The choice is clear.

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1 Trying to lower very high triglycerides? The choice is clear. Pure EPA Omega-3 Clinically proven FDA-approved Ask your doctor about VASCEPA, the first and only Pure EPA prescription Omega-3. Triglycerides are fats in the blood. Very high triglyceride levels are 500 mg/dl. Vascepa 1-gram capsules contain 1 gram of icosapent ethyl, a form of the unique Omega-3 fatty acid known as EPA, and inactive ingredients. WHAT IS VASCEPA? VASCEPA is a prescription medicine used along with a low-fat and low-cholesterol diet to lower high levels of triglycerides (fats) in adults.

2 What are triglycerides and how do they differ from cholesterol? Triglycerides, like cholesterol, are both naturally occurring fats in your blood. Although similar, they are not the same. Cholesterol is important for your cells and makes some hormones. Triglycerides store unused calories and give your body energy. However, very high levels of cholesterol or triglycerides may lead to serious health problems NIH MedlinePlus Cholesterol 2018, NIH MedlinePlus Triglycerides Test APPROXIMATELY 4 MILLION AMERICANS have very high triglycerides. You may be working with your doctor and trying hard to lower your very high triglycerides. It s time to discover VASCEPA. Pure power. Proven to work. Prescription VASCEPA, along with diet, is clinically proven to lower very high triglycerides in adults by without raising bad cholesterol (LDL-C). It can be hard work battling very high triglycerides. You may have tried eating a healthier diet and exercising more, but if your triglyceride levels are still very high it may be time to consider prescription VASCEPA. In the MARINE trial, on average, along with diet changes, adults with very high triglycerides experienced a 33% reduction without raising LDL-C vs. placebo. Individual results may vary. WHAT IS VASCEPA? (continued) It is not known if VASCEPA changes your risk of having inflammation of your pancreas (pancreatitis). 2 It is not known if VASCEPA prevents you from having a heart attack or stroke. It is not known if VASCEPA is safe and effective in children. 3

3 VASCEPA looks different because it is different. Most unproven fish oil supplements contain DHA, an Omega-3, which can raise bad cholesterol (LDL-C). Not FDA-approved to treat medical conditions, including very high triglycerides. Daily dose: It may take up to capsules a day to equal the EPA in a daily dose of VASCEPA. Reported to have fishy taste or cause fishy burps. Data on file COMMON FISH OIL VASCEPA Pure EPA Prescription Omega-3. No DHA; and VASCEPA was shown not to raise bad cholesterol (LDL-C). FDA-approved and clinically proven to lower very high triglycerides. Daily dose: Two 1-gram capsules, twice a day. No reported fishy taste or fishy burps taking 4 grams per day of VASCEPA in a clinical trial. Vascepa 1-gram capsules contain 1 gram of icosapent ethyl, a form of the unique Omega-3 fatty acid known as EPA, and inactive ingredients. MARINE trial, as compared with placebo. Discover the pure power of VASCEPA. IMPORTANT SAFETY INFORMATION WHO SHOULD NOT TAKE VASCEPA? Do not take VASCEPA if you are allergic to icosapent ethyl or any of the ingredients in VASCEPA. WHAT ARE THE POSSIBLE SIDE EFFECTS OF VASCEPA? It is not known if people who are allergic to fish or shellfish are also allergic to VASCEPA. 4 If you have liver problems and are taking VASCEPA, your doctor should do blood tests during treatment. The most common side effect of VASCEPA is joint pain. Talk to your doctor for medical advice about side effects. 5

4 VASCEPA (icosapent ethyl) is different from Lovaza (omega-3-acid ethyl esters) This chart contains FDA-approved prescription product information related to patients with very high triglycerides taking 4 grams per day. No head-to-head trials have been conducted between VASCEPA and other prescription Omega-3s, such as Lovaza. Coverage and Savings. The VASCEPA Savings Program. VASCEPA is covered without restriction for the majority of patients. With the VASCEPA Savings Card, commercially insured patients pay as little as $9 for 90 days. Subject to eligibility. Restrictions apply. VASCEPA 1 (icosapent ethyl) Lovaza 2-7 (omega-3-acid ethyl esters) Clinically proven and FDA-approved to lower very high triglycerides 1-2 Contains only one active ingredient: Pure EPA Omega-3 Not shown to raise bad cholesterol (LDL-C) 1-2 Doesn t require additional monitoring of bad cholesterol No associated increase in frequency of atrial fibrillation or flutter (irregular or rapid heart rate) 1-2 No reported burping, upset stomach, or a change in sense of taste 1-7 This VASCEPA Savings Card is active and ready to use. Present it to your pharmacist with your VASCEPA prescription to start saving now. May not be used to obtain prescription drugs paid for in part by Federal or State Healthcare Programs including Medicare, Medicaid, Medicare Advantage, Medicare Part D, Tricare, and VA. Not for use by VT residents, VT licensed medical professionals, patients under 18, where prohibited by law or patient s insurance plan, or where taxed or restricted. Maximum savings of $80 per month or $240 per 90 day supply. Eligible patients include those who participate in commercial insurance, through a healthcare exchange, or pay cash. Offer good through December 31, Lovaza should not be substituted for VASCEPA. If your pharmacist suggests switching, talk with your doctor first. Vascepa 1-gram capsules contain 1 gram of icosapent ethyl, a form of the unique Omega-3 fatty acid known as EPA, and inactive ingredients. Lovaza is a registered trademark of GlaxoSmithKline.. 1. VASCEPA [package insert]. Bedminster, NJ: Amarin Pharma, Inc; Lovaza [package insert]. Research Triangle Park, NC: GlaxoSmithKline; Omega-3-acid ethyl esters Prescribing Information. Amneal Pharmaceuticals of New York LLC Omega-3-acid ethyl esters Prescribing Information. Apotex Inc Omega-3-acid ethyl esters Prescribing Information. Par Pharmaceutical Inc Omega-3-acid ethyl esters Prescribing Information. Strides Pharma Global Pte Ltd Omega-3-acid ethyl esters Prescribing Information. Teva Pharmaceuticals IMPORTANT SAFETY INFORMATION (continued) As with all drugs, you may experience a serious side effect when taking VASCEPA. You may report side effects by calling VASCEPA or the FDA at FDA Tell your doctor if you take medicines that affect your blood clotting (anticoagulants or blood thinners). Take VASCEPA capsules whole. Do not break, crush, dissolve, or chew VASCEPA capsules before swallowing. For more information on VASCEPA, see the Patient Information on pages or call VASCEPA 6 ( ). 7

5 It is important to take the 4-gram daily dose of VASCEPA To ensure you get the full benefit of VASCEPA, it s important to take the FDA-approved 4-gram dose each day as your doctor prescribes. Available in two convenient sizes For the standard size, take two 1-gram capsules twice a day with food. If you prefer the smaller size, take four of the 0.5-gram capsules twice a day with food. The VASCEPA Clear Path Program Once a month you ll receive helpful tips like delicious healthy recipes, easy and effective exercises you can do at home, and news about VASCEPA. It s all in the once a month VASCEPA Clear Path Program. Designed to encourage you to partner with your doctor to support you on your journey. Here s a couple of Clear Path Tips to help lower very high triglycerides: Tip Simple Swaps Put a bowl of fruit and veggies on the kitchen counter and make a family pact to try to reduce salty or sugary snacks to 1-2x a week so you re all in it together! Small Steps, Big Strides The next time you go shopping or to work, try parking your car in a farther spot. A few extra steps here and there can really add up. VASCEPA Safety Information. VASCEPA has a safety profile similar to placebo. The most common side effect reported by 2.3% of patients on VASCEPA was joint pain compared to 1% on a placebo. In a clinical study, no patients taking 4 grams of VASCEPA per day reported fishy taste or fishy burps. 8 (National Heart, Lung, and Blood Institute, What Can My Family and I Do To Encourage a Healthy Weight?) For more easy, helpful tips join The VASCEPA Clear Path Program on Vascepa.com. MARINE trial, as compared with placebo. 9

6 PATIENT INFORMATION VASCEPA (pronounced vas-ee-puh) (icosapent ethyl) Capsules WHAT IS VASCEPA? VASCEPA is a prescription medicine used along with a low-fat and low-cholesterol diet to lower high levels of triglycerides (fats) in adults. It is not known if VASCEPA changes your risk of having inflammation of your pancreas (pancreatitis). It is not known if VASCEPA prevents you from having a heart attack or stroke. It is not known if VASCEPA is safe and effective in children. Do not take VASCEPA if you are allergic to icosapent ethyl or any of the ingredients in VASCEPA. See the end of this summary for a complete list of ingredients in VASCEPA. Before taking VASCEPA, tell your doctor about all of your medical conditions, including if you: have diabetes. have a low thyroid problem (hypothyroidism). have a liver problem. have a pancreas problem. are allergic to fish or shellfish. It is not known if people who are allergic to fish or shellfish are also allergic to VASCEPA. are pregnant, or planning to become pregnant. It is not known if VASCEPA will harm your unborn baby. are breastfeeding or plan to breastfeed. VASCEPA can pass into your milk, and may harm your baby. Talk to your doctor about the best way to feed your baby if you take VASCEPA. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and dietary or herbal supplements. VASCEPA can interact with certain other medicines that you are taking. Especially tell your doctor if you take medicines that affect your blood clotting (anticoagulants or blood thinners). HOW SHOULD I TAKE VASCEPA? Take VASCEPA exactly as your doctor tells you to take it. Do not change your dose or stop taking VASCEPA without talking to your doctor. Do not take more capsules than what is prescribed by your doctor. - If you are prescribed the 0.5-gram capsules, you should not take more than 8 capsules each day. - If you are prescribed the 1-gram capsules, you should not take more than 4 capsules per day. Take VASCEPA capsules whole. Do not break, crush, dissolve, or chew VASCEPA capsules before swallowing. If you miss a dose of VASCEPA, take it as soon as you remember. However, if you miss one day of VASCEPA, do not double your dose when you take it. Your doctor may start you on a diet that is low in saturated fat, cholesterol, carbohydrates, and low in added sugars before giving you VASCEPA. Stay on this diet while taking VASCEPA. Your doctor may do blood tests to check your triglyceride and other lipid levels while you take VASCEPA. WHAT ARE THE POSSIBLE SIDE EFFECTS OF VASCEPA? If you have liver problems and are taking VASCEPA, your doctor should do blood tests during treatment. The most common side effect of VASCEPA is joint pain. As with all drugs, you may experience a serious side effect when taking VASCEPA. Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of VASCEPA. Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA HOW SHOULD I STORE VASCEPA? Store VASCEPA at room temperature between 68 to 77 F (20 to 25 C). Safely throw away medicine that is out of date or no longer needed. Keep VASCEPA and all medicine out of the reach of children. General information about the safe and effective use of VASCEPA. Medicines are sometimes prescribed for purposes other than those listed in Patient Information Leaflets. Do not use VASCEPA for a condition for which it was not prescribed. Do not give VASCEPA to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for information about VASCEPA that is written for health professionals. WHAT ARE THE INGREDIENTS IN VASCEPA? Active Ingredient: icosapent ethyl Inactive Ingredients: tocopherol, gelatin, glycerin, maltitol, sorbitol, and purified water For more information, go to or call VASCEPA ( ). This patient information has been approved by the U.S. Food and Drug Administration. VASCEPA is a registered trademark of the Amarin group of companies Amarin Pharma, Inc. Bedminster NJ, All rights reserved Distributed by: Amarin Pharma, Inc. Bedminster, NJ, USA Manufactured for: Amarin Pharmaceuticals Ireland Limited Dublin, Ireland VASCEPA ( ) PP00120K 2/

7 Ask your doctor about the VASCEPA difference. Pure. The first and only Pure EPA Rx Omega-3. Proven. Clinically proven. Prescription. FDA-approved. Sign up for The VASCEPA Clear Path Program. Once a month you ll receive helpful tips like delicious healthy recipes, easy and effective exercises you can do at home, and news about VASCEPA. Visit Vascepa.com For more information on VASCEPA, see the Patient Information on pages 10-11, visit Vascepa.com, or call VASCEPA ( ). Special Savings. Details inside. Vascepa 1-gram capsules contain 1 gram of icosapent ethyl, a form of the unique Omega-3 fatty acid known as EPA, and inactive ingredients. Trademarks are owned by their respective companies; VASCEPA, Amarin, and VASCEPA/Amarin logos are registered trademarks of the Amarin group of companies Amarin Pharma, Inc. Bedminster, NJ, USA. All rights reserved. VAS-00535v2 06/18