For questions 1-5, match the following with their correct descriptions. (24-39) A. Class I B. Class II C. Class III D. TH1 E. TH2

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1 Questions Made by SI ATTENDEES!! :) Page 1 of 6 Student-Made Practice Exam Activity All questions, answers, and slide numbers are based off of Monday s SI activity, where students/attendees created possible test questions using the Updated Again Chapter 34 Powerpoint in groups. Dr. White may use a couple questions! Slide numbers are in parentheses. For questions 1-5, match the following with their correct descriptions. (24-39) A. Class I B. Class II C. Class III D. TH1 E. TH2 1. Helps activate macrophages, increase phagocytosis, and promote Tc activity 2. Molecules found only on antigen presenting cells 3. Help B cells produce antibodies 4. Include secreted proteins not required for self/non-self recognition 5. Found on almost all types of nucleated cells 6. Which of the following statements is true about superantigens? (24-39) a. Activated by antigen presenting cells with class II MHC b. Stimulate T cells to proliferate nonspecifically c. Stimulates release of massive quantities of cytokines 7. In a Papain reaction with IgG, what fragment is enzymatically cleaved into two identical fragments: a. Two Fab b. Two Fc c. One Fc and one Fab d. A & C 8. Select all that apply about T cell development: a. CD4+ TH0 cell differentiates into CTL s b. A cytotoxic T cell contacts a target cell c. CTL secrets perforin that forms pores in the target cell d. CD8+ Tc cells differentiate into Tc1, Tc2, Tc9, and Tc22

2 Questions Made by SI ATTENDEES!! :) Page 2 of 6 9. Which of the following is responsible for recognizing foreign peptides and plays a part in T cell activation? a. MHC b. Opsonin c. Vaccines d. Innate Immunity 10. manipulate immune responses to stimulate T-cell proliferation, causing a fever, drop in blood pressure, or shock/organ failure: a. B cells b. T cells c. Superantigens d. Cytokines 11. Class I MHC molecules digest antigens via, while Class II MHC molecules digest antigens via. (24-39) 12. When does the activation of a B cell occur? (40-56) a. Activated TH2 cell directly associates with the B cell b. Activated Tc cell directly associates with the B cell c. Activated TH2 cell indirectly associates with the B cell d. Activated TH1 cell directly associates with the B cell 13. Select all the true statements about antibodies. (40-56) a. Antibodies have five classes. b. Antibodies are found on the skin. c. Glycoproteins are made by activated B cells. d. Antibodies serve as antigen receptors on B cell surfaces. 14. What is the difference between primary and secondary antibody response? (40-56) a. Primary takes seconds after the initial exposure while secondary has a shorter lag and a more rapid log. b. Primary takes several days to weeks after the initial exposure while secondary is heightened memory response upon the second exposure c. Primary and secondary exposure are at equivalent speeds and rates 12. What is not one of the three major functions of induced immunity? (2) a. Respond to non-self b. Respond to self

3 Questions Made by SI ATTENDEES!! :) Page 3 of 6 c. Remember non-self d. A & C e. All of the above are major functions 13. Which of the following statements about specific immunity characteristics are false? Select all that apply. (4) a. Diversity generates minimal amounts of diverse molecules. b. Memory T and B cells are activated in the lymph nodes c. There is a stronger immune response to the second exposure of a pathogen. d. Immunity to one pathogen can be used towards immunity of another. 14. Humoral immunity is also called and is based on B cell activity. Cellular immunity is also called and is based on the action of specific kinds of. (5) 15. True or False. Primary (congenital) immunodeficiency results from genetic disorders. 16. Which are characteristics of autoimmunity? a. Caused by numerous stimuli only b. Presence of serum antibodies reacting with the self c. Leads to tissue damage d. B & C e. All of the above 17. In localized anaphylaxis, antigens can enter through: a. Skin b. Respiratory tract c. Mucus secretions e. All of the above 18. What are examples of types of immunodeficiencies? a. Primary b. Secondary c. Acquired e. A & C For questions 19-23, match the immunoglobulin with its correct description below. There is one answer for each immunoglobulin class. A. Antibody that crosses the placenta B. Antibody that is a pentamer arranged as a pinwheel

4 Questions Made by SI ATTENDEES!! :) Page 4 of 6 C. Signals B cells to start antibody production D. Elevated in parasitic infections and allergic reactions E. Monomer in serum and dimers in secretion 19. IgG 20. IgM 21. IgA 22. IgE 23. IgD 24. Which type of specific immunity is intentional exposure to a foreign molecule? (9) a. Artificially acquired passive immunity b. Naturally acquired passive immunity c. Artificially acquired active immunity d. Naturally acquired active immunity 25. Which of the following statements are true? (12-14) a. Pertussis uses a toxoid for vaccination. b. Vaccines can be used for bacteria. c. Attenauted strains have lost virulence. d. Normal flora do not ever cause disease. 26. What is the major histocompatibility complex? (16) a. A protein that enables the host to distinguish between self and non-self b. A histone that plays a role in gene regulation c. A collection of genes encoding proteins that enable a host to distinguish self and non-self 27. Select all that statements that are not true. (12-13) a. Attenuated strains are effective for vaccinating immunocompromised individuals. b. Attenuated strains often retain immunogenicity. c. Laboratory cultivation typically results in an increase of virulence in pathogens. d. Vaccination induces artificially acquired passive immunity. 28. Haptens are: (7)

5 Questions Made by SI ATTENDEES!! :) Page 5 of 6 a. Small organic molecules that stimulate the production of antibody molecules b. Only immunogenic when bound to a large carrier molecule c. Can stimulate an immune response e. A & C 29. What term describes the strength with which an antibody binds to its antigen at a given antigen binding site? (6) a. Avidity b. Epitopes c. Immunogen d. Affinity For questions 30-33, match the hypersensitivity with the correct description. Each question has one answer and each one will be used exactly once. A. Type I B. Type II C. Type III D. Type IV 30. IgE mediated 31. Results in the formation of an immune complex 32. Results in host cell lysis 33. Has a delayed response 34. Rheumatoid Arthritis and Lupus are examples of: a. Genetic disorders b. Congenital disorders c. Idiopathic disorders d. Autoimmne disorders 35. Release of physiological mediators in response to allergens cause: a. Smooth muscle contraction b. Vasodilation c. Decrease vascular permeability e. All of the above 36. What is the difference between toxin and viral neutralization? (57-58)

6 Questions Made by SI ATTENDEES!! :) Page 6 of 6 a. Toxin neutralization uses complement components, while viral neutralization forms immune complexes. b. Toxin neutralization forms immune complexes, while viral neutralization uses complement components. c. Toxin neutralization uses specific antitoxin AB, while viral neutralization uses IgG, IgM, and IgA d. A & C 37. Neutralization of extracellular viruses receives help from the C3b of the pathway. (58) 38. Toxin neutralization results in (57) a. Preventing toxin from attaching to host cells b. Preventing toxin from entering host cells c. Digestion by macrophages d. All of the above e. None of the above Questions 39 and 40 are short answer response questions. 39. When does an agglutination reaction occur? What causes it? (60) 40. When does a precipitation reaction occur? What is another name for this reaction? (60)