1 ST EUROPEAN. NASH Workshop BARCELONA, SPAIN 8-9 MARCH 2019 REQUEST FOR SUPPORT.
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1 1 ST EUROPEAN NASH Workshop BARCELONA, SPAIN 8-9 MARCH 2019 REQUEST FOR SUPPORT
2 NEEDS ASSESSMENT NEEDS ASSESSMENT Non-alcoholic fatty liver disease (NAFLD) is an emerging liver disease affecting 25 % of the population worldwide. In 10% of patients, NAFLD progresses into NASH, a fibrogenic phenotype that can potentially result in cirrhosis, liver failure and the formation of hepatocellular carcinoma. Although NAFLD is globally the most prevalent chronic liver disease and the second leading indication for liver transplant evaluation in the US 1, knowledge concerning the molecular mechanisms favoring the development and progression of the disease are not fully understood. Current understanding supports the hypothesis that environmental and genetic factors equally influence disease progression. Considering the far-reaching societal and economic burden caused by NAFLD, it is of utmost importance to identify and subsequently implement guidelines to stage, diagnose and treat the disease efficiently. In particular, there is an unmet need for approved drugs that allow the pharmacological treatment of (pre-)cirrhotic NASH. By using surrogate endpoints, the drug approval process for NASH is accelerated and approved agents are expected to enter the market in the near future 2. In detail, several agents, such as the agonist of farnesoid X receptor obeticholic acid (OCA), the dual PPARa/d agonist GFT505 or the ACC inhibitor GS4997 are currently in phase 3 clinical trials and due to their promising data expected to become available by Besides the need to assess these new treatment options for their safety, it is crucial to prepare and train clinicians and other key stakeholders accordingly. Additional gaps include the development of easy, reliable and non-invasive biomarkers to be used during diagnosis, treatment and also monitoring of disease progression. In line with this, the clinical and diagnostic validation of biomarkers were identified as the most pressing needs the NASH field suffers from. These results were obtained in a needs assessment survey conducted among key experts attending our NASH Biomarkers meeting taking place in May Having identified these two main gaps in the NASH/NAFLD field, we aim to address these unmet needs in two separate but complimentary workshops: While our NASH Biomarkers Workshop reviews the regulatory landscape and gaps in evidence needed to qualify specific biomarkers for NASH/ NAFLD, the European NASH meeting focuses on training clinicians on current and future treatment options. TARGET AUDIENCE This meeting targets clinicians active in the field of NASH/NAFLD management, especially hepatologists, endocrinologists, diabetologists, cardiologists and general practitioners and representatives of regulatory agencies ESTIMATED NUMBER OF PARTICIPANTS LEARNING OBJECTIVES After attending the meeting, the participant will be able to: Review potential future treatment options Critically assess current treatment options Outline the mode of action of new treatment options Implement strategies and guidelines used for diagnosing and treating NASH MEETING OBJECTIVES This meeting aims to: Review current treatment options and prepare the field for upcoming drugs Review the mechanistic backgrounds of new drugs and their mode of action Raise awareness for NASH among secondary stakeholders such as endocrinologists, diabetologists and cardiologists Stimulate discussion to accelerate the implementation of policies 1. Wong RJ, Aguilar M, Cheung R, et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology 2015;148: Lazaridis N and Tsochatzis E. Current and future treatment options in non-alcoholic steatohepatitis (NASH). Expert Review of Gastroenterology & Hepatology 2017; 11, 4:
3 MEETING DESCRIPTION PROGRAM By bringing together key experts involved in the clinical management of NAFLD/NASH, this meeting serves as a platform to translate science into clinical practice. Besides focusing on the primary stakeholders, namely hepatologists, we specifically aim to include secondary stakeholders, such as diabetologists, cardiologists, policy enablers and patient representatives. This allows us to stimulate cross-disciplinary discussions that ultimately move the field forward and facilitate the implementation of new policies and guidelines urgently needed to diagnose and treat NASH efficiently. Importantly, we cover the most pressing unmet needs in disease management among medical providers: we prepare the field for upcoming drugs which in turn helps clinicians to effectively use the drug once it enters the market. At the same time, we raise awareness about NASH among secondary stakeholders. Our program spans 1.5 days and includes invited lectures, poster presentations and interactive discussions with the leading experts in the field. FORMAT This interactive workshop will include plenary expert presentations, panel discussions and abstract-driven presentations. International experts in the field of NASH will give state-of-the art lectures and lead the discussions on unresolved issues. Considering that the meeting will be abstract-driven, young professionals will be given the chance to present their data to a wider audience and to connect to senior professionals. Abstracts will be selected purely on their quality of data. Participants will be given the opportunity to network during various poster sessions and a workshop dinner. 3
4 COMMITTEES WORLD S LEADING EXPERTS The European NASH Workshop proudly collaborates with a large number of international experts in the field of NASH/ NAFLD. By working together with our extensive global network of experts from various backgrounds in the field we can ensure to design and deliver the most relevant and state-of-the-art program. ORGANIZING COMMITTEE The members of the Organizing Committee (OC) are carefully selected experts and inspirational leaders in their respective fields. They come together on a frequent basis to develop the scientific program tailored to the needs of Healthcare professionals in the field. Furthermore, they identify clinical cases and research projects within their organizations/ network and review and select abstracts. They actively participate as session chairs and join the Q&A sessions, discussions and debates during the meeting. Quentin Anstee PhD Newcastle University, Newcastle United Kingdom Charles Boucher MD, PhD Erasmus Medical Center, Rotterdam, the Netherlands Helena Cortez-Pinto MD, PhD University of Lisbon Lisbon, Portugal Jeffrey Lazarus PhD Instituto de Salud Global, Barcelona, Spain Vlad Ratziu MD Universite Pierre et Marie Curie, Paris, France Manuel Romero-Gomez, MD MDIBis, Sevilla, Spain Frank Tacke MD, PhD University Hospital Aachen, Aachen Germany 4
5 SPONSORSHIP SPONSOR BENEFITS As a sponsor of the European NASH meeting, you will have the unique opportunity to connect with clinicians and researchers from academia, research institutes and governments. Engage with potential collaborators and experts and discuss the latest advancements and information in the field of NASH. Sponsoring this program will give you the following benefits: Visibility Prominent placement of your logo on conference materials (online and offline) Pre-event marketing and branding through: - Banners posted on the homepage of the website - Traffic generation to your website via the conference website - Your logo placed on monthly newsletters which are delivered to thousands of opt-in subscribers - Electronic advertising posted on several calendars linked to the event website Contribution to the program A chance to organize satellite symposia Participate in discussions Commercial benefits Exhibition opportunities Promotion option to display marketing materials such as pamphlets, flyers, postcards and other materials on the marketing table (subject to approval) [if available] Privileges Your contribution entitles you to the following privileges: Exhibition space [if available] Symposia inclusion [if available] Complimentary registrations to the event to increase your networking opportunities Other benefits described under various sponsorship levels 5
6 ABOUT US EXPERT MEDICAL EVENTS Expert Medical Events is a sister company of Virology Education, focusing on the initiation and organization of state-of-the-art educational programs and forums for international scientific exchange. Our programs are designed for healthcare and research professionals and focus on the presentation, discussion and translation of complex scientific data into future research and daily clinical practice. We work together with key experts and experienced educators to provide top quality scientific content. Our programs are precisely tailored to the needs of scientific researchers and healthcare professionals, and range from international abstract-driven workshops to small and large scale educational series, masterclasses, advisory boards, expert rounds, satellite symposia, and more. Biltstraat BJ Utrecht The Netherlands info@virology-education.com Dr Debora Bade Project manager debora@vironet.com More than 50 programs are planned for 2018 in more than 30 different cities around the globe! Wilco Keulen, PhD Content manager wilco@vironet.com OUR IMPACT IN programs 4,187 participants 2,277 accepted abstracts 59% returning participants 28,000+ opt in subscribers
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