The Irony of Anemia How to interpret the CBC
|
|
- Aileen Armstrong
- 5 years ago
- Views:
Transcription
1 Jaideep Shenoi MD Hematology Oncology Northwest Medical Specialities Tacoma, WA The Irony of Anemia How to interpret the CBC March 10 th, 2018
2 Disclosures: Advisory Board for Pharmacyclics, Janssen, Takeda, Oncopeptides AB, UptoDate No Conflicts :
3
4 Objectives: Provide an overview of the use of CBC in primary care. Anemias- how to diagnose and classify. To highlight mechanisms in anemia To improve understanding of iron metabolism in humans To help address common referral questions Polycythemia
5
6
7
8 Source: Caro J and Erslev AJ. Erythropoietin assays and their use in the study of anemias. Contrib Nephrol 1988; 66: Review.
9 html
10
11
12
13
14
15 Clinical Case: A 45-year-old W/F Fatigue 1 month. No CP. SOB/DOE. No Hematochezia, No Melena. Heavy menstrual periods 1 year. Past medical history: Postpartum Anemia - 10 years ago. Not on any meds except ASA 81mg Family history: Parents were born in Italy and died when she was in grade school. She does not know their medical history. Habits: Vegetarian who eats a lot of cereal. She does not have an urge to eat ice.
16 PHYSICAL EXAM General appearance: Pale female in no acute distress. Vital signs: BP - 125/90, HR - 88 regular, RR - 12/min. Pale conjunctiva. Gr I/VI systolic ejection murmur. Heme negative brown stool was present.
17 WBC K/ ul RBC 4 X 10^ X10^6/ul Hg% g% Hct % Plt K MCV fl/rbc RDW 16.5 Retics % Ab Retics 40K 25-75K/ul LDH U/L Correction of Reticulocyte Count [Hct/normal Hct for age and gender] x reticulocyte % [24%/40%] x 3% = 1.8% The corrected reticulocyte count in this case is less than 2%. Ab Retic count- calculated according to the formula: Reticulocyte count in % x RBC count in 10 6 /μl
18 Macrocytic Microcytic Normocytic Aplastic Anemia Blood loss Iron Def Anemia of Chronic Disease Thalassemia Sideroblastic Anemia Pernicious Anemia Liver Disease Folate Deficiency Iron Def Anemia -Transferrin Sat % or Iron/TIBC ratio <15% Anemia of Chronic Disease - Transferrin sat % or iron/tibc ratio > 15%.
19 Hyperproliferative Anemias ( destruction of RBC) Hemolysis Hypersplenism Hypoproliferative Anemias Aplastic Anemia Nutritional Anemia Iron Deficiency Anemia
20 Factors that may affect CBC parameters: iron deficiency thalassaemia medication alcohol minor infections ethnic differences gender pregnancy
21 Importance of Clinical Examination: pallor, jaundice fever, lymphadenopathy bleeding/bruising hepatomegaly, splenomegaly frequency and severity of infections, mouth ulcers, recent viral illness exposure to drugs and toxins fatigue/weight loss
22 The absolute count of each of the cell types is more useful than the total WBC. The total count may be misleading, eg: low neutrophils with an elevated lymphocyte count may produce a total white count that falls within the reference range.
23 Neutrophils Low Significant levels < 0.5 x 10 9 /L (high risk infection) Most common causes viral (overt or occult) autoimmune/idiopathic drugs Red flags person particularly unwell severity rate of change of neutropenia lymphadenopathy, hepatosplenomegaly
24 Neutrophils High Most common causes infection/inflammation Sinuses/Dental disease Necrosis/malignancy any stressor/heavy exercise Drugs/smoking pregnancy CML Red flags person particularly unwell severity rate of change of neutrophilia presence of left shift
25 Lymphocytes Lymphocyte Low not usually clinically significant Lymphocyte High isolated elevated count not usually significant Causes acute infection (viral, bacterial) smoking hyposplenism acute stress response autoimmune thyroiditis CLL
26 Monocytes Low not clinically significant Monocytes High usually not significant watch levels > 1.5 x10 9 /L more closely
27 Eosinophils Low no real cause for concern Eosinophils High Most common causes: allergy/atopy: asthma/hayfever parasites (less common in developed countries) Rarer causes: Hodgkins Myeloproliferative disorders Churg-Strauss syndrome
28 Basophils Low difficult to demonstrate Basophils High Associated with Myeloproliferative disorders other rare causes
29 Useful to use MCV to classify the Anemia Microcytic, MCV < 80 fl Normocytic, MCV fl Macrocytic, MCV > 100 fl
30
31 Microcytic Anemia The three most common causes for microcytic anaemia are: Iron deficiency Thalassemia Anemia of Chronic disease (20%)
32
33
34 Oral Iron Challenge Test Baseline Iron 31 TIBC 381 % Sat 8 Transferrin 298 Ferritin 20 1 hr Iron 335 TIBC 386 % Sat 87 Transferrin 308 2hr Iron 361 TIBC 378 % Saturation 96, Transferrin 304
35 Normocytic Anemia Common Causes : Bleeding Early Nutritional Anemia (Iron, B12, Folate Def) Anemia of renal insufficiency Anemia of chronic disease/chronic inflammation Hemolysis Primary bone marrow disorder
36 Macrocytic Anemia Common causes Alcohol Liver disease B12 or Folate Deficiency Thyroid disease Some Drugs (especially Hydroxyurea)
37 High Hemoglobin / Polycythemia / Erthrocytosis Hb often accompanied by PCV Can reflect decreased plasma volume (eg: dehydration, alcohol, cigarette smoking, diuretics) or Increased RBC mass (eg polycythemia)
38 83 y W/M h/o Testicular Lymphoma 1/2006, s/p Rt Orchiectomy, RCHOP X4 cycles and IT MTX X1 & XRT Lt Testicle, Stage IIB Prostate CA-Gleason 3+3=6 s/p Radical Prostatectomy 6/2003
39 Major Causes of Erythrocytosis Autonomous (inappropriate high) increase of Epo Erythropoietin-producing neoplasms Renal cell carcinoma Hepatocellular carcinoma Hemangioblastoma Uterine fibroids Erythropoietin-producing renal lesions (eg, cysts, hydronephrosis) Following renal transplantation
40 Appropriate increases in Erythropoietin Hypoxemia secondary to: COPD Right-to-left cardiac shunts Sleep apnea Massive obesity (Pickwickian syndrome) High altitude Red cell defects Some cases of congenital methemoglobinemia Chronic carbon monoxide poisoning (including heavy smoking) Polycythemia vera Idiopathic familial polycythemia High oxygen affinity hemoglobins
41 Miscellaneous causes Use of androgens or anabolic steroids Blood doping in athletes Self-injection of erythropoietin
42
43
44
45 Take Home Pearls: -Patients to hydrate before a blood draw -Transfusion don t order CMV neg blood, all blood is LR -All patients on Epo need Iron supplements -Thresholds for PRBC Hct 22 and Plt Transfusions 10K -Ferrous Gluconate -324mg ( 38mg elemental iron) -Ferrous Sulfate -325mg ( 65mg elemental iron) -Prenatal Vitamin- 28mg iron, Folate 800mcg, Vit B12-8mcg -others like Iron glycinate, iron fumarate
46
Anemia. A case-based approach. David B. Sykes, MD, PhD Hematology, MGH Cancer Center June 8, 2017
Anemia A case-based approach David B. Sykes, MD, PhD Hematology, MGH Cancer Center June 8, 2017 Recognizing trends Learning Objectives MCV, RDW, Ferritin, LDH, Reticulocytes Managing complex patients 1.
More informationApproach to a pale child
Approach to a pale child Dr. Dafalla Ahmed Babiker Jazan university objectives Definition of anemia Classification and causes Important points in history and physical examination Investigations. Definition
More informationHAEMATOLOGICAL EVALUATION OF ANEMIA. Sitalakshmi S Professor and Head Department of Clinical Pathology St John s medical College, Bangalore
HAEMATOLOGICAL EVALUATION OF ANEMIA Sitalakshmi S Professor and Head Department of Clinical Pathology St John s medical College, Bangalore Learning Objectives Laboratory tests for the evaluation of anemia
More informationIntroduction and Approach to Anemia
2 nd lecture in Hematology by Dr.Alaa Fadhil Alwan Introduction and Approach to Anemia Anemia is defined clinically as a blood hemoglobin or hematocrit value that is below the appropriate reference range
More informationGeneral Characterisctics
Anemia General Characterisctics Definition: anemia is a decrease in red blood cells. Happens due to underproduction, increased destruction or loss of red cells. Diagnosis of anemia: Hgb < 135 (men) Hgb
More informationI. Definitions. V. Evaluation A. History B. Physical Exam C. Laboratory evaluation D. Bone marrow examination E. Specialty referrals
I. Definitions II. III. Red blood cell life cycle Iron metabolism IV. Causes of anemia A. Kinetic approach 1. decreased production 2. increased destruction 3. blood loss B. Morphologic approach 1. normocytic
More informationTaking The Fear Out of Abnormal CBC s Problems of Production, Destruction or loss
Taking The Fear Out of Abnormal CBC s Problems of Production, Destruction or loss Joanne Eddington, MN, FNP, AOCN Providence Oncology and Hematology Care Clinic - Eastside Blood Cell Abnormalities Abnormalities
More informationBONE MARROW PERIPHERAL BLOOD Erythrocyte
None Disclaimer Objectives Define anemia Classify anemia according to pathogenesis & clinical significance Understand Red cell indices Relate the red cell indices with type of anemia Interpret CBC to approach
More informationINTERELATIONSHIP BETWEEN IDA AND VITAMIN D DEFICIENCY IS NOW ESTABLISHED
INTERELATIONSHIP BETWEEN IDA AND VITAMIN D DEFICIENCY IS NOW ESTABLISHED Rationale for Combining Iron & Vit-D Vit D deficiency and Iron deficiency Anaemia the two most menacing disorders - are inter-related
More informationAnemia 1: Fourth year Medical Students/ October/21/ 2015/ Abdallah Abbadi.MD.FRCP Professor
Anemia 1: Fourth year Medical Students/ October/21/ 2015/ Abdallah Abbadi.MD.FRCP Professor Email: abdalla.awidi@gmail.com Main Hematological diseases A- Benign Hematology 1- Anemias 2- Bleeding disorders
More informationThe Complete Blood Count
The Complete Blood Count (Cartesian Thinking at Its Best) A SEM Image of Normal Human Blood Laurie Larsson February 22, 2010 Anatomy and Philology II Dr. Danil Hammoudi Introduction A complete blood count
More informationMicrocytic Hypochromic Anemia An Approach to Diagnosis
Microcytic Hypochromic Anemia An Approach to Diagnosis Decreased hemoglobin synthesis gives rise to microcytic hypochromic anemias. Hypochromic anemias are characterized by normal cellular proliferation
More informationCollect and label sample according to standard protocols. Gently invert tube 8-10 times immediately after draw. DO NOT SHAKE. Do not centrifuge.
Complete Blood Count CPT Code: CBC with Differential: 85025 CBC without Differential: 85027 Order Code: CBC with Differential: C915 Includes: White blood cell, Red blood cell, Hematocrit, Hemoglobin, MCV,
More informationClinical implications for decreased lymphocytes (lymphopenia) o Corticosteroid therapy, adrenocortical hyperfunction, stress, shock
Learning Objectives At the completion of this program, the participants will be able to: 1. Identify the components of the CBC and Differential and their clinical implications. 2. Identify normal pediatric
More informationEvaluation of Anemia. Md. Shafiqul Bari Associate professor (Medicine) SOMC
Evaluation of Anemia Md. Shafiqul Bari Associate professor (Medicine) SOMC Definition Anemia is operationally defined as a reduction in one or more of the major RBC measurements Hemoglobin concentration
More informationDiagnostic Approach to Patients with Anemia
J KMA Special Issue Diagnostic Approach to Patients with Anemia Seonyang Park, MD Department of Internal Medicine, Seoul National University College of Medicine E mail : seonpark@snu.ac.kr J Korean Med
More informationRed cell disorder. Dr. Ahmed Hasan
Red cell disorder Dr. Ahmed Hasan Things to be learned in this lecture Definition and clinical feature of anemia. Classification of anemia. Know some details of microcytic anemia Question of the lecture:
More informationDisorders of Blood Cells & Blood Coagulation
Disorders of Blood Cells & Blood Coagulation HIHIM 409 WBC count RBC count WBC differential Hemoglobin (HGB) Hematocrit (HCT) % of volume occupied by RBCs CBC Red cell indices Mean cell volume (MCV) average
More informationApproach to the child with anemia. Nittaya Wisanuyothin,MD. Pediatrics Department, Maharat Nakhonratchasima Hospital
Approach to the child with anemia Nittaya Wisanuyothin,MD. Pediatrics Department, Maharat Nakhonratchasima Hospital Definition of anemia Hb< 2 SD or P2.5 below the mean for a healthy of the same gender
More informationInterpreting the CBC. Robert Miller PA Assistant Professor of Clinical Pediatrics and Family Medicine USC Keck School of Medicine Retired
Interpreting the CBC Robert Miller PA Assistant Professor of Clinical Pediatrics and Family Medicine USC Keck School of Medicine Retired The CBC 3 Cell Lines RBCs WBCs Platelets Assess general health Make
More informationSymptoms and Signs in Hematology (2)/ 2013
Symptoms and Signs in Hematology (2)/ 2013 Abdallah Abbadi.MD.FRCP Professor of Medicine,Hematology & Oncology University of Jordan & JUH Email: abdalla.awidi@gmail.com Case one: A 24 yr old female complains
More informationDiseases Of The Blood
Diseases Of The Blood DR. Associate Professor Of Pathology Faculty Of Medicine Ain Shams University Red Blood Cells and Anemia RBC=4-6 million/mm 2 Hb=12-18 g/dl Oxygen Carrying Molecule Hemoglobin Tetramer:
More informationDeconstructing the CBC
Deconstructing the CBC Dr. Ann M. Wexler Solano Hematology Oncology September 10, 2017 What Are the Major Components of Blood? Red Blood Cells (also called erythrocytes) White Blood Cells (also called
More informationASPEN MOUNTAIN MEDICAL CENTER. Lab Health Fair
ASPEN MOUNTAIN MEDICAL CENTER Lab Health Fair GENERAL HEALTH PANEL: CMP CMP The Comprehensive Metabolic Panel is used as a broad screening tool to evaluate organ function and check for conditions such
More informationBeyond the CBC Report: Extended Laboratory Testing in the Evaluation for Hematologic Neoplasia Disclosure
Beyond the CBC Report: Extended Laboratory Testing in the Evaluation for Hematologic Neoplasia Disclosure I am receiving an honorarium from Sysmex for today s presentation. 1 Determining the Etiology for
More informationAbnormal blood counts in children Dr Tina Biss Consultant Paediatric Haematologist Newcastle upon Tyne Hospitals NHS Foundation Trust
Abnormal blood counts in children Dr Tina Biss Consultant Paediatric Haematologist Newcastle upon Tyne Hospitals NHS Foundation Trust Regional Paediatric Specialty Trainees teaching 4 th July 2017 Scope
More informationAnemia 1: Fourth year Medical Students/ Feb/22/ Abdallah Awidi Abbadi.MD.FRCP.FRCPath Professor
Anemia 1: Fourth year Medical Students/ Feb/22/ 2018 Abdallah Awidi Abbadi.MD.FRCP.FRCPath Professor Email: abdalla.awidi@gmail.com Kidney EPO O2 Sensor Blood vessel Definition: Anemia is operationally
More informationAn Oncologist s Approach to Anemia in Adults Christie J. Hilton, DO
An Oncologists Approach to Anemia in Adults (There are not many updates) Christie Hilton DO POMA Winter Symposium 2019 Nemicolin Woodlands 8 Disclosures None 9 Objectives Define anemia Review the classification
More informationApproach to the abnormal CBC
Approach to the abnormal CBC Robert T. Means, Jr., M.D. Hematology and Blood & Marrow Transplant Division University of Kentucky and VA Medical Center Lexington KY General Considerations Always repeat
More informationYear 2003 Paper two: Questions supplied by Tricia
QUESTION 65 A 36-year-old man presents in a post-ictal state after an observed generalised seizure. Full blood investigation shows: haemoglobin 0 g/l [128-175] mean corpuscular volume (MCV) 106 fl [80-7]
More informationBlood DLC, Retic count, PCV, Hb and ESR. Dr. Tamara Alqudah
Blood DLC, Retic count, PCV, Hb and ESR Dr. Tamara Alqudah Differential Leukocyte Count (DLC) There are 5 main types of WBCs: 1. Neutrophils: 40-80% 2. Eosinophils: 1-6 % 3. Basophils: < 1-2% 4. Lymphocytes:
More informationAnemia In the Insurance Applicant What do the numbers mean?
Anemia In the Insurance Applicant What do the numbers mean? Lisa Duckett, M.D. Vice President and Medical Director September 12, 2017 Goals of the presentation Develop a consistent way to analyze Complete
More informationFBC CASES Vernon Louw Clinical Haematology 2010
FBC CASES Vernon Louw Clinical Haematology 2010 FOR EACH OF THE FOLLOWING PATIENTS, SELECT THE MOST LIKELY FINDING FROM THE ANALYSIS OF THE PERIPHERAL BLOOD. A patient with infectious mononucleosis. A
More informationAnemia in the elderly. Nattiya Teawtrakul MD., PhD
Anemia in the elderly Nattiya Teawtrakul MD., PhD Contents Definition of anemia in the elderly The impact of anemia in the elderly Etiology of anemia in the elderly Management of anemia in the elderly
More informationSusan Stegman, MD Medical Director AXA Equitable Life May 3, 2016
Susan Stegman, MD Medical Director AXA Equitable Life May 3, 2016 Underwriting impact Anemia overview Classification of anemia Specific anemia topics Iron deficiency anemia Thalassemia Megaloblastic anemia
More informationTypes of Anaemias and their Management. S. Moncrieffe, Pharm.D., MPH, Dip.Ed., RPh. PSJ CE Mandeville Hotel April 27, 2014
Types of Anaemias and their Management S. Moncrieffe, Pharm.D., MPH, Dip.Ed., RPh. PSJ CE Mandeville Hotel April 27, 2014 Objectives At the end of the presentations participants should be able to: 1. Define
More informationTable 8.1. Epidemiology of Leukemia in the United States (2010) Annual Deaths. Mean Age. Percentage of All Leukemias (%) (Number of New Cases)
Table 8.1. Epidemiology of Leukemia in the United States (2010) Type of Leukemia Annual Incidence (Number of New Cases) Percentage of All Leukemias (%) Annual Deaths Mean Age Acute lymphocytic 5,330 12
More informationSB 6331 (scanned slide available) Keith Duncan; Mills-Peninsula Hospital 52-year-old male with painful right parotid mass.
SB 6331 (scanned slide available) Keith Duncan; Mills-Peninsula Hospital 52-year-old male with painful right parotid mass. SB 6332 Shyam Raghavan/Don Born; Stanford 77-year-old male with right
More informationHematology: Challenging Cases with Your Participation COPYRIGHT
Hematology: Challenging Cases with Your Participation Reed E. Drews, MD Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA Question 1 Question 1 64-year-old man is evaluated during
More informationThe McMaster at night Pediatric Curriculum
The McMaster at night Pediatric Curriculum Wang, M. (2016). Iron Deficiency and Other Types of Anemia in Infants and Children. American Family Physician. 93 (4): 270-278. Objectives Recognize common signs
More informationQUESTIONS OF HEMATOLOGY AND THEIR ANSWERS
QUESTIONS OF HEMATOLOGY AND THEIR ANSWERS WHAT IS TRUE AND WHAT IS FALSE? Questions 1 Iron deficiency anemia a) Is usually associated with a raised MCV. b) The MCH is usually low. c) Is most commonly due
More informationFBC interpretation. Dr. Gergely Varga
FBC interpretation Dr. Gergely Varga #1 71 Y/O female, c/o weakness Test Undertaken : FBC (FBC) Sample Type: Whole Blood [ - 26.09.11 14:59] Hb 7.3 g/dl* 12.0-15.5 RBC 3.5 10^12/l * 3.80-5.60 Hct 0.24
More informationClinical & Laboratory Assessment
Clinical & Laboratory Assessment Dr Roger Pool NHLS & University of Pretoria Clinical Assessment (History) Anaemia ( haemoglobin) Dyspnoea (shortness of breath) Tiredness Angina Headache Clinical Assessment
More informationDepartment of Clinical Haematology
Diagnosis in Primary Care and referral pathway for patients with a raised haematocrit Why implement this pathway? A raised haemoglobin or haematocrit is a common finding and can be a reason for referral.
More informationHematology 101. Cindy Rogers, MT(ASCP) Diagnostics System Specialist
Hematology 101 Cindy Rogers, MT(ASCP) Diagnostics System Specialist More Acronyms...» CBC» RBC» HGB» HCT» WBC» MPV» PLT» RDW» DIFF» H&H» Complete Blood Count» Red Blood Cell» Hemoglobin» Hematocrit» White
More informationTHE KENYA POLYTECHNIC UNIVERSITY COLLEGE
THE KENYA POLYTECHNIC UNIVERSITY COLLEGE SCHOOL OF HEALTH SCIENCES AND TECHNOLOGY DEPARTMENT OF BIOMEDICAL LABORATORY SCIENCES AND TECHNOLOGY DIPLOMA IN MEDICAL LABORATORY SCIENCE END OF YEAR 1 EXAMINATION
More informationInterpreting Blood Tests Part 1. Dr Andrew Smith
Interpreting Blood Tests Part 1 Dr Andrew Smith Outline Part 1 (This Week) Introduction Which Tube!?! FBCs U+Es Part 2 (Next Week): More Electrolytes LFTs Clotting Extras Introduction Bloods are a core
More informationCombining. and New Diagnostic. to Help Clinicians Achieve. Patient Outcomes at. per Healthcare Encounter
Combining and New Diagnostic to Help Clinicians Achieve Patient Outcomes at per Healthcare Encounter Holly McDaniel, MD hmcdaniel@clinpath.com Holly.mcdaniel@bannerhealth.com Holly McDaniel, MD AP/CP and
More informationPreferred Clinical Services for Leading Age Florida August 26-27, 2015
DIAGNOSIS CODING ESSENTIALS FOR LONG-TERM CARE: CHAPTER 3, D CODES DISEASES OF THE BLOOD AND BLOOD-FORMING ORGANS AND CERTAIN DISORDERS INVOLVING THE IMMUNE MECHANISM Preferred Clinical Services for Leading
More informationOBJECTIVES Define anemia and identify the appropriate diagnostic testing necessary to diagnose anemia Discuss various types and causes of anemia Discu
ANEMIA Marjaana Krieger, MSN, RN, NP-C, AOCNP Advanced Oncology Certified Nurse Practitioner Department of Veterans Affairs/ VA Southern Nevada Healthcare System Hematology/Oncology/Infusion Clinic OBJECTIVES
More informationHow Do I Spot Anemia in
Focus on CME at Queen s University McMaster Queen s University How Do I Spot Anemia in By Isaac Odame, MB, ChB, MRCP, FRCPath, FRCPCH In this article: 1. What is anemia? 2. When should I refer? 3. What
More informationHematology 101. Blanche P Alter, MD, MPH, FAAP Clinical Genetics Branch Division of Cancer Epidemiology and Genetics Bethesda, MD
Hematology 101 Blanche P Alter, MD, MPH, FAAP Clinical Genetics Branch Division of Cancer Epidemiology and Genetics Bethesda, MD Hematocrits Plasma White cells Red cells Normal, Hemorrhage, IDA, Leukemia,
More informationPATHOLOGY & PATHOPHYSIOLOGY
PATHOLOGY & PATHOPHYSIOLOGY DISORDERS OF BLOOD DISORDERS OF BLOOD Disorders of Blood Infections Tumours Nutritional disorders Coagulation disorders Congenital disorders Septicaemia Leukemia Iron deficiency
More informationFactors affecting oxygen dissociation curve
P a g e 1 Factors affecting oxygen dissociation curve As you know, hemoglobin contains 4 heme molecules that bind 4 oxygen molecules (8 atoms). These 4 heme molecules, however, do not bind oxygen all at
More informationAplastic anamia & Sideroblastic anemia
Hematology Lecture 7 كلية التقنيات الصحية والطبية قسم التحليالت المرضية Aplastic anamia & Sideroblastic anemia اإلعداد: ظفر جبار دهاق فؤاد APLASTIC ANEMIA What is Aplastic anemia? Aplastic anemia is a
More informationDr. Hasan Fahmawi, MRCP (London), FRCP(Edin) Consultant Physician ANAEMIA
Dr. Hasan Fahmawi, MRCP (London), FRCP(Edin) Consultant Physician ANAEMIA Definition Anaemia refers to a state in which haemoglobin in the blood is below the reference range appropriate for age and
More informationNUTRITIONAL ANEMIA. IAP UG Teaching slides
NUTRITIONAL ANEMIA 1 DEFINITION Anemia is defined as a condition where the hemoglobin conc. or hematocrit of an individual is lower than the level considered normal for the person s age and sex group.
More informationClinician Blood Panel Results
Page 1 of 8 Blood Panel - Markers Out of Range and Patterns (Pattern: proprietary formula using one or more Blood Markers) Blood Panel: Check for Markers that are out of Lab Range ***NOTE*** Only one supplement
More informationExam 1 Review. Cardiopulmonary Symptoms Physical Examination Clinical Laboratory Studies
Exam 1 Review Cardiopulmonary Symptoms Physical Examination Clinical Laboratory Studies WBC Count Differential A patient had been admitted to the hospital for acute shortness of breath. A CXR examination
More informationA Practical Approach to Leukopenia/Neutropenia in Children. Vandy Black, M.D., M.Sc., FAAP OLOL Children s Hospital August 24, 2014
A Practical Approach to Leukopenia/Neutropenia in Children Vandy Black, M.D., M.Sc., FAAP OLOL Children s Hospital August 24, 2014 Disclosures EPIC trial MAST Therapeutics SUSTAIN trial Selexys Pharmaceuticals
More informationProf. Mahmoud Rushdi Faculty of Veterinary Medicine Assiut University Egypt. RBCs counts. Anaemia.
By Prof. Mahmoud Rushdi Faculty of Veterinary Medicine Assiut University Egypt ١ RBCs counts Normal Anaemia Polycythaemia Morphological Etiological Relative Absolute Size Stain Shape Inclusion Hemorrhagic
More information2. Non- hemolytic anemias 3. Normocytic Normochromic Normocytic Normochromic Blood loss. (MCV<80 fl) (MCV fl) (MCV>100 fl)
Definition of Anaemia of Anaemias Approach for diagnosis of Red cell disorders any condition resulting from a significant decrease in the total body erythrocyte mass due to decrease of Hb and or RBCs Hemoglobin
More informationComplete Blood Count PSI AP Biology
Complete Blood Count PSI AP Biology Name: Objective Students will examine how the immunological response affects molecules in the blood. Students will analyze three complete blood counts and create diagnoses
More informationChapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89
Chapter 3 Diseases of the Blood and Bloodforming Organs and Certain Disorders Involving the Immune Mechanism D50-D89 Presented by Jennifer Kurkulonis 1 FOUR MAJOR TYPES OF BLOOD CELLS White blood cells
More informationCase scenarios in Pediatric Hematology and Oncology. Dr. Zainul Aabideen Consultant, Pediatric Hematology and Oncology Burjeel Hospital
Case scenarios in Pediatric Hematology and Oncology Dr. Zainul Aabideen Consultant, Pediatric Hematology and Oncology Burjeel Hospital Objectives * To discuss and learn initial features of childhood leukemia.
More informationHematologic Disorders. Assistant professor of anesthesia
Preoperative Evaluation Hematologic Disorders Dr M.Razavi Assistant professor of anesthesia Anemia Evaluation needs to consider the extent and type of surgery, the anticipated blood loss, and the patient's
More informationUpdates in the Management of Anemia in Cancer. Taylor M. Ortiz, MD May 19, 2017
Updates in the Management of Anemia in Cancer Taylor M. Ortiz, MD May 19, 2017 Objectives Recall common causes of anemia in patients with cancer Understand risks/benefits of blood transfusion in patients
More informationHematologic changes in systemic diseases. Chittima Sirijerachai
Hematologic changes in systemic diseases Chittima Sirijerachai Systemic diseases Infection Renal diseases Liver diseases Connective tissue diseases Malignancy Anemia of chronic disease (ACD) Chronic infections:
More informationHemoglobin. Each alpha subunit has 141 amino acids, and each beta subunit has 146 amino acids.
In the previous lecture we talked about erythropoiesis and its regulation by many vitamins like vitamin B12 and folic acid, proteins, iron and trace elements copper and cobalt. Also we talked about pernicious
More informationFaculty of Medicine Dr. Tariq Aladily
Iron deficiency anemia The most common anemia worldwide Only 10% of ingested iron is absorbed Most dietary iron occurs in meat products Absorbed in duodenum Hepcidin By inhibiting ferroportin, hepcidin
More informationHaematology dilemma s to refer or not to refer?
Haematology dilemma s to refer or not to refer? NWL Pathology GP Study Day Dr Fatts Chowdhury Consultant Haematologist in Transfusion Medicine NHS Blood and Transplant Senior Honorary Clinical Lecturer
More informationAvoiding Early Cancer Claims. Presentation #4. Hank George, FALU
Avoiding Early Cancer Claims Presentation #4 Hank George, FALU Hematology and High Risk of Early Cancer Claims Mild Anemia in elders is underpriced by insurers most likely because of its high prevalence
More informationChapter 28. Media Directory. Hematopoiesis. Regulation of Hematopoiesis. Erythropoietin. Drugs for Hematopoietic Disorders
Chapter 28 Drugs for Hematopoietic Disorders Slide 35 Media Directory Epoetin Alfa Animation Upper Saddle River, New Jersey 07458 All rights reserved. Hematopoiesis Figure 28.1 Hematopoiesis Process of
More informationLisa B. Weissmann, MD
Lisa B. Weissmann, MD Anemia- Most common hematologic disorder Evaluation should be orderly Questions to ask Timing - new, old, rapidity of onset Isolated - only anemia, or other cell lines Size of cells
More informationClassification of Anaemia
Classification of Anaemia Dr Roger Pool Department of Haematology NHLS & University of Pretoria MEASUREMENT OF HAEMATOCRIT The haematocrit ratio (Hct) is the proportion of blood made up of cells - mainly
More informationPCCN Review Hematology
PCCN Review Hematology Leanna R. Miller, RN, MN, CCRN-CMC, PCCN-CSC CEN, CNRN, CMSRN, NP Education Specialist LRM Consulting Nashville, TN Anemia Definition reduction in RBC concentration Causes iron deficiency
More informationHematopoiesis, The hematopoietic machinery requires a constant supply iron, vitamin B 12, and folic acid.
Hematopoiesis, 200 billion new blood cells per day The hematopoietic machinery requires a constant supply iron, vitamin B 12, and folic acid. hematopoietic growth factors, proteins that regulate the proliferation
More informationApproach to Anemia PG CME
Approach to Anemia PG CME 2014 2017 Vikram Mathews Haematology Department Christian Medical College Vellore Definition of Anemia Beutler et al. Blood 2006. Definition of Anemia WHO definition of anemia
More informationHLS Midterm ( )
HLS Midterm (2012-2013) 1. Which of the following cells increase in level during allergic reactions? (a) Neutrophils (b) Basophils (c) Eosinophils (d) Lymphocytes (e) Monocytes 2. Which of the following
More informationOral Iron Safe, Effective, and Misunderstood Duke Debates 2017
Oral Iron Safe, Effective, and Misunderstood Duke Debates 2017 John Strouse, MD, PhD Instructor (temp) Medicine and Pediatrics Director, Adult Sickle Cell Program April 20, 2017 1 Disclosures I have no
More informationLisa B. Weissmann, MD
Lisa B. Weissmann, MD Anemia- Most common hematologic disorder Evaluation should be orderly Questions to ask Timing - new, old, rapidity of onset Isolated - only anemia, or other cell lines Size of cells
More informationLeukocytosis - Some Learning Points
Leukocytosis - Some Learning Points Koh Liang Piu Department of Hematology-Oncology National University Cancer Institute National University Health System Objectives of this talk: 1. To provide some useful
More information20/01/1439. Prof. M. Rushdi. Prof. Mahmoud Rushdi Faculty of Veterinary Medicine Assiut University Egypt.
By Prof. Mahmoud Rushdi Faculty of Veterinary Medicine Assiut University Egypt 1 CBC in Dog 2 1 Evaluation of the red blood cells (RBCs) Erythrocytes picture Determination of RBCs count (/mm 3 or T/l)
More informationComplete Blood Count (CBC) Assist.Prof. Filiz BAKAR ATEŞ
Complete Blood Count (CBC) Assist.Prof. Filiz BAKAR ATEŞ The complete blood count (CBC) is one of the most common blood test used. It analyzes the three major types of cells in blood 1. red blood cells,
More informationTopic owner: Mollie Grow MD MPH, updated June 2018
Iron deficiency Anemia UW Pediatrics Outpatient Clinical Guidelines Sources: AAP Clinical Report Diagnosis and Prevention of Iron Deficiency and Iron- Deficiency Anemia in Infants and Young Children (0
More informationMed Chem 535 ~ Diagnostic Medicinal Chemistry. Hematology ~ Erythrocytes (Red Blood Cells, RBCs)
Med Chem 535 ~ Diagnostic Medicinal Chemistry Hematology ~ Erythrocytes (Red Blood Cells, RBCs) I. Tests A. Red Blood Cell Count (RBC)* B. Hemoblobin (Hb or Hgb)* C. Hematocrit (Hct)* D. Wintrobe Indices
More informationChanges to CBC Reference Ranges
September 28, 2016 July, 2017 Changes to CBC Reference Ranges At Dynacare, our vision is to be Canada s health and wellness solutions leader. As part of our commitment and continuous efforts to enhance
More informationThe LaboratoryMatters
Laboratory Medicine Newsletter for clinicians, pathologists & clinical laboratory technologists. A Initiative. Complete Blood Count This issue highlights: CBC, while ubiquitous, is an excellent diagnostic
More informationPlatelet and WBC disorders
Division of Family Practice Platelet and WBC disorders Adrian Yee MD FRCPC Clinical hematologist Assistant Dean, undergraduate education, IMP asyee@uvic.ca When we understand that slide, we'll have won
More informationApproach To The Evalua4on And Management Of Anemia
Objec4ves Approach To The Evalua4on And Management Of Anemia Usha Perepu, MD Assistant Professor Hematology/Oncology 9/29/15 Defini4on of anemia Review the causes of anemia Laboratory evalua4on of anemia
More informationDisclosures/COI. Cases in Hematopathology. Outline. Heme Path Findings Not to Miss. Normal Peripheral Smear 6/30/2016
Disclosures/COI Cases in Hematopathology Vamsi Kota Assistant Professor Department of Hematology & Medical Oncology Leukemia/BMT I have no disclosures or conflicts of interest regarding this presentation.
More informationPediatric Hematology/Oncology: Blood, Body, and Beyond. Geoffrey S. Kannan, PhD, MD Pediatric Neuro-oncology Pediatric Hematology/Oncology
Pediatric Hematology/Oncology: Blood, Body, and Beyond Geoffrey S. Kannan, PhD, MD Pediatric Neuro-oncology Pediatric Hematology/Oncology Disclosures Nothing to disclose Discuss standard of care for common
More information11. An acute leukemia causing. 12. An adult patient presents with acute. 13. Anemia due to renal failure may be
Hematology Study online at 1. A 23 year old white female has weakness, fatigue and has developed a habit of chewing ice. What are the expected findings in regard to TIBC and Ferritin? 2. A 25 year old
More informationBLOOD. Dr. Vedat Evren
BLOOD Dr. Vedat Evren Blood Liquid suspension of formed elements Blood = Blood cells + plasma Plasma = Coagulation factors + serum Cells = Erythrocytes + Leukocytes + Thrombocytes 8 % of the total body
More informationDoes Morphology Matter in 2017
Does Morphology Matter in 2017 ISLH May 2017 Kathryn Foucar Distinguished Professor Emerita kfoucar@salud.unm.edu Objectives Recognize unique RBC and WBC abnormalities in non-neoplastic disorders Learn
More informationBorderline cytopenias. Dr Taku Sugai Consultant Haematologist
Borderline cytopenias Dr Taku Sugai Consultant Haematologist Borderline cytopenias Neutropenia Thrombocytopenia Anaemia with normal haematinics Two recent cases of cytopenias Neutropenia ANC of more than
More informationThe Evaluation and Classification of Anemia
Case studies and research for better care To refer a patient, call. The Evaluation and Classification of Anemia A diagnostic approach BY AMANDA BRANDOW, DO, MS Anemia is defined as hemoglobin concentration
More informationAPPROACHING TO PANCYTOPENIA
APPROACHING TO PANCYTOPENIA P A T C H A R E E K O M V I L A I S A K, M. D. A S S I S T A N T P R O F E S S O R D I V I S I O N O F P E D I A T R I C H E M A T O L O G Y O N C O L O G Y, D E P A R T M E
More informationMyelodysplastic Syndrome: Let s build a definition
1 MDS: Diagnosis and Treatment Update Gail J. Roboz, M.D. Director, Leukemia Program Associate Professor of Medicine Weill Medical College of Cornell University The New York Presbyterian Hospital Myelodysplastic
More information