TB e HIV nelle coorti
|
|
- Rosemary French
- 6 years ago
- Views:
Transcription
1 TB e HIV nelle coorti Antonella d Arminio Monforte Clinica di Malattie Infettive Dipartimento di Scienze della Salute Università degli Studi di Milano Presidio Ospedalero San Paolo, ASST Santi Paolo e Carlo Milano
2 Outline Tubercolosi in Europa Tb e HIV MDR e Eastern Europe Mortalità per Tb Dati Icona Recupero viro-immunologico in corso di ART
3 TB notifications by country In 2013, TB cases were reported in the EU/EEA. The notification rate was 12.7 per population (range ). Figure 1: TB notification rate per population by country, EU/EEA, 2013 < 5 per to 9 per to 19 per to 49 per per Not included or not reporting
4 TB cases of foreign origin In 2013, the proportion of TB cases of foreign origin in the EU/EEA was 28.0% (range %). Figure 6: Percentage of TB cases of foreign origin by country, EU/EEA, 2013 < 1% 1 to 24.9% 25 to 49.9% 50 to 74.9% 75% Not included or not reporting 4
5 Multidrug-resistant TB among all TB cases In 2013, the proportion of TB cases with multidrugresistance in the EU/EEA was 4.1% (range %). Figure 9: Percentage of MDR TB among all confirmed TB cases by country, EU/EEA, 2013 < 1% 1 to 1.9% 2 to 4.9% 5 to 9.9% 10% Not included or not reporting 5
6 TB/HIV co-infection In 2013, the proportion HIV positive among TB cases with known HIV status in EU/EEA was 4.9% (range %). Figure 14: Percentage of HIV-positive cases among TB cases with known HIV status, by country, EU/EEA, 2013 < 1% 1 to 4.9% 5 to 9.9% 10% Not reporting 6
7 PLOS ONE DOI: /journal.pone December 30, / 17 Objectives Rates of TB/HIV coinfection and multi-drug resistant (MDR)-TB are increasing in Eastern Europe (EE). We aimed to study clinical characteristics, factors associated with MDR-TB and predicted activity of empiric anti-tb treatment at time of TB diagnosis among TB/HIV coinfected patients in EE, Western Europe (WE) and Latin America (LA).
8 1413 patients with TB
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23 In conclusion, our analysis showed that HIV-infected patients starting cart when ART naive and with a tuberculosis diagnosis have an impaired immune recovery with cart,mainly because of differences in level of viral suppression between them and both patients with nontuberculosis AIDS and those without AIDS. Further studies need to be performed to determine whether our findings may be explained by pharmacokinetic interactions between the 2 treatments or to specific interactions between M. tuberculosis and HIV or both. Nevertheless, our results suggest that strategies aimed at preventing tuberculosis cases may increase the chances of virological and immunological response to cart
24
25 Introduction CROI 2016 Poster 751 Tuberculosis (TB) may play an important role in immune recovery and HIV replication after ART initiation among HIV-infected individuals. We examined the CD4 cell and HIV-RNA viral load changes on ART in patients without, with prevalent or a history of TB.
26 Baseline Characteristics- Cohere CROI 2016; Boston February Poster 751
27 Results CD4 cell increases were lower in patients with prevalent and recent TB compared to patients without a TB history. This effect was more pronounced in the first months of ART and in patients with higher baseline CD4 count. Patients with prevalent TB had slower overall viral load decline especially during the first months of ART. Patients with recent TB showed a slower viral load decline only during the first 6 months of ART. Non-European, especially Sub-Saharan Africa origin, was associated with lower CD4 increases and slower HIV-RNA declines, as was female sex. Older age was associated with lower CD4 increases but faster viral load declines. CROI 2016; Boston February Poster 751
28 Modelled CD4 cell trajectories (A), and HIV RNA viral load trajectories (adjusted) (B) in HIV-positive patients presenting with tuberculosis (TB) at ART start without a history of TB Fitted change for a male reference patient, 38 years, European, heterosexual, on cart at baseline A B CROI 2016; Boston February Poster 751
29 Associations of CD4 cell count and HIV-RNA viral load changes after starting ART in HIV-positive patients with prevalent TB at ART start and a recent history of TB compared to patients without a history of TB
30 Conclusions TB had a significant effect on virological and immunological response to ART which was most pronounced during the first year of ART. CD4 cell recovery after ART start was worse in patients presenting with prevalent or recent TB. Viral load decline tended to be slower only in patients with prevalent TB. These effects were more pronounced in patients from high-tb incidence countries who may require attention in clinical management. CROI 2016; Boston February Poster 751
31 TB and HIV in the cohorts: conclusions Also from data of the cohorts of HIV patients it is evident that epidemics in Eastern Europe is more dramatic, more severe and more often sustained by MDR Tb as compared to epidemics in Western Europe. In Italy, most cases of HIV-Tb occur in non Italian people, and in severely immunodepressed patients Patients with HIV-Tb have a less pronuonced immune reconsititution in the first year of ART Special attention may be required in recent TB cases starting ART
TB epidemic and progress towards the Millennium Development Goals
Open Forum 4: Key issues in TB Drug Development, August 18, 2010, Addis Ababa, Ethiopia TB epidemic and progress towards the Millennium Development Goals Haileyesus Getahun Stop TB Department, WHO Geneva,
More informationIn 2013, around 12.9 million people living with HIV had access to antiretroviral therapy.
F A C T S H E E T 2014 GLOBAL STATISTICS People living with HIV In 2013, there were 35 [33.2 37.2 ] people living with HIV. - Since the start of the epidemic, around 78 [71 87 ] people have become infected
More informationEpidemiology of tuberculosis in Europe. Marieke J. van der Werf European Centre for Disease Prevention and Control Amsterdam, 22 September 2014
Epidemiology of tuberculosis in Europe Marieke J. van der Werf European Centre for Disease Prevention and Control Amsterdam, 22 September 2014 Tuberculosis surveillance in the EU Aim: To provide a complete
More informationCan we treat our way out of the HIV epidemic?
Can we treat our way out of the HIV epidemic? Richard E. Chaisson, MD Center for AIDS Research Center for TB Research Johns Hopkins University Schoolboy s (and politician s) tricks for evading the question
More informationHIV/AIDS in East Asia
HIV/AIDS in East Asia Yonsei University Graduate School of Global Health Sohn, Myong Sei Epidemiology Global summary of the AIDS epidemic, 2008 Number of people living with HIV in 2008 Total Adults Women
More informationTuberculosis-related deaths in people living with HIV have fallen by 36% since 2004.
F A C T S H E E T 2014 GLOBAL STATISTICS People living with HIV In 2013, there were 35 [33.2 37.2 ] people living with HIV. - Since the start of the epidemic, around 78 [71 87 ] people have become infected
More informationHIV and Paediatrics in Central Europe
2nd Central and Eastern European Meeting on Viral Hepatitis and Co-Infection with HIV HIV and Paediatrics in Central Europe Mariana Mărdărescu MD PhD Consultant in Infectious Diseases Senior Doctor in
More informationProgress on the targets of Millennium Development Goal 6 in central and eastern Europe and central Asia
Progress on the targets of Millennium Development Goal 6 in central and eastern Europe and central Asia 11 October 2011 Moscow, Russian Federation Zsuzsanna Jakab WHO Regional Director for Europe Millennium
More informationTable S1. Number of eligible individuals by cohort, HIV-CAUSAL and CNICS Collaborations,
Cohort Table S1. Number of eligible individuals by cohort, HIV-CAUSAL and CNICS Collaborations, 2000-2013 No. of antiretroviraltherapy naïve individuals No. initiated cart regimen in 2000 or later No.
More informationWho is a migrant? 12/10/2018. HIV and migrants. Heterogeneous groups of persons with different migration drivers
HIV and migrants Julia del Amo has received research grants awarded to her institution from Companies BMS, Gilead, ViiV and epidemiology teaching fees from ViiV, Gilead and MSD Dr Julia del Amo National
More informationAntiretroviral Therapy Cohort Collaboration
Antiretroviral Therapy Cohort Collaboration http://www.bristol.ac.uk/art-cc/research/presentations/ 2015 22nd Conference on Retroviruses and Opportunistic Infections, Seattle, USA, February 2015 Margaret
More informationScaling up priority HIV/AIDS interventions in the health sector
TOWARDS UNIVERSAL ACCESS? Scaling up priority HIV/AIDS interventions in the health sector Yves Souteyrand, WHO October 2011 Towards universal access targets UN General Assembly High level Meeting June
More informationThe Impact of the Global Economic Crisis on HIV and AIDS. Carlos Avila. 7 December 2009 UNAIDS Geneva
The Impact of the Global Economic Crisis on HIV and AIDS Carlos Avila 7 December 2009 UNAIDS Geneva Outline 1. What the monitoring system is telling us? 2. What are the driving forces? 3. What countries
More informationSince the start t of the HIV/ 1980 s: 77.3 million people have be. In million people were liv
The HIV/AIDS Epidemic and Sustainable Development tgoals Etienne Karita, MD MSc MSPH Kigali, 8 Nov 018 IV/AIDS Burden Since the start t of the HIV/ V/AIDS epidemic i in the early 1980 s: 77.3 million people
More informationTB surveillance. Philippe Glaziou Dubrovnik, May 2009
TB surveillance Philippe Glaziou Dubrovnik, May 2009 What are the global TB targets? Outcome targets (World Health Assembly, STB Partnership) Case detection ratio > 70% Treatment success > 85% 2015 Impact
More informationThe EACS Standard of Care initiative. The Standard of Care for HIV and Coinfections in Europe meeting in Rome: a reminder
The EACS Standard of Care initiative. The Standard of Care for HIV and Coinfections in Europe meeting in Rome: a reminder Antonella d Arminio Monforte, University of Milan Cristina Mussini, University
More informationAIDS at 25. Epidemiology and Clinical Management MID 37
AIDS at 25 Epidemiology and Clinical Management Blood HIV Transmission transfusion injection drug use Sexual Intercourse heterosexual male to male Perinatal intrapartum breast feeding Regional HIV and
More informationTuberculosis and HIV coinfection still a challenge in Central and Eastern Europe
Tuberculosis and HIV coinfection still a challenge in Central and Eastern Europe Prof. A. Panteleev Pavlov First Saint Petersburg State Medical University 2 nd TB hospital, St. Petersburg 250 200 150
More informationTB in the SEA Region. Review Plans and Progress. Dr Md Khurshid Alam Hyder Medical Officer TB SEARO/WHO
TB in the SEA Region Review Plans and Progress Dr Md Khurshid Alam Hyder Medical Officer TB SEARO/WHO The SEA Region: 25% of the world s people, but >33% of TB patients Eastern M editerranean Region 5%
More informationModule 1: HIV epidemiology, transmission and prevention
Session 1 Module goals Module 1 Participants will be able to: -offer an insight into the epidemiological situation in the country and worldwide -present the HIV transmission modes and the broad approaches
More informationProgram to control HIV/AIDS
90-90-90 Program to control HIV/AIDS Hamid Sharifi Associate Professor in Epidemiology [sharifihami@gmail.com] 1 Targets for ending the AIDS epidemic 2 New HIV infections in low- and middle-income countries,
More informationThe epidemiology of tuberculosis
The epidemiology of tuberculosis Tuberculosis Workshop Shanghai, 12-22 May 28 Philippe Glaziou World Health Organization Outline Epidemiology refresher Estimates of tuberculosis disease burden Notifications
More information2010 global TB trends, goals How DOTS happens at country level - an exercise New strategies to address impediments Local challenges
Outline of what it will take Tuberculosis Elimination 25: Global and Local Challenges Anne Fanning, MD November 9, 211 21 global TB trends, goals How DOTS happens at country level - an exercise New strategies
More informationGLOBAL STATISTICS FACT SHEET 2015
FACT SHEET 2015 GLOBAL STATISTICS 15.8 people accessing antiretroviral therapy (June 2015) 36.9 [34.3 41.4 ] people globally were living with HIV (end 2014) 2 [1.9 2.2 ] people became newly infected with
More informationHIV AND LUNG HEALTH. Stephen Aston Infectious Diseases SpR Royal Liverpool University Hospital
HIV AND LUNG HEALTH Stephen Aston Infectious Diseases SpR Royal Liverpool University Hospital Introduction HIV infection exerts multiple effects on pulmonary immune responses: Generalised state of immune
More informationA smart and doable investment
90-90-90 A smart and doable investment As of December 2013 Adults and children living with HIV Adults and children newly infected Adult & child deaths due to AIDS 35.0 million [33.2 million 37.2 million]
More informationAIDS at 30 Epidemiology and Clinical Epidemiology and Management MID 37
AIDS at 30 Epidemiology and Clinical Management Blood HIV Transmission transfusion injection drug use Sexual Intercourse heterosexual male to male Perinatal intrapartum breast feeding Adults and children
More informationGLOBAL HIV STATISTICS
F A C T S H E E T W O R L D A I D S D A Y 2017 GLOBAL HIV STATISTICS 20.9 million people were accessing antiretroviral therapy in June 2017. 36.7 million [30.8 million 42.9 million] people globally were
More informationTowards universal access
Key messages Towards universal access Scaling up priority HIV/AIDS interventions in the health sector September 2009 Progress report Towards universal access provides a comprehensive global update on progress
More informationHIV and Tuberculosis in Eastern Europe
HIV and Tuberculosis in Eastern Europe Daria N. Podlekareva Meeting Standard of Care for HIV and Coinfections in Europe Rome, November 25-16 2014 TB notification rates (per 100.000) European region 2012
More informationL aderenza del trattamento e strategie
L aderenza del trattamento e strategie di prevenzione per la reinfezione HIV/HCV coinfetto alla terapia Teresa Bini UO Malattie Infettive ASST Santi Paolo e Carlo Università di Milano PWID A preliminary
More informationTB Intensive Tyler, Texas December 2-4, Tuberculosis and HIV Co-Infection. Lisa Y. Armitige, MD, PhD. December 4, 2008.
TB Intensive Tyler, Texas December 2-4, 2008 Tuberculosis and HIV Co-Infection Lisa Y. Armitige, MD, Ph.D. December 4, 2008 Tuberculosis and HIV Co Infection Lisa Y. Armitige, MD, PhD Assistant Professor
More informationThe WHO END-TB Strategy
ENDING TB and MDR-TB The WHO END-TB Strategy Dr Mario RAVIGLIONE Director Joint GDI/GLI Partners Forum WHO Geneva, 27 April 2015 This talk will deal with TB Burden Progress, Challenges Way Forward Who
More informationCommunity oriented studies. New perspectives
Community oriented studies. New perspectives Swiss HIV Cohort Study Increased Viral Load Suppression in HIV+ Persons on ART Cohort size: 4624 4852 5045 5279 5556 5830 6121 6418 6526 100 Percent of individuals
More informationGuidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents
Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents Visit the AIDSinfo website to access the most up-to-date guideline. Register for e-mail notification of guideline
More informationHIV behandeling, een internationaal perspectief LUT LYNEN DEPARTEMENT KLINISCHE WETENSCHAPPEN ITG
HIV behandeling, een internationaal perspectief LUT LYNEN DEPARTEMENT KLINISCHE WETENSCHAPPEN ITG 1981: The beginning of AIDS The different faces of AIDS in the early days HIV prevalence world map WAAROM?
More informationEvolving Realities of HIV Treatment in Resource-limited Settings
Evolving Realities of HIV Treatment in Resource-limited Settings Papa Salif Sow MD, MSc Department of Infectious Diseases University of Dakar, Senegal Introduction: ARV access in RLS Scale-up of ART has
More informationProgress against the HIV Epidemic: is the end in sight?
Progress against the HIV Epidemic: is the end in sight? Christine Hughes, BscPharm, PharmD, FCSHP Professor, Faculty of Pharmacy & Pharmaceutical Sciences University of Alberta Clinical Pharmacist, Northern
More informationInstitut Pasteur du Cambodge scientific report and 2018 prospects Rapport 2017 et programmation scientifique 2018 IMMUNOLOGY PLATFORM
Institut Pasteur du Cambodge 2017 scientific report and 2018 prospects Rapport 2017 et programmation scientifique 2018 IMMUNOLOGY PLATFORM 3.4. IMMUNOLOGY PF (total 4 pages) 3.4.1. FUNCTIONAL STRUCTURE
More informationInterventions to improve screening for latent TB: effectiveness and outcomes
Interventions to improve screening for latent TB: effectiveness and outcomes Fotinie Ntziora, Thushan DeSilva, Natasha Baker, Debbie Talbot, Louise Byrne, Karen Sherry, Sandra Booth, Janice Hobson, Karen
More informationPrevention and care towards vulnerable and stigmatized populations (MSM, drug users, sex workers)
Prevention and care towards vulnerable and stigmatized populations (MSM, drug users, sex workers) Joseph LARMARANGE - CEPED/IRD Symposium ANRS - AIDS 2012-23 July 2012 Epidemiological context» South America
More informationDate of study period: April 12 May 7, 2010 and August September, 2010
Classification of antiretroviral therapy failure using immunologic and clinical versus virologic monitoring in HIV-infected children and adolescents in Cambodia Date of study period: April 12 May 7, 2010
More informationDrug-resistant Tuberculosis
page 1/6 Scientific Facts on Drug-resistant Tuberculosis Source document: WHO (2008) Summary & Details: GreenFacts Context - Tuberculosis (TB) is an infectious disease that affects a growing number of
More informationTuberculosis: Opportunities and Challenges for Achieving HIV Epidemic Control
Tuberculosis: Opportunities and Challenges for Achieving HIV Epidemic Control Suvanand Sahu Deputy Executive Director Stop TB Partnership Secretariat Tuberculosis TB epidemic is declining very slowly We
More informationWhich Scale Up Strategies/Programmatic Mixes are most Cost-Effective? Iris Semini UNAIDS May 2018
Which Scale Up Strategies/Programmatic Mixes are most Cost-Effective? Iris Semini UNAIDS May 2018 Outline Scaling up for Impact Critical Point of the Response Choices of strategies Accelerating Implementation
More informationTB/HIV Co-Infection. Tuberculosis and HIV
TB Intensive Tyler, Texas June 2-4, 2010 TB/HIV Co-Infection Lisa Y Armitige, MD, PhD June 3, 2010 Tuberculosis and HIV Co-Infection Lisa Y Armitige, MD, PhD Medical Consultant Heartland National TB Center
More informationQuestions and Answers Press conference - Press Centre Room 3 Wednesday 16 August 2006, 14.00hrs
Questions and Answers Press conference - Press Centre Room 3 Wednesday 16 August 2006, 14.00hrs What causes TB? TB is caused by the bacterium Mycobacterium tuberculosis. Although it can cause disease in
More informationThresia Sebastian MD, MPH University of Colorado, Denver Global Health Disasters Course October 2016
Thresia Sebastian MD, MPH University of Colorado, Denver Global Health Disasters Course October 2016 1 Objectives of today s lecture Describe global goals in the fight against HIV Review the epidemiology
More informationKey issues for HIV testing and
Key issues for HIV testing and counselling in Europe Martin C Donoghoe Programme Manager HIV/AIDS, STI &Viral Hepatitis Programme WHO Europe Key issues for HIV testing & counselling in Europe HIV epidemics
More informationTUBERCULOSIS AND HIV/AIDS: A STRATEGY FOR THE CONTROL OF A DUAL EPIDEMIC IN THE WHO AFRICAN REGION. Report of the Regional Director.
30 August 2007 REGIONAL COMMITTEE FOR AFRICA ORIGINAL: ENGLISH Fifty-seventh session Brazzaville, Republic of Congo, 27 31 August Provisional agenda item 7.8 TUBERCULOSIS AND HIV/AIDS: A STRATEGY FOR THE
More informationOkinawa, Toyako, and Beyond: Progress on Health and Development
Okinawa, Toyako, and Beyond: Progress on Health and Development Prof. Michel D. Kazatchkine Executive Director The Global Fund to Fight AIDS, Tuberculosis and Malaria United Nations University, Tokyo,
More informationEventi cerebro-vascolari: davvero una nuova frontiera?
Eventi cerebro-vascolari: davvero una nuova frontiera? Leonardo Calza Clinica di Malattie Infettive, Policlinico S.Orsola-Malpighi, Università di Bologna (Lancet 2016) Changes in leading 30 causes of death,
More informationNumber of people receiving ARV therapy in developing and transitional countries by region,
Progress in numbers The last six months have seen dramatic progress toward the 3 by 5 target. Between June and, the number of people receiving antiretroviral (ARV) therapy in developing and transitional
More information227 28, 2010 MIDTERM EXAMINATION KEY
Epidemiology 227 April 28, 2010 MIDTERM EXAMINATION KEY Select the best answer for the multiple choice questions. There are 64 questions and 9 pages on the examination. Each question will count one point.
More informationPART II! IMMUNE SENESCENCE!
PART II! IMMUNE SENESCENCE! IMMUNE SENESCENCE! RESEARCH IN HIV Background Senescence: the state of being old or the process or aging Immune senescence: the immune system profile seen in the elderly Does
More informationHIV Lecture. Anucha Apisarnthanarak, MD Division of Infectious Diseases Thammasart University Hospital
HIV Lecture Anucha Apisarnthanarak, MD Division of Infectious Diseases Thammasart University Hospital End-2001 global estimates for children and adults People living with HIV/AIDS New HIV infections in
More informationAIDS Acquired Immune Deficiency Syndrom
HIV and AIDS World, Europe and Poland Dorota Chrominska-Szosland MD, PhD Nofer Institute of Occupational Medicine Lodz-Poland HIV Human Immunodeficiency Virus AIDS Acquired Immune Deficiency Syndrom 1
More informationAnnual Epidemiological Report
November 218 Annual Epidemiological Report 1 Hepatitis C in Ireland, 217 Key Facts Number of cases, 217: 62 Crude notification rate, 217: 13/1, population The number of notifications of hepatitis C decreased
More informationImmunologic and Virologic Disease Progression and Response to ART Across Geographic Regions: Outcomes from HPTN 052
Immunologic and Virologic Disease Progression and Response to ART Across Geographic Regions: Outcomes from HPTN 052 Mina C. Hosseinipour, MD, MPH Site Investigator UNC Project, Lilongwe, Malawi UNC School
More informationTuberculosis surveillance in Germany. Data of the tuberculosis report 2013
1 Tuberculosis surveillance in Germany Data of the tuberculosis report 2013 Robert Koch Institute (RKI) Respiratory Infections Unit Outline 2 Tuberculosis notification system in Germany Epidemiological
More informationThe Epidemiology of Tuberculosis in Minnesota,
The Epidemiology of Tuberculosis in Minnesota, 2011 2015 Minnesota Department of Health Tuberculosis Prevention and Control Program (651) 201-5414 Tuberculosis surveillance data for Minnesota are available
More informationAnnual Epidemiological Report
Annual Epidemiological Report March 2018 National TB surveillance in Ireland, 2017 Key Facts 321 TB cases were notified to HPSC corresponding to a crude incidence rate (CIR) of 6.7 HSE East reported the
More information511,000 (57% new cases) ~50,000 ~30,000
Latest global TB estimates - 2007 (Updated Mar 2009) All forms of TB Greatest number of cases in Asia; greatest rates per capita in Africa Multidrug-resistant TB (MDR-TB) Estimated number of cases 9.27
More informationInvesting for Impact
Global Fund Strategic Framework: Investing for Impact M&E: Capturing data to improve services Workshop to Scale Up the Implementation of Collaborative TB/HIV Activities in Africa 10-11 April, 2013; Maputo,
More informationINH Prophylaxis Therapy (IPT) should NOT be implemented for all HIV patients in the Asia Pacific
INH Prophylaxis Therapy (IPT) should NOT be implemented for all HIV patients in the Asia Pacific Thuy Le, MD DPhil Duke University School of Medicine, USA Oxford University Clinical Research Unit Hospital
More informationENDING AIDS, TB AND MALARIA AS EPIDEMICS
ENDING AIDS, TB AND MALARIA AS EPIDEMICS A SMART INVESTMENT In 2000, AIDS, tuberculosis and malaria appeared to be unstoppable. In many countries, AIDS devastated an entire generation, leaving countless
More informationENDING AIDS, TB AND MALARIA AS EPIDEMICS
ENDING AIDS, TB AND MALARIA AS EPIDEMICS A SMART INVESTMENT In 2000, AIDS, tuberculosis and malaria appeared to be unstoppable. In many countries, AIDS devastated an entire generation, leaving countless
More informationDrug Resistant Tuberculosis Biology, Epidemiology and Control Dr. Christopher Dye
Director of Health Information World Health Organization Geneva 1 1. Why TB patients are treated with drugs 2 Natural history and control of TB Fast 5/1 Slow 5/1 Uninfected Latent Active 1 1 infection/case
More informationFor any cancer and for infection-related cancer, immediate ART was associated with a lower cancer risk in the first three models but not in models D,
Immediate ART in START Cuts Risk of Infection-Linked Cancer About 75% Conference on Retroviruses and Opportunistic Infections (CROI), February 22-25, 2016, Boston Mark Mascolini People who started antiretroviral
More informationHIV e infarto miocardico: un problema dimenticato?
HIV e infarto miocardico: un problema dimenticato? Leonardo Calza Clinica di Malattie Infettive, Policlinico S.Orsola-Malpighi, Università degli Studi di Bologna CVD and HIV disease. The current issues
More informationObjective: Specific Aims:
Title: Retention to Care of HIV pregnant females in Kumasi, Ghana Brown Faculty: Aadia Rana, MD. Assistant Professor of Medicine in Division of Infectious Diseases, Awewura Kwara, Assistant Professor of
More informationWho Is Dying and Why? AIDS Mortality as a Progress Metric
Who Is Dying and Why? AIDS Mortality as a Progress Metric Sharonann Lynch HIV & TB Policy Advisor MSF Access Campaign 1 OUTLINE 1. Trends in mortality 2. Finding the RIPs among the LTFU 3. Who is dying
More informationFertility Desires/Management of Serodiscordant HIV + Couples
Fertility Desires/Management of Serodiscordant HIV + Couples William R. Short, MD, MPH Assistant Professor of Medicine Division Of Infectious Diseases Jefferson Medical College of Thomas Jefferson University
More informationCessation of cigarette smoking and the impact on cancer incidence in the D:A:D Study
Email: leah.shepherd@ucl.ac.uk CROI 2017 Cessation of cigarette smoking and the impact on cancer incidence in the D:A:D Study Leah Shepherd 1, Lene Ryom 2, Kathy Petoumenos 3, Camilla Ingrid Hatleberg
More informationTuberculosis Impact in Boston Residents: 2012
Tuberculosis Impact in Boston Residents: 2012 BOSTON PUBLIC HEALTH COMMISSION Infectious Disease Bureau Communicable Disease Control Division Number of TB Cases: Boston, 1995-2012 200 180 160 140 Number
More informationIAS 2013 Towards an HIV Cure Symposium
In chronically HIV-1-infected patients long-term antiretroviral therapy initiated above 500 CD4/mm 3 achieves better HIV-1 reservoirs' depletion and T-cell count restoration IAS 2013 Towards an HIV Cure
More informationOn the Fast-Track to end AIDS. HIV & AIDS in the Post 2015 Development Agenda
On the Fast-Track to end AIDS HIV & AIDS in the Post 2015 Development Agenda Miriam Maluwa Country Director, UNAIDS Ethiopia A i d & d e v e l o p m e n t S u m m i t A d d i s A b a b a 2-3 F e b r u
More informationHIV transmission in the migrant population. D. Paraskevis
HIV transmission in the migrant population D. Paraskevis Content Definitions Epidemiology of HIV in migrants Methods to estimate the origin of HIV acquisition Molecular epidemiology Bayes method based
More informationSummary of Key Points WHO Position Paper on BCG Vaccine, February 2018
Summary of Key Points WHO Position Paper on BCG Vaccine, February 2018 1 Introduction This position paper replaces the 2004 WHO position paper on Bacille Calmette-Guérin (BCG) vaccine and the 2007 WHO
More informationAnalysing clinical datasets: Challenges and pitfalls. Amanda Mocroft University College London
Analysing clinical datasets: Challenges and pitfalls Amanda Mocroft University College London a.mocroft@ucl.ac.uk Introduction Clinical cohort data one of most abundant sources of data Presents a real-life
More informationSummary I: TB, Opportunistic Infections, HCV/HBV Co-Infections, HPV, STI & Tumors
La Pedrera, Barcelona March 13 th 2018 Summary I: TB, Opportunistic Infections, HCV/HBV Co-Infections, HPV, STI & Tumors Dr. José M. Miró Infectious Diseases Service Hospital Clinic - IDIBAPS University
More informationOutline. AIDS & HIV in the Travis County. Global estimates for adults & children end HIV incidence worldwide
Outline AIDS & HIV in the Joshua Vest Epidemiologist Austin/ Health & Human Services Department Worldwide HIV/AIDS surveillance National Prevalence Trends Disparities Mortality Modes of exposure Risk factors
More informationOutline. Epidemiology of Pediatric HIV 10/3/2012. I have no financial relationships with any commercial entity to disclose
Nutritional, Metabolic, and Gastrointestinal Complications in Pediatric HIV Infection Tracie L. Miller, MD Department of Pediatrics University of Miami, Miller School of Medicine I have no financial relationships
More informationHow has the Polio Eradication Initiative influenced the global AIDS response? Bradley S. Hersh, MD, MPH
How has the Polio Eradication Initiative influenced the global AIDS response? Bradley S. Hersh, MD, MPH Presentation Outline Big history of global HIV epidemic Current status of HIV and the global AIDS
More informationChapter 1 Overview of Tuberculosis Epidemiology in the United States
Chapter 1 Overview of Tuberculosis Epidemiology in the United States Table of Contents Chapter Objectives.... 1 Progress Toward TB Elimination in the United States... 3 TB Disease Trends in the United
More informationHost-pathogen interactions in Multidrug-Resistant Tuberculosis
Host-pathogen interactions in Multidrug-Resistant Tuberculosis Study of the Molecular Epidemiology, Host Immune responses and Genome Based prediction and Early Identification of MDR-TB in High Tuberculosis
More informationCROI 2017 Review: Hepatitis C Coinfection
Mountain West AIDS Education and Training Center CROI 2017 Review: Hepatitis C Coinfection Brian R. Wood, MD Assistant Professor of Medicine Medical Director, Mountain West AETC ECHO Telehealth February
More informationXpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10
Xpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10 Introduction Excellent performances, rapid results, and easy to use Questions Where and how are we going
More informationProgress in scaling up HIV prevention and treatment in sub-saharan Africa: 15 years, the state of AIDS
10 th International Workshop on HIV treatment, Pathogenesis and Prevention Research in Resource-Limited setting (INTEREST, 3-6 May, 2016) Progress in scaling up HIV prevention and treatment in sub-saharan
More informationProjected Demand for HIV Diagnostic Tests
Projected Demand for HIV Diagnostic Tests John Stover, Yu Teng, Adebiyi Adesina, Eline Korenromp On behalf of the Diagnostics Forecasting Technical Working Group (CDC, CHAI, GFATM, PfSCM, UNAIDS, UNICEF,
More informationRound table discussion Patients with multiresistant virus : A limited number, but a remarkable deal Introduction
Disclosure statement: Dr. Santoro reports personal fees from ViiV Healthcare, Gilead and JANSSEN Cilag Round table discussion Patients with multiresistant virus : A limited number, but a remarkable deal
More informationECDC and Spanish Ministry of Health workshop:
ECDC and Spanish Ministry of Health workshop: Improving the monitoring of HIV among migrant populations in Europe, Madrid, 3-4 October 2013 Teymur Noori EU Commission Thank Tank on HIV/AIDS Luxembourg,
More informationKenya Perspectives. Post-2015 Development Agenda. Tuberculosis
Kenya Perspectives Post-2015 Development Agenda Tuberculosis SPEAKERS Anna Vassall Anna Vassall is Senior Lecturer in Health Economics at the London School of Hygiene and Tropical Medicine. She is a health
More informationART for prevention the task ahead
ART for prevention the task ahead Dr Teguest Guerma WHO/HQS WHO's role and vision Status of the epidemic Overview Progress and challenges in treatment and prevention scale up ART for prevention Questions
More informationAnnual Epidemiological Report
November 2018 Annual Epidemiological Report 1 HIV in Ireland, 2017 Key Facts There were 492 diagnoses of HIV notified in 2017, a rate of 10.3 per 100,000 population. The HIV rate in Ireland has been relatively
More informationEpidemiological profiles of viral hepatitis in Italy Effects of migration
Epidemiological profiles of viral hepatitis in Italy Effects of migration Hepatitis A and E T. Santantonio UOC di Malattie Infettive Università degli Studi di Foggia Azienda Ospedaliero-Universitaria Ospedali
More informationImmunologic Failure and Chronic Inflammation. Steven G. Deeks Professor of Medicine University of California, San Francisco
Immunologic Failure and Chronic Inflammation Steven G. Deeks Professor of Medicine University of California, San Francisco Plasma HIV RNA (log) 6 5 4 3 2 52 year old HIV+/HCV+ man presents with symptomatic
More informationCLINICAL PEARLS OF NEW HIV MEDICATIONS PHARMACIST OBJECTIVES TECHNICIAN OBJECTIVES. At the end of this presentation pharmacists will be able to:
CLINICAL PEARLS OF NEW HIV MEDICATIONS Cindy Lou Zoellner, PharmD, BCPS Added Qualifications in Infectious Diseases Senior Clinical Pharmacy Specialist in HIV Parkland Health & Hospital System Volunteer
More informationReasons why we will never forget. Andrea Antinori INMI L. Spallanzani IRCCS, Roma
Reasons why we will never forget Andrea Antinori INMI L. Spallanzani IRCCS, Roma SMRs according to time spent with CD4 count >500/mm3 after cart initiation in MSM 80,642 HIV-infected individuals eligible
More informationUniversal access to medicine: HIV and beyond
Universal access to medicine: HIV and beyond Dr Andrew Hill Department of Pharmacology and Therapeutics University of Liverpool United Kingdom UNAIDS STAC meeting, Lilongwe, May 15 th 2017 Universal access
More information