Date of First Patient Recruitment. Benchm ark Met. A - Permissions delayed/denied

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1 No REC Ref Title Authorisation Valid Research Date Application 1 13/EE/ /SS/1043 Date of First Patient Recruitment A Phase III Randomised Trial of Gemcitabine plus Docetaxel followed by Doxorubicin versus observation for uteruslimited high grade uterine leiomyosarcoma 28/07/ /07/2015 N/A Randomised, double-blind, multicentre Phase III trial evaluating the safety and benefit of adding Everolimus to adjuvant hormone therapy in women with poor prognosis, ER+ and HER2- primary breast cancer who remain free of disease after receiving at least 1 year of adjuvant hormone therapy 31/07/ /07/2015 N/A Benchm ark Met A - Permissions delayed/denied B - Suspended by Sponsor C - Closed by Sponsor D - Sponsor delays E - Staff Availability issues F - No Eligible Patients (No patient seen) G - No Patients Consented H - Contracting Delays I-Rare disease J-Other 3 15/LO/ /SC/1366 A Phase 3 Multicenter, Double-Blind, Randomized, Active Comparator- Controlled Clinical Trial to Evaluate the Safety and Efficacy of Doravirine (MK-1439) 100 mg Once Daily Versus Darunavir 800 mg Once Daily plus Ritonavir 100 mg Once Daily, Each in Combination with TRUVADA or EPZICOM/KIVEXA, in Treatment-Naïve HIV-1 Infected Subjects 05/08/ /08/2015 N/A EPOCH: Protocol TS-102: A phase 3 clinical trial evaluating Therasphere in patients with metastatic colorectal carcinoma of the liver who have failed first line chemotherapy 06/08/ /08/2015 N/A 5 14/LO/2182 STOP-HCC TS-103 A phase 3 clinical trial of intra-arterial TheraSphere in the treatment of patients with unresectable hepatocellular carcinoma 06/08/ /08/2015 N/A 6 15/SS/0050 A Phase 2, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled Study of GS-4997 in Subjects with Pulmonary Arterial Hypertension 12/08/ /08/2015 N/A 7 13/WM/0017 select-d: Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous Thromboembolism 13/08/ /08/2015 N/A 8 14/YH/1141 A phase II randomized, double-blind, placebo-controlled trial of radium- 223 dichloride versus placebo when administered to metastatic HER2 negative hormone receptor positive breast cancer with bone metastases treated with hormonal treatment background therapy 17/08/ /08/2015 N/A 9 15/YH/ /LO/0040 Causes of axonal polyneuropathy and the role of autoimmunity in Chronic Idiopathic Axonal Polyneuropathy (CIAP). 17/08/ /08/2015 N/A Hypertrophic Cardiomyopathy Study - Phase 2 study to evaluate the safety and efficacy of a novel compound, GS-6615 on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy 19/08/ /08/2015 N/A 11 15/YH/ /LO/ /LO/ /NW/0593 Pulmonary Rehabilitation and ACTIvity after COPD Exacerbations: A multi-centre, randomised, pilot, factorial (2x2: in-hospital exercise versus no in-hospital exercise and in-home rehabilitation plus usual care versus usual care alone), parallel arm (allocation 1:1 for each factor) trial to evaluate the feasibility of a full scale trial in terms of patients recruited in a 7 months window) randomised controlled trial. 24/08/ /08/2015 N/A Safety and Efficacy of Brimonidine Posterior Segment Drug Delivery System in Patients with Geographic Atrophy Secondary to Age-related Macular Degeneration. 24/08/ /08/2015 N/A A randomized, double-blind, placebo-controlled, prospective, multicenter, parallel group study to assess the safety and efficacy of macitentan in patients with portopulmonary hypertension 27/08/ /08/2015 N/A The effectiveness of mindfulness based cognitive group therapy for social anxiety symptoms in people living with visible skin conditions: A case series of a group intervention 27/08/ /08/2015 N/A

2 15 15/LO/1074 ExplorerTM3 A multi-centre, randomised, placebo controlled, double blinded, multiple dose trial investigating safety, pharmacokinetics and pharmacodynamics of concizumab administered subcutaneously to haemophilia A subjects. Trial ID: NN /09/ /09/2015 N/A 16 14/YH/ /LO/ /YH/ /LO/ /WA/0230 GALACTIC: GA-101 (obinutuzumab) monoclonal Antibody as Consolidation Therapy In CLL 07/09/ /09/2015 N/A A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Capecitabine and Cisplatin With or Without Ramucirumab as First-line Therapy in Patients With Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (RAINFALL) 15/09/ /09/2015 N/A A phase 3, randomized, double-blind, placebo-controlled study investigating the efficacy and safety of multiple Dupilumab dose regimens administered as monotherapy for maintaining treatment response in patients with atopic dermatitis. 18/09/ /09/2015 N/A PLATFORM: Planning Treatment for Oesophago-Gastric Cancer: A randomised maintenance therapy trial 25/09/ /09/2015 N/A ROCS: Palliative radiotherapy in addition to self-expanding metal stent for improving outcomes of dysphagia and survival in advanced oesophageal cancer: (Radiotherapy after Oesophageal Cancer Stenting) 25/09/ /09/2015 N/A 21 14/SC/ /H0706/90 A phase 3 randomized, double-blind study assessing the efficacy and safety of pf and adalimumab in combination with methotrexate in subjects with moderately to severely active rheumatoid arthritis who have had an inadequate response to methotrexate DEPICT: A phase 1/ 2 multi-centre dose escalation study of 25/09/ /09/2015 N/A simultaneous boost Intensity-modulated radiotherapy for locally advanced cervical cancer 29/09/ /09/2015 N/A 23 14/EM/ /LO/1174 A Randomized Controlled Phase 3 Study of Oral Pacritinib versus Best Available Therapy in Patients with Thrombocytopenia and Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis (PERSIST-2) 02/10/ /09/2014 No Y A Phase II Simon Two Stage Efficacy Study of Intracerebral CTX0E03 DP in Patients with Stable Paresis of the Arm Following an Ischaemic Stroke. 03/10/ /09/2014 No Y Y 25 14/WM/0057 Bypass vs. Angioplasty in Severe Ischaemia of the Leg-2 (BASIL-2 trial) 06/10/ /10/ /04/2015 No Y Y 26 14/YH/ /EM/0434 The use of audio-visual cues to aid speech understanding in noise in individuals with an Auditory Processing Disorder 14/10/ /09/ /01/2015 No Y Y Randomized multicentre pilot study of LCZ696 versus irbesartan in patients with chronic kidney disease: UK Heart and Renal Protection (HARP) III 16/10/ /10/ /02/2015 No Y 28 14/YH/ /LO/0590 The QUIET-1 Study: A Balanced Randomised Placebo Controlled Double-blind Phase IIa Study to Investigate the Efficacy and Safety of AUT00063 Versus Placebo in Subjective Tinnitus 21/10/ /10/ /01/2015 No Y A Prospective, Interventional Pharmacokinetic and Safety Study of DTG/ABC/3TC in Pregnant Women 28/10/ /10/2014 No Y Y 30 13/SW/0199 Early Venous Reflux Ablation Ulcer trial Version EVRA 30/10/ /10/ /04/2015 No Y Y 31 12/NE/0234 A randomised controlled trial of Continuous Positive Airway Pressure in patients with impaired vision due to diabetic retinopathy and concurrent Obstructive Sleep Apnoea. (ROSA Trial) 30/10/ /10/ /07/2015 No Y

3 32 14/LO/ /YH/1070 A randomised, doubleblind, parallel group, placebo controlled multicentre Phase III study to assess the efficacy and safety of olaparib versus placebo as adjuvant treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy 13/11/ /11/ /06/2015 No Y Developing a new EEG method for the early diagnosis of dementia. Using novel EEG analyses to create a diagnostic test and biomarker for use with people with dementia 19/11/ /11/ /02/2015 No Y MAMMO50: Mammographic surveillance in breast cancer patients aged 34 13/WM/ years and over 20/11/ /11/ /03/2015 No Y A prospective, randomised controlled trial to determine the safety and efficacy of steroid impregnated tape compared to standard therapy with silver nitrate in the treatment of overgranulating 35 13/WM/0400 peritoneal dialysis catheter exit sites 02/12/ /11/ /05/2015 No Y 36 14/SC/ /NW/ /EE/ /WM/0083 UPSTREAM: A randomised controlled trial to determine the clinical and cost effectiveness of invasive urodynamic studies for diagnosis and management of bladder outlet obstruction in men in the National Health Service (NHS) 04/12/ /11/ /03/2015 No Y Y Randomised Evaluation of Surgery with Craniectomy for patients Undergoing Evacuation of Acute Subdural Haematoma (RESCUEASDH) 09/12/ /12/ /03/2015 No Y A 6-month, prospective, randomized, multicenter, placebo controlled safety study of oto-104 given at 3-month intervals by intratympanic injection in subjects with unilateral Meniere s Disease followed by a 6- month open-label extension 15/12/ /12/ /02/2015 No Y LORIS: A phase 3 trial of surgery versus active monitoring for low risk ductal carcinoma in situ (DCIS) 19/12/ /12/2014 No Y 40 14/LO/ /LO/0362 TARVA: A randomised, multi-centre, non-blinded, prospective, parallel group trial of total ankle replacement (TAR) versus arthrodesis, in the treatment of patients with end stage ankle osteoarthritis, comparing clinical outcomes and cost-effectiveness. 06/01/ /01/ /04/2015 No Y Prospective, randomized, placebo-controlled, double-blind, multicenter, parallel-group, 24-week study to assess the efficacy, safety and tolerability of macitentan in subjects with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) 08/01/ /01/ /07/2015 No Y 42 14/NW/1328 A 16 Week Randomized, Double Blind, Placebo Controlled, Parallel Group, Multicentre Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200 and 400 µg of Fluticasone Propionate Twice a Day (BID) Using a Novel BiDirectional Device in Subjects with Bilateral Nasal Polyposis Followed by an 8 Week Open Label Extension - NAVIGATE I - Phase to Assess Safety 20/01/ /01/2015 No Y 43 14/LO/1428 Adjunctive Steroid Combination in Ocular Trauma (ASCOT) Study 28/01/ /01/2015 No Y 44 14/YH/ /SS/1048 Bone Vibration as a Novel Screening Tool for Long Bone Fractures: Subjective Discomfort in Adults and Potential Tolerability in Children 03/02/ /01/ /06/2015 No Y A Phase 3b, Multi-center, Randomized-withdrawal, Placebo-controlled, Double-blind, Parallel-group Trial to Compare the Efficacy and Safety of Tolvaptan (45 to 120 mg/day, split dose) in Subjects with Chronic Kidney Disease Between Late Stage 2 to Early Stage 4 Due to Autosomal Dominant Polycystic Kidney Disease 18/02/ /02/ /06/2015 No Y

4 46 13/YH/0140 EDIFY - Effect of ivabradine versus placebo on cardiac function, exercise capacity, and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction An 8-month, randomised double-blind, placebo controlled, international, multicentre study 23/02/ /02/2015 No Y 47 13/SC/ /LO/ /YH/0076 Early low dose steroids for adults admitted to hospital with influenza-like illness during a pandemic: a randomised placebo controlled trial 26/02/ /02/2015 No Y InterAACT: An international multicentre open-label randomised phase 2 advanced anal cancer trial comparing cisplatin plus 5 flurouracil versus carboplatin plus weekly paclitaxel in patients with inoperable locally recurrent or metastatic disease 03/03/ /03/2015 No Y Y The BALANCED Study: A prospective, randomised clinical trial of two levels of anaesthetic depth on patient outcome after major surgery 03/03/ /03/ /08/2015 No Y 50 13/LO/ /NW/ /LO/1513 MARS 2: A study to determine if it is feasible to recruit into a randomised trial comparing (extended) pleurectomy decortication versus no pleurectomy decortication in the multimodality management of patients with malignant pleural mesothelioma 12/03/ /03/2015 No Y Y A two part study to assess the safety, tolerability, pharmacokinetics and pharmacodynamic effects of multiple doses of QBM076 in patients with COPD 30/03/ /03/2015 No Y GS-US : A Randomized, Open Label, Phase 4 Study Evaluating the Renal Effect of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF or other Tenofovir DF-containing Regimens (Ritonavir-boosted Atazanavir plus Emtricitabine/Tenofovir DF) or Efavirenz/Emtricitabine/Tenofovir DF compared to Ritonavir-boosted Atazanavir plus Abacavir/Lamivudine in Antiretroviral Treatment-naïve HIV-1 Infected Adults with egfr =70 ml/min 31/03/ /03/2015 No Y 53 14/SW/1166 INFORM: A Multi-Centred, Randomised Trial to compare 1-Stage with 2- Stage Revision Surgery for Prosthetic Hip Joint Infection. 28/04/ /04/ /06/2015 No Y 54 14/NW/ /LO/ /WM/1190 A Phase III, multi-center, double-blind, placebo controlled, randomized withdrawal study of LCI699 following a 24 week, single-arm, open-label dose titration and treatment period to evaluate the safety and efficacy of LCI699 for the treatment of patients with Cushing s disease who are candidates for medical therapy. 14/05/ /05/ /07/2015 No Y Multicentre Phase III Double-masked Randomised Controlled Non- Inferiority Trial comparing the clinical and cost effectiveness of intravitreal therapy with ranibizumab (Lucentis) vs aflibercept (Eylea) vs bevacizumab (Avastin) for Macular Oedema due to Central Retinal Vein Occlusion (CRVO). Short Title: LEAVO. 15/05/ /05/ /08/2015 No Y Drug eluting stent for percutaneous coronary intervention of the left main artery in a real world all-comers population (IDEAL LM Study) 11/06/ /06/2015 No Y 57 14/LO/0673 A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study of Oral MLN9708 Maintenance Therapy in Patients with Multiple Myeloma Following Autologous Stem Cell Transplant - Millennium 12/06/ /06/2015 No Y Y 58 14/YH/0128 SaFaRI: Sacral nerve stimulation versus the FENIXTM magnetic sphincter augmentation for adult faecal incontinence: a Randomised Investigation 25/06/ /06/2015 No Y Y 59 14/NW/0036 ESPAC5F: European Study Group for Pancreatic Cancer Trial 5F 30/06/ /06/2015 No Y Y

5 60 14/LO/ /YH/0003 CapaCiTY study 1: Randomised trial of Habit Training Vs. Habit Training with Direct Visual Biofeedback in Adults with Chronic Constipation. 02/07/ /07/2015 No Y ZINN - Randomized, Doubleblind, Multicenter, Phase III Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban Therapy for Women in Spontaneous Preterm Labor 10/07/ /07/2015 No Y 62 14/NW/1110 International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing Sarcoma 14/07/ /07/2015 No Y Y 63 14/YH/0159 Active Patient Warming In Elective Caesarean Sections 13/10/ /10/ /10/2014 Yes 64 14/EE/1147 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs). A comparative study of normal ears versus those with vestibular deficits 14/10/ /10/ /11/2014 Yes 65 14/SC/1030 A randomised controlled trial to compare the clinical effectiveness and safety of gentamicin and ceftriaxone in the treatment of gonorrhoea 20/10/ /10/ /10/2014 Yes 66 14/NE/1079 RELIEVE 1 - A randomised, double-blind, placebo-controlled study to evaluate the efficacy of two different dose levels of Orvepitant (10 and 30 mg) compared with placebo on EGFRi-induced intense pruritus in oncology subjects 27/10/ /10/ /12/2014 Yes 67 13/EM/0424 A Phase 2, Dose-Finding, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study, Evaluating the Safety and Efficacy of Pridopidine 45 mg, 67.5 mg, 90 mg and mg Twice-Daily versus Placebo for Symptomatic Treatment in Patients with Huntington s Disease Phase 2 27/10/ /10/ /12/2014 Yes 68 12/EE/0310 Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial (CONCEPTT) 28/10/ /10/ /11/2014 Yes 69 14/NW/0270 Development of a clinical protocol to use intra-operative near infra-red fluorescent imaging in thyroid and parathyroid surgery 30/10/ /10/ /11/2014 Yes 70 14/YH/1119 Stress and Seizures - Can a brief self-help book help? 04/11/ /11/ /12/2014 Yes 71 13/LO/1328 A multicentre, randomized, double-blind, parallel group, activecontrolled study to evaluate the efficacy and safety of LCZ696 compared to valsartan, on morbidity and mortality in heart failure patients (NYHA Class II-IV) with preserved ejection fraction 13/11/ /11/ /01/2015 Yes 72 12/NW/0827 Euro Ewing 2012: International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours 20/11/ /11/ /11/2014 Yes 73 14/LO/0481 Lung HeXeRT: Advanced proton, hyperpolarised 3-helium and 129-xenon magnetic resonance imaging for lung cancer radiotherapy planning and evaluation 11/12/ /12/ /02/2015 Yes 74 13/NS/0002 Therapeutic Interventions for Stones of the Ureter (TISU): a multicentre randomised controlled trial of extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones. 11/12/ /12/ /02/2015 Yes 75 14/EM/1102 A Double-Blind, Placebo Controlled, Multicenter Study to Assess the Effect of Evolocumab on Cognitive Function in Patients with Clinically Evident Cardiovascular Disease and Receiving Statin Background Lipid Lowering Therapy: A Study for Subjects Enrolled in the FOURIER (Study ) Trial Evolocumab (AMG 145) Trial of HLA epitope-matched platelet transfusion in aplastic anaemia, 12/12/ /12/ /01/2015 Yes 76 12/LO/0695 MDS and AML patients: A comparison of HLA epitope-matched with standard HLA matched with standard HLA matched prophylactic platelet transfusions in raising the platelet count increment in alloimmunised Thrombocytopenic patients with aplastic anaemia, myelodysplastic syndrome or acute myeloid leukaemia: A double-blind randomised crossover trial 08/01/ /01/ /02/2015 Yes 77 14/YH/0152 Proof of Concept Allergy Alert Test 12/01/ /01/ /02/2015 Yes

6 78 14/LO/ /EM/ /YH/ /LO/ /WS/ /YH/ /LO/ /NE/ /EE/1113 A Multicenter Phase 3 Randomized, Open-Label Study of Bosutinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia BFORE 12/01/ /01/ /01/2015 Yes POSNOC: Positive sentinel node: adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes 16/01/ /01/ /02/2015 Yes A Phase 2, Randomized, Placebo Controlled, Double Blind, Proof of concept Study of the Efficacy and Safety of PF in Subjects with Huntington s disease 19/01/ /01/ /03/2015 Yes Study : Albiglutide versus Placebo in Subjects with new- onset type 1 diabetes mellitus 03/02/ /01/ /03/2015 Yes CAVA: Cancer and Venous Access a randomised controlled trial with associated qualitative research of venous access devices for the delivery of long-term chemotherapy 03/02/ /01/ /02/2015 Yes A Randomised Trial of the FLAMSA-BU CondItioning ReGimen in Patients with Acute Myeloid Leukaemia and Myelodysplasia UndeRgoing AllOgeneic Stem Cell Transplantation (FIGARO) 10/02/ /02/ /03/2015 Yes Demonstrating Minicare, a miniaturized biophotonics platform for fast and lab-equivalent Point-of-Care diagnostics of Cardiac Troponin-I. 16/02/ /02/ /02/2015 Yes Pressure controlled Intermittent Coronary Sinus Occlusion as an adjunct to PCI in acute coronary syndrome. An observational study evaluating the effect of PICSO treatment concomitant to ppci in patients with anterior non ST-segment Elevation Myocardial Infarction or following ppci in ST-segment Elevation Myocardial Infarction. 17/02/ /02/ /04/2015 Yes TOPAZ: A long-term follow-up study for Multiple Sclerosis patients who have completed the alemtuzumab Extension Study (CAMMS03409 STH15866) 20/02/ /02/ /03/2015 Yes 87 15/NE/0037 Assessment of the effects of Sheffield Support Snood in MND patients 06/03/ /03/ /05/2015 Yes 88 14/NW/0119 A 4 week phase 2a, multicentre, randomised, doubleblind, placebocontrolled add-on study into safety, tolerability andefficacy of 200 mg t.i.d. of PL37 in patients with peripheral neuropathic pain of diabetic origin treated with pregabalin or gabapentin 06/03/ /03/ /04/2015 Yes 89 14/YH/0085 FLAIR: Front Line Therapy in CLL: Assesment of Ibrutinib and Rituximab 13/03/ /03/ /03/2015 Yes 90 13/YH/ /SC/ /SC/1370 Sildenafil in Heart Failure (SilHF); An investigator initiated multi-national clinical research study 17/03/ /03/ /05/2015 Yes A Multicenter, Randomized, Double Blind, Placebo controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Dapagliflozin as an Add on to Insulin Therapy in Subjects with Type 1 Diabetes Mellitus 23/03/ /03/ /05/2015 Yes Collaborative European NeuroTrauma Effectiveness research in TBI: a prospective longitudinal observational study 25/03/ /03/ /05/2015 Yes 93 12/WM/ /YH/0131 A pilot study for developing and evaluating a care pathway for cognitive problems after stroke (OCS-care) 14/04/ /04/ /06/2015 Yes Using remote telemonitoring to detect early decline in lung function & streamline clinics in adults with cystic fibrosis 07/05/ /05/ /05/2015 Yes 95 14/LO/0649 Exercise training as a novel primary therapy for men with localised prostate cancer: the PANTERA trial (Prostate cancer Novel ThERApy) 07/05/ /04/ /05/2015 Yes

7 96 15/YH/0005 A Phase 3 Confirmatory Study Investigating The Efficacy And Safety Of Dupilumab Monotherapy Administered To Adult Patients With Moderate -To severe Atopic Dermatitis 08/05/ /05/ /06/2015 Yes Cognitive Rehabilitation of Attention and Memory for people with 97 14/WM/1083 Multiple Sclerosis (CRAMMS): A pragmatic randomised controlled trial 13/05/ /05/ /06/2015 Yes The RAPID-CTCA trial (Rapid Assessment of Potential Ischaemic Heart Disease with CTCA) The role of early CT Coronary Angiography in the evaluation, intervention and outcome of patients presenting to the Emergency Department with suspected or confirmed Acute Coronary 98 14/SS/1096 Syndrome 22/05/ /05/ /06/2015 Yes 99 14/YH/1178 ETOP 5-12/ EORTC (SPLENDOUR): A randomised, open-label phase III trial evaluating the addition of denosumab to standard first-line anticancer treatment in advanced NSCLC 08/06/ /06/ /07/2015 Yes /SS/ /YH/1274 MS-SMART: A Multi-Arm Phase IIb Randomised, Double Blind Placebo- Controlled Clinical Trial Comparing The Efficacy of 3 Neuroprotective Drugs in Secondary Progressive Multiple Sclerosis 08/06/ /05/ /07/2015 Yes Study of two regimens of TicagrElor compared to clopidogrel in patients undergoing ELective Percutaneous Coronary Intervention - STEEL PCI 09/06/ /06/ /06/2015 Yes /EM/0230 A Phase II Randomised, Double Blind, Placebo Controlled, Multicentre Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma 10/06/ /06/ /08/2015 Yes /YH/0188 Acceptability study on Nutricomp Drink Plus in adult patients 15/06/ /06/ /07/2015 Yes /EM/ /YH/ /YH/ /YH/1108 Behavioural activation therapy for treating post-stroke depression: a feasibility randomised controlled trial 17/06/ /06/ /07/2015 Yes Multicentre Randomised Controlled Trial of Angiotensin Converting Enzyme inhibitor (ACEi) / Angiotensin Receptor Blocker (ARB) withdrawal in advanced renal disease; The STOPACEi Trial 25/06/ /06/ /07/2015 Yes Developing electrical impedance myography of the tongue for motor system disorders EIM 08/07/ /07/ /09/2015 Yes Simple Hysterectomy And Pelvic node dissection in Early cervix cancer (SHAPE) 09/07/ /07/ /07/2015 Yes /H0505/71 Understanding the early pathological pathways in Parkinson s Disease 10/07/ /07/ /08/2015 Yes /LO/ /LO/ /YH/ /SC/1345 The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary Fibrosis with the addition of Co-trimoxazole (EME-TIPAC) 16/07/ /07/ /08/2015 Yes Effects of ODM-109 on respiratory function in patients with ALS. A randomised, double blind, placebo-controlled, cross-over, 3 period, multicentre study with open-label follow-up extension. 17/07/ /07/ /08/2015 Yes Analysis of the immune response to Fendrix as compared to double-dose Engerix B in HIV-infected non-responders to standard Hepatitis B vaccination courses. 23/07/ /07/ /09/2015 Yes The effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding. A randomised placebo-controlled trial: PRISM 24/07/ /07/ /08/2015 Yes /WS/0111 Abdominal massage for neurogenic bowel dysfunction in people with multiple sclerosis 28/07/ /07/ /09/2015 Yes /NW/1531 Comparative testing of Transfix Vacuum blood collection tubes and Cytochex blood collection tubes for FDA 510 (k) submission 04/08/ /08/ /09/2015 Yes /YH/1202 PREVAIL: PREVenting infection using Antimicrobial Impregnated Long lines 06/08/ /07/ /09/2015 Yes /SW/0144 Investigating the Energy Requirements of Spinal Cord Injured Patients 10/08/ /08/ /09/2015 Yes

8 117 15/YH/0127 An open label extension study to investigate the long term safety, tolerability and efficacy of PF in subjects with Huntington's disease who previously completed study A /09/ /08/ /09/2015 Yes /NW/0278 The feasibility of employing ambulatory fetal heart rate monitoring in small for gestational age foetuses at risk of stillbirth. 07/09/ /09/ /09/2015 Yes