1.5/3 mm diameters 50/100/150/200cm length 5/10/15/20mm Tip exposures Ordering Number G05/G10/G15/G30 series

4 Ⅱ. CoATherm AF-200, AF-150 Ⅱ-2 The Effect of RF Ablation Ablating Myoma tissue after resection The Result of Myoma Normal cell necrosis margin necrosis

5 Ⅲ. APPLICATION Ⅲ-1 1. Thyroid/Breast Benign Nodule Ablation Histopathologic change of thyroid nodule after RF ablation. A. On sonogram obtained before RF ablation, a large complex mass (solid 70%) is seen in right lobe of thyroid gland (size: cm, volume:14.07 ml). This mass is proven benign by fine needle aspiration biopsy. B. On sonogram obtained during procedure, the electrode is positioned within nodule and round hyperechogenicity from active tip is appeared. C. On sonogram obtained 4 months after RF ablation, the volume of nodule was decreased by 71%. YouTube video link:

6 Ⅲ. APPLICATION Ⅲ-2 2. Liver/Lung/Kidney Cancer Ablation 1) Under Ultrasonograph Ultrasound for guidance and monitoring during the procedure. A. Pre- treatment sonogram shows a hypoechoic metas tasis from breast cancer in the right lobe of the liver. B. The echogenicity of the tumor is increased by microbubbles immediately after ablation. Y T b id li k YouTube video link 1)Liver cancer: 2)Lung cancer:

7 Ⅲ. APPLICATION Ⅲ-3 2. Liver/Lung/Kidney Cancer Ablation 2) Under Endoscope(Thoracoscopy or Laparoscopy) To ablate the border tissue for preventing metastasis after resection of Cancer. -. The surgeon makes several small incisions in patients side. -. He or she then inserts a scope through h one of the incisions. i i -. The scope contains a tiny camera that allows the doctor to view patients lung on a TV monitor. Through the other incisions, the doctor will insert instruments. -. The surgeon takes the tumor out as well as the neighboring i part of the lung. -. The surgeon ablates the neighboring part of the remain lung, using CoATherm.

8 Ⅲ. APPLICATION Ⅲ-4 3. Myoma Mass 1) Under Ultrasonograph The change of myoma mass after RF ablation. A. On sonogram obtained before RF ablation, the size of mass was 6 cm. B. On sonogram obtained 8 months after RF ablation, the size of volume was 2.4 cm Radiofrequency Ablation induces irreversible cell death and relieves clinical symptoms of myoma. By coagulation of vessels, decreased blood supply to the mass contribute to downsize the mass as well. Postoperative adhesion and myometrium must be monitored carefully. Postoperative adhesion is mainly due to multiple punctures and serosal damage. Along with adhesion, the probability of uterine rupture during pregnancy after myolysis must be assessed. Radiofrequency myolysis is to be a effective and minimal invasive treatment modality that preserves uterus.

9 Ⅲ. APPLICATION Ⅲ-5 3. Myoma Mass 2) Under Laparoscopy Uterine Adenomyosis by RF Ablation under laparoscopy - To destroy the adenomyoma cell - To block the feeding vessel - To keep the Uterus YouTube video link:

10 Ⅲ. APPLICATION Ⅲ-6 4. Pancreas/Gallbladder Mass through EUS under CT guided CT guided RF thermal ablation in the pancreas and endobiliary RFA treatment is feasible and safe. Induced thermal lesion size can best be monitored. RF ablation can offer an alternative treatment option for pancreatic cancer and inresectable malignant bile duct obstruction. In some patient (with cancer of the body of the pancreas) who was receiving morphine because of intolerable pain, significant pain relief has been observed.

11 The End~ Thanks for your attention. APRO KOREA Inc. 3 Floor 3, Sanbon-ro 86beon-gil, Gunpo-si, Gyeonggi-do, 15847, Republic of KOREA TEL : FAX : global@apro-korea.co.kr

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