NAME: Mary Whooley MD, FACP, FAHA, FACC. era COMMONS USER NAME (credential, e.g., agency login): whooley

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1 BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Mary Whooley MD, FACP, FAHA, FACC era COMMONS USER NAME (credential, e.g., agency login): whooley POSITION TITLE: Professor of Medicine and of Epidemiology and Biostatistics, University of California, San Francisco; Staff Physician and Director of Cardiac Rehabilitation, SF VA Medical Center EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) INSTITUTION AND LOCATION DEGREE DATE FIELD OF STUDY Yale University, New Haven, CT BA 05/1987 Psychology Boston University, Boston, MA MD 05/1991 Medicine University of California, San Francisco, CA Residency 06/94 Internal Medicine University of California, San Francisco, CA Chief Residency 06/96 Internal Medicine University of California, San Francisco, CA Fellowship 06/98 Health Services Research University of California, San Francisco, CA Certificate of Completion 06/13 Implementation Science University of California, San Francisco, CA Board Certification 01/16 Clinical Informatics A. Personal Statement I am a Health Services Research Investigator, Professor of Medicine, Epidemiology and Biostatistics at UCSF, Director of Cardiac Rehabilitation at the San Francisco VA, and Board-certified Clinical Informatician. As a VA Health Services Research fellow, I validated a 2-question screening instrument for depression that is commonly referred to the Whooley questions and used internationally (JGIM, 1997). I then served as Principal Investigator of the VA- and NHLBI-funded Heart and Soul Study, a 15-year longitudinal study, which demonstrated that the adverse cardiovascular outcomes associated with depression are largely explained by poor health behaviors, especially physical inactivity (JAMA, 2008). I currently serve as Director of the VA Measurement Science QUERI, PI of PCORI-funded study, entitled Improving Delivery of Patient-Centered Cardiac Rehabilitation, San Francisco site PI for the Million Veterans Program, and UCSF site-pi for the Patient-centered SCAlable National Network for Effectiveness Research (pscanner) project.

2 B. Positions and Honors POSITIONS 7/01-6/94 Resident in Internal Medicine, University of California, San Francisco, UCSF 7/94-6/98 7/94-6/95 Clinical Instructor, Department of Medicine, University of California, San Francisco Staff Physician, San Francisco VA Medical Center, San Francisco 7/95-6/96 Chief Resident in Internal Medicine, University of California, San Francisco 7/96-6/98 Clinical Research Fellow, VA Medical Center and University of California, San Francisco 7/98-present Staff Physician, San Francisco VA Medical Center, San Francisco 7/98-6/04 Assistant Professor in Residence, Departments of Medicine, Epidemiology and Biostatistics 7/04-6/08 Associate Professor in Residence, Departments of Medicine, Epidemiology and Biostatistics 7/08- present Professor in Residence, Departments of Medicine, Epidemiology and Biostatistics, UCSF 7/10- present Vice Chair, Committee on Human Research, University of California, San Francisco 7/11- present Director, UCSF Cardiovascular/Chronic Kidney Disease Outcomes Research Group (CORG) 7/13- present Director of Cardiac Rehabilitation, San Francisco VA Medical Center 7/13-9/15 Associate Director, Chronic Heart Failure (CHF) QUERI 10/15-present Director, Measurement Science QUERI HONORS 1991 Alpha Omega Alpha Honor Medical Society 1992 Julius R. Krevans Award for Clinical Excellence (outstanding medical intern, UCSF) 1993 Keith Johnson Award (outstanding second-year medical resident, UCSF) 1995 Chief Medical Resident, University of California, San Francisco 1998 VA Health Services Research and Development Research Career Development Award 2001 Paul Beeson Physician Faculty Scholars in Aging Research Award 2001 Robert Wood Johnson Foundation Generalist Physician Faculty Scholars Award 2002 VA HSR&D Advanced Research Career Development Award 2002 Hellman Award for Early Career Faculty, University of California, San Francisco 2006 Early Career Award, American Psychosomatic Society 2006 Floyd Rector Resident Research Mentorship Award, UCSF Department of Medicine 2009 Outstanding Mentor of the Year Award, San Francisco Bay Area Clinical Research Symposium 2011 Elected to fellowship, American College of Cardiology (ACC) 2011 Elected to fellowship, American Heart Association (AHA) 2011 Elected to membership, American Society for Clinical Investigation (ASCI) 2014 Elected to membership, Association of American Physicians (AAP) 2015 Stephen B. Hulley Award for Excellence in Teaching the Methods of Clinical Research MEMBERSHIP ON FEDERAL GOVERNMENT COMMITTEES 11/02 Member, NIH Scientific Review Group ZMH1 NRB-G-03-S (Special Emphasis Panel) 3/07 & 11/07 Member, NIH Scientific Review Group ZRG1 BBBP-T-02-M (Special Emphasis Panel) 6/08, 3/09 & Temporary Member, NIH Integrated Review Group, MESH Study Section 6/09 (Biobehavioral Mechanisms of Emotion, Stress, and Health) 10/09 Member NIH Scientific Review Group ZRG1 BBBP-R (02) M (Psychopathology and Addiction Special Emphasis Panel) 6/10 Member, NIH Scientific Review Group 2010/08 ZHL1 CCT-B (C1) (Special Emphasis Panel) Member, NIH Scientific Review Group 2010/08 ZHL1 CCT-B (C2) (Special Emphasis Panel) Member, NIH Scientific Review Group 2010/08 ZHL1 CCT-B (C3) (Special Emphasis Panel) 10/10 Member, NIH Scientific Review Group 2011/01 ZRG1 BBBP-R (06) M (Biobehavioral Mechanisms of Emotion, Stress, and Health Special Emphasis Panel) 1/12 12/14 Member, VA QUERI RRP Study Sections (3 cycles per year)

3 C. Contributions to Science 1) VALIDATED A BRIEF SCREENING INSTRUMENT FOR DEPRESSION (WHOOLEY QUESTIONS) As a VA health services research fellow ( ), I recruited over 500 patients and conducted a primary data collection study to validate a 2-question screening instrument for depression that is now known as the Whooley Questions. Since this study was published (J Gen Int Med, 1997), it has been cited more than 1000 times. More importantly, the Whooley Questions have been used by numerous health care organizations, translated into many languages, and administered to millions of patients throughout the world. The United States Preventive Services Task Force recommended use of this screening instrument in primary care settings (Ann Int Med, 2009), and the National Institute for Health and Care Excellence (NICE) guidelines recommend use of this instrument in the United Kingdom. More information available at a. Whooley MA, Avins AL, Miranda J, Browner WS. Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med Jul; 12(7): PMID: b. Whooley MA, Simon GE. Managing depression in medical outpatients. N Engl J Med 2000;343: PMID: c. McManus D, Pipkin SS, Whooley MA. Screening for depression in patients with coronary heart disease (data from the Heart and Soul Study). Am J Cardiol Oct 15; 96(8): PMID: d. Elderon L, Smolderen KG, Na B, Whooley MA. Accuracy and prognostic value of American Heart Association: recommended depression screening in patients with coronary heart disease: data from the Heart and Soul Study. Circ Cardiovasc Qual Outcomes Sep; 4(5): PMID: e. Whooley M. Screening for depression: A tale of two questions. JAMA Int Med. Online Jan ) DEMONSTRATED THAT THE ASSOCIATION BETWEEN DEPRESSION AND CARDIOVASCULAR DISEASE IS EXPLAINED BY POOR HEALTH BEHAVIORS Depression has long been associated with an increased risk of cardiovascular events, but the mechanisms responsible for this association were unknown. To determine why depression is associated with an increased risk of cardiovascular events, I designed, secured funding for, and assembled The Heart and Soul Study, a prospective cohort of 1024 patients with coronary heart disease who were recruited between and followed for 15 years. This study demonstrated that the increased risk of cardiovascular events associated with depression was not explained by the expected biological mechanisms (e.g., inflammation and increased catecholamines) but rather by poor health behaviors (smoking, medication non-adherence and physical inactivity). Since this study was published (JAMA, 2008), it has been cited more than 500 times. More importantly, it identified a potentially modifiable target (health behaviors) to reduce the excess risk of cardiovascular disease associated with depression. a. Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA. Depressive symptoms and healthrelated quality of life: The Heart and Soul Study. JAMA 2003; 290: b. Whooley MA. Depression and cardiovascular disease. JAMA 2006;295: c. Whooley MA, de Jonge P, Vittinghoff E, Otte C, Moos R, Carney RM, Ali S, Dowray S, Na B, Feldman MD, Schiller NB, Browner WS. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA 2008;300: PMCID: PMC d. Whooley MA. Diagnosis and Treatment of Depression in Adults with Comorbid Medical Conditions: A 52 Year Old Man with Depression. JAMA 2012;307:

4 3) DEMONSTRATED THAT TRADITIONAL (FACILITY-BASED) DELIVERY SYSTEMS FOR CARDIAC REHABILITATION ARE NOT MEETING THE NEEDS OF PATIENTS Exercise-based cardiac rehabilitation is an evidence-based, cost effective therapy that reduces morbidity and mortality following acute myocardial infarction or coronary revascularization. Referral to cardiac rehabilitation is one of 9 performance measures for secondary prevention in patients with ischemic heart disease. Unfortunately, despite its compelling benefits, cardiac rehabilitation is vastly underutilized. We examined utilization rates among eligible Veterans and assessed barriers and facilitators associated with participation in cardiac rehabilitation. We found that the largest barrier to patient participation is geographic distance. Many Veterans live too far from a (VA or non-va) cardiac rehab facility to enroll, and even when nearby programs are available, most patients do not have the time, flexibility, transportation, social support, and/or financial resources to attend. Based on the results of this study, we have implemented a very successful home-based cardiac rehabilitation program at the San Francisco VA. a. Schopfer DW, Takemoto S, Allsup K, Helfrich CD, Ho PM, Forman DE, Whooley MA. Cardiac Rehabilitation Utilization among Veterans with Ischemic Heart Disease. JAMA Int Med 2014;174: PMID: b. Beatty A, Li S, Thomas L, Amsterdam EA, Alexander KP, Whooley MA. Trends in referral to cardiac rehabilitation after myocardial infarction: data from the NCDR J Am Coll Cardiol. 2014;63: PMCID c. Beatty A, Fukuoko Y, Whooley MA. Using Mobile Technology for Cardiac Rehabilitation: A Review and Framework for Development and Evaluation. J Am Heart Assoc. 2013; 2(6):e PMCID d. Doll JA, Hellkamp A, Ho PM, Kontos MC, Whooley MA, Peterson ED, Wang TY. Participation in Cardiac Rehabilitation Programs Among Older Patients After Acute Myocardial Infarction. JAMA Int Med. 2015; 175(10): ) DEMONSTRATED ASSOCIATIONS BETWEEN HUMAN GENOTYPES and CLINICAL PHENOTYPES As Principal Investigator of The Heart and Soul Study, I collected blood samples from 1024 patients with coronary heart disease and extracted DNA from these samples for Taqman (Single Nucleotide Polymorphism) genotyping and for measurement of leukocyte chromosome telomere length (via polymerase chain reaction). This work produced several epidemiological studies linking human genotypes with various clinical phenotypes. a. Otte C, McCaffery J, Ali S, Whooley MA. Association of a serotonin transporter polymorphism (5- HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study. Am J Psychiatry Sep; 164(9): PMID: b. Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study. PLoS One. 2010; 5(10):e PMID: ; PMCID:PMC c. Kangelaris KN, Vittinghoff E, Otte C, Na B, Auerbach AD, Whooley MA. Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. J Gen Intern Med Oct; 25(10): PMID: ; PMCID: PMC d. Farzaneh-Far R, Lin J, Epel ES, Harris WS, Blackburn EH, Whooley MA. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA Jan 20; 303(3): PMID: ; PMCID: PMC Complete List of >200 Published Articles Is Available at:

5 D. Research Support ONGOING RESEARCH SUPPORT 1 IP1 HX (QUE ), Measurement Science QUERI (PI: Whooley) Title: Measurement Science QUERI Goal: To promote the standardization of quality measurements for VA healthcare delivery. Role: PI CSPG002, VA Genomic Medicine Program (Co-PIs: Gaziano + Concato) Title: Million Veterans Program Goal: To advance healthcare by incorporating genetic information in clinical decision making. Role: Site PI for San Francisco VA NRI (PI: Park) Title: Mobile Health Strategies for Veterans with Coronary Heart Disease Goal: To compare the effect of text messaging vs. smart-phone app on med adherence Role: Co-investigator CDRN , Patient-Centered Outcomes Research Institute (PI: Ohno-Machado) Title: Patient-centered SCAlable National Network for Effectiveness Research Goal: To standardize electronic medical records across multiple healthcare organizations. Role: Site PI for UCSF IH , Patient-Centered Outcomes Research Institute (PI: Whooley) Title: Enhancing Delivery of Patient-Centered Cardiac Rehabilitation Goal: To compare referral to home-based vs. facility-based cardiac rehabilitation programs. Role: PI R01MH (PI: Ekstrand) Title: Improving Mental Health Through Integration with Primary Care in Rural India Goal: To improve treatment of mental health through integration with primary care. Role: Co-I UCSF CTSI Career Development (KL2) Award (PI: Schopfer) Title: Delivery of Cardiac Rehabilitation in Patients with Heart Failure Role: Primary Mentor UCSF CTSI Career Development (KL2) Award (PI: Park) Title: Mobile Health Strategies to Improve Medication Adherence in Coronary Heart Disease Role: Primary Mentor UL1 RR (PI: Grandis/Grady) Title: UCSF Clinical and Translational Science Institute (CTSI) Goal: To enhance Clinical and Translational research at UCSF. Role: Course director for Building a Career in Clinical Research 10/1/15 to 9/30/20 10/1/15 to 9/30/20 12/1/16 to 11/30/20 10/1/15 to 9/30/18 4/1/14 to 3/31/17 7/1/14 to 6/1/19 7/1/14 to 6/30/19 7/1/15 to 6/30/19 7/01/11 to 6/30/16 COMPLETED RESEARCH SUPPORT (last 3 years) HX-RRP (PI: Whooley) Cardiac Rehabilitation in VHA UCSF CTSI Career Development (KL2) Award (PI: Beatty) Implementing Cardiac Rehabilitation in Patients with Ischemic Heart Disease. Role: Mentor 10/1/12 to 9/30/14 7/1/13 to 6/30/14