Twin Research and Human Genetics
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1 Twin Research and Human Genetics Article title: Familial aggregation of migraine and depression: insights from a large Australian twin sample Authors: Yuanhao Yang 1, Huiying Zhao 1, Andrew C Heath 2, Pamela AF Madden 2, Nicholas G Martin 3 and Dale R Nyholt 1 Authors information: 1 Statistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia. 2 Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. 3 Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
2 Supplement materials Table S1: Twin-pair migraine-migraine: cross-tabulations Zygosity Proband group Total sample No migraine Self-report migraine ID migraine IHS migraine Any migraine Co-twin No migraine Self-report migraine ID migraine IHS migraine Any migraine MZ No migraine Self-report migraine ID migraine IHS migraine Any migraine DZ No migraine Self-report migraine ID migraine IHS migraine Any migraine Same-sex DZ No migraine Self-report migraine ID migraine IHS migraine Any migraine MZ F-F No migraine Self-report migraine ID migraine IHS migraine Any migraine MZ M-M No migraine Self-report migraine ID migraine IHS migraine Any migraine DZ F-F No migraine Self-report migraine ID migraine IHS migraine Any migraine DZ M-M No migraine Self-report migraine ID migraine IHS migraine Any migraine DZ F-M No migraine Self-report migraine ID migraine IHS migraine Any migraine DZ M-F No migraine Self-report migraine ID migraine IHS migraine Any migraine IHS: the International Headache Society; MZ: monozygotic twin pairs; DZ: dizygotic twin pairs; F: female; M: male.
3 Table S2: Twin-pair depression-depression: cross-tabulations No depression MDD Any depression Total sample No depression MDD Any depression MZ No depression MDD Any depression DZ No depression MDD Any depression Same-sex DZ No depression MDD Any depression MZ F-F No depression MDD Any depression MZ M-M No depression MDD Any depression DZ F-F No depression MDD Any depression DZ M-M No depression MDD Any depression DZ F-M No depression MDD Any depression DZ M-F No depression MDD Any depression MDD: major depressive disorder. MZ: monozygotic twin pairs; DZ: dizygotic twin pairs; F: female; M: male.
4 Table S3: Twin-pair any migraine-any depression: cross-tabulations No any depression Any depression Total sample No any migraine any migraine MZ No any migraine any migraine DZ No any migraine any migraine Same-sex DZ No any migraine any migraine MZ F-F No any migraine any migraine MZ M-M No any migraine any migraine DZ F-F No any migraine any migraine DZ M-M No any migraine any migraine DZ F-M No any migraine any migraine DZ M-F No any migraine any migraine MZ: monozygotic twin pairs; DZ: dizygotic twin pairs; F: female; M: male.
5 Table S4: Twin-pair any depression-any migraine: cross-tabulations No any migraine Any migraine Total sample No any depression any depression MZ No any depression any depression DZ No any depression any depression Same-sex DZ No any depression any depression MZ F-F No any depression any depression MZ M-M No any depression any depression DZ F-F No any depression any depression DZ M-M No any depression any depression DZ F-M No any depression any depression DZ M-F No any depression any depression MZ: monozygotic twin pairs; DZ: dizygotic twin pairs; F: female; M: male.
6 Table S5: Twin-pair IHS migraine-mdd: cross-tabulations No MDD MDD Total sample No IHS migraine IHS migraine MZ No IHS migraine IHS migraine DZ No IHS migraine IHS migraine Same-sex DZ No IHS migraine IHS migraine MZ F-F No IHS migraine IHS migraine MZ M-M No IHS migraine IHS migraine DZ F-F No IHS migraine IHS migraine DZ M-M No IHS migraine IHS migraine DZ F-M No IHS migraine IHS migraine DZ M-F No IHS migraine IHS migraine IHS: the International Headache Society; MDD: major depressive disorder; MZ: monozygotic twin pairs; DZ: dizygotic twin pairs; F: female; M: male.
7 Table S6: Twin-pair MDD-IHS migraine: cross-tabulations No IHS migraine IHS migraine Total sample No MDD MDD MZ No MDD MDD DZ No MDD MDD Same-sex DZ No MDD MDD MZ F-F No MDD MDD MZ M-M No MDD MDD DZ F-F No MDD MDD DZ M-M No MDD MDD DZ F-M No MDD MDD DZ M-F No MDD MDD IHS: the International Headache Society; MDD: major depressive disorder; MZ: monozygotic twin pairs; DZ: dizygotic twin pairs; F: female; M: male.
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