Partnerships for Vaccines Forum
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1 October 30, 2018 Partnerships for Vaccines Forum PATH s 40+ years of transformative innovation Steve Davis President & CEO, PATH
2 Photos: PATH/Aaron Joel Santos, PATH/Gabe Bienczycki, PATH/Gabe Bienczycki Partnerships for Vaccines Forum 2
3 Partnerships for Vaccines Forum 3
4 Partnerships for Vaccines Forum 4
5 Partnerships for Vaccines Forum PATH VACCINES 5
6 PATH VACCINES - Center for Vaccine Innovation & Access (CVIA) Pre-clinical & Clinical Strategies, Partnerships & Support Introduction Design & Studies Vaccine Development Partnerships Across Value Chain, Including PQ Support Immunization Data and Digital Tools. Delivery & Cold Chain Tools Policy, Advocacy, Market Shaping and Support 6 The PATH Center for M
7 Partnerships for Vaccines Forum PDP - Product Development Partnership A unique, non-profit business model bringing together public, private, academic and philanthropic sectors to develop technologies for global health. PDPs pave the way for new research on infectious diseases and accelerate the development of safe and effective vaccines, drugs and diagnostics for the most vulnerable populations as quickly and cheaply as possible. Sharing the risk Sharing the cost 7
8 Photos: PATH/Gabe Bienczycki, PATH/Gabe Bienczycki, PATH/Doune Porter Partnerships for Vaccines Forum PATH CVIA in action Priming a local manufacturer to fill a critical market gap PATH helped Bharat Biotec of India build the technical capacity to produce a highquality, low-cost rotavirus vaccine. ROTAVAC is a success story for improving affordable vaccine supply and tackling diarrhea in India and 8 around the world. Developing and introducing a vaccine in record time In partnership with the WHO and Serum Institute of India, PATH helped develop and deliver MenAfriVac, a vaccine developed specifically for Africa. The vaccine has virtually eliminated group A meningitis wherever it s been introduced. Improving supply and accessibility for polio eradication PATH provided technical assistance to Beijing Bio-Institute Biological Products in the key, early stages of WHO prequalification for its new bivalent oral polio vaccine. The vaccine will meet increased demand during this critical phase of polio eradication.
9 October 30, 2018 PATH Vaccines portfolio* includes over two dozen vaccines in development and use across 17 disease targets DISCOVERY PRECLINICAL PHASE 1 PHASE 2 PHASE 3 & REG/PQ PILOT /LAUNCH SCALE-UP HPATIC nopv 1/3 Shigella Invaplex AR-DETOX Shigella WRSS1 wsp ETEC ETVAX Respiratory syncytial virus BRV-SIIPL ROTAVAC - 5CM HPV Pfs230 IPV-dmLT ch11/1 LAIV ETEC FTA monovalent Yellow fever Shigella Sf2aWC monovalent pprts,s/as01 bopv Typhoid (TyVAC) MenAfriVac ETEC ST Truncated Shigella WC Pfs48/48 (transmission blocking) AB317 (anti-infection) SIIPL Q-LAIV, cell based nopv 2 CPS CHMI MCV-5 Maternal pertussis P2-VP8 trivalent BRV-WIBP Butantan seasonal BCHT LAIV-S SIIPL PCV10 Torlak TIV-S JE MR combination GBS hexavalent ch8/1 LAIV eerts,s/as01 Transgenic P. berghei Pfs25-EPA/AS01 & Pfs230- EPA/AS01 IVAC A/H5N1 IVAC Flu-S ENTERIC AND DIARRHEAL DISEASES MALARIA RESPIRATORY INFECTIONS AND MATERNAL IMMUNIZATION ZOONOTIC, EMERGING, AND SEXUALLY TRANSMITTED DISEASES OTHER Rotavirus ETEC/ Shigella Polio Typhoid Malaria Maternal Influenza Pneumococcus Meningococcus Human papillomavirus Japanese encephalitis Other * Portfolio snapshot current as of June 2018; does not include new/ongoing proposal development work in dengue, Zika, or Ebola, nor ongoing support to the Expanded Programme on Immunization in multiple countries. 9 CENTER FOR VACCINE INNOVATION & ACCESS
10 All of our work is built on trusted partnerships MNCs & Research Centers Public & Private Funders Developing Country Manufacturers Other PDPs & NGOs New Partners: MRI, CEPI & Others
11 Partnerships for Vaccines Forum A 15-year, multi-sector partnership became a turning point in the battle to protect children against Japanese Encephalitis 11
12 PATH/Rocky Prajapati; Partnerships for Vaccines Forum A brief introduction to Japanese encephalitis 12
13 Photos: (clockwise from left) PATH/Aaron Joel Santos, PATH/Rocky Prajapati, PATH/Rocky Prajapati, PATH/Rocky Prajapati, Partnerships for Vaccines Forum 13
14 Partnerships for Vaccines Forum A historic moment. WHO prequalification of CDIBP s JE vaccine signaled China s emergence in the global vaccine marketplace. 14
15 Partnerships for Vaccines Forum 15
16 Partnerships for Vaccines Forum 300 million Children vaccinated against JE 16
17 Photos: (clockwise from left) PATH/Aaron Joel Santos, PATH/Rocky Prajapati, PATH/Rocky Prajapati, Bill & Melinda Gates Foundation Partnerships for Vaccines Forum 17
18 Partnerships for Vaccines Forum Mind the gap : A second valley of death? 18
19 Second Valley of Death Implementation Gap Translation gap Implementation gap Discovery Preclinical Phase I-III Registration WHO policy & PQ Implementation studies Financing & Procurement Uptake
20 PATH/Rocky Prajapati; Partnerships for Vaccines Forum 20
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