BIOGRAPHICAL SKETCH INSTITUTION AND LOCATION DEGREE YY FIELD OF STUDY. Biological Science

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1 Current Position and address Franscisco Gómez Scholl Associate Professor Instituto de Biomedicina de Sevilla (IBiS) and Department of Medical Phisiology and Biophysics University of Seville Campus del Hospital Universitario Virgen del Rocío Avenida Manuel Siurot, s/n Sevilla Spain Present research area Synapse, autism, Alzheimer s disease, brain diseases, animal models, neurexins, neuroligins BIOGRAPHICAL SKETCH EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE YY FIELD OF STUDY University of Seville, Spain Biological Science 1991 Biomedical Research Institute, CSIC- Cancer Biology of PhD 1999 Universidad Autonoma de Madrid, Spain Epithelial Cells Biomedical Research Institute, CSIC-Universidad Cancer Biology of Postdoctoral 2000 Autonoma de Madrid, Spain Epithelial Cells Weill Medical College of Cornell University, New York, USA Postdoctoral 2001 Epithelial Polarity Columbia University, New York, USA Postdoctoral Neuroscience Ramón y Cajal Investigator, University of Seville Group leader Neuroscience Associate Professor, University of Seville, IBiS Group leader Current Neuroscience

2 Peer-reviewed publications Neurexin dysfunction in adult neurons results in autistic-like behavior in mice. (2014). Rabaneda LG, Robles-Lanuza E, Nieto-González JL, Scholl FG. Cell Rep 8(2): PMID: Genetic study of NRXN1β variants in Spanish patients with schizophrenia. (2014). Abasolo N, Roig B, Martorell L, Martínez-Leal R, Aguilera F, Camacho-García R, Orejuela C, Scholl FG, Martinez-Mir A, Vilella E. Schizophr Res. 159 (2-3): PMID: Rare variants analysis of neurexin-1β in autism reveals a novel start codon mutation affecting protein levels at synapses. (2013). Camacho-Garcia RJ, Hervas A, Toma C, Balmaña N, Cormand B, Martinez-Mir A, Scholl FG. Psychiatr Genet 23(6): PMID: Genetic sudy of neurexin and neuroligins genes in Alzheimer s disease. (2013). Martinez-Mir A, Gonzalez-Perez A, Gayan J, Antunez C, Marin J, Boada M, Lopez-Arrieta JM, Fernandez E, Ramirez-Lorca R, Saez ME, Ruiz A, Scholl FG, Real LM. J Alzheimers Dis 35(2): PMID: Mutations affecting synaptic levels of neurexin-1β in autism and mental retardation. (2012). Camacho-Garcia RJ, Planelles MI, Margalef M, Pecero ML, Martinez-Leal R, Aguilera F, Vilella E, Martinez-Mir A, Scholl FG. Neurobiol Dis 47(1): PMID: Presenilin/γ-secretase regulates neurexin processing at synapses. (2011). Saura CA, Servian- Morilla E, Scholl FG. PLoS ONE 6(4): e PMID: Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons. (2008). Gascon S, Paez-Gomez JA, Diaz-Guerra M, Scheiffele P, Scholl FG. J Neurosci Methods. 168(1): PMID: Silencing of neuroligin function by postsynaptic neurexins. (2007). Taniguchi, H, Gollan L, Scholl FG, Mahadomrongkul V, Dobler E, Limthong N, Peck M, Aoki C, Scheiffele. J Neurosci. 27(11): PMID:

3 Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Martín-Villar E, Scholl FG, Gamallo C, Yurrita MM, Muñoz-Guerra M, Cruces J, Quintanilla M. Int J Cancer. 113(6): PMID: Making connections: cholinesterase-domain proteins in the CNS. (2003). Scholl FG, Scheiffele P. Trends in Neurosci. 26: PMID: Neurexin mediates the assembly of presynaptic terminals. (2003). Dean C*, Scholl FG*, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. * Co-authors. Nat Neurosci. 6: PMID: Ectopic expression of PA2.26 antigen in epidermal keratinocytes leads to destabilization of adherens junctions and malignant progression. (2000). Scholl FG, Gamallo C, Quintanilla M. Lab Invest. 80: PMID: Identification of PA.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. (1999). Scholl FG, Gamallo C, Vilaró S, Quintanilla M. J Cell Sci. 112: PMID: Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis. (1997). Gandarillas A*, Scholl FG*, Benito N, Gamallo C, Quintanilla M. * Co-authors. Mol Carcinogen. 20: PMID: Chronic exposure of cultured transformed mouse epidermal cells to Transforming Growth Factorβ1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. (1995). Caulín C, Scholl FG, Frontelo P, Gamallo C, Quintanilla M. Cell Growth & Differ. 6: PMID: Expression of intermediate filament proteins by normal and transformed mouse epidermal keratinocytes in culture. (1993). Caulín C, Gandarillas A, Scholl FG, Quintanilla M. Int J Oncol 2: PMID:

4 Funding as PI Title: Synaptic Function of Neurexins in Brain Diseases: Alzheimer s Disease Funding Agency: Regional Government of Andalusia (P11-CVI-7599) Participating institutions: University of Seville, Instituto de Biomedicina de Sevilla (IBiS) From April 2013 to December 2017 Title: Implications of the mechanisms of synaptic differentiation in Autism Funding Agency: Carlos III Health Institute. Spanish Ministry of Health (PI11/01058) Participating institutions: University of Seville, Instituto de Biomedicina de Sevilla (IBiS) From January 2012 to December 2014 Title: "European High-functioning Autism network: Translational research in a phenotypically well characterised sample (EUHFAUTISM) " Funding Agency: ERANET-NEURON (European Research Projects on Mental Disorders) (PIM2010ERN-00700) Participating institutions: University of Seville, Instituto de Biomedicina de Sevilla (IBiS) (Seville, Spain), Hospital Mutua de Terrassa (Tarragona, Spain), Institut Pasteur (Paris, France), University Denis Diderot Paris 7, INSERM, Department of Psychiatry, University Paris Est Créteil, CRicm UPMC Inserm CNRS, Pitié-Salpêtrière Hospital (Paris, France), JW Goethe University (Frankfurt, Germany), German Cancer Research Center-DKFZ (Heidelberg, Germany) From March 2011 to August 2014 Principal Investigator: Thomas Bourgeron. Coordinator of the Spanish node: Francisco Gomez- Scholl. Collaborator: Amalia Martinez-Mir Title: Regulation of Neurexins by Presenilins Funding Agency: Regional Government of Andalusia (P07-CVI-02943) Participating institutions: University of Seville, Instituto de Biomedicina de Sevilla (IBiS), Universidad Autónoma de Barcelona From January 2008 to December 2012 Title: Synaptic Dysfunction and Autism

5 Funding Agency: Carlos III Health Institute. Spanish Ministry of Health (PI08/01446) Participating institutions: University of Seville, Institut Psiquiàtric Pere Mata (Reus) From January 2009 to December 2011 Title: Functional study of neurexins in neuroligin-induced synapses, implications in autism and mental retardation Funding Agency: Carlos III Health Institute. Spanish Ministry of Health (PI05/01667) Participating institutions: University of Seville From January 2006 to December 2008 Principal Investigator: Francisco Gomez-Scholl Thesis Regulation of synaptic vesicle release by beta-neurexin-neuroligin interactions. (2013). Juan Antonio Páez Gómez. Apto Cum laude Supervisors: Francisco Gómez Scholl and Guillermo Alvarez de Toledo. Study of the genetic basis of neurodevelopmental disorders: Epilepsy and Autism. (2013). Rafael Camacho García. Apto Cum laude Supervisors: Amalia Martínez Mir and Francisco Gómez Scholl Regulation of the neurexin function at the synapse presenilins. Implications in Alzheimer s disease. (2012). Emilia Servián Morilla. Apto cum laude Supervisor: Francisco Gómez Scholl