Detection of IgA-class anti-hev antibody

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1 Detection of IgA-class anti-hev antibody Hiroaki OKAMOTO E IgA-HE IgA HEV E HEV E E E 10 E 1997 E E 1, E 3 HEV HEV 5 A B C A B C E 6, 7 E HEV E go.jphoudou200308h html 11 5 E 500 HEV 12 HEV ,200 E E A B C E IgA-HE E E Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine ( Yakushiji, Shimotsuke-shi, Tochigi-ken)

2 HEV 13, 14 HEV HEV E 3 4 E 1 1 HEV IgA-HE enzyme-linked immunosorbent assay, ELISA IgA HEV 16, 17 4 HE-J1 ORF2 550N 110 HEV HEV mock mock IgA HEV BF horseradish peroxidase IgA IgM IgG HEV IgM IgG 1 BF nm 675 mean7sd IgA HEV 0.642IgM HEV IgG HEV OD IgA-HE OD OD 2 1 IgM IgM IgM IgA HEV 16, 17 HEV RNA E IgA HEV 1 HEV E 55 3 HEV E HEV E IgA HEV IgM HEV HEV 3 4 HEV 1 4 OD E IgM HEV 97.5 IgA HEV 98.8 IgA HEV A B C Window 162 2

3 16, 17 IgM IgA HEV ELISA OD IgM HEV OD0.440 ; IgA HEV OD0.642 E IgM 16, 17 IgA HEV IgM HEV IgA HEV IgA HEV 3 HEV 7 10 IgM HEV IgA HEV 16 E 2,781 A B C 127 B C IgM HEV 16 OD IgA HEV OD HEV RNA IgM HEV IgA HEV 70 OD IgM HEV IgA HEV E HEV E IgA HEV IgM HEV 16 E IgM HEV IgA HEV

4 E 15 HEV RNA IgM HEV IgA HEV 16 IgM HEV IgA HEV 3 2 IgM HEV 1 IgA HEV IgM HEV IgA HEV IgA HEV E IgM IgG 4 2 IgM

5 IgM 17 IgM HEV ,782 IgA HEV ,782 E E IgA 4 IgM HEV IgA HEV 2.5 vs. 1.2 E IgA HEV IgA , , IgA Chlamydia trachomatis Chlamydia pneumoniae IgA A B C IgA HAV IgA HBc IgA HCV IgM IgA HEV IgM IgA HEV E gold standard RT- PCR HEV RNA ELISA HEV IgA-HE E HEV E Kwo PY, Schlauder GG, Carpenter HA, et al. Acute hepatitis E by a new isolate acquired in the United States. Mayo Clin Proc : , Meng XJ, Purcell RH, Halbur PG, et al. A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A : , Takahashi K, Iwata K, Watanabe N, et al. Full-genome nucleotide sequence of a hepatitis E virus strain that may be indigenous to Japan. Virology : 9-12, Okamoto H, Takahashi M, Nishizawa T, et al. Analysis of the complete genome of indigenous swine hepatitis E virus isolated in Japan. Biochem Biophys Res Commun : , Mitsui T, Tsukamoto Y, Yamazaki C, et al. Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. J Med Virol : , Suzuki K, Aikawa T, Okamoto H. Fulminant hepatitis E in Japan. N Engl J Med ; 1456, Mizuo H, Suzuki K, Takikawa Y, et al.: Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan. J Clin Microbiol : , Tei S, Kitajima N, Takahashi K, et al. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet : , Yazaki Y, Mizuo H, Takahashi M, et al.sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be foodborne, as suggested by the presence of hepatitis E virus in pig liver as food. J Gen Virol : , Matsuda H, Okada K, Takahashi K, et al.: Severe hepatitis

6 E virus infection after ingestion of uncooked liver from a wild boar. J Infect Dis : 944, Tamada Y, Yano K, Yatsuhashi H, et al.: Consumption of wild boar linked to cases of hepatitis E. J Hepatol : , A E 21 23, Haqshenas G, Shivaprasad HL, Woolcock PR, et al. Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States. J Gen Virol : , Johne R, Plenge-Bönig A, Hess M, et al. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol : , Okamoto H. Genetic variability and evolution of hepatitis E virus. Virus Res : , Takahashi M, Kusakai S, Mizuo H, et al. Simultaneous detection of immunoglobulin AIgAand IgM antibodies against hepatitis E virushevis highly specific for diagnosis of acute HEV infection. J Clin Microbiol : 49-56, E IgA HEV IgA anti-hev EIA. : , Ozawa N, Shimizu M, Imai M, et al. Selective absence of immunoglobulin A1 or A2 among blood donors and hospital patients. Transfusion : 73-76, Yoshizawa H, itoh Y, Iwakiri S, et al. Diagnosis of type A hepatitis by fecal IgA antibody against hepatitis A antigen. Gastroenterology : , Nomura M, Imai M, Tsuda F, et al. Immunoglobulin A antibody against hepatitis B core antigen in the acute and persistent infection with hepatitis B virus. Gastroenterology : , Sato S, Fujiyama S, Tanaka M, et al. IgM and IgA antibodies generated against hepatitis C virus core antigen in patients with acute and chronic HCV infection. Dig Dis Sci : , Nagasaki F, Ueno Y, Kanno N, et al. A case of acute hepatitis with positive autoantibodies who actually had hepatitis E virus infection. Hepatol Res : , Dalton HR, Fellows HJ, Stableforth W, et al. The role of hepatitis E virus testing in drug-induced liver injury. Aliment Pharmacol Ther : , Davern TJ, Chalasani N, Fontana RJ, et al. Drug-Induced Liver Injury NetworkDILIN. Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology : , 2011.

E E Hepatitis E SARS 29, Lancet. E A B Enterically-Transmitted Non-A, Hepatitis E. Virus HEV nm. 1.35g/cm s ALT AST HEV HEV

E E Hepatitis E SARS 29, Lancet. E A B Enterically-Transmitted Non-A, Hepatitis E. Virus HEV nm. 1.35g/cm s ALT AST HEV HEV 7850 2004 Hepatitis E Tian-Cheng LI Naokazu TAKEDA Tatsuo MIYAMURA SARS 8 Lancet E E E Hepatitis E VirusHEV E E HEV HEV E 1955 29,000 E E A A B Enterically-Transmitted Non-A, Non-B Hepatitis 1983 Balayan