African Access Initiative (AAI)
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1 AAI African Access Initiative (AAI) African Consortium for Cancer Clinical Trials (AC 3 T) Highlights
2 African Access Initiative (AAI) African Consortium for Cancer Clinical Trials (AC 3 T) AAI AAI Approach Driven by Africa - for Africa - the African Access Initiative (AAI) is a partnership of companies, governments, healthcare providers, and nonprofit organizations focused on building sustainable access to cancer treatments. Using data generated at the country level by African hospitals and governments, AAI is expanding access to cancer medicines and technologies, strengthening healthcare infrastructure, and building clinical oncology and R&D capacity in Africa. The Right Solution at the Right Time AAI Goals Provide access to prioritized cancer medicines and technologies Identify and engage target African countries and hospitals Prepare custom analyses of cancer markets, payer systems, capabilities, and gaps for each country/hospital Match participating companies oncology portfolios with country/hospital needs Strengthen laboratory capacity to diagnose and monitor cancer patients Build oncology healthcare provider and researcher expertise Increase access to new and established cancer medicines and technologies through clinical trials Our Partners Develop innovative business models and access agreements aligned with country/hospital priorities and company interests Coordinate delivery of oncology medicines, technologies, and training Ministries of Health AC 3 T: Access through Clinical Trials Under the purview of AAI, BVGH launched the African Consortium for Cancer Clinical Trials (AC 3 T) to foster and implement cancer clinical trials led by investigators in Africa. AC 3 T is designed to build clinical trial capacity and address the cancer data gap in Africa while increasing access to prioritized cancer diagnostics, medicines, and quality treatment for African patients. AC 3 T Goals Increase access to new and established cancer medicines and technologies through clinical trials Kickoff in Kigali Address the cancer data gap in African ethnicities Galvanize support for African investigator-initiated cancer clinical trials at ready now cancer centers and hospitals Build clinical trial capacity in ready soon cancer centers and hospitals AAI partners and global health leaders gather in Kigali, Rwanda, to launch AC 3 T. Empower pharmaceutical and biotechnology companies to conduct investigational cancer drug studies in Africa 1
3 AAI & AC 3 T Milestones Feb 2016 AAI concept presented to UN High-Level Panel on Access to Medicines June 2017 Early 2017 AORTIC, IFPMA/Access Accelerated, Pfizer, and Takeda join AAI AAI launched at BIO International Convention Mid 2017 Country-specific strategies planned with Ministers of Health and AAI hospital leadership Feb 2018 Laboratory equipment placed at Nigerian hospital May 2018 AC 3 T clinical trials readiness assessment implemented July 2018 Early 2018 Capacity building fellowships initiated AAI needs assessments analyzed and custom drug reports shared June 2018 AAI/AC 3 T events held at BIO Convention Nov 2017 AC 3 T launched at AORTIC International Conference Aug 2018 AC 3 T request for interest (RFI) launched By Africa, for Africa Needs Assessments AAI Hospital Needs Assessments ensure that AAI and AC 3 T are driven by Africa, for Africa by generating country-level data on cancer burden and current practices, treatment gaps, capacity building needs, and technology and drug priorities. AC 3 T Checklist Mapping Capacity Data gathered from completed Needs Assessments and AC 3 T Checklists map hospital capacity and define AAI and AC 3 T priorities. Data Management Access Barriers Ethics Review Capabilities Cancer Burden Healthcare Capacity Diagnostic Capabilities Hospital Information Used & Needed Drugs Treatment Options Medicine Access AC 3 T Checklists assess a hospital s cancer clinical trial infrastructure, experience, and readiness. Research Activities & Needs Research Collaboration & Experience Site Security Human Resources Laboratory Systems Financial Administration 2
4 AAI Hospital Needs Assessment and AC 3 T Checklist Summary AAI/AC 3 T Countries Top 5 Cancers Côte d Ivoire Kenya Breast (6,681*) *# of adult patients diagnosed annually at 23 AAI hospitals Nigeria Cervical (4,397) Prostate (2,996) Colorectal (1,660) Lymphoma (2,065) Cameroon Rwanda Diagnostic Equipment Priorities Fume/tissue culture hood Incubator Microscope Microtome Spectrophotometer Water bath Flow cytometer PCR & RT-PCR machines Oncology Team Human Resource Gaps Diagnostic pathology Radiotherapy Oncology nursing Oncology pharmacy Oncology surgery Pediatric oncology Biostatistician Epidemiologist Oncology Clinical Trials in Africa** Cancers Studied Leukemia/ Lymphoma (9) Breast (7) Cervical (4) Gastric Head & Neck Ovarian Renal AAI Hospitals Clinical Trial Capabilities GCP Certifications Trial Site Locations Pharmacology Quality Assurance Protocol Development Logistics Finance Management Ethics/Regulatory Affairs Data Management Clinical Trial Management Percentage of AAI Hospitals with Capability Ghana (2) Uganda (4) Data Analysis Ethiopia (1***) Trial Sponsors (excluding Academic) ANZ Breast Cancer Trials Group: 2 Breast Cancer Research Foundation: 2 International Breast Cancer Study Group: 1 International Society of Pediatric Oncology: 1 National Surgical Adjuvant Breast and Bowel Project: 1 NIH/FIC/NCI: 5 Novartis: 1 Pfizer: 1 Roche: 2 Sanofi: 1 Spanish Breast Cancer Research Group: 1 Cancer Medicines Studied Anthracycline (undisclosed): 1 Capecitabine: 3 Cyclophosphamide: 1 Docetaxel: 2 Epirubicin: 2 Fluorouracil: 1 Methotrexate: 1 Paclitaxel: 1 Taxane (undisclosed): 1 Côte d Ivoire Nigeria (9) Cameroon (11) Trial Phases Phase I: 2 Phase II: 17 Phase III: 3 Phase IV: 1 Botswana Malawi (7) Zimbabwe (2) Kenya (5) Tanzania **sub-saharan Africa, excluding South Africa ***# of clinical trials conducted in country 3
5 Needs Assessments Drive AAI and AC 3 T Activities Strengthening Diagnostic Laboratories Nigeria s Federal Medical Center is enhancing its diagnostic pathology laboratory with five high-value instruments donated by Pfizer The pathology laboratory at the University Teaching Hospital of Kigali in Rwanda is advancing towards the achievement of international accreditation with the support of Merck & Co., Inc. experts Building Clinical Oncology and Research Cameroon s Bonassama District Hospital is augmenting its breast cancer surgery and hematology capabilities with training from Henry Ford Health System and Muhimbili University of Health and Allied Sciences experts Côte d'ivoire is addressing the high burden of prostate cancer in Africa through its participation in the Men of African Descent and Carcinoma of the Prostate Consortium Moi Teaching & Referral Hospital in Kenya is increasing its cancer clinical trials site appeal with the guidance of Merck & Co., Inc. experts AAI Activities in Development Oncology Surgery: Oncology surgery fellowships and observerships for general surgeons in Kenya, Nigeria, and Rwanda Radiology & Radiotherapy: Radiology and radiotherapy workshops, short-term radiotherapy refresher courses, and radiation therapy technician certification program in Kenya, Nigeria, and Rwanda Cancer Research: Prostate cancer research project in Rwanda Diagnostic Pathology: Disease-specific biopsy and diagnostic pathology training in Côte d'ivoire, Kenya, and Nigeria Oncology Nursing: Didactic and hands-on training of general nurses in oncology nursing Clinical Oncology Certifications: Comprehensive didactic and hands-on training programs culminating in certifications from accredited institutes and universities Clinical Oncology: Disease-specific and multidisciplinary clinical oncology workshop and tumor boards in Côte d'ivoire and Rwanda 4
6 Communications Snapshot Africa s Emerging Cancer Crisis: A Call to Action AAI white paper asserts need for cancer clinical trials in Africa AAI Video Partners and stakeholders speak to AAI and AC 3 T priorities BIO Buzz Show Daily AAI and AC 3 T milestones featured in article BVGH s African Access Initiative Expands to Rwanda Arise News and THISDAY Nigerian media showcases AAI and AC 3 T Nigeria s National Cancer Control Plan (NCCP) Launch At the invitation of the Minister of Health, BVGH presented AAI and AC 3 T International Drug Companies Join BVGH to Tackle Cancer Crisis in Africa Cancer Crisis in Africa Prompts BVGH s New African Access Initiative Breast Cancer More Aggressive, Deadlier in African Women than Caucasian Women Devex Q&A AAI s unique approach to Africa s cancer crisis described Thank you to our AAI and AC 3 T Partners BIO Ventures for Global Health 401 Terry Avenue North, Sea le, WA USA Twi
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