IMMUNOLOGY TEST REPERTOIRE
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1 IMMUNOLOGY TEST REPERTOIRE For Laboratory general enquiries Tel Department of Medical Biochemistry and Immunology University Hospital of Wales Heath Park Cardiff CF14 4XW Immunology Department Open Monday Friday am to 17:15 pm Contact :- Mo Moody (Lead Biomedical Scientist in Immunology) For clinical advice contact: Dr Tariq El-Shanawany - Consultant Clinical Immunologist Dr Stephen Jolles - Consultant Clinical Immunologist Dr Paul Williams - Consultant Clinical Immunologist Consultants secretaries Tel or
2 ANA Centromere dsdna Crithidia ENA screen ENA profile (Ro/La/Sm/RNP/Jo-1/Scl70) MCV ANCA MPO PR3 ANCA profile (MPO,PR3,BPI,Elastase, Cathepsin G, Lysozyme and Lactoferrin ) GBM Cardiolipin (IgG and IgM) Beta 2 Glycoprotein (IgG and IgM) handling / Methodology Reference range Turnaround (target working days) Overnight (Room Temp) ELISA <20 IU/ml 5 U.K.NS Overnight (Room Temp) ELISA Negative 5 U.K.NS Overnight (Room Temp) ELISA Negative 5 U.K.NS Overnight (Room Temp) ELISA <20 U/ml 5 U.K.NS Overnight (Room Temp) ELISA Negative 5 U.K.NS Suspected CTD/SLE CREST SLE Confirmation of dsdna CTD CTD Rheumatoid arthritis ( to CCP) Small vessel vasculitis ANCA confirmation and monitoring Overnight (Room Temp) ELISA Negative 5 UK NS ANCA confirmation and monitoring Overnight (Room Temp) ELISA Negative 5 UK NS MPO/PR3 negative ANCA Overnight (Room Temp) ELISA <20 U/ml 5 U.K.NS Overnight (Room Temp) ELISA IgG <10 U/ml, IgM <7U/ml 5 U.K.NS Overnight (Room Temp) ELISA <5 U/ml 5 U.K.NS Goodpasture's Anti phospholipid Anti phospholipid 2
3 TTG (IgA) TTG(IgG) Endomysial (IgA) Liver auto (GPC/LKM/SMA/AMA) Adrenal Pancreatic islet cell Ovarian Cardiac muscle Skeletal muscle Pemphigus Pemphigoid requireme nt handling / Methodology Reference range Turnaround Overnight (Room Temp) ELISA <10 U/ml 5 U.K.NS Overnight (Room Temp) ELISA <10 U/ml 5 U.K.NS Overnight (Room Temp) IIF Negative 5 exchange Overnight (Room Temp) IIF Negative 5 UK NS Overnight (Room Temp) IIF Negative 5 exchange Overnight (Room Temp) IIF Negative 5 No Overnight (Room Temp) IIF Negative 5 No Coeliac disease Coeliac disease in IgA deficient patients Coeliac disease/ Dermatitis herpetiformis Pernicious anaemia/liver disease/ Autoimmune hepatitis/pbc Autoimmune Addison's and polyglandular autoimmunity Type 1 diabetes /LADA Premature ovarian failure/ Polyglandular autoimmunity Dressler's /post MI/Cardiomyopathy Myasthaenia gravis Bullous skin disease Bullous skin disease 3
4 handling / CH50 Same day or transport frozen AP50 Same day or transport frozen Methodology Reference range Turnaround Haemolytic assay exchange & International Complement scheme Haemolytic assay exchange & International Complement Complement Complement scheme C3/C4 Overnight (Room Temp) Nephelometry / g/l 5 UK NS SLE/HAE/ Renal disease/ Vasculitis C1q Overnight (Room Temp) RID mg/l 10 Pilot scheme Deficiency/Acquired angioedema/ Immune complex disease C2 Overnight (Room Temp) RID mg/l 10 Pilot scheme Deficiency/ Consumption/ Immune complex disease C5 Overnight (Room Temp) RID mg/l 10 Pilot scheme Terminal pathway C6 Overnight (Room Temp) RID mg/l 10 Pilot scheme Terminal pathway C7 Overnight (Room Temp) RID mg/l 10 Pilot scheme Terminal pathway C8 Overnight (Room Temp) RID mg/l 10 Pilot scheme Terminal pathway C9 Overnight (Room Temp) RID mg/l 10 Pilot scheme Terminal pathway C1 esterase inhibitor (Immunochemical) C1 esterase inhibitor (Functional) Overnight (Room Temp) Nephelometry g/l 5 UK NS HAE & acquired angioedema Same day or transport frozen ELISA >68% normal 10 UK NS Type 2 HAE & acquired angioedema Factor H Overnight (Room Temp) RID mg/l 10 exchange ahus/ddd Factor I Overnight (Room Temp) RID mg/l 10 exchange Deficiency 4
5 handling / Methodology Reference range Turnaround Factor B Overnight (Room Temp) RID mg/l 10 No Anti-C1q Overnight (Room Temp) ELISA <10 U/ml 10 IUIS/ICS International External Quality Assessment TCC (C5-9 complex) EDTA Plasma Same day or transport frozen MBL Overnight (Room Temp) ELISA <50ng/ml =, ng/ml = equivocal, >100ng/ml = normal Deficiency SLE with renal involvement ELISA <80 ng/ml 10 Pilot scheme Complement activation 10 International Complement scheme Recurrent infection especially in childhood Anti-C1 esterase inhibitor (IgG, IgA and IgM) Overnight (Room Temp ELISA Detects high titre anti- C1INH (positive or negative) 30 UK NS Acquired Angioedema (AAE) 5
6 Lymphocyte phenotypes B cell memory phenotyping Naive T cells TCR alpha beta double negative T cells Lymphocyte proliferation * Neutrophil function (NBT) * Neutrophil function (DHR) * MHC Class 1 and 2 expression Adhesion markers (CD11a/11b/11c/18) TCR V beta spectrotyping CD40 expression on B lymphocytes * (5ml) (5ml) handling / Methodology Reference range Turnaround Flowcytometry Age related 2 NS Leukocyte Immunophenot yping Flowcytometry Age related 2 No Same day Flowcytometry See report 4 No Same day Functional assay Positive=Norm al Same day Flowcytometry Positive=Norm al 2 No 2 No Primary and secondary immuno CVID Primary immuno/ monitoring T cell reconstitution ALPS Immuno CGD CGD Bare lymphocyte Suspected adhesion molecule Primary immuno /monitoring T cell reconstitution CD40 6
7 BTK on monocytes * L-selectin (CD62 ligand) shedding * CD40Ligand expression (CD4+ T cells) * (5ml) (5ml) handling / Methodology Reference range Turnaround Room temp. within 3 hours Same day Flowcytometry See report 3 No Total IgE Overnight (Room Temp) FEIA Age related 5 U.K.NS Specific IgE (Entire Phadia Overnight (Room Temp) FEIA See report 5 U.K.NS catalogue available see GB/Allergens/ImmunoCAP- Allergens/ ISAC Allergy Microarray See en-gb/laboratories/allergy/ Products/ImmunoCAP-ISAC/ XLA Suspected TLR signalling defect XL-HIGM (CD40L ) Atopy/Allergy/Hyper IgE Type 1 Hyper-sensitivity/ allergy Overnight (Room Temp) Microarray See report 10 Pilot scheme Complex allergic disease/ idiopathic anaphylaxis Tryptase Same day or frozen. For investigation of anaphylaxis - 3 samples at times 0, 2 and 24 hrs FEIA (RAST) See report 5 U.K.NS Immunoglobulins (IgG/A/M) Overnight (Room Temp) Nephelometry Age related 5 U.K.NS Birmingham IgD Overnight (Room Temp) RID 5 Pilot scheme Electrophoresis Overnight (Room Temp) CZE Normal 5 U.K.NS Immunofixation Overnight (Room Temp) Immunofixation Negative 5 U.K.NS Birmingham, U.K.NS Anaphylaxis/ Mastocytosis Immuno & lymphoproliferative disorder Hyper IgD/Fever Syndromes Myeloma/ MGUS Myeloma /MGUS 7
8 handling / Methodology Reference range Turnaround Bence Jones protein Urine (20ml) Overnight (Room Temp) Urine EPH Negative 5 U.K.NS Oligoclonal bands Paired Overnight (Room Temp) Isoelectic Negative 5 U.K.NS & CSF (2ml focusing each) IgG subclasses Overnight (Room Temp) Nephelometry Age related 5 U.K.NS Myeloma/ MGUS Multiple sclerosis Immuno Rheumatoid factor Overnight (Room Temp) Nephelometry <20 IU/ml 5 U.K.NS Alpha 1 antitrypsin Overnight (Room Temp) Nephelometry Age related 5 U.K.NS Birmingham Alpha 1 antitrypsin (faeces) Faeces (1g formed stool) Frozen Nephelometry Age related 5 No Beta 2 microglobulin Overnight (Room Temp) Nephelometry mg/l 5 U.K.NS Free light chains Overnight (Room Temp) Nephelometry See report 5 U.K.NS High sensitivity CRP Overnight (Room Temp) Nephelometry <3.0mg/L 5 U.K.NS Antibodies to Hib Overnight (Room Temp) ELISA See report 5 U.K.NS Antibodies to Tetanus Overnight (Room Temp) ELISA See report 5 U.K.NS Antibodies to Pneumococcus Overnight (Room Temp) ELISA See report 5 U.K.NS Molecular Immunology - Please contact the laboratory for further details Seropositive Rheumatoid Arthriris Emphysema/ cirrhosis/ prolonged neo-natal jaundice/family screening Protein losing enteropathy Monitoring myeloma and renal disease Monitoring plasma cell dyscrasia Cardiac risk factors Suspected immuno/ response to vaccination Suspected immuno/ response to vaccination Suspected immuno/ response to vaccination Please contact the department for current prices 8
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