Curriculum Vitae Last Update: 8/6/2018
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1 Curriculum Vitae Last Update: 8/6/2018 PERSONAL DATA Name: Karen E. James Citizenship: United States EDUCATION Years Degree Institution (Area of Study) B.A. Cornell University College of Arts and Sciences (Biology wirh concentration in Microbiology) Ithaca, NY M.D. Tufts University School of Medicine (Medicine) Boston, MA Intern University of Rochester Medical Center, Golisano Children s Hospital (Pediatrics) Rochester, NY Resident University of Rochester Medical Center, Golisano Children s Hospital (Pediatrics) Rochester, NY Fellow The Children s Hospital of Philadelphia (Rheumatology) Philadelphia, PA M.S. University of Pennsylvania (Clinical Epidemiology) Philadelphia, PA BOARD CERTIFICATIONS 10/24/ American Board of Pediatrics (Pediatrics), Certified Present 03/29/ American Board of Pediatrics (Sub: Peds Rheumatology), Certified Present CURRENT LICENSES/CERTIFICATIONS Present State License (UT) - Physician (MD) ACADEMIC HISTORY Pediatrics (Pediatric Immunology and Rheumatology), 09/01/ /18/ /01/2016 Hire, Tenure Track, Instructor Pediatrics (Pediatric Rheumatology), 05/19/ Present 05/19/2017 Division Switch, Instructor PROFESSIONAL EXPERIENCE Full-Time Positions Present Attending Physician, Rheumatology, Primary Children's Hospital, Salt Lake City, UT James, Page 1
2 SCHOLASTIC HONORS 2006 Graduated with Distinction, B.A., Cornell University, College of Arts and Sciences, Ithaca, NY 2010 Glasgow-Rubin Citation for Academic Achievement, American Medical Women s Association 2011 Strong Star Award, employee recognition award, patient nominated, University of Rochester Medical Center, Golisano Children s Hospital at Strong, Rochester, NY 2013 Travel Award, American College of Rheumatology Annual Meeting 2014 Travel Award, American College of Rheumatology Annual Meeting 2015 Travel Award, American College of Rheumatology, Rheumatology Research Workshop 2015 Pediatric Research Award, Rheumatology Research Foundation 2018 CARRA Travel Award for VERITY-Brigham Course in Rheumatology Clinical Research ADMINISTRATIVE EXPERIENCE Administrative Duties Co-Author & Co-Organizer, Children's Hospital of Developed and maintained a repository of letters of medical necessity for divisional use Present Coding and Compliance- Physician Champion for the Division of Pediatric Rheumatology, University of Utah Work with coding representatives to improve accuracy in coding of diseases and severity, and with physicians in the division to improve documentation to support accurate coding Present ICentra Physician Advocate, Division of Rheumatology- assist division with trouble-shooting division specific Icentra issues and implementation of improvements. Professional Organization & Scientific Activities Present Subcommittee Member, Childhood Arthritis & Rheumatology Research Alliance, Anti-Neutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis Workgroup Collaborating with international Pediatric Rheumatologists to develop a consensus treatment plan for ANCA-Associated Vasculitis Present Subcommittee Member, Childhood Arthritis & Rheumatology Research Alliance, Chronic Recurrent Multi-Focal Osteomyelitis (CRMO) Working Group Collaborating with other Pediatric Rheumatologists to develop classification criteria for CRMO Present Subcommittee Member, Childhood Arthritis & Rheumatology Research Alliance, Sjögren's Working Group Collaborating with other Pediatric Rheumatologists to develop diagnostic algorithms and improve care for Pediatric Sjögren's Syndrome Present Literature Review Team Member, Vasculitis Guidelines, American College of Rheumatology, Invited member of team performing the comprehensive literature search for the development of the American College of Rheumatology's guidelines for the diagnosis and management of several forms of vasculitis, including ANCA- Associated Vasculitis, Takayasu's, Giant Cell Arteritis, Kawasaki Disease, Polyarteritis Nodosa. James, Page 2
3 UNIVERSITY COMMUNITY ACTIVITIES Division Level Present Clinical Director, University of Utah, Developed program to provide point of care joint ultrasounds for Pediatric Rheumatology Division CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES Alpha Omega Alpha American College of Rheumatology Childhood Arthritis & Rheumatology Research Alliance FUNDING Pending Grants 07/01/19-06/30/22 Investigator Award "A Population-Based Study of ANCA-Associated Vasculitis" Principal Investigator: Karen E. James Rheumatology Research Foundation Role: Principal Investigator Past Grants 07/01/14-06/30/15 Clinical Pharmacoepidemiology Training Grant National Institutes of Health Role: Awardee 08/01/15-06/30/16 Amgen Fellowship Training Award American College of Rheumatology/Research and Education Foundation/Amgen Role: Awardee Active Contracts 03/20/17-08/15/18 Pediatric Vasculitis Initiative Principal Investigator: David Cabral University of British Columbia Role: Site Principal Investigator 07/01/17-06/30/19 NIH Pediatric Research Loan Repayment: "ANCA Testing in a Pediatric Population National Institute of Allergy and Infectious Diseases Role: Awardee 09/14/17 - Present Protocol A : Efficacy, Safety, Tolerability, and Pharmacokinetics of Tofacitinib for Treatment of Systemic Juvenile Idiopathic Arthritis (sjia) with Active Systemic Features in Children and Adolescent Subjects Pfizer, Inc. Role: Site Sub-Investigator Past Contracts 04/04/17-04/01/18 Secukinumab (AIN457)-A three-part randomized, double-blind, placebocontrolled study to investigate the efficacy and safety of secukinumab treatment in Juvenile Idiopathic arthritis subtypes of psoriatic and enthesitis-related arthritis Novartis Role: Site Principal Investigator James, Page 3
4 TEACHING RESPONSIBILITIES/ASSIGNMENTS Small Group Teaching 2009 Facilitator, Tufts University School of Medicine, Interviewing and the Patient- Doctor Relationship Fellow Educator, Children's Hospital of Philadelphia, Resident education on general rheumatology topics, including bedside teaching, and hands on workshop for residents on how to perform a joint exam. Trainee Supervision Fellow Present Supervisor, University of Utah. Education of adult Rheumatology fellows during inpatient rounds Present Supervisor, University of Utah. Precept weekly clinic for adult rheumatology fellows to see pediatric rheumatology patients. Resident Present Supervisor, University of Utah. Education of pediatric residents during inpatient Rounds. Educational Lectures Didactic Lectures Department/Division Conferences 2013 Long term safety and efficacy of rilonacept in patients with systemic juvenile idiopathic arthritis, Pediatric Rheumatology Journal Club, Children s Hospital of 2013 Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies, Pediatric Rheumatology journal club, Children s Hospital of 2013 Efficacy of rituximab for remission induction in ANCA-associated vasculitis, Pediatric Rheumatology Journal Club, Children s Hospital of Philadelphia, Philadelphia PA 2014 Efficacy of rituximab for remission induction in ANCA-associated vasculitis, Pediatric Rheumatology journal club, Children s Hospital of Philadelphia, Philadelphia, PA 2014 Anti-proteinase 2 antibodies as a marker of relapse in granulomatosis with polyangiitis, Pediatric Rheumatology Journal Club, Children s Hospital of 2014 Morphea and neurological changes, Pediatric Rheumatology and Neurology Joint Conference, Children s Hospital of Philadelphia, Philadelphia PA 2014 Impact of Medication Withdrawal Method on Flare-free Survival in Patients with Juvenile Idiopathic Arthritis on Combination Therapy, Pediatric Rheumatology Journal Club, Children s Hospital of 2015 Blood flow in the hands of systemic sclerosis patients with ulcers, Pediatric Rheumatology Journal Club, Children s Hospital of 2015 AAV: Use of plasma exchange for hospitalized children, Penn Rheumatology Trainee Research Day, University of Pennsylvania, Philadelphia, PA James, Page 4
5 PEER-REVIEWED JOURNAL ARTICLES 1. Garner MR, James KE, Callahan MC, Wiedmann M, Boor KJ (2006). Exposure to salt and organic acids increases the ability of Listeria monocytogenes to invade Caco-2 cells but decreases its ability to survive gastric stress. Appl Environ Microbiol, 72(8), James KE, Xiao R, Merkel PA, Weiss PF (2017). Clinical course and outcomes of childhood-onset granulomatosis with polyangiitis. Clin Exp Rheumatol, 35 Suppl 103(1), James KE, Xiao R, Merkel PA, Weiss PF (2017). Variation in the Treatment of Children Hospitalized With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in the US. Arthritis Care Res (Hoboken), 69(9), PENDING PUBLICATIONS Journal Articles 1. James KE, Xiao R, Merkel PA, Weiss PF. Effect of early treatment and renal morbidity on readmission in children hospitalized with anti-neutrophil cytoplasmic antibody associated vasculitis Manuscript under revisions for resubmission 1. Molin NL Graham ME James KE Park AH. ENT Manifestations of Granulomatosis with Polyangiitis in a Pediatric Population. Manuscript in preparation. (Last 3 Years) 1. James KE, Xiao R, Merkel PA, Weiss PF (October 2016). Initiation of Dialysis in Pediatric ANCA- Associated Vasculitis [Abstract]. Arthritis & Rheumatology, 68(suppl 10). UNPUBLISHED POSTER PRESENTATIONS 1. Welsh SS, Rodgers N, James KE, Heinert E, Evers RH, Dadiz R (2013). Implementation of a peercreated multimedia bundle to improve intern and staff satisfaction with neonatal ICU (NICU) orientation. Poster session presented at Pediatric Academic Societies Annual Meeting, Washington D.C. ORAL PRESENTATIONS Invited/Visiting Professor Presentations International 2014 James KE. Rituximab use in free-standing children s hospitals across the United States. National Institutes of Health Pharmacoepidemiology Journal Club, International Webinar. Local/Regional Present James KE. Deficiency of Adenosine Deaminase 2: More Than Vasculitis. Utah Rheumatology Association, 19th Annual Rheumatology Meeting, Salt Lake City, UT Grand Rounds Presentations Nov 2013 James KE. Cytoxan-Rituximab Rounds, Pediatric Rheumatology Grand Rounds Feb 2014 James KE. Cytoxan-Rituximab Rounds, Pediatric Rheumatology Grand Rounds May 2014 James KE. Cytoxan-Rituximab Rounds, Pediatric Rheumatology Grand Rounds June 2014 James KE. Immunosuppression and Progressive Multifocal Leukoencephalopathy. James, Page 5
6 Oct 2014 June 2015 Rheumatology Grand Rounds Conference Series, Children s Hospital of James KE. Cytoxan-Rituximab Rounds, Pediatric Rheumatology Grand Rounds James KE. Complement Deficiencies in Systemic Lupus Erythematosus. Rheumatology Grand Rounds Conference Series, Children s Hospital of OTHER SCHOLARLY ACTIVITIES Clinical Studies Present "Chronic Non-bacterial Osteomyelitis (CNO)." This is a division collaboration looking at the presentation and disease course of children with CNO Present "A Population-based Study of ANCA-Associated Vasculitis in Utah." This is a retrospective study that will build a well-characterized, population-based cohort of patients with AAV to describe epidemiology, outcomes, and draw comparisons btw children and adults. This will utilize the genealogies in the Utah Population Database to study the heritability of AAV, and shared heritability with other autoimmune diseases Present "Antineutrophil Cytoplasmic Antibody (ANCA) Testing in a Pediatric Population." This retrospective cohort study looks at performance characteristics of testing specifically in pediatric populations, as well indications used for testing, diseases associated with false positives, and outcomes of those with false positive testing Present "Granulomatosis with polyangiitis cases presenting to Primary Children's Hospital." This is a collaboration with the ENT division, focusing on ENT manifestations in pediatric GPA. James, Page 6
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