eontents NOTE TO THE READER... 9 LIST OF PARTICIPANTS... Il PREAMBLE... 17

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1 eontents NOTE TO THE READER LIST OF PARTICIPANTS Il PREAMBLE Background Objective and Scope Selection of Topics for Monographs Data for Monographs The Working Group Working Procedures Exposure Data " 20 Studies of Cancer in Humans Studies of Cancer in Experimental Animais Other Data Relevant to an Evaluation of Carcinogenicity and Its Mechanisms.. 27 Summary of Data Reported Evaluation References GENERA REMARKS THE MONOGRAHS Infection with schistosomes (Schistosoma haematobium, S. mansoni and S. japonicum) Exposure data Structure and biology of schistosomes Taxonomy Structure Life cycle and biology of the adult worm Methods for detection of infection History taking Clinical diagnosis Parasitological tests Immunological tests Establishment of absence of infection... 50

2 CONTENTS 1.3 Epidemiology of infection " Geographical distribution Risk factors for infection " Aggregation of infection Prevalence and intensity of infection Sex-related patterns of infection Relationship of morbidity to intensity of infection Relationship of morbidity to mortality from infection " Clinical disease in humans (other than cancer) Treatment and control.... " Treatment Control Studies of cancer in humans Descriptive studies Schistosoma haematobium Schistosoma mansoni Schistosoma japonicum.. ; Case reports and case series Schistosoma haematobium Schistosoma mansoni Schistosoma japonicum Cohort study Case-control studies (with retrospective exposure assessment) Schistosoma haematobium Schistosoma japonicum Studies of cancer in animais Infection wi th Schistosoma haematobium alone Mouse Rat Hamster Opossum Nonhuman primate Infection with Schistosoma haematobium in combination with administration of known carcinogens Acetylaminofluorene ortho-aminoazotoluene N-Nitrosamines Infection with Schistosoma mansoni alone Mouse Mastomys natalensis Hamster Nonhuman primate... 85

3 CONTENTS 3.4 Infection with Schistosoma mansoni in combination with administration of known carcinogens Amino-5-azotoluene Naphthylamine and 2-acetylaminofluorene Infection with Schistosoma mansoni in combination with administration of compounds used or evaluated in the past as antischistosomal agents " Infection with Schistosoma japonicum al one Infection with Schistosoma japonicum in combination with administration of known carcinogens Dimethylaminobenzene Acetylaminofluorene Other data relevant for evaluation of carcinogenicity and Its mechanisms Pathology of infection Humans Experimental systems " Other observations relevant to the interpretation of carcinogenicity and mechanisms of carcinogenesis Humans Experimental systems Summary of data reported and evaluation Exposure data Human carcinogenicity data Animal carcinogenicity data Other relevant data Evaluation References Infection with liver flukes (Opisthorchis viverrini, O. jelineus and Clonorchis sinensis) Exposure data Structure and biology of liver flukes Taxonomy Structure Life cycle and biology of the adult worm Immune response to infection Methods for detection of infection Qualitative faecal examination for eggs Quantitative faecal assessment of intensity of infection Serological tests for helminth-specific antibody and antigen Intradermal tests Epidemiology of infection Geographical distribution Risk factors for infection

4 CONTNTS Age- and sex-related patterns of infection.... " Aggregation of infection Clinical disease in humans (other than cancer) Treatment and control " Studies of cancer in humans " Descriptive studies " Opisthorchis viverrini Opisthorchis feiineus Case reports and case series Opisthorchis viverrini Opisthorchis felineus " Clonorchis sinensis Case-control studies Opisthorchis viverrini Clonorchis sinensis " Studies of cancer in animais " Infection with Opisthorchis viverrini alone " Infection with Opisthorchis viverrini in combination with administration of known carcinogens N-Nitrosodimethylamine N-Nitrosodiethylamine N-Nitrosodihydroxydi-n-propylamine Infection with Opisthorchis viverrini in combination with administration of other modifyng factors Infection with Opisthorchis feiineus Infection with Clonorchis sinensis alone Rat Cat Dog Infection with Clonorchis sinensis in combination with administration of known carcinogens AfatoxIn Bi N-Nitrosodimethylamine Acetylaminofluorene Other data relevant for evaluation of carcinogenicity and its mechanisms. " Pathology of infection Humans Experimental systems Comparison of hum ans and experimental animais Other observations relevant to the interpretation of carcinogenicity and mechanisms of carcinogenesis Humans

5 CONTENTS Experimental systems Summary of data reported and evaluation Exposure data Human carcinogenicity data Animal carcinogenicity data Other relevant data Evaluation References " 162 Infection with Helicobacter pylori Exposure data Structure and biology of HeIicobacter pylori Taxonomy Biology Agent-host relationship Methods for detection of infection Methods based on gastric biopsy specimens Methods based on gastric juice samples Methods based on faecal specimens Methods based on dental plaque and saliva samples Methods based on blood samples Urea breath test Epidemiology of infection Prevalence Risk factors for infection Routes of transmission Clinical disease in humans (other than cancer) Gastritis Duodenal ulcer disease Gastric ulcer disease Hypertrophic protein-iosing gastritis Childhood diseases Treatment and control Antibiotics and acid suppressive therapy Vaccination Studies of cancer in humans Descriptive studies Geographical correlations Time trends Socioeconomic trends Case series Gastric carcinoma

6 CONTNTS Gastric lymphoma Cohort studies GastrIc carcinoma Gastric Iymphoma Case-control studies Gastric carcinoma Other cancers Intervention studies Studies of cancer in experimental animais Infection with Helicobacter pylori alone Infection with Helicobacter pylori in combination with administration of known carcinogens Infection with other Helicobacter species' Infection with other Helicobacter species in combination with administration of known carcinogens Other data relevant for evaluation of carcinogenicity and its mechanisms Pathology of infection Humans Experimental systems " Other observations relevant to the interpretation of carcinogenicity and mechanisms of carcinogenesis Humans Experimental systems Summary of data reported and evaluation Exposure data Human carcinogenicity data Animal carcinogenicity data Other relevant data Evaluation References SUMMARY OF FINAL EVALUATIONS CUMULATIVE INDEX TO THE MONOGRAPHS SERIES