Supplement 2: Extracted studies

Transcription

1 Supplement 2: Extracted studies First author Journal Year Participants Country of study Drugs compared Participants Hepatotoxicity extractable? Development of active TB? Agarwal (42) Urology and Nephrology 2004 End stage renal disease patients receiving renal transplantation 85 Yes Bailey(64) Annals of Internal 1974 Tuberculin reactive hospital employees 178 Yes Bush(29) 1965 Household contacts Japan 2,238 Yes Chan(59) 2012 Male prison inmates with terms more than six months Taiwan ; 373 Yes Comstock(65) The American Review of 1967 Individuals over two months of age 6,064 Yes Cowie(60) Tubercle and Lung Disease 1996 Gold miners with chronic silicosis South Africa Yes Debre(76) Epidemiology 1973 Young people with recent tuberculin conversion France 2,970 Yes Del Castillo(30) Bull Quezon Institute 1965 Household contacts Philippines 293 Yes

2 Egsmose(31) World Health Organization 1965 Household contacts of pulmonary TB cases Kenya 775 Yes Falk(77) Chest 1978 Outpatient clinics for veterans diagnosed with inactive pulmonary TB 7,036 Yes Ferebee(32) 1962 Household contacts of active TB cases 6,219 households Yes Ferebee(78) 1963 Patients in mental hospitals 25,210 Yes Fitzgerald(43) Acquired Immune Deficiency Syndromes 2001 HIV positive, but symptom free, Haiti 237 Yes Geijo(33) Enfermedades Infecciosas y Microbiología Clínica 2007 Individuals meeting the 1990 CDC recommendations ; - 96 Yes Yes Gordin(44) 1997 HIV positive, over Yes Yes Gordin (20;21) the American Medical Association/Clinical Infectious Diseases 2000/ 2004 HIV positive, Mexico, Haiti, Brazil ; - 1,583 Yes Yes

3 Gupta(34) Tuberculosis 1993 Children of TB patients ; - ; Yes Halsey(45) Lancet 1998 HIV positive adults from outpatient clinics and general community Haiti ; Yes Hawken(46) AIDS 1997 HIV positive, years of age Kenya 684 Yes Hong Kong Chest Service/TB Research Centre, Madras/ British Medical Research Council(61) The American Review of 1992 Silicosis patients under 65 Hong Kong ; - ; 679 Yes Horwitz(63) World Health Organization 1966 Over 15 years of age. Regimen allocated by village Greenland ; at placebo levels 8,081 Yes Yes Union Against Tuberculosis Committee on Prophylaxis(66) World Health Organization 1982 Mostly years of age Czechoslovakia, Finland, German Democratic Republic, Hungary, Poland, Romania, Yugoslavia 27,830 Yes

4 Jimenez- Fuentes(79) 2013 Immigrants (within last 5 years) from high-burden countries ; Yes Yes John(47) Transplantation 1994 Haemodialysis patients 184 Yes Yes Leung(62) Chest 2003 Silicosis patients Hong Kong ; - 76 Yes Madhi(26) 2011 Infants between days of life South Africa, Botswana 1,351 Yes Yes Magdorf(40) Pneumologie 1994 Children, recent TST conversion Germany ; ; Yes Martinez Alfaro(35) Medicina Clinica 1998 Inclusion criteria: 1990 CDC guidelines ; Yes Yes Martinez Alfaro(48) Medicina Clinica 2000 HIV positive, 1990 CDC and ATS recommendations ; Yes Yes Martinson(49) 2011 HIV positive, over 18 South Africa ; - ; - RPT 1,148 Yes Yes Matteelli(50) 1999 HIV positive, over 18 Italy ; - RFB 44 Yes

5 Menzies(80) American Respiratory and Critical Care 2004 Respiratory hospital patients, over 18 Canada ; 116 Yes Menzies(81) Annals of Internal 2008 Hospital patients over 18 years of age Canada, Saudi Arabia, Brazil ; 840 Yes Mohammed(51) 2007 HIV positive (WHO clinical stage three or four), over 18 years of age South Africa 98 Yes Yes Mount(36) 1962 Household contacts of active TB cases 2,814 Yes Naqvi(52) Nephrology, dialysis, transplantation 2010 Renal transplant recipients Pakistan 402 Yes Pape(53) Lancet 1993 Individuals newly diagnosed with HIV, Haiti 118 Yes Portilla(27) Enfermedades Infecciosas y Microbiología Clínica 2003 HIV negative intravenous drugs users 37 Yes Quigley(25) AIDS 2001 HIV positive, over 15 year olds Zambia ; - 1,053 Yes Rivero(54) Enfermedades Infecciosas y Microbiología Clínica 2007 HIV positive ; - ; Yes Yes

6 Sanchez- Arcilla(82) Medicina Clinica 2004 Homeless ; Yes Samandari(55) Lancet 2011 HIV positive, 18 years or older Botswana 1,995 Yes Yes Schechter(37) American Respiratory and Critical Care 2006 Household contacts of pulmonary TB Brazil RPT-; Yes Yes Spyridis(28) Clinical Infectious Diseases 2007 Children under 15 in a TB clinic without active TB Greece ; Yes Sterling(4) 2011 Close contacts, Canada, Brazil, ; - RPT 7,731 Yes Yes Swaminathan(56) PLoS ONE 2012 HIV positive adults (plus some with CTX); - EMB (plus some with CTX) 712 Yes Tortajada(38) 2005 Contacts with recent TST conversion, under 35 ; Yes Veening(39) Union of Tuberculosis 1968 Recruits in marine camp of Royal Navy exposed to an infectious TB case Netherlands 261 Yes

7 Vikrant(57) Transplant infectious disease 2005 Renal transplant recipients, over 14 years of age 109 Yes Yes Whalen/Johnson (22;23) /AIDS 1997/ 2001 HIV positive, year old males and non-pregnant females Uganda ; - ; - - 2,736 Yes Yes White(83) Correctional Health Care 2012 Prison inmates diagnosed with LTBI at entry ; 364 Yes Xie(58) Sichuan University 2009 Chinese patients with rheumatoid arthritis receiving long-term methotrexate therapy China MTX; - MTX 201 Yes Zar(41) British Medical Journal 2007 HIV positive children South Africa Placebo- CTX; - CTX 263 Yes For these two entries a single study is represented, but two publications. In each case one presented the most up-to-date results for the number of active TB cases (Gordin 2000/Johnson) and the other hepatotoxicity (Gordin 2004/Whalen). ATS- American Thoracic Society; CDC- Centres for Disease Control and Prevention, ; CTX- co-trimoxazole; EMB- ethambutol; IGRAinterferon-γ release assay; - isoniazid; MTX- methotrexate; PPD-purified protein derivative; - pyrazinamide; RFB- rifabutin; rifampicin; RPT- rifapentine; TST- tuberculin skin test; TB- tuberculosis