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1 BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Malow, Beth Ann Professor of Neurology and Pediatrics era COMMONS USER NAME (credential, e.g., Burry Chair in Cognitive Childhood Development agency login) EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) INSTITUTION AND LOCATION DEGREE (if applicable) MM/YY FIELD OF STUDY Northwestern University, Evanston, IL BS 06/84 Medical Science Northwestern University, Chicago, IL MD 06/86 Medicine School of Public Health, University of Michigan, Ann Arbor, MI MS 04/97 Clinical Research A. Personal Statement Dr. Malow will serve as a collaborator on this proposal. She is the Associate Director of Vanderbilt s Clinical Research Center, Director of Vanderbilt s Sleep Core, Principal Investigator for Vanderbilt s Autism Treatment Network (ATN), and Director of the Vanderbilt Sleep Division. Dr. Malow holds a Master Degree in Clinical Research Design and Statistical Analysis from the University of Michigan. She has served as PI on an NIH/NICHD clinical trial using supplemental melatonin to treat insomnia in children with autism and also as PI on a Health Resources and Services Administration-funded multicenter clinical trial of parent sleep education in children with autism. Her role on this project will be to serve as a mentor, advisor, and expert scientific reviewer. B. Positions and Honors Research Associate, Burke Rehabilitation Center, Cornell University, White Plains, New York Intern, Beth Israel Medical Center, New York, New York Resident, Harvard-Longwood Neurological Training Program, Boston, Massachusetts Postdoctoral Fellow, Clinical Neurophysiology, National Institutes of Health, Bethesda, Maryland Assistant Professor of Neurology, Department of Neurology, University of Michigan Associate Professor of Neurology, Department of Neurology, University of Michigan, Ann Arbor, Michigan (with tenure) Associate Professor of Neurology and Division Chief, Sleep Disorders, Department of Neurology, Vanderbilt University, Nashville, Tennessee (with tenure) 2007-Pres Professor of Neurology and Division Chief, Sleep Disorders, Department of Neurology, Vanderbilt University, Nashville, Tennessee (with tenure) 2003-Pres Medical Director, Vanderbilt Sleep Disorders Center, Vanderbilt University, Nashville, Tennessee 2003-Pres Investigator, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 2004-Pres Associate Director, Vanderbilt Clinical Research Center, Vanderbilt University, Nashville, Tennessee 2005-Pres Director, Vanderbilt Sleep Research Core, Vanderbilt University, Nashville, Tennessee 2010-Pres Professor of Pediatrics (Secondary Appointment) 2011-Pres Burry Chair in Cognitive Childhood Development
2 Honors 1985 Alpha Omega Alpha, Northwestern University 2002 Elected Member, American Neurological Association (ANA) 2007, 09, 10 Professional Research Consultants (PRC) Five Star Customer Service Award for Excellence in Quality of Physician Care (top 10% of physicians nationally) 2008 Health Care Provider Award, Mayor s Advisory Committee for People with Disabilities 2009 Pfizer Visiting Professorship in Neurology 2010 Robert Haslam Lectureship in Pediatrics, Hospital for Sick Children, Toronto 2011 Burry Chair in Cognitive Childhood Development, Department of Pediatrics 2012 Sleep Science Award, American Academy of Neurology Experience Clinical Research Subcommittee, American Academy of Neurology (AAN) Research Committee, American Academy of Sleep Medicine Scientific Program Subcommittee, Sleep Disorders Topic Chair, AAN 2001-Pres. Ad-hoc Reviewer, NIH-NINDS Clinical Trials Study Section Science Committee, AAN 2008-Pres Chair, ANA/NINDS Career Development Symposium 2009 NIMH Review Panel for ARRA Projects in Autism Spectrum Disorders 2012 Scientific Program Committee, International Meeting for Autism Research C. Selected Peer-Reviewed Publications (17 out of 79 total) 1. Malow BA. Weatherwax K, Chervin R, Hoban T, Marzec M, Martin C, Binns L. Identification and treatment of obstructive sleep apnea in adults and children with epilepsy: a prospective pilot study. Sleep Medicine 2003; 4: PMID: Sacco R, Malow BA, Williams LS. The state of patient-oriented research in neurology. Neurology 2004;62(7): PMID: Malow BA, Marzec ML, McGrew SG, Wang L, Henderson LM, Stone WL. Characterizing sleep in children with autism spectrum disorders: A multidimensional approach. SLEEP 2006;29(12): PMID: McGrew SG, Malow BA, Henderson L, Wang L, Song Y, Stone WL. A developmental and behavioral questionnaire for autism spectrum disorders. Pediatric Neurology 2007; 37(2): PMID: Andersen IM, Kaczmarska J, McGrew SG, Malow BA. Melatonin for insomnia in children with autism spectrum disorders. Journal of Child Neurology 2008; 23(5): PMID: Malow BA, Foldvary-Schaefer N, Vaughn BV, Selwa LM, Chervin RD, Weatherwax KJ, Wang L, Song, Y. Treating obstructive sleep apnea in adults with epilepsy: A randomized pilot trial. Neurology 2008; 71(8): PMID: Malow BA, Crowe C, Henderson L, McGrew S, Wang L, Song Y, Stone WL. A Sleep Habits Questionnaire for Children with Autism Spectrum Disorders. Journal of Child Neurology 2009; 24(1): PMID: Reed HE, McGrew SG, Artibee K, Surdyka K, Goldman SE, Frank K, Wang L, Malow BA. Parent-based sleep education workshops in autism. Journal of Child Neurology 2009;24(8): PMID: Goldman SE, Surdyka K, Cuevas R, Adkins K, Wang L, Malow BA. Defining the Sleep Phenotype in Children with Autism. Dev Neuropsychol Sep;34(5): PMID: Leu RM, Beyderman L, Botzolakis EJ, Surdyka K, Wang L, Malow BA. Relation of Melatonin to Sleep Architecture in Children with Autism. J Autism Dev Disord Aug 4. PMID: Goldman SE, McGrew S, Johnson KP, Richdale AL, Clemons T, and Malow BA. Sleep is associated with problem behaviors in children and adolescents with autism spectrum disorders. Research in Autism Spectrum Disorders 2011; 5:
3 12. Goldman SE, Richdale AL, Clemons T, and Malow BA. Sleep behaviors in autism spectrum disorders Variations in age from early childhood through adolescence. Journal of Autism and Developmental Disorders (4): Adkins KW, Goldman SE, Fawkes D, Surdyka K, Wang L, Song Y, Malow BA. A pilot study of shoulder placement for actigraphy in children. Behavioral Sleep Medicine 10(2): Goldman SE, Surdyka K, Bichell T, Malow BA. Sleep in Children and Adolescents with Angelman Syndrome: Association with Parent Sleep and Stress. Journal of Intellectual Disability Research 2012; 56(6): Malow BA, Adkins KW, McGrew SG, Wang L, Goldman SE, Fawkes D, Burnette C. Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes. Journal of Autism and Developmental Disorders 2012;42(8): Malow BA, Byars K, Johnson K, Weiss S, Bernal P, Goldman SE, Panzer R, Coury D, Glaze DG. A practice pathway for the identification, evaluation and management of insomnia in children and adolescents with autism spectrum disorders. (Pediatrics, in press) 17. Adkins KW, Molloy C, Weiss SK, Reynolds A, Goldman SE, Burnette C, Clemons T, Fawkes D, Malow BA. Effects of a standardized pamphlet on insomnia in children with autism spectrum disorders. (Pediatrics, in press) D. Research Support Ongoing Research Support Autism Speaks Malow (PI) 01/01/11 12/31/13 Autism Treatment Network Clinical Treatment Center The major goal of the project is to establish an Autism Treatment Network site at Vanderbilt to develop standards of care for the medical management of children with autism spectrum disorders. Role: Site PI and Sleep Specialist. Dr. Malow also is the facilitator for the ATN sleep subcommittee. NIH/NINDS 1 U10 NS Malow (PI) 09/30/11-08/31/18 Vanderbilt Site for Network of Excellence in Neuroscience Clinical Trials The major goal of this project is to establish a site for neuroscience clinical trials at Vanderbilt. Health Resources and Services Administration Perrin (PI) 09/01/11 08/31/14 The major goal of this project is to support guideline development within the Autism Treatment Network nationally and at the Vanderbilt site Role: Site Co-PI and Sleep Specialist. Dr. Malow has led the development of a guideline/algorithm to evaluate insomnia in children with autism and is working to disseminate the algorithm at ATN sites. Health Resources and Services Administration Perrin (PI) 04/01/12 08/31/14 Subcontract for Iron Treatment of Sleep Disorders in Children with Autism Spectrum Disorder (Dr. Ann Reynolds, PI) The major goal of this project is to determine the effects of iron supplementation on sleep in children with autism, and the role of restless legs syndrome/periodic limb movements of sleep. Role: Site PI Health Resources and Services Administration Perrin (PI) 03/01/09 08/31/12 Subcontract for Parent-Based Sleep Education Program for Children with Autism Spectrum Disorders The major goal of this project is to develop and test a multicenter nurse-based parent sleep education program for children with autism Role: Principal Investigator on Project Subcontract. Dr. Malow is the overall PI for this multisite project.
4 NIH/NCRR 1 UL1 RR Bernard (PI) 10/01/07 09/30/12 Clinical and Translational Science Award This is an NCRR grant to support Vanderbilt Institute of Clinical and Translational Research. Dr. Malow directs the Vanderbilt Sleep Research Core and is Associate Director of the General Clinical Research Center. Project Director on Administrative Supplement to NIH/NCRR UL1 Measuring Sleep in Autism: Use of Wireless, Comfortable, and Home-Based Tools September 30, 2009-May 31, 2012 NIH/NHLBI RO1-HL DeBaun (PI) 09/01/10 08/31/14 Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia The major goal of this project is to examine the role of asthma and sleep-related breathing on morbidity in children with sickle cell disease. Role: Co-investigator and Director, Sleep Reading Center. Dr. Malow provides centralized scoring of sleep studies for this multisite trial. Autism Speaks Clinical and Translational Research Award Goldman (PI) 02/01/12-01/31/15 Characterization of the Sleep Phenotype in Adolescents and Adults with Autism Spectrum Disorder The major goal of this project is to define the sleep phenotype in adolescents and adults with autism. Role: Co-Investigator Completed Research Support Autism Speaks Stone (PI) 01/01/08 12/31/10 Autism Treatment Network Clinical Treatment Center The major goal of the project is to establish an Autism Treatment Network site at Vanderbilt to develop standards of care for the medical management of children with autism spectrum disorders. Role: Site co-pi and Sleep Specialist; Chair of ATN Sleep Committee. Health Resources and Services Administration Perrin (PI) 09/01/08 08/31/11 The major goal of this project is to support guideline development within the Autism Treatment Network nationally and at the Vanderbilt site Role: Site Co-PI and Sleep Specialist. Dr. Malow also has led the development of a guideline/algorithm to evaluate insomnia in children with autism and serves on the NICHQ committee to pilot the algorithm at ATN sites. R01HD Malow (PI) 04/01/08-03/31/11 NIH/NICHD Melatonin for Sleep in Children with Autism: Safety, Tolerability, and Dosing The major goal of this project is to study the dose-response, including pharmacokinetics in relation to polysomnography, of melatonin in children with autism spectrum disorders. ARRA Administrative Supplement to expand pharmacokinetic studies Autism Speaks/National Alliance for Autism Research Malow (PI) 12/15/06-12/14/08 Melatonin for Insomnia in Children with Autism: A Pilot Study The major goal of this project is to pilot a trial of melatonin for insomnia in children with autism. Vanderbilt Kennedy Center Hobbs/Marino Discovery Grant Malow (PI) 10/01/05 12/31/08 Insomnia in Children with ASD: Functional Candidate Polymorphisms The major goal of this project is to explore genetic variants of insomnia in autism spectrum disorders. Organization for Autism Research Malow (PI) 01/01/07-03/31/08 Parental Sleep Education Program for Children with Autism Spectrum Disorders
5 The major goal of this project is to pilot a parental sleep education program for children with autism spectrum disorders, measuring the effects of the intervention on sleep, daytime behavior, and parental stress levels.
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