Matthew M. Clasen Cell Phone:

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1 Education 4400 Massachusetts Avenue NW Washington, DC Matthew M. Clasen Cell Phone: The American University Ph.D. Candidate (expected graduation date May, 2018) Behavior, Cognition, & Neuroscience PhD Program Center for Behavioral Neuroscience M.A. in Behavior, Cognition, and Neuroscience (received 5/7/16) Advisor: Anthony Riley PhD. Psychopharmacology Lab GPA: 3.95 James Madison University Graduated May 2014 Degree: B.S. in Psychology Minor: Biology GPA: 3.5 Northern Virginia Community College Graduated May 2011 Degree: Associate of Science Focus: Psychology GPA: 3.8 Academic Awards Belle Haven Country Club: Bag Boy Scholarship Award (November, 2010) Northern Virginia Community College: Award for Academic Excellence in Psychology (April, 2011) James Madison University: Centennial Scholarship Program Award (June, 2011) James Madison University: Outstanding Achievement in Research Award (April, 2013) James Madison University: Dean s Award for Best Research Poster (April, 2013) James Madison University: 11 th Annual Colonial Academic Alliance Undergrad Research Conference Award (April, 2013) James Madison University: National Conference on Undergratuate Research Student Scholarship Award (October, 2013) American University: Center for Behavioral Neuroscience s Summer Research Award Receipient. (April, 2017)

2 Research Grant Awards Travel Grants: Clasen, Matthew. The effect of caffeine and rem sleep deprivation on free operant responding. (October, 2012). $300 received from James Madison University s Department of Psychology to attend and present at the Southeastern Association for Behavior Analysis Conference. Columbia, SC. Clasen, Matthew. Strategic differences on a radial arm maze task in a rodent model of ADHD. (March, 2013) $300 received from James Madison University s Department of Psychology to attend and present at the annual meeting for the Association for Psychological Sciences. Washington D.C. Clasen, Matthew. The effects of brief paradoxical sleep deprivation on radial arm maze performance in the Spontaneously Hypertensive Rat. (March, 2013). $300 received from James Madison University s Department of Psychology to attend and present at the annual meeting for the Associated Professional Sleep Societies. Baltimore, MD. Clasen, Matthew. The effect of cocaine on delay discounting in the Spontaneously Hypertensive Rat. (April, 2013). All expenses paid by James Madison University s Office of Sponsored Events to attend and present at the annual meeting for the Colonial Academic Alliance Undergraduate Research Conference. Newark, DA. Clasen, Matthew. The effect of cocaine on delay discounting in the Spontaneously Hypertensive Rat. (September, 2013). $300 received from James Madison University s Department of Psychology to attend and present at the annual meeting for the Society for Neuroscience. San Diego, CA. Clasen, Matthew. The effect of cocaine on delay discounting in the Spontaneously Hypertensive Rat. (March, 2013). All expenses paid by James Madison University s Office of Sponsored Events to attend and present at the annual meeting for the National Conference on Undergraduate Research. Lexington, KY. Clasen, Matthew. Adolescent drug pre-exposure fails to attenuate taste avoidance conditioning. (January, 2016). Selected to receive a stipend/travel prize that covers expenses to attend and present at and present at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction. San Antonio, Texas. Clasen, Matthew. Cocaine increases permeability in the blood-brain-barrier in the hippocampus: Implications for drug use and abuse. (January, 2017). Selected to receive a stipend/travel prize that covers expenses to attend and present at and present at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction. San Antonio, Texas. Research Grants: Clasen, Matthew. $500 awarded from James Madison University s Department of Psychology for research materials needed to conduct the project, The effect of cocaine on delay discounting in the Spontaneously Hypertensive Rat. (2013) Clasen, Matthew. $1008 awarded from James Madison University s Department of Communication and Speech Disorders for research materials needed to conduct the project, Auditory masking in a rodent model of ADHD. (2013) Clasen, Matthew. $1000 awarded from the Mellon Foundation at American University for research materials needed to conduct the project, The assessment of methylphenidate upon conditioned taste avoidances within adolescence. (2014)

3 Clasen, Matthew. $ awarded from the Mellon Foundation at American University for research materials needed to conduct the project, In vivo manipulation of parabrachial neurons on the aversive effects of cocaine. (2015) Clasen, Matthew. $470 awarded from the Mellon Foundation at American University for research materials needed to conduct the project, Assessment of the discriminative stimulus properties of the second-generation bath salt α-pvp. (2016) Clasen, Matthew. $500 awarded from the Mellon Foundation at American University for research materials needed to conduct the project, Assessing the effects of a western diet on compulsive cocaine intake. (2017) Conference Presentations Bradley, C., Peterson, D., McVay, S., Corbett, T., Henry, E., Sequeira, S., Clasen, M., Crosby, T., & Dyche, J. (2012, October). The Effects of caffeine and REM sleep deprivation on free operant responding under a vi30 s schedule of reinforcement. Poster session presented at the meeting of the Southeastern Association for Behavior Analysis, Columbia, SC. Clasen, M., Sequeira, S., McVay, S., Cooke, C., Houhoulis, S., Jeter, A., Keegan, R., Shemery, A., Williams, D., Yohn, C., Dyche, J., & Holt, D. (2013, April). The effects of cocaine on delay discounting in the spontaneously hypertensive rat. Poster session presented at the meeting of the Virginia Association for Behavior Analysis, Harrisonburg, VA. McVay, S., Clasen, M., Sequeira, S., Cooke, C., Houhoulis, S., Jeter, A., Keegan, R., Shemery, A., Williams, D., Yohn, C. Dyche, J., & Holt, D. (2013, April). The effects of brief paradoxical sleep deprivation on radial arm maze performance. Poster session presented at the meeting of the Virginia Association for Behavior Analysis, Harrisonburg, VA. Clasen, M., Sequeira, S., McVay, S., Cooke, C., Houhoulis, S., Jeter, A., Keegan, Shemery, A., Williams, D., Yohn C., Dyche, J., & Holt, D. (2013, April). The effects of cocaine on delay discounting in the spontaneously hypertensive rat, preliminary data. Poster session presented at the meeting of the Colonial Academic Alliance Undergraduate Research Conference, Lexington, KY. Clasen, M., Sequeira, S., McVay, S., O Malley, J. Shemery, A., Dyche, J., & Holt, D. (2013, November). The effects of cocaine on delay discounting in the spontaneously hypertensive rat. Poster session presented at the meeting of the Society for Neuroscience, San Diego, CA. Clasen, M., Sequeira, S., McVay, S., O Malley, J. Shemery, A., Dyche, J., & Holt, D. (2014, March). The effects of cocaine on delay discounting in the spontaneously hypertensive rat. Poster session presented at the National Conference on Undergraduate Research, Newark, DE. Clasen, M., Sequeira, S., Franssen, C., Dyche, J., & Holt, D. (2014, August). The effects of cocaine on delay discounting in the spontaneously hypertensive rat. Poster session presented at the NIDA/NIAAA and APA Divisions 28/50 Early Career Investigator Meeting, Washington, DC. Franssen, RA, Hauver, AJ, LaFerve, J, Clasen, M, Gaffney, K, Pardes, A, Pruett, R, Uyguner, H, Vassallo, M, Franssen, CL. (2014, November). Maternal rats use the frontal cortex to discriminate between own and alien pups. Poster session presented at the meeting of the Society for Neuroscience, Washington, DC. Hauver, AJ, LeFerve, J, Mills, J, Russel, C, Clasen, M, Gaffney, K, Pardes, A, Pruett, R, Uyguner, H, Vassallo, M, Franssen, CL, Franssen, RA. (2015, April). Discrimination between own and alien pups in the maternal tat. Poster session presented at the Symposium for Young Neuroscientists and Professors of the Southeast (SYNAPSE), High Point, NC.

4 Amarante, L., Caetano, M., Clasen, M., Swanson, K.., Wetzell, B., & Laubach, M. (2015, November). Frontal cortical circuits for the control of consummatory behavior. Poster session presented at the meeting of the Society for Neuroscience, Washington, DC. Hempel, B., Wakeford, A., Clasen, M., Friar, M., & Riley, A. (2016, March). Δ 9 -tetrahydrocannabinol (THC) history fails to affect THC s ability to induce place preferences in rats. Poster session presented at the meeting of Marijuana and Cannabinoids: A Neuroscience Research Summit, Bethesda, MD. Wakeford, A., Wetzel, B., Pomfrey, R., Clasen., M., Taylor, W., Hempel, B., & Riley, A. (2016, April). The Effects of Cannabidiol Pre-treatment on 9-Tetrahydrocannabinol (THC) Self-Administration in Rats. Poster session presented at the meeting of ASPET at Experimental Biology, San Diego, CA. Riley, A., Kearns, D., Hargrave, S., Jones, S., Sample, C., Clasen, M., & Davidson, T. (2016, June). Cocaine impairs permeability of the blood-brain-barrier in the hippocampus: Implications for drug use and abuse. Poster session presented at the annual meeting of the College on Problems of Drug Dependence, Palm Springs, CA. Clasen, M., Wetzell, B., & Riley, A. (March, 2016). Adolescent drug pre-exposure fails to attenuate taste avoidance conditioning. Poster presented at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction (BBC), San Antonio, TX. Clasen, M., Hempel, B., & Riley, A. (October, 2016). Pre-exposure to cocaine or morphine attenuates taste avoidance conditioning in adolescent rats: drug specificity in the US pre-exposure effect. Poster presented at the annual meeting of the Mid- Atlantic Pharmacological Society (MAPS), Philadelphia, PA. Hempel, B., Clasen, M., Nelson, K., Woloshchuk, & Riley, A. (October, 2016). The effects of cannabidiol on Δ9- tetrahydrocannabinol (THC) induced place aversions and taste avoidance in male and female rats. Poster presented at the annual meeting of the Mid-Atlantic Pharmacological Society (MAPS), Philadelphia, PA. Nelson, K., Hempel, B., Clasen, M., Rice, K., & Riley, A. (October, 2016). Affective properties of 2nd generation Bath Salt α-pyrrolidinopentiophenone (α-pvp): An assessment of aversion and reward. Poster presented at the annual meeting of the Mid-Atlantic Pharmacological Society (MAPS), Philadelphia, PA. Hempel, B., Wakeford, A., Nelson, K., Clasen, M., Woloshchuk, C., Riley, A. (October, 2016). An assessment of sex differences in the affective properties of Δ9-tetrahydrocannabinol (THC). Poster presented at the annual meeting of the Carolina Cannabinoid Collaborative Conference, Philadelphia, PA. Hempel, B., Nelson, K., Clasen. M., Woloshchuk, C., & Riley, A. (March, 2017). The effects of cannabidiol on Δ9- tetrahydrocannabinol (THC) induced place aversions and taste avoidance in male and female rats. Poster presented at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction (BBC), San Antonio, TX. Nelson, K., Hempel, B., Clasen, M., Rice, K., & Riley, A. (March, 2017). Affective properties of 2nd generation Bath Salt α-pyrrolidinopentiophenone (α-pvp): An assessment of aversion and reward. Poster presented at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction (BBC), San Antonio, TX. Taylor, W., Wakeford, A. Wetzell, B., Pomfrey, R., Clasen. M., Hempel, B., & Riley, A. (March, 2017). Delta-9- tetrahydrocannabinol (THC) self-administration in male and female Long-Evans rats. Poster presented at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction (BBC), San Antonio, TX.

5 Hempel, B., Nelson, K., Clasen, M., & Riley, A. (August, 2017). The role of sex and phytocannabinoid content on Delta-9- tetrahydrocannabinol s (THC) affective properties. Poster presented at the annual NIDA/NIAAA and APA Divisions 28/50 Early Career Investigator Meeting, Washington, DC. Nelson, K., Hempel, B., Clasen. M., & Riley, A. (August, 2017). Assessment of the aversive and rewarding properties of the second generation bath salt α-pyrrolidinopentiophenone (α-pvp). Poster presented at the annual NIDA/NIAAA and APA Divisions 28/50 Early Career Investigator Meeting, Washington, DC. Clasen, M., Riley, A., Kearns, D., Hargrave, S., Jones, S., Sample, C., & Davidson, T. (August, 2017). Cocaine impairs permeability of the blood-brain-barrier in the hippocampus: Implications for drug use and abuse. Poster presented at the annual NIDA/NIAAA and APA Divisions 28/50 Early Career Investigator Meeting, Washington, DC. Oral Presentations Clasen, M. (October, 2013). The effects of cocaine on delay discounting in the spontaneously hypertensive rat. Oral presentation given to the Psychopharmacology Laboratory at American University, Washington, DC. Clasen, M., Wetzell, B., & Riley, A. (June, 2015). Assessment of methylphenidate and lithium chloride pre-exposure on conditioned taste avoidance learning in adolescence. Oral presentation given at the annual retreat for the Center for Behavioral Neuroscience at American University, Washington, DC. Clasen, M., Riley, A., Kearns, D., Hargrave, S., Jones, S., Sample, C., & Davidson, T. (June, 2016). Cocaine impairs permeability of the blood-brain-barrier in the hippocampus: Implications for drug use and abuse. Oral presentation given at the annual retreat for the Center for Behavioral Neuroscience at American University, Washington, DC. Clasen, M., Riley, A., Kearns, D., Hargrave, S., Jones, S., Sample, C., & Davidson, T. (March, 2017). Cocaine impairs permeability of the blood-brain-barrier in the hippocampus: Implications for drug use and abuse. Oral presentation given at the annual meeting of Behavior, Biology, and Chemistry: Translational Research in Addiction (BBC), San Antonio, TX. Riley, A., Hempel, B., & Clasen, M. (April, 2017). Sex Differences in Drug Addiction. Oral presentation given at the Symposium on Sex Differences at American University, Washington, DC. Clasen, M., Flax, S., Hempel, B., Cheng, K., Rice, K., & Riley, A. (June, 2017). Antagonism of the kappa opioid receptor attenuates Delta-9-tetrahydrocannabinol (THC) induced place aversions in adult male Sprague-Dawley rats. Oral presentation given at the annual retreat for the Center for Behavioral Neuroscience at American University, Washington, DC. Articles Clasen, M., Wetzell, B., & Riley, A. (2016). Adolescent rats fail to demonstrate a LiCl-induced pre-exposure effect: Implications for the balance of drug reward and aversion in adolescence. Learning and Behavior, 44(4), PubMed ID: Hempel, B., Wakeford, A., Clasen, M., Friar, M., & Riley, A. (2016). Delta-9-tetrahydrocannabinol (THC) history fails to affect THC's ability to induce place preferences in rats. Pharmacology, Biochemistry and Behavior, 144(1), 1-6. PubMed ID:

6 Hempel, B., Wakeford, A., Nelson, K., Clasen, M., Woloshchuk, C., & Riley, A. (2016). An assessment of sex differences in Δ 9-Tetrahydrocannabinol (THC) taste and place conditioning. Pharmacology, Biochemistry and Behavior, 153, PubMed ID: Clasen, M., Hempel, B., & Riley, A. (2017). Pre-exposure to cocaine or morphine attenuates taste avoidance conditioning in adolescent rats. Developmental Psychobiology, 9999(1), 1-9. PubMed ID: Wakeford, A., Wetzel, B., Pomfrey, R., Clasen, M., Taylor, W., Hempel, B., & Riley, A. The effects of cannabidiol (CBD) on 9 -tetrahydrocannabinol (THC) self-administration in male and female Long-Evans rats. Experimental and Clinical Pharmacology, 25(4), PubMed ID: Nelson, K., Hempel, B., Clasen, M., Rice, K. and Riley, A. Assessment of the rewarding and aversive effects of the second-generation 'bath salt' alpha-pyrolidinopentiophenone (α-pvp). Pharmacology, Biochemistry and Behavior, 156, PubMed ID: Davidson, T., Hargrave, S., Kearns, D., Clasen, M., Jones, S., Wakeford, A., Sample, C., & Riley, A. Selective effects of cocaine on hippocampal cognitive and blood-brain-barrier function. Drug and Alcohol Dependence. (Awaiting decision) Clasen, M., Flax, S., Cheng, K., Rice, K., & Riley, A. Effect of norbinaltorphimine on 9 -tetrahydrocannabinol (THC)-induced place aversions in adult Sprague-Dawley rats. Pharmacology, Biochemistry and Behavior. (In revision) Clasen, M., Sanon, T., Hempel, B., Nelson, K., Kearns, D., Davidson, T., & Riley, A. The lifelong consumption of a Western diet increases compulsive cocaine intake in male Sprague-Dawley rats. (In preparation) Review Articles, Book Chapters, and Encyclopedia Entries Riley, A., Clasen, M., & Friar, M. (2016). Conditioned taste avoidance drug discrimination procedure: Assessments and applications. In: Porter, J., Prus, A. (Eds.). Drug Discrimination: A Behavioral Approach for Understanding Subjective Drug Effects. Springer-Verlag. PubMed ID: Clasen, M., Hempel, B., & Riley, A. (2017). Taste aversion. In: Zeigler-Hill, V. & Shackelford, T. Encyclopedia of Personality and Individual Differences. Springer-Verlag. (In press) Riley, A., Hempel, B., & Clasen, M. Sex as a biological variable: Drug use and abuse. Special Issue: Physiology and Behavior s proceedings of the American University conference on Sex Differences in the Brain and Behavior. (In Press) Teaching and Mentorship Experience Classes Taught American University: Research Methods in Psychology (PSY 301; summer 2016) Drugs and Behavior (PSY 240; summer 2017) Northern Virginia Community College:

7 Psychology as a Natural Science (PSY 201; summer, 2016, fall 2016, spring 2017, summer 2017) Psychopharmacology and Substance Abuse (PSY 260; fall 2017) Readings in Neuroscience (PSY 295; fall 2017) Classes Prepared Biopsychology Drugs in America Teaching Assistantships Psychology of Learning (PSY 390): Dr. Daniel Holt (Spring 2013) Biopsychology (PSY 385): Dr. Catherine Franssen (Fall 2013) History and Systems of Psychology (PSYC 502): Dr. Maria Gomez (Fall 2014) Physiological Psychology (PSYC 501): Dr. Maria Gomez (Fall 2014) Psychology as a Natural Science (PSYC 115): Dr. Maria Gomez (Spring 2015) Drugs and Behavior (PSYC 240): Dr. Anthony L. Riley (spring 2015, fall 2015, fall 2016, fall 2017) Psychology as a Natural Science (PSYC 115): Dr. Anthony L. Riley (spring 2016, spring 2017) Drugs in America (PSY 497): Dr. Anthony L. Riley (fall 2017) Student Mentorship Experiences William Taylor: Undergraduate Student (fall 2014-fall 2016), American University, Washington, DC. CJ Woloschchuk: Undergraduate Student (fall 2014-fall 2016), American University, Washington, DC. Katherine Nelson: Graduate Student (fall 2015-present), American University, Washington, DC. Thery Sanon: Undergraduate Student (spring 2017-present), American University, Washington, DC. Jose Vela: Undergraduate Student (fall 2017-present), Northern Virginia Community College, Alexandria, VA. Laboratory Experience (self-proficient in the following areas) Behavioral Assessments: Delay Discounting 8-Arm Radial Arm Maze Conditioned Taste Avoidance Conditioned Place Preference Taste Aversion Model of Drug Discrimination Learning Intravenous Self-Administration Pharmacological Skills: Dose calculations Drug and solution mixing Intraperitoneal and sub-cutaneous injections Surgical Skills: Jugular catheter implantation surgery for self-administration (survival surgery; rat) Femoral catheter implantation surgery for self-administration (survival surgery; rat) Stereotaxic surgery (survival surgery; rat) Stereotaxic surgery for implantation of light sensitive opsin containing AAV s and ferrule for optogenetics (survival surgery; rat)

8 Implantation of DREADDs AAV (survival surgery; rat) Tissue Collection: Cardiac perfusion (rat) Rapid brain extraction (rat) Rapid brain dissection (rat) Tail vein blood collection (rat) Methyl butane preservation (rat) Tissue Processing: Sledge microtome sectioning of the rat brain Frozen cryostat sectioning of the rat brain Micro-punch brain dissection of the rat brain using a frozen cryostat Cellular and Molecular Methods in Neuroscience Western Blot Analysis (rat brain) Blood brain barrier analysis using sodium fluorescein (rat brain) Immediate early gene expression (c-fos & Npas4; rat brain) Implantation of various adeno-associated viruses (AAV s) into the rat brain (DREADDs, optogenetic probes, CRE dependent AAV s, & non-cre dependent AAV s) Microscopy: Light microscopy Fluorescent microscopy Software and Hardware Skills Experience constructing and repairing Med PC operant boxes Experience running Med PC software MED-PC software programing Microsoft Office: Word, Excel, PowerPoint SPSS (Statistical Package for the Social Sciences) FIJI Adobe Photoshop Python toolbox R Studio Research Invitations Long Wood University: June 2013 Invited to work in Dr. Adam Franssen s Research lab Practiced rat profusions and brain extractions Practiced cryostat techniques for well and dry slide mounting Studied and performed Immunohistochemistry May 30 th - 31 st

9 Boston University: July 2013 Invited to work in Dr. Kathleen Kantak s Research lab Studied and performed cocaine self-administration surgeries and techniques Experience surgically implanting femoral catheters Experience with rat post-surgical care June 27 th July 11 th American University: Summer 2015 June 10 th August 11 th Invited to work in Dr. Mark Laubach s Research lab under a private grant Studied and performed stereotaxic surgery for optogenetics and DREADDs for behavioral assessments Performed perfusions and tissue processing for fluorescent imaging Performed immunohistochemistry Performed light and fluorescent microscopy for neuroanatomical tract tracing Performed behavioral assessments Professional and Editorial Services Psychopharmacology: Drugs, the Brain, and Behavior (2 nd Ed.): Sinauer Press September, 2015 Edited chapter 4; Methods of Research in Psychopharmacology Edited chapter 9: Drug Abuse and Addiction References available upon request.