MINOTI HIREMATH S-124, Department of Biology, 1910 University Drive, MS1515, Boise, ID Cell: (718)

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1 MINOTI HIREMATH S-124, Department of Biology, 1910 University Drive, MS1515, Boise, ID Cell: (718) CURRENT POSITION Research Assistant Professor January 2011-Present Boise State University, Department of Biology, Idaho INBRE Investigator Research: Investigating epithelial mesenchymal interactions regulated by PTHrP, Wnt and Bmp signaling in embryonic mammary development. Using conditional deletion models to understand the contributions of stromal signaling in breast cancer. Exploring the mechanisms underlying the crosstalk between estrogen receptor and PTHrP signaling in the pathogenesis and treatment of breast cancer. EDUCATION Post-Doctoral Associate, November 2007-December 2010 Yale University, New Haven, CT. Department of Internal Medicine, Section of Endocrinology Advisor: John Wysolmerski, M.D. Ph.D Cell Biology, August July 2007 New York University School of Medicine, New York, NY. Department of Cell Biology Advisor: Pamela Cowin, Ph.D. Ph. D. candidate, Department of Genetics, August 2001-May 2002 University of Georgia, Athens, GA. M. B. B. S. (Bachelor of Medicine and Surgery), August January 2001 Byramjee Jeejeebhoy Medical College, University of Pune, India HONORS AND AWARDS: ASBMR Young Investigator Travel Award, Amount: $ Travel monies for first authors of abstracts that are highest ranked in their categories. MSTMRI Small Project Award, Amount $7, Crosstalk between PTHrP and Estrogen Receptor in Mammary Development and Breast Cancer. Idaho INBRE Investigator support, Amount $59, Department of Defense Postdoctoral Fellowship, Amount: $243, Role of Mesenchymal Wnt Signaling in Mediating the Effects of PTHrP in the Mammary Gland.

2 Department of Defense Predoctoral Fellowship, Amount: $90, Beta-catenin and Progesterone in Hormone Receptor Negative Breast Cancer. RESEARCH EXPERIENCE Boise State University, Boise, ID Research Assistant Professor. Epithelial-mesenchymal interactions in embryonic mammary development. Role of stromal Wnt signaling in breast cancer formation. Interactions between PTHrP and Estrogen Receptor signaling in breast cancer present Yale University, New Haven, CT Postdoctoral Associate, Advisor: Dr. John Wysolmerski Intersections between PTHrP, Wnt and Bmp signaling during mammary mesenchyme specification and breast cancer. Demonstrated regulation of Wnt signaling by PTHrP during embryonic mammary development using transgenic Wnt signaling reporter mice. Analyzed requirement for Wnt signaling during mammary mesenchyme specification by deletion of beta-catenin and Lef1. Used conditional deletion models to demonstrate the role of BMP signaling during early mammary development New York University, New York, NY Graduate Student, Advisor: Dr. Pamela Cowin Beta-catenin and progesterone signaling in mammary development and breast cancer. Demonstrated two populations of beta-catenin responsive cells in the mammary gland that differed in their location and requirement for progesterone signaling. Used transgenic and knockout mouse models to demonstrate that progesterone signaling restrains the progression of beta-catenin induced mammary hyperplasias to tumors. University of Georgia, Athens, GA Graduate Research Assistant Cultured human embryonic stem cells and measured rate of division by BrdU incorporation in the laboratory of Dr. Steven Stice. Cloned and analyzed splice variants of Kit ligand mutations in ENU-mutagenized mice in the laboratory of Dr. Mary Bedell. Cloned K.Lactis telomeres in the laboratory of Dr. Michael McEachern. PUBLICATIONS Hiremath M, Dann P, Fischer J, Shi W and Wysolmerski JJ. Signaling pathways in embryonic mammary development: The PTHrP-Wnt connection. Manuscript in preparation. Hiremath M, Lydon JP and Cowin P. Progesterone Receptor Predisposes Breast To β-catenin- Induced Hyperplasia But Delays Tumor Progression. Manuscript in preparation.

3 Boras-Granic K, Van Houten J, Hiremath M and Wysolmerski JJ. Parathyroid Hormone-Related Protein is not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland. Manuscript under review at PLOS One. Mukherjee A, Soyal SM, Li J, Ying Y, Szwarc MM, He B, Kommagani R, Hodgson MC, Hiremath M, Cowin P, Lydon JP. A mouse transgenic approach to induce β-catenin signaling in a temporally controlled manner. Transgenic Res Dec 2. Hens JR, Dann P, Hiremath M, Pan T, Chodosh L and Wysolmerski JJ. Analysis of Gene Expression in PTHrP-/- Mammary Buds Supports a Role for BMP Signaling and MMP2 in the Initiation of Ductal Morphogenesis..Dev Dyn 2009 Nov;238(11): Teissedre B, Pinderhughes A, Incassati A, Hatsell SJ, Hiremath M, Cowin P. MMTV-Wnt1 and -D89b-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS ONE. 2009; 4(2):e4537. Epub 2009 Feb 19. Hiremath M, Lydon JP and Cowin P. The Pattern Of β-catenin-responsiveness within the Mammary Gland is Regulated by Progesterone Receptor. Development Oct;134(20): Hiremath M and Cowin P. Cadherins in metastasis in New Developments in Metastasis Suppressor Research. Nova Publishers, Ed. Jackson P, Hatsell. SJ, Hiremath. M, Shamamian. P and Cowin.P. Molecular and cellular biology of breast cancer in Breast Cancer. Second Edition, In Breast Cancer Ed. Roses D, Hatsell S, Rowlands T, Hiremath M, Cowin P. Beta-catenin and Tcfs in mammary development and cancer. J Mammary Gland Biol Neoplasia Apr;8(2): INVITED TALKS March 2011 June 2010 October rd Annual Symposium of the Idaho Academy of Sciences, Caldwell, ID. Boise State University, Department of Biology. Boise, ID. Young Investigators Meeting, Translational Health Sciences Institute, Cambridge, MA POSTER PRESENTATIONS Hiremath M, Dann P, Shi W, Wysolmerski JJ (2011). Pthrp-Induced BMP Signaling Plays A Role In Specification Of The Mammary Mesenchyme. Poster to be presented at the American Society for Bone and Mineral Research. San Diego, CA., September Selected as a plenary poster and for Young Investigator Travel Award. Hiremath M, Dann P, Fischer J, Wysolmerski JJ (2011). Pthrp-Induced Wnt Signaling Plays A Role In Specification Of The Mammary Mesenchyme. Poster at the Gordon Research Conference on Mammary Gland Biology. Newport, RI., June, 2011.

4 Hiremath M, Dann P and Wysolmerski JJ (2010). Pthrp-Induced Wnt Signaling Plays A Role In Specification Of The Mammary Mesenchyme. Poster presented at the John B. Warshaw Developmental Biology Symposium, New Haven, CT, October Hiremath M, Dann P and Wysolmerski JJ (2010). Pthrp-Induced Wnt Signaling Plays A Role In Specification Of The Mammary Mesenchyme. Poster presented at the ENDO Society Meeting, San Diego, CA, June Selected for presidential poster competition. Hiremath M and Wysolmerski JJ (2009). Pthrp-Induced Wnt Signaling Plays A Role In Specification Of The Mammary Mesenchyme. Poster presented at the Gordon Research Conference on Mammary Gland Biology. Newport, RI., June, Hiremath M and Wysolmerski JJ (2009). Pthrp-Induced Wnt Signaling Plays A Role In Specification Of The Mammary Mesenchyme. Poster presented at the American Society for Bone and Mineral Research. Montreal, CA., September Selected as a plenary poster. Hiremath M and Cowin P (2007). Progesterone receptor and beta-catenin signaling in alveolar development and breast cancer. Poster presented at the Gordon Research Conference on Mammary Gland Biology. Newport, RI., June Hiremath M and Cowin P (2005). Beta-catenin and progesterone in alveolar development and breast cancer. Poster presented at the Gordon Research Conference on Mammary Gland Biology. Newport, RI., June Hiremath M and Cowin P (2005). Beta-catenin and progesterone in hormone receptor negative breast cancer. Poster presented at the Era of Hope Conference, Philadelphia, PA., June Formenti S.C, Hiremath M, Yang A, Demaria S and Cowin P. Beta-catenin induces a population of radio-resistant alveolar stem/progenitors that progress to form hormone-independent breast tumors in mice. Presented as a poster at the 47th Annual meeting of the American Society of Therapeutic Radiology and Oncology, Denver, CO., June Hiremath M and Cowin P (2005). Beta-catenin and progesterone in alveolar development and breast cancer. Poster presented at the Keystone Symposium on Cancer and Development, Banff, CA., February TEACHING EXPERIENCE Co-Instructor with Dr. Jesse Barber Fall 2011 Boise State University, Department of Biology Functional and Comparative Anatomy, ZOOL 301 The evolutionary development of vertebrate anatomy, fishes through mammals. Dissection of the shark, salamander, and cat plus demonstrations of other vertebrate types. Contributed to course design, teaching, evaluation, laboratory experimental design and demonstration of dissection.

5 Co-Instructor with Dr. Julia Oxford. Spring 2011 Boise State University, Department of Biology Developmental Biology, BIOL 451/551 A developmental biology course that includes lecture and laboratory components. Contributed to course design, teaching, evaluation and laboratory experimental design. Lecturer in Yale College Seminar Series Fall 2010 Towards a New Understanding of Breast Cancer, (CSBK231) A seminar course designed to study the connections between molecular and cellular process in relation to breast cancer. Used groups exercises, blogging and debating strategies to help students develop a better understanding of the biology of breast cancer and its treatment. Guest Lecturer Spring 2005 Cell Biology, New York University Moderated group discussion sessions on Wnt signaling for a small group of graduate students. Graduate Teaching Assistant August 2000 December 2000 Department of Genetics, University of Georgia, Athens, GA Genetics laboratory course for undergraduate biology majors. Taught basic concepts of cellular structure and function and Mendelian genetics. Designed and graded exams. Graduate Teaching Assistant January 2001 May 2001 Concepts in Biology (BIOL1103L) laboratory course for undergraduate non-biology majors. Taught molecular biology and using model organisms genomics and to illustrate basic biological principles Medical Intern February March 2000 Byramjee Jeejeebhoy Medical College, Pune, India Conducted lectures in rural AIDS education for high school students. Taught Anatomy and Physiology to nursing students at Ruby Hall Clinic, Pune, India. MENTORING: Charla Taylor, Summer student, NYU 2004 Rebecca Smith, Intel Science Scholar, Summer Student, NYU 2004, 2005 Rengin Azeglou, Rotating Graduate Student, NYU Spring 2005 Jennifer Fischer, Summer Student, Yale University 2009, 2010 Kelsey Bruch, Undergraduate, Boise State University Summer and Fall 2011 Hannah Dyah, Undergraduate, Boise State University Fall 2011 SERVICE Panelist, Women in Science seminar at Yale University School of Medicine. October 2010

6 PROFESSIONAL ASSOCIATIONS Affiliate Member, Mountain States Tumor Medical Research Institute (MSTMRI). Idaho INBRE (IDeA Network of Biomedical Research Excellence). Idaho Academy of Science. New York Academy of Sciences (NYAS). American Association for the Advancement of Science (AAAS). American Society for Bone and Mineral Research (ASBMR). REFERENCES Dr. John Wysolmerski, M.D, Professor, Department of Internal Medicine, Yale University, Section of Endocrinology, S120, TAC, 333 Cedar Street, New Haven, CT Tel: Dr. Julia Oxford, Ph.D, Professor, Department of Biological Sciences, Boise State University, 1910 University Drive, MS 1515, Boise, ID Tel: Dr. Jennifer Frederick, Ph.D. Associate Director, Graduate Teaching Center Yale University, HGS 120, PO Box New Haven, CT Tel: (203) Dr. Pamela Cowin, Ph.D, Professor, Department of Cell Biology and Dermatology, New York University, MSB 621, 550 1st Avenue, New York, NY Tel: