SCE Questions. Dr T
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1 SCE Questions Dr T
2 #RenalSCE
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5 Question 1
6 A 33 year old man presented with a renal calculi, he eventually passes a stone which gets analysed and is mostly calcium oxalate in its composition. He is wondering what are the chances of him getting another stone. What is the chance of him having one or more stones in the next 10 years? 1. 20% 2. 30% 3. 50% 4. 60% 5. 80%
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8 Question 2
9 A 24 year old man presents with his third renal stone. Microscopy reveals the image shown below. Following his previous stones he has been drinking 4-5 litres of water per day, he is on a low salt diet and is taking potassium citrate. What is the most appropriate medication to start? 1. Tiopronin 2. Sodium Bicarbonate 3. Bendroflumethiazide 4. Amiloride 5. Perindopril Taken from Wikipedia Lance Wheeler
10 Cystinuria AR Inheritance Prevalence 1: % all stone formers Cystinuria is the most common defect in the transport of an amino acid. Often confused with Cystinosis (doesn t cause cysteine stones) Cystine is not the only amino acid which is poorly reabsorbed in cystinuria but it is the least soluble of all naturally occurring amino acids. Cystine precipitate out of urine forming calculi in the urinary tract.
11 Cystinuria treatment Hydration Low sodium diet (sodium promotes cysteine accumulation in urine) Urine alkalisation Potassium Citrate, if not tolerated Sodium bicarbonate (sodium content other stones) Changing diet more fruit and veg less meat Chelation Tiopronin Penicillamine Captopril
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13 Question 3
14 A 55 year man presents with his 5th renal stone in the last 2 years. His past medical history includes diabetes, hypertension and morbid obesity(roux-en-y) treated with an operation 5 years previously. His BMI is now 28. His egfr is now down to 25mls/min. What is the most likely reason for his renal stone? 1. Fat Malabsorption 2. Increased green smoothie intake 3. High sodium intake 4. Excess glycoxylate production due to enzyme deficit 5. Autosomal Recessive mutation of SLC3A1 gene
15 Enteric Hyperoxaluria The result of malabsorption from gastric bypass surgeries (Roux-en-Y) or other causes of malabsorption such as - orlistat, pancreatitis, etc. Fat malabsorption leads to increased oxalate absorption. Other causes of oxalate nephropathy High doses of intravenous doses of vitamin C, Ethylene glycol - monohydrated calcium oxalate crystals may be seen with ethylene glycol toxicity. Some foods/drinks containing large amounts of oxalate Star fruit, Green smoothie Rhubarb
16 Treatment Calcium carbonate Pre meals Reversal of surgery
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18 Weddelites: Calcium oxalates 2(H2O) Dihydrate Whewellites: calcium oxalates (H2O) Monohydrate Calcium oxalate crystals can be found in urine ph values ranging from <5.5 to 6.7 but are seen mostly with ph <
19 Other stones Brushite CaH 2 PO 4 (2H 2 O) (Like alkaline urine) Struvite NH 4 MgPO 4 6H 2 O (Like alkaline urine) Urate C 5 H 4 N 4 O 3 (Like acidic urine)
20 More on stones Click here
21 Question 4
22 51 Man, originally presented in childhood with failure to thrive, hypophospataemia, episodic hypovalaemia, glycosuria, aminoaciduria hyperchloraemic metabolic acidosis and nephrocalcinosis (as shown below). Developed progressive renal impairment. What is this most likely cause of this condition. 1. Cystinosis 2. Lowe oculo-cerebral-renal syndrome 3. Gordons syndrome 4. Dent Disease 5. Lead Poisoning
23 Causes of Fanconi Syndrome Genetic Dent Disease (X-linked recessive nephrolithiasis) Cystinosis Tyrosinaemia type 1 Galactosaemia Wilson s disease Lowe oculo-cerebral-renal syndrome Mitochondrial myopathies Drugs Cisplatinum Tenofovir Ifosfamide (NT) Gentamicin Nivolumab Heavy metals Lead Cadmium Mercury (NA) M-protein disorders Amyloidosis Light chain disease
24 Dent Disease X-linked recessive mainly affects males While symptoms and severity vary, they usually begin in childhood and worsen over time. The most common feature of Dent disease is proteinuria (protein in the urine). Other common features; hypercalciuria, nephrocalcinosis and renal calculi. Less common features include rickets and mildy short stature. Progressive kidney problems often lead to end stage renal failure by early to mid-adulthood. There are two forms of Dent disease which are distinguished based on their genetic causes. Dent disease type 1 is caused by a mutation in the CLCN5 gene. Dent disease type 2 is caused by a mutation in the OCRL gene. Males with this form are also at increased risk for mild intellectual disability and hypotonia. nt-disease
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26 Familial Primary emkhssech3gdhblgoa direct.com
27 Question 5
28 33 year old man, originally presented at 6 months of age with failure to thrive, renal impairment and photophobia. In childhood he had glycosuria and aminoaciduria. It is documented that he has hepatomegaly He developed renal failure requiring dialysis at the age of 10. He has received a renal transplant and is treated with mercaptamine. He sees you in transplant clinic looking to discuss planning a family. He wishes to know the inheritance of this condition? 1. Autosomal Recessive 2. Autosomal Dominant 3. X linked Recessive 4. X linked Dominant 5. Spontaneous Mutation
29 Cystinosis Autosomal Recessive defect in the transport of cystine out of lysosomes Fanconi syndrome Photophobia (corneal cystine crystals) Hypothyroidism Renal failure - ~10 years of age Diabetes from pancreatic involvement Hepatomegaly Infertility Epilepsy & cerebral atrophy Treatment: Cysteamine (mercaptamine) Monitor levels of leukocyte cystine levels
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33 Stones
34 Those at risk of recurrent stones
35 General factors Early onset of urolithiasis (especially children and teenagers) Familial stone formation Brushite-containing stones (CaHPO4.2H2O) Uric acid and urate-containing stones Infection stones Solitary kidney (the kidney itself does not particularly increase the risk of stone formation, but prevention of stone recurrence is of more importance) Diseases associated with stone formation Hyperparathyroidism Metabolic syndrome Nephrocalcinosis Polycystic kidney disease (PKD) Gastrointestinal diseases (i.e., jejuno-ileal bypass, intestinal resection, Crohn s disease, malabsorptive conditions, enteric hyperoxaluria after urinary diversion) and bariatric surgery [19] Sarcoidosis Spinal cord injury, neurogenic bladder Environmental factors Chronic lead exposure
36 Genetically determined stone formation Cystinuria (type A, B and AB) Primary hyperoxaluria (PH) Renal tubular acidosis (RTA) type I 2,8-Dihydroxyadeninuria Xanthinuria Lesch-Nyhan syndrome Cystic fibrosis Drug-induced stone formation (see Table 4.11) Anatomical abnormalities associated with stone formation Medullary sponge kidney (tubular ectasia) Ureteropelvic junction (UPJ) obstruction Calyceal diverticulum, calyceal cyst Ureteral stricture Vesico-uretero-renal reflux Horseshoe kidney Ureterocele
37
38 Recommendations Strength Rating Prescribe thiazide + potassium citrate in case of hypercalcuria. Strong Advise oxalate restriction if hyperoxaluria is present. Weak 2b Offer potassium citrate in enteric hyperoxaluria. Weak 3-4 Offer calcium supplement in enteric hyperoxaluria. Weak 2 Advise reduced dietary fat and oxalate in enteric hyperoxaluria. Weak 3 Prescribe potassium citrate and sodium bicarbonate in case of Strong 1b hypocitraturia. Prescribe allopurinol in case of hyperuricosuria. Strong 1a Offer febuxostat as second-line treatment of hypericosuria. Strong 1b Advise avoiding excessive intake of animal protein in Strong 1b hypericosuria. Advise restricted intake of salt if there is high urinary sodium excretion. Strong 1b 1a
39 Primary hyperoxaluria type 1 is caused by mutations in a gene called AGXT. This gene gives the body instructions for making an enzyme called alanine-glyoxylate aminotransferase. This enzyme is found in cell structures called peroxisomes in liver cells. It converts a compound called glyoxylate to the amino acid glycine. Autosomal Recessive Mutations in the AGXT gene lead to a decrease in the amount or function of the enzyme, preventing the breakdown of glyoxylate. This is turn causes glyoxylate to accumulate, and it is converted to oxalate instead of glycine. Excess oxalate that is not excreted from the body then combines with calcium to form calcium oxalate, which damages the kidneys and other organs. Recommendation Prescribe pyridoxine for primary hyperoxaluria. Strength rating Strong Liver and Kidney transplant
40
41 Radiopaque Calcium oxalate dehydrate (Wheddellite) Calcium oxalate monohydrate (Whewellite) Calcium phosphates Poor radiopacity Magnesium ammonium phosphate Cystine Radiolucent Uric acid Ammonium urate Xanthine Brushite Drug-stones
42 Crystalopathies/stones Co-Trimoxazole Aciclovir Ciprofloxacin Indinavir / other proteasome inhibitors
43 Recommendations Strength rating Prescribe thiazide in case of hypercalciuria. Advise patients to acidify their urine in case of high urine ph. Strong Weak
44 Recommendation Prescribe pyridoxine for primary hyperoxaluria. Recommendations Prescribe potassium citrate. Advise patients to take calcium supplements with meals. Advise patients to follow a diet with a low fat and oxalate content. Strength rating Strong Strength rating Weak Strong Weak Recommendations Prescribe potassim citrate to alkalinise the urine in urate stone formers. Prescribe allopurinol in hyperuricosuric urate stone formers. Strength rating Strong Strong
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47 Recommendations Surgically remove the stone material as completely as possible. Prescribe antibiotics in case of persistent bacteriuria. Prescribe ammonium chloride, 1 g, two or three times daily to ensure urinary acidification. Prescribe methionine, mg, one to three times daily, as an alternative, to ensure urinary acidification. Strength rating Strong Strong Weak Weak
48 Renal Tubular Acidosis
49 RTA 1 Distal Hypokalaemia improves with increase in ph Connective tissue - Sjogrens, SLE/RA Drugs Amphotercin, Toluene, ifosfamide, lithium Sickle cell Immunoglobulins - Cryoglobulins, dysparaprotein MM,AL,LCDD Interstitial nephritis Transplant rejection Hypercalcaemia Nephrocalconosis Hereditary RTA 2 Proximal Hypokalaemia worsens with increase in ph Fanconi Lowe (XL) Dent (XL) Cystinosis (AR) Metals Wilsons, Lead, Cadmium Drugs Tenofovir, Cisplatin, Gentamicin, Tetracyclines, Acetazolamide, Topiramate, lenalidomide, ifosfamide Hereditary fructose deficiency Myeloma/LCDD Sjogrens
50 Lupus Obstruction Sickle cell RTA 1 with hyperkalaemia Pseudohypoaldosteronism type I/II Amiloride Pentamidine RTA 4 with hyperkalaemia Diabetes Mellitus Sickle cell Lead Lupus Heparin Calcineurin inhibitor Obstruction
51 Other tubular Disorders
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53 Acidosis BP Gordon syndrome Hypomagnesaemi RTA Type 1&2 RTA Type 4 a & Hypercalcuria Potassium PHA type 1
54 Liddle Syndrome Conn Syndrome Glucocorticoid Remedial aldosteronism BP Alkalosis Potassium Gitelman Bartter
55 Proximal Convoluted Tubule Disturbance of active transport process prta Fanconi syndrome Dent syndrome Lowe syndrome
56 Loop of Henle Bartter (NKCC2) Familial hypomagnesaemia with hypercalciuria (Claudin 16 or 19)
57 Distal Convoluted Tubule Gitelman Gordon (NCC) Distal RTA
58 Collecting duct Liddle Pseudohypoaldosteronism (ENAC) Nephrogenic D I (AVRP2 or AQP2) Hereditary SIADH (AVP-NP2) Distal RTA (vh+atpase, AE1)
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