IOM Workshop. Why Sex Specific Report of Scientific Data Is Important. August 30, 2011
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1 IOM Workshop Why Sex Specific Report of Scientific Data Is Important August 30, 2011 The Society for Women s Health Research 1025 Connecticut Avenue, NW, Suite 701 Washington, DC Phone: Fax: Web:
2 Society for Women's Health Research (SWHR) SWHR works to raise awareness that: women and men are different, both biologically and physiologically sex and gender differences exist and they need to be identified and their implications understood for diagnosis and treatment Scientific Advisory Meetings ( ) Engaged the scientific and clinical research communities in discussions regarding the importance of sex differences in diseases and health conditions
3 Scientific Advisory Meetings (SAM) Women'sHealthandthe Environment(1993) PromotingHealthyBehaviorinYoung Women(1994) Gender Based Biology: What Does It Mean and Why Does It Matter?(1995) GeneticsandWomen shealth(1996) TowardaWomen shealthoutcomesresearchagenda (1997) Bridging the Gap between Basic and Clinical Research: Neurology, Immunity,andPharmacology(1998) Frontiers of Sex-Based Biology: Musculoskeletal Health, Metabolism anddigestivediseases(1999) NutritionResearch:The UniqueNeeds ofwomen(2000) Frontiers of Sex-Based Biology: Drug Addiction, Sexually Transmitted Diseases,Pain(2000) SexDifferencesin Neuroscience(2002) SexDifferencesin Lung Cancer:FromGenes tobehavior(2003)
4 Regional SAM Meetings Held in response to the April 2001 Institute of Medicine (IOM) report, "Exploring the Biological Contributions to Human Health: Does Sex Matter? Subgroup Analysis and Statistical Design in Clinical Research, Washington, DC (July 2001) Sex Differences in Autoimmunity, Boston MA (November 2001) Sex Differences in Fetal and Neonatal Development, Stanford, CA (March 2002) Sex Differences in Cardiovascular Disease, Madison, WI (July 2002) Sex Differences in Environmental Exposures, Research Triangle Park, NC (November 2002)
5 Sex And Gene Expression Conference From , SWHR convened 7 SAGE conferences that focused on the emerging field of sex-based biology. These conferences explored the frontiers of how biological sex influences the expression of genetic information throughout life-from embryonic development through adulthood Participants included leading established researchers and new researchers in biochemistry, genetics, and molecular, developmental, and cellular biology
6 What A Difference An X Makes: The State of Women s Health Research Scientific conference designed to raise awareness about the importance of sex differences in various diseases and conditions that affect both men and women or woman disproportionately 2008-October 3 rd 2010-July 16 th 2011-July 22 nd Geared towards a multidisciplinary audience: Academic researchers, service providers (clinicians and nurses), patient advocacy groups, federal agency employees, representatives of the pharmaceutical industry, media reporters, and science writers, etc
7 SWHR Interdisciplinary Networks Interdisciplinary Studies in Sex-differences (ISIS) Networks : Sex, Gender, Drugs and the Brain Metabolism Musculoskeletal Health Cardiovascular Disease SWHR/Susan G. Komen Network for the Study of Exercise and Breast Cancer
8 Organization for the Study of Sex Differences (OSSD) Established by SWHR in 2006 OSSD is the only scientific membership society in North America dedicated to promoting interdisciplinary research on biological sex differences Annual conference Biology of Sex Differences (BSD) is the official journal of the Organization for the Study of Sex Differences
9 Recent Journal Reporting of Sex Differences Of Mice and Women: The Bias in Animal Models (Science, Vol. 327, 26 March 2010) Putting gender on the agenda (Nature Vol. 465, Issue no. 7299, 10 June 2010) Enrolling Pregnant Women in Research-Lessons from the H1N1 Influenza Pandemic (NEJM, 362;24, 6/17/2010
10 SWHR 2010 Journal Survey Journals reviewed: 1. Journal of the National Cancer Institute (JNCI) 2. Circulation Journal 3. Journal Of the American Medical Association (JAMA) 4. New England Journal of Medicine (NEJM) 5. Endocrinology 6. The American Journal of Physical Medicine & Rehabilitation 7. British Medical Journal 8. Lancet 9. Immunology 10. Gastroenterology 11. Urology
11 SWHR 2010 Journal Survey Journal of the National Cancer Institute (JNCI) Methods. Where appropriate, clinical and epidemiologic studies should be analyzed to see if there is an effect of sex or any of the major ethnic groups. If there is no effect, it should be so stated in Results. Circulation Journal General Preparation Instructions. Please provide sexspecific and/or racial/ethnic-specific data when appropriate, in describing the outcomes of epidemiologic analyses or clinical trials; or specifically state that no sexbased or racial/ethnic-based differences were present.
12 Federal Agencies Federal Agencies NIH/FDA IOM recommendation sent a clear message that sex is important variable through every sphere of biomedical research Need for data standardization across trial sites VA/DoD Special Edition, Women s Health Issues (2011) 18 peer reviewed articles on current status of women s health research and treatment. Vogt, et al (2011) Females report only slightly less exposure to combat than males. No differences in reports of perceived threat in war zone, resilience appears similar across genders
13 SEXX MATTERS! Thank You
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