Estimation of the heritability of a newly developed ketosis risk indicator and the genetic correlations to other traits in three German cattle breeds
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1 Estimation of the heritability of a newly developed ketosis risk indicator and the genetic correlations to other traits in three German cattle breeds H. Hamann 1, A. Werner 2, L. Dale 2, P. Herold 1 1 State Office for Spatial Information and Land Development Baden-Württemberg, Germany 2 Association for Performance and Quality Testing Baden-Württemberg, Germany Slide 1, February, 11, 2018
2 Goal and derivation of the KetoMIR index: KetoMIR index: based on logistic regression numeric range between 0 and 1 partition in three classes healthy : low risk : high risk : Calibration set Validation set (n= ) (n=2.966) Sensitivity: Specificity Slide 2, February, 11, 2018
3 cum. prob. function prob. function Probability functions of the KetoMIR index and derivaton of KetoMIR classes healthy low risk high risk high risk low risk healthy Slide 3, February, 11, 2018
4 Distribution of KetoMIR classes for breeds and weeks in milk Fleckvieh (Dual purpose Simmental) Braunvieh (German Brown) Deutsch Holstein (German Holstein) high risk low risk healthy Weeks in milk Slide 4, February, 11, 2018
5 Breeding strategies: Selection against ketosis liability: - based on a single (first) test day record (strategy I) breaking the peaks in the KetoMIR curve - based on the average of several test day records (strategy II) lowering the general level of the KetoMIR curve Slide 5, February, 11, 2018
6 KetoMIR index 1.00 Breeding strategies Initial curve (hypothetical) 0.75 Strategy I 0.50 Strategy II Days in milk
7 Data: Fleckvieh: Braunvieh: Deutsch Holstein: lactations with information for the first three test day records (analysed separately or as average) Repeatability model (within breed): HYS, lactation number, days in milk, permanent environmental effect, animal effect Slide 7, February, 11, 2018
8 How is the KetoMIR index genetically related to other traits of interest? Genetic correlations between KetoMIR index and traits for milk components Milk yield SCS TD Fleckvieh Braunvieh Deutsch Holstein Ø Ø Slide 8, February, 11, 2018
9 How is the KetoMIR index genetically related to other traits of interest? Genetic correlations between KetoMIR index and traits for milk components Fat content Protein content Fat-protein-ratio TD Fleckvieh Braunvieh Deutsch Holstein Ø Ø Ø Slide 9, February, 11, 2018
10 Data: Fleckvieh: Braunvieh: Deutsch Holstein: lactations with information for the first three test day records (analysed separately or as average) Repeatability model (within breed): HYS, lactation number, days in milk, permanent environmental effect, animal effect Multitrait model (within breed): HYS, lactation number, days in milk, animal effect Slide 10, February, 11, 2018
11 Heritabilities of the KetoMIR index (multitrait model) 1. lact. 2. lact. 3. lact. Trait h 2 h 2 h 2 Fleckvieh 1. TD / x. l TD / x. l TD / x. l Ø / x. L Braunvieh 1. TD / x. l TD / x. l TD / x. l Ø / x. L Deutsch- Holstein 1. TD / x. l TD / x. l TD / x. l Ø / x. L Slide 11, February, 11, 2018
12 Genetic correlations of the KetoMIR index between lactations (multitrait model) 1. to 2. lact. 1. to 3. lact. 2. to 3. lact. Trait r g r g r g Fleckvieh 1. TD / x. l TD / x. l TD / x. l Ø / x. L Braunvieh 1. TD / x. l TD / x. l TD / x. l Ø / x. L Deutsch- Holstein 1. TD / x. l TD / x. l TD / x. l Ø / x. L Slide 12, February, 11, 2018
13 Conclusion: Data collecting as a matter of the routine milk analyses Genetic background of the KetoMIR index is proven Mixture of multitrait and repeatability models Decision of a breeding value evaluation for the KetoMIR index - based on a single test day record - based on the average of several test day records Applying random regression models to the data Calculation of economic weights Slide 13, February, 11, 2018
14 Thank you for your attention!
15 Is the KetoMIR index (classes) heritable? Heritabilities for the KetoMIR index, catecorical and binary classes Fleckvieh (Dual purpose Simmental) Braunvieh (German Brown) Deutsch Holstein (German Holstein) TD Index C3 B050 B075 TD Index C3 B050 B075 TD Index C3 B050 B Ø Ø Ø Slide 15, February, 11, 2018
16 How is the KetoMIR index genetically related to ketosis? Genetic correlations between ketosis (clinical) and the KetoMIR index and categorical classes Fleckvieh Braunvieh Deutsch Holstein TD Index C3 Index C3 Index C Ø Slide 16, February, 11, 2018
17 Can the KetoMIR index be used as auxiliary trait in breeding programmes? - Is the KetoMIR index (classes) heritable? - How is the KetoMIR index genetically related to ketosis? - How is the KetoMIR index genetically related to other traits of interest? Slide 17, February, 11, 2018
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