Pharmacology Final. 2-Which of the following side effect is not related to atropine?

Transcription

1 Pharmacology Final 1-Which of the following is inhibitory CNS neurotransmitter? a) Acetylcholine b) Dopamine c) Glutamate d) GABA* 2-Which of the following side effect is not related to atropine? a) Dryness of mouth b) Retention of urine c) Tachycardia d) Blurred vision e) Meiosis * 3-which of the following receptors is predominate in lung? a) Alpha1 b) Alph2 c) Beta1 d) Nicotinic receptor e) beta2 * 4-which of the following chemical bounds would create an irreversible combination of an antagonist with its receptor? a) Ionic bound b) Hydrogen bound c) Van der waals bound e) Covalent bound*

2 5-in pharmacokinetics what does the acronym ADME stand for? a) Administration,differentiation,metabolism and exertion. b) absorption,differentiation,metabolism and exertion. c) Administration,distribution,metabolism and exertion. d) Administration,differentiation,metabolism and exertion. e) There is more than one correct answer f) Absorption,distribution,metabolism and exertion.* 6-for a drug given orally, the primary site of drug absorption is : a) The esophagus b) The stomach c) The large intestine e) The upper portion of the small intestine * 7-which of the following statement coneeming the blood brain barrier and the passage of the drugs from the systemic circulation into the cerebrospinal fluid is incorrect? a) The higher the lipid solubility of a drug,the more likely it will cross into the CSF. b) Inflammation of the meninges improves the likelihood that drugs will cross the blood -brain barrier as compared to the normal state. c) p-glycoprotein serves to pump drugs back into the systemic circulation from endothelium cells lining the blood brain barrier. e) ionized drugs are more likely to cross into the CSF than un-ionized drugs* 8-for drug such as piroxicam with a 40 hour half-life and being dosed Once daily (i.e..every 24 hours),steady will be reached shortly following which DOSE? a) 1 st dose. b) 5th dose c) 3rd dose d) 12th dose e) 8th dose* 9-the volume of fluid which drug can be completely removed per unit of time (rate of drug removal ) is termed: a) Distribution b) Metabolism c) Excretion e) Clearance*

3 10-which of the following CYP enzymes is associated with metabolism of the greatest number of drugs and thus most likely to be involved in drug-drug interaction? a) CYP2C9 b) CYP2D6 c) CYP2E1 d) CYP1A2 e) CYP3A4* 11-biotransformation usually result in a product which is more : a) Likely to produce side effects b) Likely to distribute intracellular c) Lipid soluble than the original drug d) Water soluble than the original drug * e) Likely to be reabsorbed by kidney tubules 12-which route of drug administration is most likely to lead first-pass effect? a) Sublingual b) Intravenous c) Intramuscular e) Oral* 13-drugs associated with low efficacy are characterized by: a) High therapeutic dose* b) Small therapeutic dose c) Low therapeutic indices d) High bioavailability e) None of the listed characteristics 14-metoprolol and atentolol : a) Are nonselective beta antagonists b) Have intrinsic sympathomimetic activity c) Have an an ansesthetic action e) Are members of beta 1 selective antagonists group* 15-ephedrine cause: a) Miosis b) Hypotension c) Bronchodilation* d) Bradycardia e) There is more than one correct answer

4 16-wich of the following drugs would be the most effective anti-motion sickness drug for a person planning to travel? a) Atropine b) Scopolamine * c) Darifenacin d) Tropicamide 17-which of the following is correct regarding the neuromuscular blockers (NMBs)? a) Nonadenopolarzing NMBs are administered orally b) Nonadenopolarzing NMBs affect diaphragm muscles first c) Cholinesterase inhibitors reduce the effects of nondepolarizing NMBs* 18-drug discover & development usually start with: a) Phase 0 clinical drug trials b) An idea or hypothesis* c) Acute toxicity studies d) Preclinical studies on tissues and animals 19-which of the following would up-regulate postsynaptic beta1 adrenergic receptors? a) Daily use of propranolol,a beta 1 receptor antagonist* b) Daily use of formoterol,a beta 2 receptor agonist c) Daily use isoproterenol, beta 1 receptor agonist 20-which of the following statement most accurately describes a system having spare receptor? a) Agonist affinity for spare receptor is less than their affinity for "non spare" receptor. b) A single drug-receptor interaction result in many cellar response elements being activate.* c) The number of spare receptor determines the maximum effect d) Spare receptor are sequestered in the cytosol. 21-which of the following is correct regarding somatic motor neurons? a) Responses in the somatic motor neurons are generally slower than in the autonomic nervous system. b) Somatic motor neurons innervate smooth muscles. c) The neurotransmitter at the somatic motor neuron ganglin is norepinephrine d) The neurotransmitter at the somatic motor neuron ganglin is acetylcholine e) Somatic motor neuron do not have ganglia*

5 22-which of the following physiological changes could happen when a person is attacked by a lion : a) Increases in lacrimation (tears) b) Constriction of the pupil (miosis) c) Increases in gastric motility d) Increases in heart rate* e) There is more than one correct answer 23- which of the following is correct regarding sympathetic &parasympathetic systems? a) Acetylcholine activates muscarinic receptor * b) norepinephrine activates muscarinic receptor c) Acetylcholine activates adrenergic receptor 24-Which of the following drugs or classes of drugs will be useful in treatment poisoning with atropine? a) Malathion b) Muscarinic antagonists c) Nicotinic antagonists d) Physostigmine* e) There is more than one correct answer 25-the earliest evidence that a drug is stored in tissue is: a) An increase in plasma protein binding b) A large apparent volume of distribution * c) An increase in the number of free drug excreted in the urine d) A decrease in the amount of free drug excreted in the urine 26-the intensity of the pharmacologic action of a drug is most dependent on : a) The elimination on half-life of the drug b) Concentration of the drug at the receptor site* c) Minimum toxic concentration (MTC) d) Minimum effective concentration (MTE) 27-the incidence of adverse drug reaction rises with age in adult especially after 65 years because of:

6 28-patient (70 kg) received 2000mg of vancomycin as an IV loading dose. The peak plasma concentration of vancomycin was reported to be 28.5 mg/l the apparent volume of distribution is: a) 10 L/KG b) 7 L/KG c) 70 L/KG d) 1 L/KG* 29-which of the following symptom would you except to see in a patient exposed to sarin? a) Dry mouth b) Tachycardia c) Dilation of the pupils ' d) Constriction of pupils(moisis)* 30)which of the following drug id considered to be the agent of cho ice for anaphylactic reaction? a) Clonidine b) Isoproterenol c) Epinephrine* d) Terbutatine Done by:buthainah mfm فليس الحلم ما تراه ي ف نومك..الحلم هو ما يمنعك من النوم

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