Separation Anxiety Disorder and Adult Onset Panic Attacks Share a Common Genetic Diathesis
|
|
- Milton Farmer
- 6 years ago
- Views:
Transcription
1 Separation Anxiety Disorder and Adult Onset Panic Attacks Share a Common Genetic Diathesis Roxann Roberson-Nay, PhD Virginia Commonwealth University Department of Psychiatry
2 The SAD PD link Don Klein proposed that childhood separation anxiety disorder (SAD) was a precursor of panic disorder (PD), a condition that generally emerges in early adulthood. During the past three decades, mixed evidence has emerged from three types of studies that either support or challenge the possibility of an etiologic link between SAD and PD: the prospective course of childhood SAD into adulthood these studies either examine retrospective report parent-child aggregation of PD-SAD.
3 Prospective Studies In a follow-up study of 54 children referred for treatment of SAD, 7% of individuals with a history of SAD developed PD whereas no participant in the comparison group developed PD. No other anxiety disorder was more prevalent in adults with a history of SAD relative to comparison participants, although the overwhelming majority of SAD children did not develop PD.
4 Prospective Studies A second longitudinal study reinterviewed children (ages 9-13) approximately 7.5 years after receiving treatment and observed: 27.8% - SAD 12.5% - Social Phobia 14.3% - Overanxious Disorder
5 Prospective/High-Risk Study A follow-up study of children at high and low risk for PD and major depressive disorder (MDD) ascertained through parent probands treated for PD, MDD, or control parents (total n=233) Results indicated that offspring with a history of childhood SAD were at greatest risk for developing PD and agoraphobia, with an OR of approximately 9.0 for both disorders. Odds of developing MDD were 3.2 for children with a history of SAD.
6 Family Studies Several family aggregation studies document greater frequency of SAD diagnoses among offspring of parents with PD, relative to offspring of healthy parents. SAD also has been linked to parental MDD with some consistency.
7 Limitation of Family Studies Cannot disaggregate genetic and common environment, BUT twin studies can!! With twin data, we can decompose phenotypic covariation into additive genetic (A) common (shared) environmental (C) i.e., family environment unique or non-shared environmental (E) components i.e., experiences unique to the individual (e.g., loss of a close friend)
8 So What do Twin Studies Tell Us about SAD and PD Twin studies suggest a heritable component to SAD, with the genetic contribution being higher for females ( ) compared with males ( ) and unique environmental factors being more significant for males ( ) relative to females ( ). For adult PD, only genetic (.47) and unique environmental factors (.57) emerge as significant influences; common (shared) environment does not appear to be an important factor.
9 Current Study Determine whether genetic risk factors associated with childhood SAD also relate specifically to development of panic attacks in young adulthood. We define our phenotype as panic attacks versus PD for several reasons: most all of the adult twins in our sample had not yet passed through the age of risk for PD; individuals may carry a genetic risk for a particular psychiatric syndrome that may not be expressed at a diagnostic level, but may be detectable at subthreshold levels. PD has a low lifetime prevalence rate (approximately %) thereby decreasing the amount of information available for complex twin modeling.
10 Types of Twins Monozygotic (MZ; identical ): result from fertilization of a single egg by a single sperm; share 100% of genetic material. Dizygotic (DZ, fraternal or nonidentical ): result from independent fertilization of two eggs by two sperm; share on average 50% of their genes.
11 ABD/YAFU Study Virginia Twin Study of Adolescent Behavioral Development (VTSABD) + Young Adult Follow-up (YAFU). The VTSABD was designed as an epidemiological study of twins for genetically informative analysis. 1,437 twin pairs: 27.1% monozygotic [MZ] female 16.1% dizygotic [DZ] female 20.7% MZ male 15.0% DZ male 21.0% opposite-sex DZ [OSDZ]
12 Quantitative vs. Qualitative Sex Effects Male and female same sex twins allows a test of quantitative sex differences, i.e., whether the magnitudes of genetic and environmental effects differ by sex for a specific phenotype. Including opposite sex twins allows a test of qualitative sex differences, which test whether different genetic and shared environmental effects are important for males and females. If different genetic influences are important for males and females, then opposite sex twins will be less genetically similar for the trait relative to DZ same-sex twins.
13 ABD Sample Three longitudinal waves conducted during childhood and adolescence (Child & Adolescent Psychiatric Assessment [CAPA]). The mean ages were years (±2.59; range ) at the wave one assessment years (±2.4; range ) at the wave two assessment 15.5 years (+1.6; range ) at the wave three assessment About 6.45% (n=176) subjects met criteria for SAD Approximately 19.6% (n=563) met criteria for OAD
14 YAFU Sample These twins were contacted by phone and evaluated as young adults (i.e., age > 18) using the Structured Clinical Interview for DSM-III-R. The mean age at YAFU assessment was 21.4 years (+2.0; range 18-27). Of the twins who participated in the YAFU, approximately 265 of 2275 (11.65%) individuals met our criteria for a panic attack.
15 Cholesky Decomposition Twin 1 Twin2 1 or.5 1 or A 1 A 2 A 1 A 2 a 11 a 21 a 22 a 11 a 21 a 22 X 1 Y 1 X 2 Y 2 X=SAD Y=AOPA X=SAD Y=AOPA
16 Cholesky Decomposition Twin 1 1 or.5 1 or.5 Twin2 Path estimate a 21 reflects the additive genetic contribution of phenotype 1 on phenotype A 1 A 2 a 11 a 21 a A 1 A 2 a 11 a 21 a 22 X 1 Y 1 X 2 Y 2 X=SAD Y=AOPA X=SAD Y=AOPA
17 Multifactorial Threshold Model of Disease Single threshold Multiple thresholds unaffected affected normal mild mod severe Disease liability Disease liability
18 Twin modeling Examined full ACE models, which tested for quantitative and qualitative sex effects The Akaike Information Criterion (AIC) used to determine the best fitting model (lower better) The best fitting ACE model was then simplified by successively eliminating parameters (i.e., submodels: AE, CE); Cannot have an E only model. A C E
19 Twin modeling Examined full ACE models, which tested for quantitative and qualitative sex effects The Akaike Information Criterion (AIC) used to determine the best fitting model (lower better) The best fitting ACE model was then simplified by successively eliminating parameters (i.e., submodels: AE, CE); Can t have an E only model. A C E
20 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
21 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
22 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
23 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
24 Bivariate Relations: SAD and AOPA A 1 A Childhood SAD AOPA 35% SAD = Separation Anxiety Disorder AOPA = Adult Onset Panic Attacks/Disorder E 1 E 2
25 Bivariate Relations: SAD and AOPA A 1 A Childhood SAD AOPA E 1 E 2 1%.64% SAD = Separation Anxiety Disorder AOPA = Adult Onset Panic Attacks/Disorder
26 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
27 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
28 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
29 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
30 Bivariate Relations: OAD and AOPA A 1 A Childhood OAD AOPA 0% OAD = Overanxious Disorder AOPA = Adult Onset Panic Attacks/Disorder E 1 E 2
31 Bivariate Relations: OAD and AOPA A 1 A Childhood OAD AOPA 0% 41% OAD = Overanxious Disorder AOPA = Adult Onset Panic Attacks/Disorder E 1 E 2
32 Bivariate Relations: OAD and AOPA A 1 A Childhood OAD AOPA E 1 E 2 7% 52% OAD = Overanxious Disorder AOPA = Adult Onset Panic Attacks/Disorder
33 SAD and AOPA GAD and AOPA A 1 A 2 A 1 A Childhood SAD AOPA Childhood OAD AOPA E 1 E 2 E 1 E 2
34 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
35 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
36 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
37 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
38 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
39 Trivariate Cholesky Decomposition 36% 0% A1 A2 A Childhood SAD Childhood OAD Adult Onset Panic Attacks E1 E2 E3
40 Multifactorial Threshold Model of Disease Single threshold Multiple thresholds unaffected Disease liability affected no panic panic PD attack Disease liability
41 Note: Qual=qualitative sex effects; Quan=quantitative sex effects; + indicates the presence of either qualitative or quantitative sex effects or - indicates their absence from the model. The AE and CE models are nested submodels of the ACE model. * indicates the best fitting model.
42 Summary We found evidence of a shared genetic diathesis between childhood SAD (versus childhood OAD) and AOPA in a large general population twin sample. Our findings suggest that a genetic liability is set in motion during childhood, and this liability contributes to development of panic in the presence of environmental events experienced into adulthood.
43 Summary In a related manner, while OAD was not genetically associated with AOPA, this childhood syndrome did share about 10% unique environmental risk with AOPA. The trivariate Cholesky decomposition suggested moderate (21%) shared environmental risk between childhood SAD and OAD, with no significant, shared genetic pathway.
44 Summary A developmental psychopathology perspective that focuses on the ethologic roots of SAD and its developmental trajectory is clearly needed to guide clinical research questions. Because children with SAD, like individuals with PD, exhibit hypersensitivity to cues of impending suffocation during exposure to rising levels of CO 2, Klein s suffocation false-alarm theory may have important implications in the understanding of this childhood disorder. DIDN T HE SAT THIS
45 Limits of Twin Models Twin models do a good job of sorting out contributions of genes and environment. BUT do not help with identifying specific genes and environmental factors. Need other methods segregation analysis linkage and association (genes) discordant twins multivariate kinship studies (environment) translational animal models
46 Acknowledgement of Co-Authors Lindon J. Eaves, Ph.D. Kenneth S. Kendler, M.D. John M. Hettema, M. Judy L. Silberg, Ph.D. K01-Mentored Research Scientist Development Award from the NIMH (Primary Mentor: Kenneth S. Kendler)
Genetic and Environmental Contributions to Obesity and Binge Eating
Genetic and Environmental Contributions to Obesity and Binge Eating Cynthia M. Bulik,* Patrick F. Sullivan, and Kenneth S. Kendler Virginia Institute for Psychiatric and Behavioral Genetics of Virginia
More informationMajor Depression and Generalised Anxiety Disorder:
Major Depression and Generalised Anxiety Disorder: Same Genes, (Partly) Kenneth S. Kendler, M.D. Different Environments Revisited Abstract: In both clinical and epidemiological samples, major depression
More informationAn Examination of the Developmental Pathways Model for Oppositional Defiant Disorder in a Twin Sample
University of Colorado, Boulder CU Scholar Psychology and Neuroscience Graduate Theses & Dissertations Psychology and Neuroscience Spring 1-1-2013 An Examination of the Developmental Pathways Model for
More informationLongitudinal Stability of Genetic and Environmental Influences on Irritability: From Childhood to Young Adulthood.
This is an author produced version of a paper accepted by American Journal of Psychiatry. This paper has been peerreviewed but does not include the final publisher proofcorrections or journal pagination.
More informationORIGINAL ARTICLE. The Structure of Genetic and Environmental Risk Factors for Anxiety Disorders in Men and Women
ORIGINAL ARTICLE The Structure of Genetic and Environmental Risk Factors for Anxiety Disorders in Men and Women John M. Hettema, MD, PhD; Carol A. Prescott, PhD; John M. Myers, MS; Michael C. Neale, PhD;
More informationContrast Effects and Sex Influence Maternal and Self-Report Dimensional Measures of Attention-Deficit Hyperactivity Disorder
DOI 10.1007/s10519-014-9670-x ORIGINAL RESEARCH Contrast Effects and Sex Influence Maternal and Self-Report Dimensional Measures of Attention-Deficit Hyperactivity Disorder J. L. Ebejer S. E. Medland J.
More informationCommon and unique genetic contributions to conduct disorder and two stages of alcohol dependence development in women
Washington University School of Medicine Digital Commons@Becker Posters 2007: Alcohol Use Across the Lifespan 2007 Common and unique genetic contributions to conduct disorder and two stages of alcohol
More informationBivariate Analysis of Disordered Eating Characteristics in Adolescence and Young Adulthood
CE ACTIVITY Bivariate Analysis of Disordered Eating Characteristics in Adolescence and Young Adulthood Melissa A. Munn, MPE 1,2 * Michael C. Stallings, PhD 1,2 Soo Hyun Rhee, PhD 1,2 Laura E. Sobik, PhD
More informationInteraction of Genes and the Environment
Some Traits Are Controlled by Two or More Genes! Phenotypes can be discontinuous or continuous Interaction of Genes and the Environment Chapter 5! Discontinuous variation Phenotypes that fall into two
More informationSerena M. King, Ph.D., L.P. Associate Professor of Psychology
Serena M. King, Ph.D., L.P. Associate Professor of Psychology sking02@hamline.edu Chuck E. Cheese: A Gambling Gateway Restaurant? http://newsfeed.time.com/2011/05/17/chuck e cheese a gambling gateway restaurant/
More informationPreliminary Conclusion
1 Exploring the Genetic Component of Political Participation Brad Verhulst Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Theories of political participation,
More informationObsessive compulsive disorder, tics and anxiety in 6-year-old twins
Psychological Medicine, Page 1 of 10. f 2006 Cambridge University Press doi:10.1017/s0033291706008816 Printed in the United Kingdom Obsessive compulsive disorder, tics and anxiety in 6-year-old twins DEREK
More informationAustralian children of alcoholic female twins
Washington University School of Medicine Digital Commons@Becker Posters 2005: Alcoholism and Comorbidity 2005 Australian children of alcoholic female twins Wendy S. Slutske Follow this and additional works
More informationDiscontinuous Traits. Chapter 22. Quantitative Traits. Types of Quantitative Traits. Few, distinct phenotypes. Also called discrete characters
Discontinuous Traits Few, distinct phenotypes Chapter 22 Also called discrete characters Quantitative Genetics Examples: Pea shape, eye color in Drosophila, Flower color Quantitative Traits Phenotype is
More informationPanic symptoms, cigarette smoking and drinking in adolescent female twins
Washington University School of Medicine Digital Commons@Becker Posters 2003: Drinking and the High School Student 2003 Panic symptoms, cigarette smoking and drinking in adolescent female twins Michele
More informationThe role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence
Drug and Alcohol Dependence 87 (2007) 46 53 The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence Tanya M.M. Button a,, Soo Hyun Rhee a,b,
More informationThis is an electronic reprint of the original article. This reprint may differ from the original in pagination and typographic detail.
This is an electronic reprint of the original article. This reprint may differ from the original in pagination and typographic detail. Author(s): Salmela-Aro, Katariina; Read, Sanna; Vuoksimaa, Eero; Korhonen,
More informationORIGINAL ARTICLE. The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression
ORIGINAL ARTICLE The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression Peter McGuffin, MB, PhD, FRCP, FRCPsych; Fruhling Rijsdijk, PhD; Martin Andrew, MB, MRCPsych;
More informationSUMMARY AND DISCUSSION
Risk factors for the development and outcome of childhood psychopathology SUMMARY AND DISCUSSION Chapter 147 In this chapter I present a summary of the results of the studies described in this thesis followed
More informationThe role of family conflict as a moderator of alcoholism outcomes among offspring of alcoholics
Washington University School of Medicine Digital Commons@Becker Posters 2004: Alcoholism and the Latest Genetics and Neuroscience Findings 2004 The role of family conflict as a moderator of alcoholism
More informationThe structure of genetic and environmental risk factors for three measures of disordered eating
Psychological Medicine, 1999, 29, 925 934. 1999 Cambridge University Press Printed in the United Kingdom The structure of genetic and environmental risk factors for three measures of disordered eating
More informationORIGINAL ARTICLE. Introduction
ORIGINAL ARTICLE (2009) 14, 1051 1066 & 2009 Nature Publishing Group All rights reserved 1359-4184/09 $32.00 www.nature.com/mp Sociodemographic and psychopathologic predictors of first incidence of DSM-IV
More informationIs ADHD Always a Childhood Onset Disorder? Towards Understanding Adult Onset ADHD
Is ADHD Always a Childhood Onset Disorder? Towards Understanding Adult Onset ADHD Joseph Biederman, MD Professor of Psychiatry Harvard Medical School Chief, Clinical and Research Programs in Pediatric
More informationGenetic and environmental risk factors for the weight and shape concerns characteristic of bulimia nervosa
Psychological Medicine, 1998, 28, 761 771. 1998 Cambridge University Press Printed in the United Kingdom Genetic and environmental risk factors for the weight and shape concerns characteristic of bulimia
More informationSEMs for Genetic Analysis
SEMs for Genetic Analysis Session 8, Lecture 4 2/3/06 Basic Genetic Analysis of Twin Samples Using SEMs SEMs and variance explained Motivating example Simple correlation test The heritability concept Structural
More informationBPD In Adolescence: Early Detection and Intervention
BPD In Adolescence: Early Detection and Intervention Blaise Aguirre, MD Medical Director 3East Residential Instructor in Psychiatry Harvard Medical School Quick Points The idea that we have to wait until
More informationMajor depression and phobias: the genetic and environmental sources of comorbidity
Psychological Medicine, 13, 23, 361-371. Copyright 13 Cambridge University Press Major depression and phobias: the genetic and environmental sources of comorbidity KENNETH S. KENDLER, 1 MICHL C. NEALE,
More informationInteraction of Genes and the Environment
Some Traits Are Controlled by Two or More Genes! Phenotypes can be discontinuous or continuous Interaction of Genes and the Environment Chapter 5! Discontinuous variation Phenotypes that fall into two
More informationTwin Research and Human Genetics
Twin Research and Human Genetics Article title: Familial aggregation of migraine and depression: insights from a large Australian twin sample Authors: Yuanhao Yang 1, Huiying Zhao 1, Andrew C Heath 2,
More informationA Twin Study Examining the Development of Rumination and its Role as a Transdiagnostic Risk Factor for Psychopathology
University of Colorado, Boulder CU Scholar Psychology and Neuroscience Graduate Theses & Dissertations Psychology and Neuroscience Spring 1-1-2015 A Twin Study Examining the Development of Rumination and
More informationArticle. Low Extraversion and High Neuroticism as Indices of Genetic and Environmental Risk for Social Phobia, Agoraphobia, and Animal Phobia
Article Low Extraversion and High Neuroticism as Indices of Genetic and Environmental Risk for Social Phobia, Agoraphobia, and Animal Phobia O. Joseph Bienvenu, M.D., Ph.D. John M. Hettema, M.D., Ph.D.
More informationIn Australian twins participating in three different
Heritability and Stability of Resting Blood Pressure in Australian Twins Jouke-Jan Hottenga, 1 John B. Whitfield, 2 Eco J. C. de Geus, 1 Dorret I. Boomsma, 1 and Nicholas G. Martin 2 1 Department of Biological
More informationGENETIC AND ENVIRONMENTAL INFLUENCES ON ANXIOUS/DEPRESSION
Chapter 8 GENETIC AND ENVIRONMENTAL INFLUENCES ON ANXIOUS/DEPRESSION A Longitudinal Study in 3- to 12-Year-Old Children Dorret I. Boomsma, Ph.D. C.E.M. van Beijsterveldt, Ph.D. Meike Bartels, Ph.D. James
More informationPSY337 Psychopathology Notes
PSY337 Psychopathology Notes DSM Definition of mental s: clinically significant set of symptoms that result in some type of impact in an individual s life. No single rule, which captures a broad definition
More informationSibling Resemblance for Psychiatric Disorders in Offspring at High and Low Risk for Depression
/. Child Psychol. Psychiat. Vol. 36, No. 8, pp. 13.5.S-1.S63, 1995 Elsevier Science Ltd. Printed in Great Britain Pei^amon 0021-9630/9.5 $9..5() + 0.00 0021-9630(95)00060-7 Sibling Resemblance for Psychiatric
More informationThe Relationship Between the Genetic and Environmental Influences on Common Internalizing Psychiatric Disorders and Mental Well-Being
Behav Genet (2011) 41:641 650 DOI 10.1007/s10519-011-9466-1 ORIGINAL RESEARCH The Relationship Between the Genetic and Environmental Influences on Common Internalizing Psychiatric Disorders and Mental
More informationReview Article Sex Differences in Genetic and Environmental Influences on Adolescent Depressive Symptoms: A Meta-Analytic Review
Depression Research and Treatment Volume 2015, Article ID 476238, 7 pages http://dx.doi.org/10.1155/2015/476238 Review Article Sex Differences in Genetic and Environmental Influences on Adolescent Depressive
More informationGeneralist Genes and Learning Disabilities
Psychological Bulletin Copyright 2005 by the American Psychological Association 2005, Vol. 131, No. 4, 592 617 0033-2909/05/$12.00 DOI: 10.1037/0033-2909.131.4.592 Generalist Genes and Learning Disabilities
More informationJ. Sleep Res. (2012) Regular Research Paper
J. Sleep Res. (2012) Regular Research Paper Modeling the direction of causation between cross-sectional measures of disrupted sleep, anxiety and depression in a sample of male and female Australian twins
More informationThe Inheritance of Complex Traits
The Inheritance of Complex Traits Differences Among Siblings Is due to both Genetic and Environmental Factors VIDEO: Designer Babies Traits Controlled by Two or More Genes Many phenotypes are influenced
More informationGenetic contribution to the relationship between personality and depressive symptoms among older women
Psychological Medicine (2010), 40, 1357 1366. f Cambridge University Press 2009 doi:10.1017/s0033291709991401 Genetic contribution to the relationship between personality and depressive symptoms among
More informationDiscussion. were best fit by models of determination that did not include genetic effects.
A Behavior Genetic Investigation of the Relationship Between Leadership and Personality Andrew M. Johnson 1, Philip A. Vernon 2, Julie Aitken Harris 3, and Kerry L. Jang 4 1 Faculty of Health Sciences,The
More informationPhenotypic, Genetic, and Environmental Correlations between Reaction Times and Intelligence in Young Twin Children
J. Intell. 2015, 3, 160-167; doi:10.3390/jintelligence3040160 Brief Report OPEN ACCESS Journal of Intelligence ISSN 2079-3200 www.mdpi.com/journal/jintelligence Phenotypic, Genetic, and Environmental Correlations
More informationAggregation of psychopathology in a clinical sample of children and their parents
Aggregation of psychopathology in a clinical sample of children and their parents PA R E N T S O F C H I LD R E N W I T H PSYC H O PAT H O LO G Y : PSYC H I AT R I C P R O B LEMS A N D T H E A S SO C I
More informationEvidence for shared genetic influences on selfreported ADHD and autistic symptoms in young adult Australian twins
Washington University School of Medicine Digital Commons@Becker Open Access Publications 2008 Evidence for shared genetic influences on selfreported ADHD and autistic symptoms in young adult Australian
More informationExamining the Origins of Gender Differences in Marital Quality: A Behavior Genetic Analysis
Journal of Family Psychology Copyright 2006 by the American Psychological Association 2006, Vol. 20, No. 4, 605 613 0893-3200/06/$12.00 DOI: 10.1037/0893-3200.20.4.605 Examining the Origins of Gender Differences
More informationReliability of a lifetime history of major depression: implications for heritability and co-morbidity
Psychological Medicine, 998, 28, 857 870. 998 Cambridge University Press Printed in the United Kingdom Reliability of a lifetime history of major depression: implications for heritability and co-morbidity
More informationEffects on psyche/emotions/relationships/distress. Part II
Effects on psyche/emotions/relationships/distress Part II May 5, 2003 Discussion Leaders: Carole Dorham, Jennifer Hogansen, & Allison Lau Psy 607: Trauma as etiology Trauma as etiology 1 Overview Six articles:
More informationClass Objectives: 8/31/2014. Anxiety is a future-oriented apprehension or sense of dread
Chapter 8 Anxiety, Obsessive-Compulsive, and Trauma and Stressor-Related Disorders Class Objectives: What is Anxiety? How are anxiety, fear and panic similar? Different? What is Generalized Anxiety Disorder?
More informationThe Genetic and Environmental Sources of Resemblance Between Normative Personality and Personality Disorder Traits
Virginia Commonwealth University VCU Scholars Compass Psychiatry Publications Dept. of Psychiatry 2017 The Genetic and Environmental Sources of Resemblance Between Normative Personality and Personality
More informationJournal of Research in Personality
Journal of Research in Personality 43 (2009) 737 746 Contents lists available at ScienceDirect Journal of Research in Personality journal homepage: www.elsevier.com/locate/jrp Temperament in middle childhood:
More informationGenetics of psychiatric disorders Dr Radwan Banimustafa
Genetics of psychiatric disorders Dr Radwan Banimustafa Schizophrenia Is a chronic relapsing psychotic disorder which affects young population and interfere with: - Thoughts - Perception - Volition - Behavior
More informationHeritability of Anxious-Depressive and Withdrawn Behavior: Age-Related Changes During Adolescence
NEW RESEARCH Heritability of Anxious-Depressive and Withdrawn Behavior: Age-Related Changes During Adolescence Diane J. Lamb, M.Sc., Christel M. Middeldorp, M.D., Ph.D., Catarina E.M. van Beijsterveldt,
More informationIs Suicide Genetic? In Search of Intermediate Phenotypes. NIMH Support and Financial Disclosures
Is Suicide Genetic? In Search of Intermediate Phenotypes David A. Brent, M.D. The 8th Annual Guze Symposium on Alcoholism February 21, 2008 Supported by MH56612, MH56390 NIMH Support and Financial Disclosures
More informationMARC Project 4: Australian Children of Alcoholic Female Twins
MARC Project 4: Australian Children of Alcoholic Female Twins Mary Waldron, Valerie S. Knopik, Theodore Jacob, Anne Glowinski, Nicholas Martin, & Andrew Heath Background Although it has been widely embraced
More informationGenetic and Environmental Transmission of Political Attitudes Over a Life Time
Genetic and Environmental Transmission of Political Attitudes Over a Life Time Peter K. Hatemi Carolyn L. Funk Sarah E. Medland Hermine M. Maes Judy L. Silberg Nicholas G. Martin Lindon J. Eaves University
More informationThe epidemiology of emerging adulthood psychiatric disorders
The epidemiology of emerging adulthood psychiatric disorders William Copeland, PhD Center for Developmental Epidemiology Duke University Society for the Study of Emerging Adulthood October 2011 No conflicts
More informationIMPLICATIONS OF GENE- ENVIRONMENT INTERPLAY FOR APPROACHES TO SUBSTANCE ABUSE AND COMORBIDITY
Ppt. Oslo 3 th Nov 9 IMPLICATIONS OF GENE- ENVIRONMENT INTERPLAY FOR APPROACHES TO SUBSTANCE ABUSE AND COMORBIDITY By Michael Rutter PERCENTAGE OF GENETIC INFLUENCE REPORTED IN BEHAVIORAL GENETIC STUDIES
More informationGenetic Influences on Childhood Competencies: A Twin Study
Genetic Influences on Childhood Competencies: A Twin Study JAMES J. HUDZIAK, M.D., WILLIAM COPELAND, B.A., LAWRENCE P. RUDIGER, PH.D., THOMAS M. ACHENBACH, PH.D., ANDREW C. HEATH, D.PHIL., AND RICHARD
More informationChronic irritability in youth that may be misdiagnosed as bipolar disorder. Ellen Leibenluft, M.D.
Chronic irritability in youth that may be misdiagnosed as bipolar disorder Ellen Leibenluft, M.D. Chief, Section on Bipolar Spectrum Disorders Emotion and Development Branch National Institute of Mental
More informationGenetic and environmental influences on juvenile antisocial behaviour assessed on two occasions
Psychological Medicine, 2000, 30, 1315 1325. 2000 Cambridge University Press Printed in the United Kingdom Genetic and environmental influences on juvenile antisocial behaviour assessed on two occasions
More informationIs ADHD Always a Childhood Onset Disorder? Towards Understanding Adult Onset ADHD
Is ADHD Always a Childhood Onset Disorder? Towards Understanding Adult Onset ADHD Joseph Biederman, MD Professor of Psychiatry Harvard Medical School Chief, Clinical and Research Programs in Pediatric
More informationImaging Genetics: Heritability, Linkage & Association
Imaging Genetics: Heritability, Linkage & Association David C. Glahn, PhD Olin Neuropsychiatry Research Center & Department of Psychiatry, Yale University July 17, 2011 Memory Activation & APOE ε4 Risk
More informationMAJOR DEPRESSIVE DISORDER IN A FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDER WITH PEDIATRIC PROBANDS
Research Article DEPRESSION AND ANXIETY 28 : 501 508 (2011) MAJOR DEPRESSIVE DISORDER IN A FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDER WITH PEDIATRIC PROBANDS Gregory L. Hanna, M.D., 1 Joseph A. Himle,
More informationGenetic and environmental influences on eating behaviors in 2.5- and 9-year-old children: a longitudinal twin study
Dubois et al. International Journal of Behavioral Nutrition and Physical Activity 2013, 10:134 RESEARCH Open Access Genetic and environmental influences on eating behaviors in 2.5- and 9-year-old children:
More informationCauses of Stability of Aggression from Early Childhood to Adolescence: A Longitudinal Genetic Analysis in Dutch Twins
Behavior Genetics, Vol. 33, No. 5, September 2003 ( 2003) Causes of Stability of Aggression from Early Childhood to Adolescence: A Longitudinal Genetic Analysis in Dutch Twins C. E. M. van Beijsterveldt,
More informationSMOKING CIGARETTES IS COMMON among adolescents,
HUIZINK ET AL. 5 Tobacco, Cannabis, and Other Illicit Drug Use Among Finnish Adolescent Twins: Causal Relationship or Correlated Liabilities?* ANJA C. HUIZINK, PH.D., ESKO LEVÄLAHTI, PH.D, TELLERVO KORHONEN,
More informationResolving multiple epigenetic pathways to adolescent depression
Journal of Child Psychology and Psychiatry 44:7 (2003), pp 1006 1014 Resolving multiple epigenetic pathways to adolescent depression Lindon Eaves, 1 Judy Silberg, 1 and Alaattin Erkanli 2 1 Virginia Institute
More informationQuantitative Trait Analysis in Sibling Pairs. Biostatistics 666
Quantitative Trait Analsis in Sibling Pairs Biostatistics 666 Outline Likelihood function for bivariate data Incorporate genetic kinship coefficients Incorporate IBD probabilities The data Pairs of measurements
More informationGenetic and Environmental Influences on the Individual Differences of Temperament in Primary School Children
Available online at www.sciencedirect.com ScienceDirect Procedia - Social and Behavioral Scienc es 86 ( 2013 ) 435 440 V Congress of Russian Psychological Society Genetic and Environmental Influences on
More informationPredicting Offspring Conduct Disorder Using Parental Alcohol and Drug Dependence
Predicting Offspring Conduct Disorder Using Parental Alcohol and Drug Dependence Paul T. Korte, B.A. J. Randolph Haber, Ph.D. Abstract Introduction: Previous research has shown that the offspring of parents
More informationParenting as Phenotype: A Behavioral Genetic Approach to Understanding Parenting
The University of San Francisco USF Scholarship: a digital repository @ Gleeson Library Geschke Center Psychology College of Arts and Sciences 2012 Parenting as Phenotype: A Behavioral Genetic Approach
More informationToday s Topics. Cracking the Genetic Code. The Process of Genetic Transmission. The Process of Genetic Transmission. Genes
Today s Topics Mechanisms of Heredity Biology of Heredity Genetic Disorders Research Methods in Behavioral Genetics Gene x Environment Interactions The Process of Genetic Transmission Genes: segments of
More informationBias in Correlations from Selected Samples of Relatives: The Effects of Soft Selection
Behavior Genetics, Vol. 19, No. 2, 1989 Bias in Correlations from Selected Samples of Relatives: The Effects of Soft Selection M. C. Neale, ~ L. J. Eaves, 1 K. S. Kendler, 2 and J. K. Hewitt 1 Received
More informationChapter 5 INTERACTIONS OF GENES AND THE ENVIRONMENT
Chapter 5 INTERACTIONS OF GENES AND THE ENVIRONMENT Chapter Summary Up to this point, the traits you have been studying have all been controlled by one pair of genes. However, many traits, including some
More informationThe equal environments assumption, which holds
An Investigation of a Measure of Twins Equal Environments Karen S. Mitchell, 1,2 Suzanne E. Mazzeo, 1,3 Cynthia M. Bulik, 4 Steven H. Aggen, 2,5 Kenneth S. Kendler, 2,5 and Michael C. Neale 2,5,6 1 Department
More informationHHS Public Access Author manuscript Twin Res Hum Genet. Author manuscript; available in PMC 2015 October 01.
Shared genetic and environmental influences on early temperament and preschool psychiatric disorders in Hispanic twins Judy L. Silberg 1,2, Nathan Gillespie 1,2,3, Ashlee A. Moore 1,4, Lindon J. Eaves
More informationLearning Abilities and Disabilities
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE Learning Abilities and Disabilities Generalist Genes, Specialist Environments Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry,
More informationLife-Span Development Thirteenth Edition
Life-Span Development Thirteenth Edition Natural Selection and Adaptive Behavior Natural Selection: an evolutionary process by which those individuals of a species that are best adapted are the ones that
More informationAnxiety disorders in mothers and their children: prospective longitudinal community study
Anxiety disorders in mothers and their children: prospective longitudinal community study Andrea Schreier, Hans-Ulrich Wittchen, Michael Höfler and Roselind Lieb Summary The relationship between DSM IV
More informationKeywords: classical twin study, behavioural genetics, Mx, SEM, genetic model fitting
Fruhling Rijsdijk is a lecturer in Quantitative Behavioral Genetics at the Social, Genetic & Development Psychiatry Research Centre of the Institute of Psychiatry, King s College London. She works on the
More informationMultifactorial Inheritance. Prof. Dr. Nedime Serakinci
Multifactorial Inheritance Prof. Dr. Nedime Serakinci GENETICS I. Importance of genetics. Genetic terminology. I. Mendelian Genetics, Mendel s Laws (Law of Segregation, Law of Independent Assortment).
More informationMental Health Problems in Individuals with Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder
Mental Health Problems in Individuals with Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder Presenter: Date: Jacqueline Pei, R. Psych., PhD Carmen Rasmussen, PhD May 5, 2009 The FASD Learning
More informationMULTIFACTORIAL DISEASES. MG L-10 July 7 th 2014
MULTIFACTORIAL DISEASES MG L-10 July 7 th 2014 Genetic Diseases Unifactorial Chromosomal Multifactorial AD Numerical AR Structural X-linked Microdeletions Mitochondrial Spectrum of Alterations in DNA Sequence
More informationFrequency of church attendance in Australia and the United States: models of family resemblance
Twin Research (1999) 2, 99 107 1999 Stockton Press All rights reserved 1369 0523/99 $12.00 http://www.stockton-press.co.uk/tr Frequency of church attendance in Australia and the United States: models of
More informationPRIOR STUDIES HAVE SUGGESTED an association
664 JOURNAL OF STUDIES ON ALCOHOL AND DRUGS / SEPTEMBER 2013 A Twin Study of Alcohol Dependence, Binge Eating, and Compensatory Behaviors MELISSA A. MUNN-CHERNOFF, PH.D., a,b, * ALEXIS E. DUNCAN, PH.D.,
More informationJournal of Abnormal Psychology
Journal of Abnormal Psychology A Study of Changes in Genetic and Environmental Influences on Weight and Shape Concern Across Adolescence Tracey D. Wade, Narelle K. Hansell, Ross D. Crosby, Rachel Bryant-Waugh,
More informationA Twin-Family Study of Suicidality and Illicit Drug Use in Young People
A Twin-Family Study of Suicidality and Illicit Drug Use in Young People Qiang (John) Fu, 1,2 Andrew C. Heath, 2 Kathleen K. Bucholz 2 1 Saint Louis University School of Public Health 2 Midwest Alcoholism
More informationRunning Head: Longitudinal genetic analysis of anxiety sensitivity. Longitudinal genetic analysis of anxiety sensitivity
Longitudinal genetic analysis of anxiety sensitivity 1 Running Head: Longitudinal genetic analysis of anxiety sensitivity Longitudinal genetic analysis of anxiety sensitivity Journal: Developmental Psychology
More informationMOLECULAR EPIDEMIOLOGY Afiono Agung Prasetyo Faculty of Medicine Sebelas Maret University Indonesia
MOLECULAR EPIDEMIOLOGY GENERAL EPIDEMIOLOGY General epidemiology is the scientific basis of public health Descriptive epidemiology: distribution of disease in populations Incidence and prevalence rates
More informationTwin Studies of Eating Disorders: A Review
Twin Studies of Eating Disorders: A Review Cynthia M. Bulik,* Patrick F. Sullivan, Tracey D. Wade, and Kenneth S. Kendler Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry,
More informationChapter 2 Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability
Chapter 2 Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability Eric Turkheimer and Erin E. Horn In 3, our lab published a paper demonstrating that the heritability
More informationContrasting models of genetic co-morbidity for cannabis and other illicit drugs in adult Australian twins
Psychological Medicine, 2007, 37, 49 60. f 2006 Cambridge University Press doi:10.1017/s0033291706009287 First published online 1 November 2006 Printed in the United Kingdom Contrasting models of genetic
More informationMendelian & Complex Traits. Quantitative Imaging Genomics. Genetics Terminology 2. Genetics Terminology 1. Human Genome. Genetics Terminology 3
Mendelian & Complex Traits Quantitative Imaging Genomics David C. Glahn, PhD Olin Neuropsychiatry Research Center & Department of Psychiatry, Yale University July, 010 Mendelian Trait A trait influenced
More informationNumerous studies have produced evidence that depression
A Twin Study of Depression Symptoms, Hypertension, and Heart Disease in Middle-Aged Men JEFFREY F. SCHERRER, MA, HONG XIAN, PHD, KATHLEEN K. BUCHOLZ, PHD, SETH A. EISEN, MD, MSC, MICHAEL J. LYONS, PHD,
More informationLiability Threshold Models
Liability Threshold Models Frühling Rijsdijk & Kate Morley Twin Workshop, Boulder Tuesday March 4 th 2008 Aims Introduce model fitting to categorical data Define liability and describe assumptions of the
More informationWhen Assessing Twin Concordance, Use the Probandwise Not the Pairwise Rate
VOL. 18, NO. 2, 1992 When Assessing Twin Concordance, Use the Probandwise Not the Pairwise Rate 171 by Matt McGue Abstract Cenetidsts and twin researchers have long debated the relative merits of two alternative
More informationNIH Public Access Author Manuscript JAMA Psychiatry. Author manuscript; available in PMC 2015 September 01.
NIH Public Access Author Manuscript Published in final edited form as: JAMA Psychiatry. 2014 September 1; 71(9): 989 996. doi:10.1001/jamapsychiatry.2014.359. Patterns of Heterotypic Continuity Associated
More informationDan Koller, Ph.D. Medical and Molecular Genetics
Design of Genetic Studies Dan Koller, Ph.D. Research Assistant Professor Medical and Molecular Genetics Genetics and Medicine Over the past decade, advances from genetics have permeated medicine Identification
More informationWhat can we learn from twins about study and subject choice?
What can we learn from twins about study and subject choice? Kathryn Asbury Psychology in Education Research Centre, Department of Education, University of York How do we know about genetic influences
More information