TGF-β. transforming. growth factor. growth factor-β TGF-β. Transforming growth factor-β TGF-β. Smad. DNA Smad Smad cofactor. transcription factor Smad
|
|
- Mitchell Phillips
- 5 years ago
- Views:
Transcription
1 TGF-β Smad cofactors 2 Transforming growth factor-β TGF-β TGF-β Smad Smad DNA Smad Smad cofactor TGF-β Maid Maid Smad cofactor Smad cofactor TGF-β -β signal transduction transcription factor Smad 1980 transforming growth factor-β TGF-β TGF-β transforming growth factor TGF-β 1984 TGF-β 1990 TGF-β Smad TGF-β
2 TGF-β epithelial-mesenchymal transition, EMT TGF-β TGF-β Harold Moses 2006 molecular Jekyll and Hyde of cancer 3 TGF-β TGF-β apc min adenoma adenocarcinoma progression xenograft model 4 TGF-β 1 TGF-β tumor initiating cells tumor initiating cells tumorigenicity TGF-β 5 tumor initiating cells β TGF-β Smad 9 TGF-β TGF-β 1 TGF-β tumor initiating cells TGF-β
3 TGF-β Smad cofactors 67 2 I II TGF-β II I 2 4 II I I Smad2 Smad3 C- 2 Smad2/3 1 Smad4 3 Smad / 1 Smad DNA Smad binding element, SBE AGAC 10 Smad DNA SBE DNA Smad DNA Smad Smad cofactor Smad-Smad cofactor synexpression group Smad Smad cofactor 1 TGF-β TGF-β II I 2 4 II I I Smad2 Smad3 2 Smad2/3 1 Smad4 3 Smad /
4 68 Smad cofactor Smad Smad cofactor 2 TGF-β TGF-β Smad cofactor Smad cofactor synexpression group TGF-β TGF-β Maternal Id-like molecule Maid mrna 11,12 HHM human homologue of Maid Maid 360 helix-loop-helix HLH basic HLH DNA Id-like molecule Id HLH Smad bait yeast two hybrid Maid TGF-β TGF-β Maid 13 TGF-β 2 Smad cofactors Smad A E Smad cofactor D 1 4 Smad cofactor Smad-Smad cofactor synexpression group
5 TGF-β Smad cofactors 69 Maid TGF-β EMT Maid Maid TGF-β Maid TGF-β TGF-β p21 WAF c-myc Maid TGF-β EMT Snail Snail Maid Maid DNA Maid TGF-β 15 Maid synexpression group Maid Smad cofactor Olig1 Smad Smad cofactor Smad- Smad cofactor 3 TGF-β YY-1 14 Maid Smad cofactor Smad cofactor 3 Maid Smad cofactor A Maid synespression group B Maid Smad cofactor B Olig1 Smad Smad cofactor Smad Smad cofactor
6 Smad Smad 15 Smad cofactor 2 3 Smad Hill Forkhead Mix Smad2 Smad2 16 TGF-β p21 WAF p21 WAF Smad cofactor controversial Piccolo p53 Smad HepG2 p21 WAF p53 p53 TGF-β 17 Massague HaCaT FoxO C/EBP Smad synexpression groups 18 FoxO p21 WAF Smad ChIP-Chip HaCaT 19 p21 WAF Smad Smad cofactor Ets1 Ets1 TGF-β p21 WAF Smad cofactor Smad cofactor synexpression group bhlh Olig1 Maid Smad cofactor 13 Olig1 ubiquitous Olig1 mrna DNA Olig1 TGF-β 10 Olig1 TGF-β Smad Smad-Olig1 synexpression group plasminogen activator inhibitor-1 (PAI-1), plateletderived growth factor-b (PDGF B), connective tissue growth factor (CTGF), procollagen 1 CTGF DEC1 IL-11 Olig1 TGF-β ChIP-Chip Smad2/3 Ets1 AP-2 Sp1 p53 E2F thyroid transcription factor-1 vitamin D receptor VDR Myc 19 Smad cofactor Smad cofactor Maid
7 TGF-β Smad cofactors 71 TGF-β TGF-β in vivo TGF-β tgfb1 -/- TGF-β tgfb1 +/- 20 tgfb1 +/- TGF-β 30 TGF-β TGF-β haploinsufficiency tumor suppressor TGF-β TGF-β TGF-β Smad Smad cofactor 4A TGF-β synexpression group Smad cofactor Smad Maid Smad cofactor cofactor 4B Maid Smad cofactor utilization TGF-β in vivo Smad cofactor Sp1 Olig1 ubiquitous Smad cofactor tissue- 4 Smad cofactor A Smad Smad cofactor TGF-β A Smad cofactor B C D Smad cofactor Smad cofactor A B C D TGF-β Smad cofactor B Maid Smad cofactor 3 Smad cofactor B Smad cofactor Maid C Smad cofactor TGF-β
8 72 specific Smad cofactor VDR p53 Smad cofactor / conditional Smad cofactor VDR Smad 19 Smad VDR TGF-β D 21 Smad cofactor preference Smad cofactor TGF-β cellular context Smad cofactor Maid Smad-Smad cofactor Maid Smad-Smad cofactor Smad comprehensive TGF-β Moses HL, Roberts AB: The discovery of TGF-β: A historical perspective. In: Derynck R, Miyazono K, eds. The TGF-β family. Cold Spring Harbor Laboratory Press, New York; 1 28, Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J: Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Pro Natl Acad Sci USA, 100: , Bierie B, Moses HL: TGFβ: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer, 6: , Arteaga CL, McPherson JM: Development of TGF-β-based therapeutic agents: Capitalizing on TGF-β s mechanism of action and signal transduction pathways. In: Derynck R, Miyazono K, eds. The TGF-β family. Cold Spring Harbor Laboratory Press, New York; , Penuelas S, Anido J, Prieto-Sanchez RM, Folch G, Barba I, et al.: TGF-β increases glioma-initiating cell self renewal through the induction of LIF in human glioblastoma. Cancer Cell, 15: , Tang B, Yoo N, Vu M, Mamura M, Nam J-S, et al.: Transforming growth factor-β can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model. Cancer Res, 67: , Ohgushi M, Kuroki S, Fukamachi H, O Reilly LA, Kuida K, et al. Transforming growth factor β- dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Mol Cell Biol, 25: , Ehata S, Hanyu A, Hayashi M, Aburatani H, Kato Y, et al. Transforming growth factor-β promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res, 67: , Shi Y, Massagué J: Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell, 113: , Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, et al.: Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitortype 1 gene. EMBO J, 17: , Hwang SY, Oh B, Fuchtbauer A, Fuchtbauer EM, Johnson KR, et al.: maid: a maternally transcribed novel gene encoding a potential negative regulator of bhlh proteins in the mouse egg
9 TGF-β Smad cofactors 73 and zygote. Dev Dyn, 209: , Terai S, Aoki H, Thorgeirsson S: Human homologue of Maid: a dominant inhibitory helix-loophelix protein associated with liver-specific gene expression.hepatology, 32: , Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, et al.: An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGFβ signalling. EMBO J, 27: , Miyazawa K, Shinozaki M, Hara T, Furuya T, Miyazono K: Two major Smad pathways in TGF-β superfamily signalling. Genes Cells, 7: , Germain S, Howell M, Esslemont GM, Hill CS:Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev, 14: , Cordenonsi M, Dupont S, Maretto S, Insinga A, Imbriano C, et al.: Links between tumor supressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell, 113: , Gomis R, Alarcon C, He W, Wang Q, Seoane J, et al.: A FoxO-Smad synexpression group in human keratinocytes. Pro Natl Acad Sci USA, 103: , Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, et al: Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor β signaling. Mol Cell Biol, 29: , Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, et al.: Nuclear factor YY1 inhibits transforming growth factor β- and bone morphogenetic protein-induced cell differentiation. Mol Cell Biol, 23: , Tang B, Böttinger EP, Jakowlew SB, Bagnall K, Mariano J, et al.: Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency. Nat Genet, 4: , Yanagisawa J, Yanagi Y, Masuhiro Y, Suzawa M, Watanabe M, et al.: Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators. Science, 283: , 1999.
Control of Cell Proliferation by Peptide Growth Factors. Autocrine Growth Factor Production Causes Malignant Transformation?
Control of Cell Proliferation by Peptide Growth Factors Autocrine Growth Factor Production Causes Malignant Transformation? Transforming Activities From Condition Media from a Tumor Cell Line Condition
More informationBiological functions: role as tumor suppressor. Growth inhibitor. Inducer of apoptosis. Effects on cell differentiation.
TGF-beta and cancer Isabel Fabregat Departament de Ciències Fisiòlogiques II, Universitat de Barcelona Institut de Investigació Biomèdica de Bellvitge (IDIBELL) E-mail: ifabregat@ub.edu Máster en Oncología
More informationMASTER EN ONCOLOGÍA MOLECULAR 2011 TGF-BETA
MASTER EN ONCOLOGÍA MOLECULAR 2011 TGF-BETA Joan Seoane ICREA Research Professor Vall d Hebron Institute of Oncology Vall d Hebron University Hospital Barcelona jseoane@vhio.net Glioma Stupp et al. New
More informationCancer. The fundamental defect is. unregulated cell division. Properties of Cancerous Cells. Causes of Cancer. Altered growth and proliferation
Cancer The fundamental defect is unregulated cell division. Properties of Cancerous Cells Altered growth and proliferation Loss of growth factor dependence Loss of contact inhibition Immortalization Alterated
More informationFrom crypt stem cell to colorectal cancer
19 3 2007 6 Chinese Bulletin of Life Sciences Vol. 19, No. 3 Jun., 2007 1004-0374(2007)03-0321-05 ( 510405) Wnt Notch BMP R735.35; R730.21 A From crypt stem cell to colorectal cancer WEN Bin*, CHEN Weiwen
More informationCancer. The fundamental defect is. unregulated cell division. Properties of Cancerous Cells. Causes of Cancer. Altered growth and proliferation
Cancer The fundamental defect is unregulated cell division. Properties of Cancerous Cells Altered growth and proliferation Loss of growth factor dependence Loss of contact inhibition Immortalization Alterated
More informationThe splicing regulation and clinical significance of epithelial splicing regulatory protein 1 in invasion and metastasis of epithelial ovarian cancer
The splicing regulation and clinical significance of epithelial splicing regulatory protein 1 in invasion and metastasis of epithelial ovarian cancer Jie Tang MD, Ph.D, Professer Vice director of Department
More informationThe Hallmarks of Cancer
The Hallmarks of Cancer Theresa L. Hodin, Ph.D. Clinical Research Services Theresa.Hodin@RoswellPark.org Hippocrates Cancer surgery, circa 1689 Cancer Surgery Today 1971: Nixon declares War on Cancer
More informationCancer and Oncogenes Bioscience in the 21 st Century. Linda Lowe-Krentz
Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz December 1, 2010 Just a Few Numbers Becoming Cancer Genetic Defects Drugs Our friends and family 25 More mutations as 20 you get older
More informationTRANSFORMING GROWTH FACTOR-β AND SMAD4 REGULATION OF INVASIVE AND METASTATIC BEHAVIOR IN CANCER CELLS. Sheng-Ru Shiou.
TRANSFORMING GROWTH FACTOR-β AND SMAD4 REGULATION OF INVASIVE AND METASTATIC BEHAVIOR IN CANCER CELLS By Sheng-Ru Shiou Dissertation Submitted to the Faculty of the Graduate School of Vanderbilt University
More informationMechanisms of Gene Regulation and Signal! Transduction in Hypoxia!
Mechanisms of Gene Regulation and Signal! Transduction in Hypoxia! Lorenz Poellinger! Dept. of Cell and Molecular Biology! Karolinska Institutet, Stockholm, Sweden! Normoxia - O 2 availability is in balance
More informationHormones and Cancer Research Unit Department of Medicine, McGill University Dr. Jean-Jacques Lebrun
Hormones and Cancer Research Unit Department of Medicine, McGill University www.hcru.mcgill.ca Dr. Jean-Jacques Lebrun TGF /Smad signaling pathways CELLULAR AND MOLECULAR BIOLOGY Institut de recherches
More informationRoles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes. Sciences, University of Tsukuba, Ibaraki , Japan
* Manuscript Roles of mono-ubiquitinated in the formation of Smad transcriptional complexes Bei Wang a,b, Hiroyuki Suzuki a,b *, and Mitsuyasu Kato a a Department of Experimental Pathology, Graduate School
More informationNeoplasia 18 lecture 6. Dr Heyam Awad MD, FRCPath
Neoplasia 18 lecture 6 Dr Heyam Awad MD, FRCPath ILOS 1. understand the role of TGF beta, contact inhibition and APC in tumorigenesis. 2. implement the above knowledge in understanding histopathology reports.
More informationCancer and Oncogenes Bioscience in the 21 st Century. Linda Lowe-Krentz October 11, 2013
Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz October 11, 2013 Just a Few Numbers Becoming Cancer Genetic Defects Drugs Our friends and family 200 180 160 140 120 100 80 60 40
More informationSUPPLEMENTARY INFORMATION
DOI: 10.1038/ncb2607 Figure S1 Elf5 loss promotes EMT in mammary epithelium while Elf5 overexpression inhibits TGFβ induced EMT. (a, c) Different confocal slices through the Z stack image. (b, d) 3D rendering
More informationEXPRESSION OF TRANSFORMING GROWTH FACTOR BETA RECEPTORS IN NEUROBLASTOMA CELL LINES WITH DIFFERENT TUMORGENICITIES
EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA RECEPTORS IN NEUROBLASTOMA CELL LINES WITH DIFFERENT TUMORGENICITIES Tanmayi Mankame Department of Biology, Fordham University, Bronx, NY Email: tanmayimankame@yahoo.com
More informationnumber Done by Corrected by Doctor Maha Shomaf
number 19 Done by Waseem Abo-Obeida Corrected by Abdullah Zreiqat Doctor Maha Shomaf Carcinogenesis: the molecular basis of cancer. Non-lethal genetic damage lies at the heart of carcinogenesis and leads
More informationBIO360 Fall 2013 Quiz 1
BIO360 Fall 2013 Quiz 1 1. Examine the diagram below. There are two homologous copies of chromosome one and the allele of YFG carried on the light gray chromosome has undergone a loss-of-function mutation.
More informationBIO360 Fall 2013 Quiz 1
BIO360 Fall 2013 Quiz 1 Name: Key 1. Examine the diagram below. There are two homologous copies of chromosome one and the allele of YFG carried on the light gray chromosome has undergone a loss-of-function
More informationPREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
Award Number: W81XWH 15 1 0650 TITLE: ALK and TGF-Beta Resistance in Breast Cancer PRINCIPAL INVESTIGATOR: Xin-Hua Feng CONTRACTING ORGANIZATION: Baylor College of Medicine Houston, TX 77030 REPORT DATE:
More informationGenetics and Cancer Ch 20
Genetics and Cancer Ch 20 Cancer is genetic Hereditary cancers Predisposition genes Ex. some forms of colon cancer Sporadic cancers ~90% of cancers Descendants of cancerous cells all cancerous (clonal)
More informationProfiles of gene expression & diagnosis/prognosis of cancer. MCs in Advanced Genetics Ainoa Planas Riverola
Profiles of gene expression & diagnosis/prognosis of cancer MCs in Advanced Genetics Ainoa Planas Riverola Gene expression profiles Gene expression profiling Used in molecular biology, it measures the
More informationCancer DEREGULATION OF CELL CYCLE CONTROL IN ONCOGENESIS. D. Kardassis Division of Basic Sciences University of Crete Medical School and IMBB-FORTH
E6 2006-2007: 2007: Molecular Biology of Cancer DEREGULATION OF CELL CYCLE CONTROL IN ONCOGENESIS D. Kardassis Division of Basic Sciences University of Crete Medical School and IMBB-FORTH Literature *
More informationsilent epidemic,. (WHO),
Tel: 02-740-8686; E-mail: hhbkim@snu.ac.kr silent epidemic,. (WHO),. 5 3, 1. 50 70. 50%, 25%, 20% (12~35%). 2.8% 0.7% 4. ( ). bone remodeling (osteoblast), (osteoclast),.. 3~4.. 70% (osteocyte) (bone lining
More informationRegulation of Gene Expression in Eukaryotes
Ch. 19 Regulation of Gene Expression in Eukaryotes BIOL 222 Differential Gene Expression in Eukaryotes Signal Cells in a multicellular eukaryotic organism genetically identical differential gene expression
More informationmirna Dr. S Hosseini-Asl
mirna Dr. S Hosseini-Asl 1 2 MicroRNAs (mirnas) are small noncoding RNAs which enhance the cleavage or translational repression of specific mrna with recognition site(s) in the 3 - untranslated region
More informationCancer genetics
Cancer genetics General information about tumorogenesis. Cancer induced by viruses. The role of somatic mutations in cancer production. Oncogenes and Tumor Suppressor Genes (TSG). Hereditary cancer. 1
More informationcells is enhanced by proinflammatory cytokines derived from RAW macrophage cells
Journal of Biochemistry Advance Access published December 7, 2011 Regular Paper, (field, Cell; topic, Signal transduction) TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells
More informationThe Biology and Genetics of Cells and Organisms The Biology of Cancer
The Biology and Genetics of Cells and Organisms The Biology of Cancer Mendel and Genetics How many distinct genes are present in the genomes of mammals? - 21,000 for human. - Genetic information is carried
More informationMolecular biology :- Cancer genetics lecture 11
Molecular biology :- Cancer genetics lecture 11 -We have talked about 2 group of genes that is involved in cellular transformation : proto-oncogenes and tumour suppressor genes, and it isn t enough to
More informationMultistep nature of cancer development. Cancer genes
Multistep nature of cancer development Phenotypic progression loss of control over cell growth/death (neoplasm) invasiveness (carcinoma) distal spread (metastatic tumor) Genetic progression multiple genetic
More informationCONTRACTING ORGANIZATION: McGill University Health Center
AD Award Number: W81XWH-11-1-0009 TITLE: Studying the Roles of GRK2-Mediated Smad2/3 Phosphorylation as a Negative Feedback Mechanism of TGF-Beta Signaling and a Target of Breast Cancer Therapeutics. PRINCIPAL
More informationVIII Curso Internacional del PIRRECV. Some molecular mechanisms of cancer
VIII Curso Internacional del PIRRECV Some molecular mechanisms of cancer Laboratorio de Comunicaciones Celulares, Centro FONDAP Estudios Moleculares de la Celula (CEMC), ICBM, Facultad de Medicina, Universidad
More informationCYLD Negatively Regulates Transforming Growth Factor-β Signaling via Deubiquitinating Akt
Supplementary Information CYLD Negatively Regulates Transforming Growth Factor-β Signaling via Deubiquitinating Akt Jae Hyang Lim, Hirofumi Jono, Kensei Komatsu, Chang-Hoon Woo, Jiyun Lee, Masanori Miyata,
More informationTGF-b Receptor Inhibitors Target the CD44 high /Id1 high Glioma-Initiating Cell Population in Human Glioblastoma
rticle TGF-b Receptor Inhibitors Target the CD44 high /Id1 high Glioma-Initiating Cell Population in Human Glioblastoma Judit nido, 1 ndrea Sáez-orderías, 1 lba Gonzàlez-Juncà, 1 Laura Rodón, 1 Gerard
More informationType of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures
Type of file: PDF Size of file: 0 KB Title of file for HTML: Supplementary Information Description: Supplementary Figures Supplementary Figure 1 mir-128-3p is highly expressed in chemoresistant, metastatic
More informationSupplementary Figure 1. The mir-182 binding site of SMAD7 3 UTR and the. mutated sequence.
Supplementary Figure 1. The mir-182 binding site of SMAD7 3 UTR and the mutated sequence. 1 Supplementary Figure 2. Expression of mir-182 and SMAD7 in various cell lines. (A) Basal levels of mir-182 expression
More informationA role for Id in the regulation of TGF-b-induced epithelial mesenchymal transdifferentiation
(2004) 11, 1092 1101 & 2004 Nature Publishing Group All rights reserved 1350-9047/04 $30.00 www.nature.com/cdd A role for Id in the regulation of TGF-b-induced epithelial mesenchymal transdifferentiation
More informationFoxm1 Transcription Factor is Required for Lung Fibrosis and Epithelial to Mesenchymal Transition.
Manuscript EMBO-2012-82682 Foxm1 Transcription Factor is Required for Lung Fibrosis and Epithelial to Mesenchymal Transition. David Balli, Vladimir Ustiyan, Yufang Zhang, I-Ching Wang, Alex J. Masino,
More informationConvergent and Divergent Mechanisms in Aging and Cancer
Convergent and Divergent Mechanisms in Aging and Cancer Mariana S. De Lorenzo, PhD Department of Cell Biology & Molecular Medicine delorems@umdnj.edu LEARNING OBJECTIVES 1. To identify convergent and divergent
More informationBIO360 Quiz #1. September 14, Name five of the six Hallmarks of Cancer (not emerging hallmarks or enabling characteristics ): (5 points)
Name: BIO360 Quiz #1 September 14, 2012 1. Name five of the six Hallmarks of Cancer (not emerging hallmarks or enabling characteristics ): (5 points) 2. The controversial hypothesis that only a small subset
More informationRole of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients
Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients H.B. Wang, W.G. Song, H.Q. Liu, F. Fang and Y. Xiao Department of Radiotherapy and Chemotherapy
More informationoncogenes-and- tumour-suppressor-genes)
Special topics in tumor biochemistry oncogenes-and- tumour-suppressor-genes) Speaker: Prof. Jiunn-Jye Chuu E-Mail: jjchuu@mail.stust.edu.tw Genetic Basis of Cancer Cancer-causing mutations Disease of aging
More informationTITLE: Autophagy and TGF-Beta Antagonist Signaling in Breast Cancer Dormancy at Premetastatic Sites
AD Award Number: W81XWH-13-1-0109 TITLE: Autophagy and TGF-Beta Antagonist Signaling in Breast Cancer Dormancy at Premetastatic Sites PRINCIPAL INVESTIGATOR: Xuejun Jiang CONTRACTING ORGANIZATION: Sloan-Kettering
More informationRegulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
Cells 2014, 3, 981-993; doi:10.3390/cells3040981 Review OPEN ACCESS cells ISSN 2073-4409 www.mdpi.com/journal/cells Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination Feng Xie 1, Zhengkui
More informationIdentification and characterization of genes responsive to apoptosis: Application of DNA chip technology and mrna differential display
Histol Histopathol (2000) 15: 1271-1 284 http://www.ehu.es/histol-histopathol Histology and H istopat hology Cellular and Molecular Biology Invited Revie W Identification and characterization of genes
More informationBCHM3972 Human Molecular Cell Biology (Advanced) 2013 Course University of Sydney
BCHM3972 Human Molecular Cell Biology (Advanced) 2013 Course University of Sydney Page 2: Immune Mechanisms & Molecular Biology of Host Defence (Prof Campbell) Page 45: Infection and Implications for Cell
More informationSupplemental Data Macrophage Migration Inhibitory Factor MIF Interferes with the Rb-E2F Pathway
Supplemental Data Macrophage Migration Inhibitory Factor MIF Interferes with the Rb-E2F Pathway S1 Oleksi Petrenko and Ute M. Moll Figure S1. MIF-Deficient Cells Have Reduced Transforming Ability (A) Soft
More informationGlioblastoma Multiforme
Glioblastoma Multiforme Highly malignant, invasive, difficult-to-treat primary brain tumor" " Frequency: 9,000 cases/year (peak age, 55 65 years)" " Recurrence: rapid growth; size may double every 10 days"
More informationCHAPTER VII CONCLUDING REMARKS AND FUTURE DIRECTION. Androgen deprivation therapy is the most used treatment of de novo or recurrent
CHAPTER VII CONCLUDING REMARKS AND FUTURE DIRECTION Stathmin in Prostate Cancer Development and Progression Androgen deprivation therapy is the most used treatment of de novo or recurrent metastatic PCa.
More informationInflammatory Cells and Metastasis
Inflammatory Cells and Metastasis Experimentelle Krebsforschung SS 07 Gerhard Christofori Institute of Biochemistry and Genetics Department of Clinical-Biological Sciences Center of Biomedicine University
More informationRAS Genes. The ras superfamily of genes encodes small GTP binding proteins that are responsible for the regulation of many cellular processes.
۱ RAS Genes The ras superfamily of genes encodes small GTP binding proteins that are responsible for the regulation of many cellular processes. Oncogenic ras genes in human cells include H ras, N ras,
More informationCancer Biology Course. Invasion and Metastasis
Cancer Biology Course Invasion and Metastasis 2016 Lu-Hai Wang NHRI Cancer metastasis Major problem: main reason for killing cancer patients, without it cancer can be cured or controlled. Challenging questions:
More informationThe novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
The EMBO Journal (2004) 23, 3780 3792 & 2004 European Molecular Biology Organization All Rights Reserved 0261-4189/04 www.embojournal.org The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target
More informationA Genetic Program for Embryonic Development
Concept 18.4: A program of differential gene expression leads to the different cell types in a multicellular organism During embryonic development, a fertilized egg gives rise to many different cell types
More informationRath, N., and Olson, M. (2016) Regulation of pancreatic cancer aggressiveness by stromal stiffening. Nature Medicine, 22(5), pp. 462-463. There may be differences between this version and the published
More informationMicroarray Analysis and Liver Diseases
Microarray Analysis and Liver Diseases Snorri S. Thorgeirsson M.D., Ph.D. Laboratory of Experimental Carcinogenesis Center for Cancer Research, NCI, NIH Application of Microarrays to Cancer Research Identifying
More informationPathway Map Reference Guide
Pathway Map Reference Guide Focus Attention-grabber Your Pathway The most popular cell signaling pathways Sample & Assay Technologies Table of contents AKT Signaling 4 camp Signaling 5 Cellular Apoptosis
More informationMesenchymal progenitor cells in intramuscular connective tissue development
Mesenchymal progenitor cells in intramuscular connective tissue development Min Du, Ph.D. Professor and Endowed Chair Department of Animal Sciences Washington State University Pullman, WA Beef Quality:
More informationReview. TGFβ in Cancer. Leading Edge
Leading Edge Review TGFβ in Cancer Joan Massagué 1, * 1 Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA *Correspondence:
More informationApoptosis Oncogenes. Srbová Martina
Apoptosis Oncogenes Srbová Martina Cell Cycle Control point Cyclin B Cdk1 Cyclin D Cdk4 Cdk6 Cyclin A Cdk2 Cyclin E Cdk2 Cyclin-dependent kinase (Cdk) have to bind a cyclin to become active Regulation
More informationChapter 9. Cells Grow and Reproduce
Chapter 9 Cells Grow and Reproduce DNA Replication DNA polymerase Addition of a nucleotide to the 3 end of a growing strand Use dntps as substrate Release of pyrophosphate Initiation of Replication Replication
More informationAlan G. Casson FRCSC Professor of Surgery & VP Integrated Health Services University of Saskatchewan & Saskatoon Health Region
Identification and Characterization of Stem-like Cells in Human Esophageal Adenocarcinoma and Normal Epithelial Cell Lines No disclosures / conflict of interest Alan G. Casson FRCSC Professor of Surgery
More informationTGF-β signaling in tumor suppression and cancer progression
TGF-β signaling in tumor suppression and cancer progression Rik Derynck 1, Rosemary J. Akhurst 2 & Allan Balmain 2,3 Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide
More informationInner Nuclear Membrane Protein MAN1 and Regulation of R-Smad Signaling
4th International Melorheostosis Association Conference Inner Nuclear Membrane Protein MAN1 and Regulation of R-Smad Signaling Howard J. Worman Columbia University New York, NY The Nuclear Envelope By
More informationAward Number: W81XWH mirna Involved in Six1-Induced Breast Cancer TITLE: PRINCIPAL INVESTIGATOR: Anna Smith
AD Award Number: W81XWH-10-1-0296 TITLE: mirna Involved in Six1-Induced Breast Cancer PRINCIPAL INVESTIGATOR: Anna Smith CONTRACTING ORGANIZATION: University of Colorado Anschutz Medical Campus Aurora,
More informationHGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion
Research article HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion Kristina E. Hoot, 1 Masako Oka, 2 Gangwen Han, 2 Erwin Bottinger, 3 Qinghong Zhang, 4 and
More informationAn autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
MBoC ARTICLE An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition Philip A. Gregory a,b, *, Cameron P. Bracken a,b, *, Eric Smith
More informationDiscovery and Optimization of Inhibitors of STAT3 Activation for the Treatment of Squamous Cell Carcinoma of the Head and Neck
Discovery and ptimization of Inhibitors of STAT3 Activation for the Treatment of Squamous Cell Carcinoma of the Head and Neck Feng Zhang Wipf Group Research Topic Seminar 02-09-2013 1 Feng Zhang @ Wipf
More informationMicroRNA dysregulation in cancer. Systems Plant Microbiology Hyun-Hee Lee
MicroRNA dysregulation in cancer Systems Plant Microbiology Hyun-Hee Lee Contents 1 What is MicroRNA? 2 mirna dysregulation in cancer 3 Summary What is MicroRNA? What is MicroRNA? MicroRNAs (mirnas) -
More informationIntroduction. Cancer Biology. Tumor-suppressor genes. Proto-oncogenes. DNA stability genes. Mechanisms of carcinogenesis.
Cancer Biology Chapter 18 Eric J. Hall., Amato Giaccia, Radiobiology for the Radiologist Introduction Tissue homeostasis depends on the regulated cell division and self-elimination (programmed cell death)
More informationAperTO - Archivio Istituzionale Open Access dell'università di Torino
AperTO - Archivio Istituzionale Open Access dell'università di Torino From the nucleus to the mitochondria and backthe odyssey of a multitask STAT3 This is the author's manuscript Original Citation: From
More informationHepatocellular carcinoma (HCC), is the third leading cause
TAZ regulates cell proliferation and epithelial mesenchymal transition of human hepatocellular carcinoma Heng Xiao, 1,3 Ning Jiang, 2,3 Baoyong Zhou, 2 Qiang Liu 2 and Chengyou Du 2 1 Division of Hepatobiliary
More information1. Basic principles 2. 6 hallmark features 3. Abnormal cell proliferation: mechanisms 4. Carcinogens: examples. Major Principles:
Carcinogenesis 1. Basic principles 2. 6 hallmark features 3. Abnormal cell proliferation: mechanisms 4. Carcinogens: examples Carcinogenesis Major Principles: 1. Nonlethal genetic damage is central to
More informationDetermination Differentiation. determinated precursor specialized cell
Biology of Cancer -Developmental Biology: Determination and Differentiation -Cell Cycle Regulation -Tumor genes: Proto-Oncogenes, Tumor supressor genes -Tumor-Progression -Example for Tumor-Progression:
More informationCell Cycle and Cancer
142 8. Cell Cycle and Cancer NOTES CELL CYCLE G 0 state o Resting cells may re-enter the cell cycle Nondividing cells (skeletal and cardiac muscle, neurons) o Have left the cell cycle and cannot undergo
More informationRegulation of EMT by TGFb in cancer
FEBS Letters 586 (2012) 1959 1970 journal homepage: www.febsletters.org Review Regulation of EMT by TGFb in cancer Carl-Henrik Heldin a,, Michael Vanlandewijck a, Aristidis Moustakas a,b a Ludwig Institute
More informationBioNSi: A Discrete Biological Network Simulator Tool
BioNSi: A Discrete Biological Network Simulator Tool Amir Rubinstein 1, Noga Bracha 1, Liat Rudner 1, Noga Zucker 1, Hadas E. Sloin 2, and Benny Chor 1 1 Blavatnik School of Computer Science, Tel Aviv
More informationSupplementary Materials for
www.sciencesignaling.org/cgi/content/full/6/305/ra106/dc1 Supplementary Materials for Controlling Long-Term Signaling: Receptor Dynamics Determine Attenuation and Refractory Behavior of the TGF-β Pathway
More informationIL-24 AND ITS ROLE IN WOUND HEALING
IL-24 AND ITS ROLE IN WOUND HEALING Nancy J. Poindexter, Ryan Williams, Garth Powis, Sunil Chada, and Elizabeth A. Grimm & Introgen Therapeutics, Inc., Houston, TX IL-24/MDA 24/MDA-77 is a Tumor Suppressor
More informationComputational Systems Biology: Biology X
Bud Mishra Room 1002, 715 Broadway, Courant Institute, NYU, New York, USA L#5:(October-18-2010) Cancer and Signals Outline 1 2 Outline 1 2 Cancer is a disease of malfunctioning cells. Cell Lineage: Adult
More informationEmerging Role of MicroRNA in Pancreatic Cancer
Emerging Role of MicroRNA in Pancreatic Cancer The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation Accessed Citable Link
More informationEarly Embryonic Development
Early Embryonic Development Maternal effect gene products set the stage by controlling the expression of the first embryonic genes. 1. Transcription factors 2. Receptors 3. Regulatory proteins Maternal
More informationMenachem Elimelech. Science and Technology for Sustainable Water Supply
Menachem Elimelech Science and Technology for Sustainable Water Supply Traditional methods for water purification are chemical and energy intensive. Highly effective, low-cost, robust technologies for
More informationCELL CYCLE REGULATION AND CANCER. Cellular Reproduction II
CELL CYCLE REGULATION AND CANCER Cellular Reproduction II THE CELL CYCLE Interphase G1- gap phase 1- cell grows and develops S- DNA synthesis phase- cell replicates each chromosome G2- gap phase 2- cell
More informationIntracellular and extracellular TGF-β signaling in cancer: some recent topics
Front. Med. 2018, 12(4): 387 411 https://doi.org/10.1007/s11684-018-0646-8 REVIEW Intracellular and extracellular TGF-β signaling in cancer: some recent topics Kohei Miyazono ( ), Yoko Katsuno, Daizo Koinuma,
More informationMicroRNA expression profiling and functional analysis in prostate cancer. Marco Folini s.c. Ricerca Traslazionale DOSL
MicroRNA expression profiling and functional analysis in prostate cancer Marco Folini s.c. Ricerca Traslazionale DOSL What are micrornas? For almost three decades, the alteration of protein-coding genes
More informationSummary and Concluding Remarks
Summary and Concluding Remarks Chapter 6 The intestinal epithelium provides an excellent model system for investigating molecular mechanisms regulating cell lineage establishment, stem cell proliferation,
More informationEmerging" hallmarks of cancer, a. Reprogramming of energy metabolism b. Evasion of the immune system, Enabling characteristics, a.
HALLMARKS OF CANCER - Together dictate the malignant phenotype. 1. Self-sufficiency in growth signals 2. Insensitivity to growth inhibitory signals 3. Evasion of cell death 4. Limitless replicative potential
More informationSupplemental Data. TGF-β-mediated mir-181a expression promotes breast cancer metastasis by targeting Bim.
Supplemental Data TGF-β-mediated mir-181a expression promotes breast cancer metastasis by targeting Bim. Molly A. Taylor 1, Khalid Sossey-Alaoui 2, Cheryl L. Thompson 3, David Danielpour 4, and William
More informationKaryotype analysis reveals transloction of chromosome 22 to 9 in CML chronic myelogenous leukemia has fusion protein Bcr-Abl
Chapt. 18 Cancer Molecular Biology of Cancer Student Learning Outcomes: Describe cancer diseases in which cells no longer respond Describe how cancers come from genomic mutations (inherited or somatic)
More informationQuantitative modeling and analysis of the transforming growth factor β signaling pathway
Quantitatie modeling and analysis of the transforming growth factor β signaling pathway Seung-Wook hung, Fayth L. Miles, arlton R. ooper, Mary. Farach-arson, and Babatunde A. Ogunnaike Uniersity of Delaware,
More informationThe role of G9a gene in various cancers
Health Biotechnology and Biopharma (2017), 1(3): 5-11 Minireview Article The role of G9a gene in various cancers Hassan Taghizadeh 1, Eskandar Taghizadeh 2 * 1 Cellular and Molecular Research Center, Yasuj
More informationExpression Pattern of Smad Proteins in Diffuse Large B-cell Lymphomas
The Korean Journal of Pathology 2004; 38: 301-5 Expression Pattern of Smad Proteins in Diffuse Large B-cell Lymphomas Department of Pathology, Dankook University College of Medicine, Cheonan, Korea Received
More informationAbnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S100A9
Abnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S1A9 Joanna Nikitorowicz-Buniak UCL Division of Medicine Systemic sclerosis
More informationsupplementary information
DOI: 10.1038/ncb1875 Figure S1 (a) The 79 surgical specimens from NSCLC patients were analysed by immunohistochemistry with an anti-p53 antibody and control serum (data not shown). The normal bronchi served
More informationPart-4. Cell cycle regulatory protein 5 (Cdk5) A novel target of ERK in Carb induced cell death
Part-4 Cell cycle regulatory protein 5 (Cdk5) A novel target of ERK in Carb induced cell death 95 1. Introduction The process of replicating DNA and dividing cells can be described as a series of coordinated
More informationPresent State of Gene Diagnosis and Future Prospects
Clinical Medicine: Cancer Present State of Gene Diagnosis and Future Prospects JMAJ 45(3): 118 124, 2002 Eiichi TAHARA Chairman, Hiroshima Cancer Seminar Foundation Abstract: The entire base sequence of
More informationAtrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
(Courtesy of Magda Stumpfova. Used with permission.) Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy M.D. Gomes, S.H. Lecker, R.T. Jagoe, A. Navon, and A.L. Goldberg PNAS,
More information