LIX1 APOD RRM2 FAIM2 MGST1 UHRF1 PPIA BEX1

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1 C2orf80 1

2 C2orf80 A2M ANXA1 APOD ARL4A BEX1 C1S C3 CD44 CHI3L1 CHI3L2 CLU DPYD DSCAM EMP3 FN1 GBP1 GEM GLIPR1 GRIA2 IDH1 LIX1 MAP2 MDK MGST1 MIR3917 NAMPT PCMTD2 PPIA PTN PTPRZ1 S100B SCG3 SERPINA3 TCF12 TRIB2 TSPAN7 UHRF1 APBB3 FAIM2 L2HGDH NDNF RRM2 SFRP4 SPC25 TOPORS Glioblastoma Gliomasphere Target Gene

3 Gliomasphere GO: cell-type specic apoptotic process GO: Inf sodium-dependent phosphate transport GO: Inf phosphate ion homeostasis GO: Inf divalent inorganic anion homeostasis GO: Inf trivalent inorganic anion homeostasis GO: Inf regulation of sodium-dependent phosphate transport GO: Inf negative regulation of sodium-dependent phosphate transport GO: negative regulation of neuron apoptotic process GO: regulation of apoptotic process GO: regulation of programmed cell death GO: regulation of phosphate transport GO: photoreceptor cell outer segment organization GO: keratinocyte apoptotic process GO: regulation of keratinocyte apoptotic process GO: positive regulation of keratinocyte apoptotic process GO: negative regulation of neuron death GO: regulation of cell death GO: retinal cone cell dierentiation GO: retinal cone cell development GO: monovalent inorganic anion homeostasis GO: regulation of neuron apoptotic process GO: neuron apoptotic process GO: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan GO: cerebellar granular layer development GO: cerebellar Purkinje cell layer morphogenesis GO: cerebellar Purkinje cell layer formation GO: cerebellar Purkinje cell dierentiation GO: positive regulation of epidermal cell dierentiation GO: retinal rod cell development GO: regulation of neuron death GO: apoptotic process GO: programmed cell death GO: phosphate ion transport GO: deoxyribonucleoside diphosphate metabolic process GO: positive regulation of epidermis development GO: negative regulation of apoptotic process GO: negative regulation of programmed cell death GO: neuron death GO: cell death GO: death GO: cell dierentiation in hindbrain GO: camera-type eye photoreceptor cell dierentiation GO: negative regulation of cell death GO: positive regulation of receptor internalization GO: oxoglutarate metabolic process GO: retina layer formation GO: cerebellar cortex formation GO: negative regulation of anion transport 3

4 Glioblastoma GO: e complement activation GO: e inammatory response GO: e defense response GO: e protein activation cascade GO: e platelet degranulation GO: e immune system process GO: e response to stimulus GO: e humoral immune response mediated by circulating immunoglobulin GO: e immune response GO: e humoral immune response GO: e acute inammatory response GO: e response to wounding GO: e single-multicellular organism process GO: multicellular organismal process GO: platelet activation GO: response to stress GO: wound healing GO: immunoglobulin mediated immune response GO: B cell mediated immunity GO: cytokine production GO: negative regulation of hydrolase activity GO: interleukin-8 secretion GO: blood coagulation GO: hemostasis GO: coagulation GO: system development GO: negative regulation of peptidase activity GO: negative regulation of endopeptidase activity GO: secretion by cell GO: extracellular matrix disassembly GO: peptide cross-linking GO: regulation of complement activation GO: regulation of protein activation cascade GO: regulation of peptidase activity GO: nervous system development GO: exocytosis GO: learning or memory GO: single-organism developmental process GO: regulation of proteolysis GO: cell dierentiation GO: regulation of lipid metabolic process GO: regulation of humoral immune response GO: developmental process GO: regulation of body uid levels GO: negative regulation of catalytic activity GO: regulation of cytokine production GO: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO: regulation of multicellular organismal process GO: cognition GO: innate immune response GO: secretion GO: lipid localization GO: leukocyte migration GO: response to glucocorticoid GO: gliogenesis GO: response to corticosteroid GO: acute-phase response GO: regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO: axon development GO: interleukin-8 production GO: positive regulation of cellular metabolic process GO: cellular developmental process GO: neurogenesis GO: negative regulation of cytokine production GO: multicellular organismal development GO: regulation of acute inammatory response GO: prostate gland development GO: regulation of inammatory response GO: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily do GO: negative regulation of proteolysis GO: positive regulation of axon extension GO: response to interleukin-1 4

5 GO: lymphocyte mediated immunity GO: response to steroid hormone GO: negative regulation of response to DNA damage stimulus GO: adaptive immune response GO: negative regulation of protein metabolic process GO: negative regulation of protein processing GO: proteolysis GO: peptide metabolic process GO: organ development GO: Inf microglial cell activation GO: Inf type IIa hypersensitivity GO: Inf regulation of type IIa hypersensitivity GO: Inf positive regulation of type IIa hypersensitivity GO: Inf positive regulation of activation of membrane attack complex GO: Inf type II hypersensitivity GO: Inf hypersensitivity GO: Inf regulation of hypersensitivity GO: Inf positive regulation of hypersensitivity GO: Inf regulation of type II hypersensitivity GO: Inf positive regulation of type II hypersensitivity GO: Inf positive regulation of humoral immune response GO: Inf glyoxylate cycle GO: Inf purine nucleobase catabolic process GO: Inf uracil catabolic process GO: Inf thymidine catabolic process GO: Inf NADPH regeneration GO: Inf nicotinamide metabolic process GO: Inf uncoating of virus GO: Inf beta-alanine metabolic process GO: Inf beta-alanine biosynthetic process GO: Inf uracil metabolic process GO: Inf defecation GO: Inf regulation of prostaglandin biosynthetic process GO: Inf positive regulation of prostaglandin biosynthetic process GO: Inf regulation of neutrophil apoptotic process GO: Inf positive regulation of neutrophil apoptotic process GO: Inf lipoprotein lipid oxidation GO: Inf regulation of lipoprotein oxidation GO: Inf negative regulation of lipoprotein oxidation GO: Inf DNA rewinding GO: Inf interleukin-10 biosynthetic process GO: Inf lipoprotein modication GO: Inf lipoprotein oxidation GO: Inf regulation of interleukin-10 biosynthetic process GO: Inf negative regulation of interleukin-10 biosynthetic process GO: Inf positive regulation of complement activation GO: Inf pyrimidine deoxyribonucleoside catabolic process GO: Inf regulation of lipoprotein lipid oxidation GO: Inf negative regulation of lipoprotein lipid oxidation GO: Inf macrophage proliferation GO: Inf microglial cell proliferation GO: Inf prolactin secretion GO: Inf dendrite self-avoidance GO: Inf cellular response to lipid hydroperoxide GO: Inf neutrophil clearance GO: Inf negative regulation of phospholipase A2 activity GO: Inf regulation of neuronal signal transduction GO: Inf positive regulation of tau-protein kinase activity GO: Inf positive regulation of neurobrillary tangle assembly GO: Inf positive regulation of protein activation cascade GO: Inf negative regulation of T cell migration GO: Inf negative regulation of skeletal muscle cell dierentiation GO: Inf regulation of unsaturated fatty acid biosynthetic process GO: Inf positive regulation of unsaturated fatty acid biosynthetic process GO: cellular amide metabolic process GO: negative regulation of molecular function GO: cell activation GO: regulation of endopeptidase activity GO: activation of immune response GO: regulation of catalytic activity GO: anatomical structure development GO: regulation of protein processing GO: endocrine system development GO: behavior GO: reproductive structure development 5

6 GO: single-organism behavior 6

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