Activities at the Heidelberg Ion Therapy Center (HIT)

Transcription

1 Activities at the Heidelberg Ion Therapy Center (HIT) The people A. Mairani (now INFN), F. Sommerer (Uniklinikum Heidelberg), I. Rinaldi (DKFZ Heidelberg), K. Parodi (HIT and University of Heidelberg) Still 1 open postdoc position for FLUKA simulations for PET

2 The Heidelberg Ion Therapy Center (HIT) Low-LET modality: Protons (later also He) High-LET modality: Carbon (later also Oxygen) Start of clinical operation: 15 th November 2009 Based on more than 10 years of experience at GSI Compact design 2 ion sources for different ion selection within minutes Heavy ion synchrotron 3 Treatment rooms 2 horizontal, fixed beam 1 isocentric ion gantry 1 QA / exp. cave

3 The role of MC at HIT Treatment planning system at HIT: first CE labeled ion TPS system (Syngo PT Planning, Siemens) based on pencil beam algorithms Application of MC at HIT to support: Startup and Commissioning: Generation of accelerator beam library ( LIBC ) and TPS input data ( meas. time) Validation of TPS dose calculations: in water equivalent system and in patient anatomy (CT) Dedicated Quality Assurance: imaging of emerging radiation for treatment verification (PET, prompt )

4 Why using FLUKA? Protons (183 MeV/u) in water 12 C ions (400 MeV/u) in water Exp. Data (points) taken at HIT: D. Schardt, P. Steidl, K. Parodi, S. Brons; FLUKA simulation: K. Parodi Exp. Data (points) taken at GSI: Haettner et al, Rad. Prot. Dos FLUKA simulation: A. Mairani (published in Il Nuovo Cimento )

5 Mixed Radiation Field in Carbon Ion therapy 12 C ions (400 MeV/u) on Water phantoms Carbon Beam Attenuation Build-up of secondary fragments Exp. Data (POINTS) FLUKA (LINES) Exp. Data (STARS) FLUKA (POINTS with lines) Exp. Data from Haettner et al, Rad. Prot. Dos MC simulations from A. Mairani, PhD Thesis 2007, A. Mairani et al to be published

6 MC for the Heidelberg Ion Therapy Center (HIT) To be published Ion species p, 12 C (later also 3 He, 16 O) Beam delivery Scanning with active energy variation GSI) Required parameters: 255 Energy steps 4 Foci 10 Intensities Focus (FWHM) in Isocentre (mm) 12 HIT (Nominal focus from FLUKA b) Energy (MeV/u) Taking into account desired 4 10 mm ISO for higher E and physical limitation from scattering in monitor system and air HIT, Heidelberg, Germany

7 MC for the Heidelberg Ion Therapy Center (HIT) Generation of basic input data for TPS FLUKA calculation of depth dose profiles in water w/wo ripple filter (RiFi) for all the 255 energies delivered by accelerator for p and 12 C HIT 12 C + 3mm HIT Dose (MC: MeVcm 2 /g; Meas. Norm. to area) Dose (MC: MeVcm 2 /g; Meas. Norm. to area) Depth (cm) Parodi, Mairani et al to be published Depth (cm)

8 MC for the Heidelberg Ion Therapy Center (HIT) FLUKA dose calculations of irradiated fields for comparison with measurements and TPS calculation to support TPS commissioning Meas.: ICs in water phantom + data acquisition system from C. Karger (DKFZ) Beam eye view Along depth Along depth FLUKA: ~ 10 8 p out of irradiated Parodi, Mairani, Brons, Sommerer, HIT

9 From dose in water to dose in patient CT FLUKA CT based calculations: formalism originally developed for proton passive delivery at MGH for PET/CT post treatment verification XiO TPS MC dose MC PET PET/CT Meas. Field 2 Field 1 mgy mgy Bq/ml Bq/ml Parodi et al., IJROBP extended to scanned proton and carbon ion beam delivery, including biological dose modeling

10 MC for biological dose GSI / HIT FLUKA interfaced during runtime with the Local-Effect-Model (M. Scholz et al, GSI) used by GSI / HIT Validation for two opposing fields with H shaped target TPS (TRiP98): biological planning and optimization for CHO cells FLUKA LEM: forward calculation of the optimized plan FLUKA TRiP98 Exp data Exp. Data and analytical calculations: Krämer et al, PMB 48 (2003) 2063 MC Calculations: A. Mairani et al, Poster P104 Exp. Data and TPS calculations: Krämer et al, PMB 48 (2003) 2063 MC Calculations: A. Mairani et al, to be submitted

11 A. Mairani et al IEEE CR 2008, A. Mairani et al, to be published FLUKA MC versus TPS for carbon ion GSI Clivus Chordoma Patient Absorbed/Biological Dose mgy FLUKA - LEM mgye TRiP mgy TRiP mgye

12 Ongoing activities Summary and Outlook - Adaptation of work done for MGH Boston and GSI to HIT for clinical CTbased recalculation of treatment plans (Florian) - Standard and novel imaging techniques for in-vivo dose verification (Ilaria) Relevant achievements so far - PMB paper Sommerer et al (on his PhD work) was selected as featured paper, 250 times download in the first 6 weeks (advertised on Medicalphysicsweb) Awards in the last year - Schmelzer Preis for A. Mairani PhD Thesis (Darmstadt, 01/2010) - IEEE Medical Imaging Young Investigator for K. Parodi (Orlando, 10/2009 Future activities of possible general interest - EU project ENVISION for MC application to PET (HIT, CERN, INFN) - Validation of FLUKA models for helium and oxygen beams

13 (Intensity modulated raster scan, 12 C at 430 Mev/u, October 15 th 2007)