BIOLOGICAL TREATMENT. dr. A.A.A.A. Kusumawardhani,SpKJ(K) 2009

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1 BIOLOGICAL TREATMENT dr. A.A.A.A. Kusumawardhani,SpKJ(K) 2009

2 Psychiatric treatment Comprehensive Eclectic-Holistic Psychoeducative Organobiologic Sociocultural

3 Therapy in Psychiatry Biological / Physical treatment: a. Drugs / Psycho-pharmacotherapy b. ECT/ Electro Convulsion Therapy c. Others Psychological treatment: - Psychotherapy individual/group - Psychotherapy - supportive - re-educative - re-constructive

4 Psycho-pharmacotherapy PSYCHOTROPIC DRUGS > Major action at CNS : - Thinking process - Mood - Motoric function / behaviour Clinical effect Clasification: 1. Antipsychotics/Neuroleptic/Major Tranquilizer 2. Antidepresant 3. Antianxiety/Anxyolytic sedatives/minor Tranq. 4. Antimanic/Mood stabilizer

5 Antipsychotics Classification: * Typical DA phenothiazine & Nonfenothiazine * Atypical SDA # High Potency # Low Potency

6 Pharmacokinetic of antipsychotics (1) Age : geriatric clearence Genetic : ethnics different metabolism Substance Abuse behaviour : * smoking metabolisms * alcohol metabolisms, liver function & nutrition Medical condition : * liver diseases, ex. Cirrhosis hepatis * Congestive Heart failure blood flow clearence

7 Pharmacokinetic of antipsychotics (2) Enzyme inducers *carbamazepine, phenytoin, ethambutol, barbiturate Clearance Inhibitors * SSRI, TCA, beta blocker dll. Changes in binding protein * stress, hipoalbumin, hepatic/renal failure.

8 Pharmacodynamic Mode of action : DA & SDA psychotics symptoms (hallucination, delusion, etc.) Dopamine Receptor Antagonis: * nigrostriatal system * mesolimbocortical system * tuberoinfundibuler system

9

10 Nigrostriatal pathway Substantia Nigra to Striatum. Motor control. Death of neurons in this pathway can result in Parkinson's Disease Mesolimbic and Mesocortical pathways Ventral Tegmental Area to Nucleus Accumbens, Amygdala & Hippocampus, and Prefrontal Cortex. Memory. Motivation and emotional response. Reward and desire. Addiction. Can cause hallucinations and schizophrenia if not functioning properly Tuberoinfundibular pathway Hypothalamus to Pituitary gland. Hormonal regulation. Maternal behavior (nurturing). Pregnancy. Sensory processes Dopamine Pathway

11 Release of dopamine (green) at synapses from an axon terminal (left). Dopamine is shown binding to receptors on the postsynaptic membrane (right). Dopamine receptors being blocked by an antipsychotic drug (red). Dopamine can no longer bind to the receptors on the post-synaptic membrane, so it is as if there is less dopamine in the brain.

12 Classification (chemical structure) Phenothiazines - Aliphatic : Chlorpromazine, Promazine, Triflupromazine - Piperidine : Thioridazine, Promazine, - Piperazine : Fluphenazine, Trifluoperazine

13 Classification (chemical structure) Thioxanthenes : Chlorprothixine, Thiothixene Butyrophenones : Haloperidol, Droperidol Dibenzoxazepine : Loxapine Dihydroindoles : Molindone Diphenylbutylpiperidines : Pimozide

14 Side effects (1) Neurologic : *acute (acute extrapyramidal syndrome) # acathisia # acute dystonia # parkinsonism # Neuroleptic Malignan Syndrome *chronic # tardive dyskinesia

15 Side effects (2) Cardiovascular effect * Orthostatic (Postural) Hypotension * Sudden Unexplained Death GIT * peripheral anticholinergic effects Liver, hepatology, renal, skin & eye Endocrinal dysfunction Sexual dysfunction

16 Initial Treatment Principal gradually increase dosage --> optimal dose ( 1 3 weeks) Stabilisation (up to 8-10 weeks) Maintenance (months years)

17 Side effects management (1) SE Parkinsonism use antiparkinsons drugs, such as: * artane (trihexyphenidil) * congentin (benztropin) * diphenhydramin (benadryl) (do not use routinely) NMS : *stop antypsychotic *treat symptomatically *observe vital signs

18 Side effects management (2) Tardive dyskinesia : * make a clear diagnosis ensure effective AP * use only minimal dose * caution in usage for children, geriatric, and patients with mood disorders * do regular examination for side effects * TD + give an informed consent, lower the dosage change drug * when TD getting worse stop the drug change/try Clozapin

19 ANTIDEPRESANT Classification. * derivative of tricyclic AD Imipramin - Tofranil Amitriptilin- - Laroxyl Amineptin - Survector * derivative of tetracyclic AD Maproptilin - Ludiomil Mianserin - Tolvon

20 Antidepresant (1) Monoaminoxidase Inhibitor MAOI & RIMA -moclobemide (Aurorix) Serotonergic (SSRI) - Sertralin - Fluoxetine - Fluvoxamin - Paroxetin

21 Antidepresant (2) Purpose: Heal / decrease depresive symptoms Mode of action : Increase NT concentration especially norepinephrin & serotonin

22 Antidepresant (3) Side effects: 1. Hypotension (geriatric) 2. Cardio effects (EKG abnormality) 3. Otonomic symptoms 4. CNS effect 5. Allergy 6. hematology problems 7. psychological symptoms (manic, restlessness)

23 Antidepresant (3) MAOI side effects: - hypotension & hypertension - hepatologic problem - otonomic - neurological (paresthesia,convulsion) - oedema - hematologic - psychologic disturbances - crisis hypertention

24 Antidepresant (4) Treatment Principals: - start from low dosage therapeutical effect appears within 2 / 3 weeks - maintenance phase minimal 6 months & can last for 3 5 years

25 Tricyclic Antidepressant

26 Selective Serotonin Reuptake Inhibitors

27 MAOI Monoamine Oxidase Inhibitor

28 ANTIANXIETY CLASSIFICATION 1. Derivative of Benzodiazepine - diazepam - valium - bromazepam - lexotan - lorazepam - ativan - clobazam - frisium - alprazolam - xanax Buspiron -buspar 2. Derivative of Gliserol - meprobamat 3. Der. Of Barbiturate - phenobarbital

29 Antianxiety (1) Purpose : Decrease anxiety - sedative effects - relaxation - amnesia - antiepilepsy Therapeutic Principal: - do not use high dosage - do not use more than 1 month

30 Antianxiety (2) Side Effects - drowsiness - headache - dysarthri - ataxia - appetite - dependent - withdrawal effects

31 MOOD STABILIZER Main purpose: control manic condition & prevent relapses Lithium : Indications: manic/depressive episode Effective doses : meq/l plasma level (start with 300 mg/day p.o)

32 Antimanic (1) Side Effecs : - soft tremor - diarrhea & vomiting - fatigue & vertigo - ataxia & rough tremor - declining consciousness - convulsion - oligouria & anuria - oedeme

33 Antimanic (2) Mood Stabilizer 1. Lithium salt Lithium carbonate 2. Others Carbamazepine - Priadel - Theralith - Tegretol Valproic Acid/Devalproate - Depakote

34 ELECTRO CONVULSION THERAPY (ECT) Main Indication: Major Depression Electrify the brain (using 2 elektrodes placed on temporal region) convulsion like that of grandmal epileptic

35 ECT (1) Preparation : - patient physical check up (Cardiovascular,pulmo,bones,brain) - Informed consent - fasting minimal 6 hours before ECT - prepare the patient to remain calm : distract their attention, give premedication - remove false teeth, jewelry, hair pin - nurse assistance for preventing luxasio/fracture

36 ECT (2) Tools preparation : - ECT machine - wet cotton for underlying electrodes - oxygen tube & mask - mucous suction - drugs : coramine, adrenalin - rubber teeth holder - flat bed

37 ECT (3) Execution : - Patient is laid down without pillow, in baggy hospital clothes - Rubber teeth holder Nurses hold : lower jaw/ head; shoulder; hip & knee - Doctor place the elektrodes tonic convulsion -->clonic convulsion apneu breath normally (important phase)

38 ECT (4) Post ECT observation : - important - until vital condition become normal, still unconcious, usually falling asleep; sometimes restless & moving uncontrollably nurses must keep watching until the patient is fully councious.

39 ECT (5) - after regaining consciousness, the patient often confused, disoriented and amnestic nurses help orientation and memory by communicating in stages, giving a calming and non- irritating environment.

40 OTHER BIOLOGICAL THERAPY Light therapy Sleep Deprivation & Alteration of Sleep Schedules Psychosurgery Orthomolecular therapy Subcoma Insulin therapy Coma therapy Carbon Dioxide therapy

41

42 Resource: Comprehensive Texbook of Psychiatry Kaplan HI, Saddock BJ

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