Physiology & Development of Chronic Fear (Behavioral Neuroendocrinology Lab)

Size: px
Start display at page:

Download "Physiology & Development of Chronic Fear (Behavioral Neuroendocrinology Lab)"

Transcription

1 Physiology & Development of Chronic Fear (Behavioral Neuroendocrinology Lab) Sonia Cavigelli (PI) Rebecca Crouse (Res Tech II) Michael Caruso (Grad Student)

2 Temperament, Physiology, and Health Animal A Individual A interest physiology approach health Stimuli fear physiology Individual B withdraw health Overarching Question: How do individual difference in behavior and physiology influence health trajectories?

3 Current Lab Projects The Physiology & Development of Behavioral Inhibition (Cavigelli) Adolescent Asthma & Adult Fear (Crouse) Adolescent Social Stress & Adult Fear (Caruso)

4 The Physiology & Development of Behavioral Inhibition Sonia A. Cavigelli Christina M. Ragan Kerry C. Michael

5 Behavioral Inhibition / Shyness in Children Behavioral Inhibition: withdrawal or extreme motor inhibition in response to unfamiliar objects, people, events ~ 15% of children - stable trait: across time & situations (physical/social) - identify in infancy or childhood

6 BI: Health & Physiology Health Risks: - allergies, perhaps asthma - mood disorders (anxiety, depression, ) - in older adults, evidence of faster mortality rates Physiology (fear/stress reactivity ) - glucocorticoid (cortisol) levels (HPA) - cardiovascular reactivity - amygdala activity - short allele of 5-HTT promoter (5-HTTLPR)

7 Behavioral Inhibition ~ Chronic glucocorticoid elevation Kagan et al. 1987

8 Consequences of chronic glucocorticoid elevation Allostatic load hypothesis: cumulative wear-and-tear of physiological systems (McEwen & Stellar 1993) e.g.» Hippocampal cell death» Cognitive impairment» Altered immune function» Reduced androgen production» Shortened life span?

9 Developing an Animal Model - Evidence of temperament/personality: behavioral stability across conditions & time - Experimental manipulations & controls: - environment - physiology - genetics - and interactions - Longitudinal studies - birth to death McClintock, 1982

10 Background: Behavioral Stability & Underlying Physiological Biases Questions: tests of rodent behavioral inhibition: - trait emerges in infancy and is stable? - associated with physiology? - glucocorticoid production? - pro-inflammatory response? - cardiovascular function? - relation to life span? - relation to maternal care experience?

11 Test of Behavioral Inhibition Non-Social Social Adapted from: Takahashi, 1992 & 1994 Cavigelli & McClintock (2003), PNAS, 100: Cavigelli et al. (2007), Physiology & Behavior, 92: 897

12 Approach Latency in Social Arena Behavioral & Glucocorticoid Responses Young Adults Sprage-Dawley male rats (4 mos): - latency to explore in Novel Non-Social and Social Arenas - glucocorticoid production NON-INHIBITED MIXED INHIBITED 20 % Corticosterone (ng/ml NON-INHIBITED HI/HI INHIBITED HI/LO LO/HI LO/LO Approach Latency in Non-Social Arena min 40 min 24 hr Time Cavigelli et al. (2007), Physiology & Behavior, 92: 897

13 Behavioral Stability Young Adults r 59 = 0.39 p < 0.01 Cavigelli et al. (2009), Physiology & Behavior, 98: 205

14 Glucocorticoid Stability Young Adults Cavigelli et al. (2007), Physiology & Behavior, 92: 897 Cavigelli et al. (2009), Physiology & Behavior, 98: 205

15 Swelling Response to KLH (mm) - Day 1 IL-6 (pg/ml) Pro-Inflammatory Response Inhibited Neophilic Non-Inhibited Neophobic Plasma TNF-a (pg/ml) High CORT Neophobic Low CORT Neophilic Inhibited Non-Inhibited At Tail Clip 24-hrs later Hours post-lps injection Non-Inhibited Neophilic t 14 = 4.07 p <.01 Neophobic Inhibited Time Cavigelli et al. (2008); Michael et al. (in prep)

16 Life Span 32% shorter lifespan Cavigelli et al. (2009), Physiology & Behavior, 98: 205

17 Conclusions 1) Behavioral inhibition in outbred rodent model: a) identify at weaning (did not show data) b) stable over time 2) Peripheral biological correlates of BI (could account for health-related outcomes) a) constant ~30% increase in glucocorticoid production b) elevated pro-inflammatory response c) elevated cardiovascular response to novelty 3) Shortened life span

18 Neonate-Mother Interactions Predict Inhibition? Questions: - Does early neonatal or maternal behavior predict offspring inhibition in rodent model? (high sibling BI variance: analyses conducted within litters)

19 Within-litter variance in neonate perioral contact & maternal licking (2-3 fold differences within litters) Ragan et al. (2012), Developmental Psychobiology, 54: 199 Cavigelli et al. (2010), Behavioural Processes, 84: 696

20 Mothers preferentially-lick neonate sibs that make frequent perioral contact Ragan et al. (2012), Developmental Psychobiology, 54: 199

21 Latency to Physical Novelty in Adulthood Latency to Physical Novelty in Adulthood Neonate & mother behaviors predict adult sibling inhibition (opposite direction of prediction) F01 F02 F04 F10 F01 F02 F04 F Perioral Contact/Hrs. Observed r 68 = 0.27, p < Licks/Hrs. Observed r 68 = 0.27, p < 0.05 Similar β values in multiple regression Ragan et al. (2012), Developmental Psychobiology, 54: 199

22 Final Conclusions Rodent BI similar behavioral and physiological characteristics as human behavioral inhibition rodent model allows for experimental, longitudinal/developmental, and intervention studies Physiological correlates of BI may account for differential health outcomes (asthma, anxiety) neuronal, immune, cardiovascular Future research environmental conditions that alter physiology / minimize negative health outcomes focus on early social interactions & epigenetics

23 Funding: NICHD NIMH NIA PSU Collaborators: Robert H. Bonneau (Hershey Med. Ctr) Laura C. Klein (Penn State Univ.) Eric Loken (Penn State Univ.) Martha K. McClintock (U. Chicago) Noah Sandstrom (Williams Coll.) Cynthia Stifter (Penn State Univ.) David J. Vandenbergh (Penn State U) Jason R. Yee (U. Chicago) Students: Kerry C. Michael Catherine E. Barrett Colleen Kovacsics Many undergraduate assistants

24 Research Technician: Rebecca Crouse Asthma and Anxiety Mechanisms behind asthmainternalizing disorder co-morbidity: novel mouse model

25 Possible Mechanisms? 1. Highly stressful experiences of potentially life-threatening respiratory distress with severely labored breathing 2. Chronically-elevated inflammatory responses in the airways

26 How does Early-Life Stress Affect Neuroendocrine Development? - Michael Caruso Adolescence is associated with a marked increase Social behavior (Spear, 2000) Psychopathology (Kessler et al., 2005) Human and rodent adolescents have unique glucocorticoid responses to stress Sensitive period for adverse effects of stress? Social stressors more relevant for developmental stage? Romeo (2010)

27 Adolescent vs. Children Stroud et al. (2009) Gunnar et al. (2009)

PROFESSIONAL AND RESEARCH EXPERIENCE

PROFESSIONAL AND RESEARCH EXPERIENCE Sonia A. Cavigelli Department of Biobehavioral Health 219 Biobehavioral Health Bldg. Pennsylvania State University University Park, PA 16802 phone: (814) 863-0210 email: s-cavigelli@psu.edu EDUCATION Ph.D.

More information

The Pennsylvania State University. The Graduate School. Huck Institutes of Life Sciences

The Pennsylvania State University. The Graduate School. Huck Institutes of Life Sciences The Pennsylvania State University The Graduate School Huck Institutes of Life Sciences SIBLING VARIANCE IN EARLY LIFE SOCIAL INTERACTIONS PREDICTS ADULT ANXIETY-RELATED BEHAVIOR AND PHYSIOLOGY IN RODENTS

More information

Effects of Early Handling on Rat Performance in a Radial Arm Maze Task

Effects of Early Handling on Rat Performance in a Radial Arm Maze Task Effects of Early Handling on Rat Performance in a Radial Arm Maze Task Quentin M. Smith 15 and Robert T. Herdegen III Department of Psychology, Hampden-Sydney College, Hampden-Sydney, VA 23943 Abstract

More information

Social and Emotional Influences on Physiological Stress in Infants, Children and Adolescents

Social and Emotional Influences on Physiological Stress in Infants, Children and Adolescents Social and Emotional Influences on Physiological Stress in Infants, Children and Adolescents Emma K. Adam Program on Human Development and Social Policy School of Education and Social Policy Northwestern

More information

Toxic Stress & the Developing Brain: Risk & Resilience Rosalind J. Wright, MD, MPH

Toxic Stress & the Developing Brain: Risk & Resilience Rosalind J. Wright, MD, MPH Toxic Stress & the Developing Brain: Risk & Resilience Rosalind J. Wright, MD, MPH Horace W. Goldsmith Professor Dean for Translational Biomedical Sciences Department of Pediatrics & Department of Environmental

More information

Section C. Intrinsic and Extrinsic Influences on Infant and Early Childhood Regulatory Development

Section C. Intrinsic and Extrinsic Influences on Infant and Early Childhood Regulatory Development This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this

More information

Diurnal Cortisol Rhythms: Social Determinants and Role as a Risk, State or Scar Marker for Major Depressive Disorder in Youth

Diurnal Cortisol Rhythms: Social Determinants and Role as a Risk, State or Scar Marker for Major Depressive Disorder in Youth Diurnal Cortisol Rhythms: Social Determinants and Role as a Risk, State or Scar Marker for Major Depressive Disorder in Youth Emma K. Adam Human Development and Social Policy, School of Education and Social

More information

Epigenetic and Neurodevelopmental Perspectives on Variation in Parenting Behavior

Epigenetic and Neurodevelopmental Perspectives on Variation in Parenting Behavior Parenting Science and Practice ISSN: 1529-5192 (Print) 1532-7922 (Online) Journal homepage: http://www.tandfonline.com/loi/hpar20 Epigenetic and Neurodevelopmental Perspectives on Variation in Parenting

More information

CHAPTER 9. Biological Foundations of Personality. The Biological Tradition. Temperament

CHAPTER 9. Biological Foundations of Personality. The Biological Tradition. Temperament CHAPTER 9 Biological Foundations of Personality The Biological Tradition Phineas Gage (1823-1860) Temperament Individual differences in general mood or quality of emotional response that are moderately

More information

The Brain on Stress. How the social environment gets under the skin (Biological embedding over the lifecourse) Bruce S. McEwen, Ph.D.

The Brain on Stress. How the social environment gets under the skin (Biological embedding over the lifecourse) Bruce S. McEwen, Ph.D. The Brain on Stress How the social environment gets under the skin (Biological embedding over the lifecourse) Bruce S. McEwen, Ph.D. Alfred E. Mirsky Professor Head, Harold and Margaret Milliken Hatch

More information

The First R Relationships: How Love Builds Brains

The First R Relationships: How Love Builds Brains The First R Relationships: How Love Builds Brains Jean Clinton BMus MD FRCP(C) McMaster University and Children s Hospital Department of Psychiatry and Behavioural Neurosciences Offord Centre for Child

More information

Understanding the potency of stressful early life experiences on brain and body function

Understanding the potency of stressful early life experiences on brain and body function Available online at www.sciencedirect.com Metabolism Clinical and Experimental 57 (Suppl 2) (2008) S11 S15 www.metabolismjournal.com Understanding the potency of stressful early life experiences on brain

More information

CALIFORNIA STATE UNIVERSITY, SACRAMENTO

CALIFORNIA STATE UNIVERSITY, SACRAMENTO COLLEGE OF EDUCATION DEPARTMENT OF SPECIAL EDUCATION, REHABILITATION AND SCHOOL PSYCHOLOGY CALIFORNIA STATE UNIVERSITY, SACRAMENTO School Psychology Diagnostic Clinic 6000 J Street Sacramento, California

More information

Clinical Relevance of Biological Alterations in PTSD. Rachel Yehuda, PhD Mount Sinai School of Medicine New York, NY

Clinical Relevance of Biological Alterations in PTSD. Rachel Yehuda, PhD Mount Sinai School of Medicine New York, NY Clinical Relevance of Biological Alterations in PTSD Rachel Yehuda, PhD Mount Sinai School of Medicine New York, NY New developments in PTSD Conceptual shift New findings of prevalence, longitudinal course,

More information

Resilience in Health Disparities. Edith Chen, Ph.D. American Psychosomatic Society meeting Patricia R. Barchas Lecture March 9, 2018

Resilience in Health Disparities. Edith Chen, Ph.D. American Psychosomatic Society meeting Patricia R. Barchas Lecture March 9, 2018 Resilience in Health Disparities Edith Chen, Ph.D. American Psychosomatic Society meeting Patricia R. Barchas Lecture March 9, 2018 Poverty and Health Percentage) 20" 16" 12" 8" High"poverty"(100%)" 100

More information

Society for Prevention Research 2018 Call for Papers Author Abstract Submission Questions. Research Foci

Society for Prevention Research 2018 Call for Papers Author Abstract Submission Questions. Research Foci Society for Prevention Research 2018 Call for Papers Author Abstract Submission Questions Research Foci Please select your Research Foci. (Select all that apply) Academic Achievement ADHD Addiction Aging

More information

Epigenetic Pathways Linking Parental Effects to Offspring Development. Dr. Frances A. Champagne Department of Psychology, Columbia University

Epigenetic Pathways Linking Parental Effects to Offspring Development. Dr. Frances A. Champagne Department of Psychology, Columbia University Epigenetic Pathways Linking Parental Effects to Offspring Development Dr. Frances A. Champagne Department of Psychology, Columbia University Prenatal & Postnatal Experiences Individual differences in brain

More information

Epigenetics and trauma

Epigenetics and trauma Epigenetics and trauma Influence of trauma on mental health Patrick McGowan, PhD Biological Sciences, UTSC Cell and Systems Biology, Psychology University of Toronto patrick.mcgowan@utoronto.ca Leuven,

More information

The Emerging Intersection of Physical and Mental Health During the Early Life Course. Lilly Shanahan

The Emerging Intersection of Physical and Mental Health During the Early Life Course. Lilly Shanahan The Emerging Intersection of Physical and Mental Health During the Early Life Course Lilly Shanahan University of North Carolina at Chapel Hill -- University of Zurich, Switzerland, starting summer 2016

More information

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PSYCHIATRY PARENT INTERVIEW FOR CHILD SYMPTOMS (P. I. C. S.

THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PSYCHIATRY PARENT INTERVIEW FOR CHILD SYMPTOMS (P. I. C. S. A Child s Name or ID: Date: 2013 THE HOSPITAL FOR SICK CHILDREN DEPARTMENT OF PSYCHIATRY PARENT INTERVIEW FOR CHILD SYMPTOMS (P. I. C. S. - 6) Revised for DSM-III - R (1989) and DSM-IV (1995, 2008) GENERAL

More information

PSYC G Psychobiology of Stress Fall 2012 Dr. Russell Romeo Phone: (212)

PSYC G Psychobiology of Stress Fall 2012 Dr. Russell Romeo Phone: (212) PSYC G4492 -- Psychobiology of Stress Fall 2012 Dr. Russell Romeo rromeo@barnard.edu Phone: (212) 854-5903 I. Bulletin description II. Full course description III. Rationale for giving the course IV. Schedule

More information

Oxytocin and Early Experience. Sue Carter The Brain Body Center Department of Psychiatry University of Illinois at Chicago

Oxytocin and Early Experience. Sue Carter The Brain Body Center Department of Psychiatry University of Illinois at Chicago Oxytocin and Early Experience Sue Carter The Brain Body Center Department of Psychiatry University of Illinois at Chicago At the center of the neuroendocrine mechanisms for parental behavior (both sexes)

More information

The Pennsylvania State University. The Graduate School. Department of Human Development and Family Studies AN EXAMINATION OF TEMPERAMENTAL

The Pennsylvania State University. The Graduate School. Department of Human Development and Family Studies AN EXAMINATION OF TEMPERAMENTAL The Pennsylvania State University The Graduate School Department of Human Development and Family Studies AN EXAMINATION OF TEMPERAMENTAL APPROACH/WITHDRAWAL AND RESPONSES TO NOVEL FOODS ACROSS INFANCY

More information

Searching for the Cause of Autism:

Searching for the Cause of Autism: Searching for the Cause of Autism: How genetics and social experience may intersect Dr Lane Strathearn, MBBS FRACP PhD Professor, Department of Pediatrics, University of Iowa Physician Director, Center

More information

NIH Public Access Author Manuscript Clin Obstet Gynecol. Author manuscript; available in PMC 2014 September 01.

NIH Public Access Author Manuscript Clin Obstet Gynecol. Author manuscript; available in PMC 2014 September 01. NIH Public Access Author Manuscript Published in final edited form as: Clin Obstet Gynecol. 2013 September ; 56(3): 556 565. doi:10.1097/grf.0b013e318299d2a8. Epigenetic Basis for the Development of Depression

More information

Drug addicted mothers show reduced brain reward response to their infants: Can oxytocin reverse the trend?

Drug addicted mothers show reduced brain reward response to their infants: Can oxytocin reverse the trend? Drug addicted mothers show reduced brain reward response to their infants: Can oxytocin reverse the trend? Dr. Lane Strathearn, MBBS FRACP PhD Stead Family Professor, Department of, University of Iowa

More information

Hormones and Behavior

Hormones and Behavior Hormones and Behavior 66 (2014) 517 524 Contents lists available at ScienceDirect Hormones and Behavior journal homepage: www.elsevier.com/locate/yhbeh Regular article Temperament moderates the influence

More information

Neuroscience Foundations of ncbt

Neuroscience Foundations of ncbt Neuroscience Foundations of ncbt So much to know! Informed by several neuroscience findings related to: Brain terminology, location, and function Brain development Memory formulation and reconsolidation

More information

ABNORMAL PSYCHOLOGY: PSY30010 WEEK 1 CHAPTER ONE (pg )

ABNORMAL PSYCHOLOGY: PSY30010 WEEK 1 CHAPTER ONE (pg ) WEEK 1 CHAPTER ONE (pg. 25-54) Abnormal psychology (also known as psychopathology): is concerned with understanding that nature, causes and treatment of mental disorders. To understand mental disorders,

More information

Stress: The Good, Bad, and the Ugly Part One. Catherine Nelson, Ph.D. University of Utah

Stress: The Good, Bad, and the Ugly Part One. Catherine Nelson, Ph.D. University of Utah Stress: The Good, Bad, and the Ugly Part One Catherine Nelson, Ph.D. University of Utah Cathy.nelson@utah.edu Course Overview: Stress Session One Definitions Physiology Toxic Stress Risk factors for experiencing

More information

Commentary: Differentiated Measures of Temperament and Multiple Pathways to Childhood Disorders

Commentary: Differentiated Measures of Temperament and Multiple Pathways to Childhood Disorders Journal of Clinical Child and Adolescent Psychology 2004, Vol. 33, No. 1, 82 87 Copyright 2004 by Lawrence Erlbaum Associates, Inc. Commentary: Differentiated Measures of Temperament and Multiple Pathways

More information

Stress: The Good, Bad, and the Ugly Part Three: Intervention. Catherine Nelson, Ph.D. University of Utah

Stress: The Good, Bad, and the Ugly Part Three: Intervention. Catherine Nelson, Ph.D. University of Utah Stress: The Good, Bad, and the Ugly Part Three: Intervention Catherine Nelson, Ph.D. University of Utah Cathy.nelson@utah.edu Session Three Overview Review Intervention with Children and Youth Behavioral

More information

Life course origins of mental health inequalities in adulthood. Amélie Quesnel-Vallée McGill University

Life course origins of mental health inequalities in adulthood. Amélie Quesnel-Vallée McGill University Life course origins of mental health inequalities in adulthood Amélie Quesnel-Vallée McGill University 1 Inequalities in life expectancy Between countries Across the world 82 yrs 37 yrs 47 yrs 57 yrs Source:

More information

Biological and Experimental Psychology School of Biological and Chemical Sciences Individual Differences in Environmental Sensitivity

Biological and Experimental Psychology School of Biological and Chemical Sciences Individual Differences in Environmental Sensitivity Biological and Experimental Psychology School of Biological and Chemical Sciences Individual Differences in Environmental Sensitivity Michael Pluess, PhD CYFS Signature Event Series, University of Nebraska-Lincoln

More information

The Importance of Attachment in Adolescence. Lesley Bell Therapeutic Social Worker

The Importance of Attachment in Adolescence. Lesley Bell Therapeutic Social Worker The Importance of Attachment in Adolescence Lesley Bell Therapeutic Social Worker What is Attachment Attachment is a deep and enduring emotional bond that connects one person to another across time and

More information

The Resilient Revolution takes on

The Resilient Revolution takes on The Resilient Revolution takes on Attachment, Adverse Childhood Experiences(ACEs) and Neuroscience A Tale of Pathologies? Dr Derek Blincow Blackpool 2018 Grand Theory in Adversity and Child Development

More information

I Was Wired This Way

I Was Wired This Way I Was Wired This Way The Effects of Negative Life Events on Brain Development Negative life experiences in childhood can be a significant source of stress. Children and youth are especially sensitive to

More information

Early Life Roots of Health. Ann Bullock, MD Director Division of Diabetes Treatment and Prevention Indian Health Service

Early Life Roots of Health. Ann Bullock, MD Director Division of Diabetes Treatment and Prevention Indian Health Service Early Life Roots of Health Ann Bullock, MD Director Division of Diabetes Treatment and Prevention Indian Health Service What Happens Early Affects the Rest of Our Lives many adult diseases should be viewed

More information

Depression. Depression Temperament Personality. October 31, 2006

Depression. Depression Temperament Personality. October 31, 2006 Depression * a note to the class on the use of electronics October 31, 2006 Depression How do we define depression? What is the difference between clinical depression and depressed affect? What are some

More information

= add definition here. Definition Slide

= add definition here. Definition Slide = add definition here Definition Slide Definition Slides Developmental Psychology = a branch of psychology that studies physical, cognitive, and social change throughout the life span. Zygote = the fertilized

More information

Emotional Development

Emotional Development Emotional Development How Children Develop Chapter 10 Emotional Intelligence A set of abilities that contribute to competent social functioning: Being able to motivate oneself and persist in the face of

More information

1. Family aggregation and long-term outcome of psychopathology in children and adolescents in the Danish Three Generation Study (3GS)

1. Family aggregation and long-term outcome of psychopathology in children and adolescents in the Danish Three Generation Study (3GS) Aalborg CAP research programme 2016 1. Family aggregation and long-term outcome of psychopathology in children and adolescents in the Danish Three Generation Study (3GS) Objectives: Study of the aggregation

More information

THE SCIENCE OF SELF-REGULATION: IMPLICATIONS FOR PROGRAMS AND POLICIES FOR CHILDREN AND FAMILIES IN POVERTY

THE SCIENCE OF SELF-REGULATION: IMPLICATIONS FOR PROGRAMS AND POLICIES FOR CHILDREN AND FAMILIES IN POVERTY THE SCIENCE OF SELF-REGULATION: IMPLICATIONS FOR PROGRAMS AND POLICIES FOR CHILDREN AND FAMILIES IN POVERTY Clancy Blair, PhD Department of Applied Psychology Steinhardt School of Culture, Education, and

More information

1/30/2018. Risk factors: substance exposure. MY LAB S RESEARCH: Risk factors: Toxicants (BPA)

1/30/2018. Risk factors: substance exposure. MY LAB S RESEARCH: Risk factors: Toxicants (BPA) Risk factors: substance exposure Cocaine Exposure Cannabis Exposure Tobacco Exposure Roussotte F, Soderberg L, et al. 2012. J Neurodev Disorders. 4:22. Marround HE, Tiemeier H, et al. 2016. Biological

More information

Mind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders

Mind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders Mind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders John F. Cryan Ph.D. Professor & Chair Department of Anatomy & Neuroscience & Principal Investigator, Alimentary Pharmabiotic

More information

Capstone Project: Stress and how it effects the brain. Corey Miller Student ID: Dave Banninga COMM

Capstone Project: Stress and how it effects the brain. Corey Miller Student ID: Dave Banninga COMM Capstone Project: Stress and how it effects the brain Corey Miller Student ID: 4238910 Dave Banninga COMM1088 03 Capstone Research Project For this research project the topic I have decided to go with

More information

Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress Regulation

Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress Regulation 5348 The Journal of Neuroscience, April 6, 2011 31(14):5348 5352 Brief Communications Neonatal Novelty-Induced Persistent Enhancement in Offspring Spatial Memory and the Modulatory Role of Maternal Self-Stress

More information

BEHAVIORAL INHIBITION: Linking Biology and Behavior within a Developmental Framework

BEHAVIORAL INHIBITION: Linking Biology and Behavior within a Developmental Framework Annu. Rev. Psychol. 2005. 56:235 62 doi: 10.1146/annurev.psych.55.090902.141532 Copyright c 2005 by Annual Reviews. All rights reserved First published online as a Review in Advance on August 18, 2004

More information

STRESS, POVERTY, AND THE DEVELOPMENT OF EXECUTIVE FUNCTIONS IN CHILDREN: AN EDUCATIONAL CRISIS IN THE MAKING

STRESS, POVERTY, AND THE DEVELOPMENT OF EXECUTIVE FUNCTIONS IN CHILDREN: AN EDUCATIONAL CRISIS IN THE MAKING STRESS, POVERTY, AND THE DEVELOPMENT OF EXECUTIVE FUNCTIONS IN CHILDREN: AN EDUCATIONAL CRISIS IN THE MAKING Clancy Blair, PhD Department of Applied Psychology NYU Neuroscience and Education Lab New York

More information

Background Paper: Shy Children. Briana Jackson. University of Pittsburgh. December 2011

Background Paper: Shy Children. Briana Jackson. University of Pittsburgh. December 2011 1 Background Paper: Shy Children Briana Jackson University of Pittsburgh December 2011 2 Shy Children Being shy is a highly occurring trait. It is seen in our family members, friends, partners, peers,

More information

Childhood trauma and its impact on emotional brain circuits, mood disorder and treatment outcomes

Childhood trauma and its impact on emotional brain circuits, mood disorder and treatment outcomes Childhood trauma and its impact on emotional brain circuits, mood disorder and treatment outcomes Leanne (Lea) Williams, PhD med.stanford.edu/williamslab Learning objectives a) Understand the prevalence

More information

Behavioural Brain Research

Behavioural Brain Research Behavioural Brain Research 226 (2012) 345 350 Contents lists available at SciVerse ScienceDirect Behavioural Brain Research j ourna l ho mepage: www.elsevier.com/locate/bbr Short communication Functional

More information

M3 Pediatric Clerkship

M3 Pediatric Clerkship M3 Pediatric Clerkship The overall goals for the third year Pediatric Clerkship are to educate future physicians to provide competent, effective and compassionate care of patients by developing clinical

More information

How does adversity in childhood get under the skin

How does adversity in childhood get under the skin How does adversity in childhood get under the skin What can we learn from neuroscience and epigenetics? Eamon McCrory Professor of Developmental Neuroscience & Psychopathology, UCL Consultant Clinical

More information

The Aboriginal Mental Health & Wellbeing Workforce Forum 2017 HOW CAN WE REDUCE THE RATES OF SUICIDE IN THE ABORIGINAL COMMUMITIES?

The Aboriginal Mental Health & Wellbeing Workforce Forum 2017 HOW CAN WE REDUCE THE RATES OF SUICIDE IN THE ABORIGINAL COMMUMITIES? The Aboriginal Mental Health & Wellbeing Workforce Forum 2017 HOW CAN WE REDUCE THE RATES OF SUICIDE IN THE ABORIGINAL COMMUMITIES? The rate of suicide among young Indigenous men is the highest in the

More information

Hammen Publications since 2000

Hammen Publications since 2000 Hammen, 1 Hammen Publications since 2000 Rao, U., Daley, S., & Hammen, C. (2000). Relationship between depression and substance use disorders in adolescent women during the transition to adulthood. Journal

More information

Week 2: Disorders of Childhood

Week 2: Disorders of Childhood Week 2: Disorders of Childhood What are neurodevelopmental disorders? A group of conditions with onset in the developmental period Disorders of the brain The disorders manifest early in development, often

More information

Are Fake Sugars Contributing to the Obesity Epidemic? Prenatal and early-life exposure to non-nutritive sweeteners and cardiometabolic health

Are Fake Sugars Contributing to the Obesity Epidemic? Prenatal and early-life exposure to non-nutritive sweeteners and cardiometabolic health Are Fake Sugars Contributing to the Obesity Epidemic? Prenatal and early-life exposure to non-nutritive sweeteners and cardiometabolic health Meghan Azad, PhD Children s Hospital Research Institute of

More information

Early experiences and the development of emotional learning systems in rats

Early experiences and the development of emotional learning systems in rats Callaghan and Richardson Biology of Mood & Anxiety Disorders 2013, 3:8 Biology of Mood & Anxiety Disorders REVIEW Early experiences and the development of emotional learning systems in rats Bridget L Callaghan

More information

Recent advances in the study of biological alterations in post-traumatic stress disorder (PTSD)

Recent advances in the study of biological alterations in post-traumatic stress disorder (PTSD) Psychiatr Clin N Am 25 (2002) xi xv Preface Recent advances in the study of biological alterations in post-traumatic stress disorder (PTSD) Rachel Yehuda, PhD Guest Editor This issue of The Psychiatric

More information

Family-centered Stress Management for Childhood Cancer: A Multimodal Intervention for Children Newly Diagnosed with Cancer and their Families

Family-centered Stress Management for Childhood Cancer: A Multimodal Intervention for Children Newly Diagnosed with Cancer and their Families Family-centered Stress Management for Childhood Cancer: A Multimodal Intervention for Children Newly Diagnosed with Cancer and their Families Linda Ewing, Ph.D., RN Department of Psychiatry University

More information

THE PENNSYLVANIA STATE UNIVERSITY SCHREYER HONORS COLLEGE DEPARTMENT OF BIOBEHAVIORAL HEALTH

THE PENNSYLVANIA STATE UNIVERSITY SCHREYER HONORS COLLEGE DEPARTMENT OF BIOBEHAVIORAL HEALTH THE PENNSYLVANIA STATE UNIVERSITY SCHREYER HONORS COLLEGE DEPARTMENT OF BIOBEHAVIORAL HEALTH EXAMINING A NOVEL METHODOLOGY OF LONG-TERM LOW-DOSE EXOGENOUS CORTICOSTERONE SUPPLEMENTATION IN NEOPHILIC RATS

More information

Sex-dependent effects of maternal corticosterone and SSRI treatment on hippocampal neurogenesis across development

Sex-dependent effects of maternal corticosterone and SSRI treatment on hippocampal neurogenesis across development Gobinath et al. Biology of Sex Differences (2017) 8:20 DOI 10.1186/s13293-017-0142-x RESEARCH Sex-dependent effects of maternal corticosterone and SSRI treatment on hippocampal neurogenesis across development

More information

On the nature, and nurture, of childhood shyness

On the nature, and nurture, of childhood shyness On the nature, and nurture, of childhood shyness Louis A. Schmidt, Ph.D. Professor Department of Psychology, Neuroscience & Behaviour McMaster Integrative Neuroscience Discovery and Study Offord Centre

More information

Department of Psychiatry\Behavioral Health 200 Mercy Drive, Suite 201 Dubuque, IA or

Department of Psychiatry\Behavioral Health 200 Mercy Drive, Suite 201 Dubuque, IA or Department of Psychiatry\Behavioral Health 200 Mercy Drive, Suite 201 Dubuque, IA 52001 563 584 3500 or 800 648 6868 C H I L D H I S T O R Y F O R M Today s Date: Child s Name: Date of Birth: Age: Grade:

More information

Temperament, Personality and Developmental Psychopathology: A Review Based on the Conceptual Dimensions Underlying Childhood Traits

Temperament, Personality and Developmental Psychopathology: A Review Based on the Conceptual Dimensions Underlying Childhood Traits Child Psychiatry Hum Dev (2010) 41:313 329 DOI 10.1007/s10578-009-0171-8 REVIEW PAPER Temperament, Personality and Developmental Psychopathology: A Review Based on the Conceptual Dimensions Underlying

More information

ADHD & Addictions -What We Know

ADHD & Addictions -What We Know ADHD & Addictions -What We Know Dr. David Teplin, Psy.D., C.Psych. 4th CADDAC Annual Conference, Toronto October 14, 2012 1 Introduction Adult ADHD commonly co-exists with several other disorders, including

More information

Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences

Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences Psychopharmacology (2011) 214:141 154 DOI 10.1007/s00213-010-2118-y REVIEW Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences

More information

The Effects of Fibroblast Growth Factor on Anxiety Induced by Maternal Care. Emily Lowry

The Effects of Fibroblast Growth Factor on Anxiety Induced by Maternal Care. Emily Lowry Running head: FGF2, ANXIETY, AND MATERNAL CARE The Effects of Fibroblast Growth Factor on Anxiety Induced by Maternal Care By Emily Lowry A thesis submitted to the Faculty of Arts and Social Sciences in

More information

Effects of Adverse Early-Life Events on Aggression and Anti-Social Behaviours in Animals and Humans

Effects of Adverse Early-Life Events on Aggression and Anti-Social Behaviours in Animals and Humans REVIEW ARTICLE Effects of Adverse Early-Life Events on Aggression and Anti-Social Behaviours in Animals and Humans J. Haller*, G. Harold, C. Sandi and I. D. Neumann *Institute of Experimental Medicine,

More information

The Pennsylvania State University. The Graduate School. College of the Liberal Arts THE DEVELOPMENT OF EARLY PROFILES OF TEMPERAMENT:

The Pennsylvania State University. The Graduate School. College of the Liberal Arts THE DEVELOPMENT OF EARLY PROFILES OF TEMPERAMENT: The Pennsylvania State University The Graduate School College of the Liberal Arts THE DEVELOPMENT OF EARLY PROFILES OF TEMPERAMENT: CHARACTERIZATION, CONTINUITY, AND ETIOLOGY A Thesis in Psychology by

More information

LM- 51 Cognitive neuroscience

LM- 51 Cognitive neuroscience LM- 51 Cognitive neuroscience The master course in Cognitive Neuroscience is particularly suited to students interested in understanding the neural correlates of the cognitive processes as well as the

More information

COMT EFFECT ON AGGRESSION IN CHILDREN WITH & WITHOUT ADHD (British Cohort) blems (t-scores) Aggressive Behaviour Prob. n =

COMT EFFECT ON AGGRESSION IN CHILDREN WITH & WITHOUT ADHD (British Cohort) blems (t-scores) Aggressive Behaviour Prob. n = GENE-ENVIRONMENT ENVIRONMENT INTERDEPENDENCE By Michael Rutter 445oslo1109a 1 SOME BACKGROUND CONSIDERATIONS RE DISORDERS With rare exceptions, most mental disorders are multifactorial Heritability of

More information

Development and Prediction of Hyperactive Behaviour from 2 to 7 Years in a National Population Sample

Development and Prediction of Hyperactive Behaviour from 2 to 7 Years in a National Population Sample Development and Prediction of Hyperactive Behaviour from 2 to 7 Years in a National Population Sample Elisa Romano, Ph.D. University of Ottawa Richard E. Tremblay, Ph.D. Abdeljelil Farhat, Ph.D. Sylvana

More information

Prenatal alcohol exposure and metabolic disease in adulthood

Prenatal alcohol exposure and metabolic disease in adulthood 8 th International Research Conference on Adolescents and Adults with FASD Prenatal alcohol exposure and metabolic disease in adulthood Prof Karen Moritz Director Child Health Research Centre University

More information

NIH Public Access Author Manuscript Nat Rev Neurosci. Author manuscript; available in PMC 2010 March 5.

NIH Public Access Author Manuscript Nat Rev Neurosci. Author manuscript; available in PMC 2010 March 5. NIH Public Access Author Manuscript Published in final edited form as: Nat Rev Neurosci. 2009 June ; 10(6): 446 457. doi:10.1038/nrn2649. Psychobiology and molecular genetics of resilience Adriana Feder

More information

Epigenetics, Stress and the Brain. Epigenetics. The Epigenome. Stress 9/19/12

Epigenetics, Stress and the Brain. Epigenetics. The Epigenome. Stress 9/19/12 Epigenetics, Stress and the Brain Epigenetics Andrew Z. Fire and Craig C. Mello won the Nobel prize in Medicine and Physiology in 2006 for their discovery of "RNA interference gene silencing by double-stranded

More information

The Role of Emotion Suppression in Reaction Time and Threat Response During Highly Intense Stress. Alan Neider Briarcliff High School

The Role of Emotion Suppression in Reaction Time and Threat Response During Highly Intense Stress. Alan Neider Briarcliff High School The Role of Emotion Suppression in Reaction Time and Threat Response During Highly Intense Stress Alan Neider Briarcliff High School Purpose/Introduction This experiments goal was to determine the role

More information

A Developmental Perspective on the Role of Genes on Substance Use Disorder. Elisa M. Trucco, Ph.D., Florida International University

A Developmental Perspective on the Role of Genes on Substance Use Disorder. Elisa M. Trucco, Ph.D., Florida International University A Developmental Perspective on the Role of Genes on Substance Use Disorder Elisa M. Trucco, Ph.D., Florida International University Despite recent technological advances in genotyping, understanding how

More information

Chapter Three BRIDGE TO THE PSYCHOPATHOLOGIES

Chapter Three BRIDGE TO THE PSYCHOPATHOLOGIES Chapter Three BRIDGE TO THE PSYCHOPATHOLOGIES Developmental Psychopathology: From Infancy through Adolescence, 5 th edition By Charles Wenar and Patricia Kerig When do behaviors or issues become pathologies?

More information

The Pennsylvania State University The Graduate School Human Development and Family Studies PATTERNS OF ADRENOCORTICAL REACTIVITY AND RECOVERY TO

The Pennsylvania State University The Graduate School Human Development and Family Studies PATTERNS OF ADRENOCORTICAL REACTIVITY AND RECOVERY TO The Pennsylvania State University The Graduate School Human Development and Family Studies PATTERNS OF ADRENOCORTICAL REACTIVITY AND RECOVERY TO EMOTIONAL CHALLENGES IN EARLY CHILDHOOD: RELATIONS TO CHILD

More information

NEUROBIOLOGY ALCOHOLISM

NEUROBIOLOGY ALCOHOLISM NEUROBIOLOGY ALCOHOLISM THERE HAS BEEN A MAJOR THEORETICAL SHIFT IN MEDICATION DEVELOPMENT IN ALCOHOLISM Driven by animal models of intermittent ethanol administration followed by termination, then access

More information

Issues in the timing of integrated early interventions: contributions from nutrition, neuroscience, and psychological research

Issues in the timing of integrated early interventions: contributions from nutrition, neuroscience, and psychological research Ann. N.Y. Acad. Sci. ISSN 0077-8923 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Issue: Integrating Nutrition and Early Childhood Development Interventions Issues in the timing of integrated early interventions:

More information

MY.JHSPH.EDU HOME About the Center Projects Faculty and Staff Publications Contact Us PFRH Home Contact Us ADDRESS Johns Hopkins Bloomberg School of Public Health Department of Population, Family and Reproductive

More information

Current Directions in the Study of Risk And Adversity in Early Childhood

Current Directions in the Study of Risk And Adversity in Early Childhood Current Directions in the Study of Risk And Adversity in Early Childhood Annual Meeting of the North Carolina Psychiatric Association September 26, 2014 Charles H. Zeanah, M.D. Institute of Infant and

More information

THE PENNSYLVANIA STATE UNIVERSITY SCHREYER HONORS COLLEGE DEPARTMENT OF BIOLOGY

THE PENNSYLVANIA STATE UNIVERSITY SCHREYER HONORS COLLEGE DEPARTMENT OF BIOLOGY THE PENNSYLVANIA STATE UNIVERSITY SCHREYER HONORS COLLEGE DEPARTMENT OF BIOLOGY INVESTIGATING CONSISTENCY AND STABILITY OF TEMPERAMENT IN TWO STRAINS OF RATTUS NORVEGICUS KAYLLIE WANG Spring 2012 A thesis

More information

Stressed out! The science and practice of stress management. Bonnie A. McGregor, Ph.D.

Stressed out! The science and practice of stress management. Bonnie A. McGregor, Ph.D. Stressed out! The science and practice of stress management Bonnie A. McGregor, Ph.D. % endorsing item (n = 134) Cancer survivors beliefs about cancer causes 60 50 40 30 20 10 0 Genetics Stress God's will

More information

Curriculum Vitae. Eric D. Finegood

Curriculum Vitae. Eric D. Finegood Eric D. Finegood Department of Applied Psychology New York University 627 Broadway 8 th Floor New York, NY 10012 EMAIL: efinegoo@nyu.edu TEL: (248) 505-7146 EDUCATION 2012 2018 (expected) New York University

More information

Psychopathic traits in children: Potential for early interventions. Essi Viding Developmental Risk and Resilience Unit, UCL

Psychopathic traits in children: Potential for early interventions. Essi Viding Developmental Risk and Resilience Unit, UCL Psychopathic traits in children: Potential for early interventions Essi Viding Developmental Risk and Resilience Unit, UCL e.viding@ucl.ac.uk Antisocial behaviour: Different subtypes Callous-unemotional

More information

Effects of Stress on the Body. Dr. Gary Mumaugh

Effects of Stress on the Body. Dr. Gary Mumaugh Effects of Stress on the Body Dr. Gary Mumaugh SELYE S CONCEPT OF STRESS Development of the stress concept Through many experiments, Selye exposed animals to noxious agents and found that they all responded

More information

Chapter 3: Biological foundations Genes, temperament, and more

Chapter 3: Biological foundations Genes, temperament, and more Week 3 readings Chapter 3: Biological foundations Genes, temperament, and more - 4 aspects of biology that contribute to children`s social development 1. Biological preparedness: gives babies a head start

More information

Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?

Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge? Vaiserman and Koliada Human Genomics (2017) 11:34 DOI 10.1186/s40246-017-0129-z REVIEW Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge? Alexander M. Vaiserman * and Alexander

More information

The Role of the Immune System in Translating Early-Life Experience to Later-Life Brain and Behavior

The Role of the Immune System in Translating Early-Life Experience to Later-Life Brain and Behavior The Role of the Immune System in Translating Early-Life Experience to Later-Life Brain and Behavior STACI D. BILBO DEPARTMENT OF PSYCHOLOGY AND NEUROSCIENCE DUKE UNIVERSITY Thanks to! Dr. Mark Hutchinson

More information

Allostatic Load/Multisystem Indices: Brain Responses that Predict Health Behaviors & Outcomes

Allostatic Load/Multisystem Indices: Brain Responses that Predict Health Behaviors & Outcomes Allostatic Load/Multisystem Indices: Brain Responses that Predict Health Behaviors & Outcomes RAJITA SINHA, Ph.D. Professor of Psychiatry, Neurobiology and Child Study Yale University School of Medicine

More information

The Pennsylvania State University. The Graduate School. College of Health and Human Development

The Pennsylvania State University. The Graduate School. College of Health and Human Development The Pennsylvania State University The Graduate School College of Health and Human Development CHILDREN S POSITIVE AFFECT AND BEHAVIOR PROBLEMS: THE ROLE OF TEMPERAMENTAL STYLES, PARENTAL BEHAVIORS, AND

More information

MEDICAL ASPECTS OF TRAUMA

MEDICAL ASPECTS OF TRAUMA MEDICAL ASPECTS OF TRAUMA Toxic Stress and Health Heather C. Forkey, M.D. Foster Children Evaluation Service (FaCES) UMass Children s Medical Center Worcester MA Disclosure slide I have no actual or potential

More information

The Influences of Early Temperament and Emotion Regulation on Social Competence in Middle Childhood

The Influences of Early Temperament and Emotion Regulation on Social Competence in Middle Childhood University of Miami Scholarly Repository Open Access Dissertations Electronic Theses and Dissertations 2013-07-22 The Influences of Early Temperament and Emotion Regulation on Social Competence in Middle

More information

Tony Charman: Longitudinal studies for autism research

Tony Charman: Longitudinal studies for autism research VIEWPOINT Tony Charman: Longitudinal studies for autism research BY TONY CHARMAN 24 JANUARY 2012 1 / 8 2 / 8 3 / 8 4 / 8 Facing forward: When Tony Charman first began studying autism in the 1980s, long-term

More information

Beyond Licking and Grooming: Maternal Regulation of Infant Stress in the. Context of Routine Care 1. Amie Ashley Hane and Lauren E.

Beyond Licking and Grooming: Maternal Regulation of Infant Stress in the. Context of Routine Care 1. Amie Ashley Hane and Lauren E. Running head: BEYOND LICKING AND GROOMING Beyond Licking and Grooming: Maternal Regulation of Infant Stress in the Context of Routine Care 1 Amie Ashley Hane and Lauren E. Philbrook Corresponding author:

More information

Roots of Adult Disease Traced to Early Childhood Adversity

Roots of Adult Disease Traced to Early Childhood Adversity Contact: Millicent Lawton Center on the Developing Child millicent_lawton@harvard.edu (617) 496-0429 Roots of Adult Disease Traced to Early Childhood Adversity Early childhood programs could prevent chronic

More information