From bio-guided to personalized oncology
|
|
|
- Samson Higgins
- 5 years ago
- Views:
Transcription
1 From bio-guided to personalized oncology Rafii A Département de chirurgie Gynécologique, université de montpellier Department of Genetic Medicine, WCMC
2 NO CONFLICT OF INTEREST
3 Personalized genomic based medicine Diagnostic THERAPEUTIQUE Breast and ovarian cancer: BRCA Colon Cancer: HNPCC Endometrial Cancer: Lynch Hormone receptor: SERM, anti-aromatase Her2 amplification and herceptin, KRAS in colorecta cancer: cetumximab, pamitumumab EGFR mutation or amplification in NSCLC: EGFR inhibitor BRAF in melanoma Bcr-abl: Glivec
4 Predictive Factors: Improving treatment choice Pronostic factors: Treating less patients
5 What informations do we obtain?
6 BIOLOGY Gene expressed by the tumor at a specific timepoint Chromosome abnormalities of the specimen biopsied The mutational profile of the tumor biopsied
7 Principle 1: The signaling pathways implicated in survival and progression are regulated by genomic, genetic and epigenetic alterations Driver vs passenger mutation Direct target Herceptin From Garraway L. JCO PARP Inhibitor Indirect target Melanoma Pancreas Ras Colon CDKN2A PI3K CDK inhibitor PI3K targeted From L Garraway
8 Principle 2: Agents targeting the common pathway disrupted in cancers are available In 2004: 11 targeted therapies from 4 categoriesenter clinical trials IN2012: 15 FDA approval, 150 are in trials For the first time biology matches therapeutics From L Garraway
9 Principle 3 : technology matches clinical timeframe FAST RUN In house computational biologists Ovary
10 70% of N- patients and 40 to 50% of N+ are cured by chemotherapy and radiation therapy. Most of them will recieve hormonal therapy or chemotherapy.
11 Breast cancer and genomic
12 Selected genes Estrogen Proliferation HER2 Invasion Others Refernce ER PR Bcl2 SCUBE2 Ki-67 STK15 Survivin Cyclin B1 MYBL2 GRB7 HER2 Stromelysin 3 Cathepsin L2 CD68 GSTM1 BAG1 Beta-actin GAPDH RPLPO GUS TFRC -BCL2 : antiapoptotique / induite par ER+ -Scube 2 : angiogénèse?invasion? -STK15 = Aurora A kinase, ser/thr K phase G2-> M -Survivin : anti apoptotique -Cyclin B: cycle -MYBL2 : FT interagit Rb, en amont cyclin A -GRB7 : prot adaptatrice domaine SH2 -Stromelysin MMProtéinase -Cathepsin L2 : protéinase -CD68 : fixation sélectine / Scavenger receptors -BAG1: proteosomal protein, apoptose? -Gluthathione-Stransferase Mu1 : métab/ détox housekeeping
13 Etude d impact décisionnel SWITCH Multicentric prospective trial Objectives: mesure the impact of Oncotype Dx on therapeutic decision sin patinents ER+, HER2- Gligorov et al, ASCO 2012.
14 Genetic profiling 46 years old women Past medical history of sarcoma at 24 Years Breast IDC, 2 CM, Classical approach Lumpectomy, sentinel node
15 Personalized approach Emergency sequencing Germline p53 mutation Bilateral mastectomy, sentinel node and Immediate reconstruction
16 When should we evaluate the familal risk? 3 or more breast cancers 1 breast cancer associated to I ovarian cancer 1 breast cancer ine a man Bilateral breast cancer or under 40 1 breast cancer< 35 ans or triple neg <50 or medullaire, 1 ovarian adenocarcinoma< 60 RPC St-Paul 2011
17 When should we evaluate the familail risk? Weird cases? 100+ Risque Cumulé (%) BRCA Cancer ovarien Sporadique+ Age MC King ASCO 2008
18
19 (*) Genome-wide association study : Etudes pan-génomique Breast cancer and genomic Situations Cliniques Présent Futur Risk/ early diagnostics Localized cancer BRCA 1, 2. Expression Prediciting response to therapy (Chemo) GWAS* Epigénomix Profiling Cell Free DNA NGS Advanced Cancer CTCs ctdna NGS characterization of tumor
20
21 Circos Plot P1, Difference Data Lymph node-ovary Lymph node-peritoneum
22 Why should I be interested by this? A" Genome"Targeted"A,"B,"C"," D."Z" A"Vs"B" A " B " C " Phase"1" Randomised"to" personalized"
23 Integration of clinical context Genomic analysis based on the clinical context Biology based contextualized treatment ICARE DYNACT Feedback system
Is Gene Expression Profiling the Best Method for Selecting Systemic Therapy in EBC? Norman Wolmark Miami March 8, 2013
Is Gene Expression Profiling the Best Method for Selecting Systemic Therapy in EBC? Norman Wolmark Miami March 8, 2013 Changing Phases claudin low Lum A Lum B Basal Her2 NIH Consensus Development Panel,
Rationale For & Design of TAILORx. Joseph A. Sparano, MD Albert Einstein College of Medicine Montefiore-Einstein Cancer Center Bronx, New York
Rationale For & Design of TAILORx Joseph A. Sparano, MD Albert Einstein College of Medicine Montefiore-Einstein Cancer Center Bronx, New York Declining Breast Cancer Mortality & Event Rates in Adjuvant
BREAST CANCER. Dawn Hershman, MD MS. Medicine and Epidemiology Co-Director, Breast Program HICCC Columbia University Medical Center.
BREAST CANCER Dawn Hershman, MD MS Florence Irving Assistant Professor of Medicine and Epidemiology Co-Director, Breast Program HICCC Columbia University Medical Center Background Breast cancer is the
Harmesh Naik, MD. Hope Cancer Clinic PERSONALIZED CANCER TREATMENT USING LATEST IN MOLECULAR BIOLOGY
Harmesh Naik, MD. Hope Cancer Clinic PERSONALIZED CANCER TREATMENT USING LATEST IN MOLECULAR BIOLOGY A NEW GENE A DAY.WHILE YOU ARE ENJOYING MORNING COFFEE From cancer.gov GOALS FOR THE CME TODAY A brief
Assessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint
Assessment of Risk Recurrence: Adjuvant Online, OncotypeDx & Mammaprint William J. Gradishar, MD Professor of Medicine Robert H. Lurie Comprehensive Cancer Center of Northwestern University Classical
Genomic Profiling of Tumors and Loco-Regional Recurrence
1 Genomic Profiling of Tumors and Loco-Regional Recurrence Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program UF Health Cancer Center at Orlando Health Professor of Surgery,
Molecular Characterization of Breast Cancer: The Clinical Significance
Molecular Characterization of : The Clinical Significance Shahla Masood, M.D. Professor and Chair Department of Pathology and Laboratory Medicine University of Florida College of Medicine-Jacksonville
8/8/2011. PONDERing the Need to TAILOR Adjuvant Chemotherapy in ER+ Node Positive Breast Cancer. Overview
Overview PONDERing the Need to TAILOR Adjuvant in ER+ Node Positive Breast Cancer Jennifer K. Litton, M.D. Assistant Professor The University of Texas M. D. Anderson Cancer Center Using multigene assay
She counts on your breast cancer expertise at the most vulnerable time of her life.
HOME She counts on your breast cancer expertise at the most vulnerable time of her life. Empowering the right treatment choice for better patient outcomes. The comprehensive genomic assay experts trust.
High False-Negative Rate of HER2 Quantitative Reverse Transcription Polymerase Chain Reaction of the Oncotype DX
High False-Negative Rate of HER2 Quantitative Reverse Transcription Polymerase Chain Reaction of the Oncotype DX Test: An Independent Quality Assurance Study DAVID J DABBS, MD Professor and Chief of Pathology
Seigo Nakamura,M.D.,Ph.D.
Seigo Nakamura,M.D.,Ph.D. Professor of Surgery Director of Breast Center Showa University Hospital Chairman of the board of directors Japan Breast Cancer Society Inhibition of Estrogen-Dependent Growth
The Latest Research: Hormonal Therapies
The Latest Research: Hormonal Therapies Sameer Gupta, M.D., M.P.H 9/29/2018 Attending Physician, Hematology/Oncology Bryn Mawr Hospital Clinical Assistant Professor, Jefferson Medical College Disclosures
Comparison of prognostic signatures for ER positive breast cancer in TransATAC:
Comparison of prognostic signatures for ER positive breast cancer in TransATAC: EndoPredict, a high performance test in node negative and node positive disease Ivana Sestak, PhD Centre for Cancer Prevention
The Oncotype DX Assay in the Contemporary Management of Invasive Early-stage Breast Cancer
The Oncotype DX Assay in the Contemporary Management of Invasive Early-stage Breast Cancer Cancer The Biology Century Understanding and treating the underlying tumor biology Cancer genetic studies demonstrate
Modern classification of breast cancer-should we stick with morphology or convert to molecular profiles?
Modern classification of breast cancer-should we stick with morphology or convert to molecular profiles? Ian Ellis Professor of Cancer Pathology Molecular Medical Sciences University of Nottingham Dept
The Oncotype DX Assay A Genomic Approach to Breast Cancer
The Oncotype DX Assay A Genomic Approach to Breast Cancer Pathology: 20 th and 21 st Century Size Age Phenotype Nodal status Protein/Gene Genomic Profiling Prognostic & Predictive Markers Used in Breast
Breast Cancer. Excess Estrogen Exposure. Alcohol use + Pytoestrogens? Abortion. Infertility treatment?
Breast Cancer Breast Cancer Excess Estrogen Exposure Nulliparity or late pregnancy + Early menarche + Late menopause + Cystic ovarian disease + External estrogens exposure + Breast Cancer Excess Estrogen
Harmesh Naik, MD. Hope Cancer Clinic
Harmesh Naik, MD. Hope Cancer Clinic A brief review of adjuvant therapy of breast cancer Summarize selected new developments in adjuvant therapy of breast cancer Discussion is limited to early stage breast
30 years of progress in cancer research
Breast Cancer Molecular Knowledge Integrated in Clinical Practice Personalized Medicine Laura J. Esserman UCSF Comprehensive Cancer Center Retreat Breast Cancer Management Advances 80-90s 1) Screening
Oncotype DX reveals the underlying biology that changes treatment decisions 37% of the time
Oncotype DX reveals the underlying biology that changes treatment decisions 37% of the time Even when treatment decisions based on traditional measures seem conclusive, Oncotype DX can lead to a different
TAILORx: Established and Potential Implications for Clinical Practice
TAILORx: Established and Potential Implications for Clinical Practice Joseph A. Sparano, MD Study Chair, TAILORx Vice-Chair, ECOG-ACRIN Cancer Research Group Hello Healthcare Summit Berlin, Germany March
So much has changed. Breast Cancer Update. Terri Cusick MD FACS
So much has changed. Breast Cancer Update Terri Cusick MD FACS Disclosure: Myriad Genetics Speakers Beaureau Biggest Changes Nipple sparing mastectomies Chemotherapy decisions based on tumor biology
CDx in oncology Prof. Christophe Le Tourneau, MD, PhD FEAM Geneva September 27, 2018
CDx in oncology Prof. Christophe Le Tourneau, MD, PhD Institut Curie Paris & Saint-Cloud France Head, Department of Drug Development and Innovation (D 3 i) INSERM U900 Research unit Versailles Saint-Quentin-en-Yvelines
Breast cancer classification: beyond the intrinsic molecular subtypes
Breast cancer classification: beyond the intrinsic molecular subtypes Britta Weigelt, PhD Signal Transduction Laboratory CRUK London Research Institute Summary Breast cancer heterogeneity Molecular classification
Presenter: Dr. Suman Rao May 13, 2016
Presenter: Dr. Suman Rao May 13, 2016 1 2010 Breast Cancer Estimates 207,090 NEW CASES 4% Melanoma of Skin 2% Thyroid 31% Breast 13% Lung & Bronchus 2% Pancreas 11% Colon & Rectum 4% Ovary 6% Uterus 3%
Recent advances in breast cancers
Recent advances in breast cancers Breast cancer is a hetrogenous disease due to distinct genetic alterations. Similar morphological subtypes show variation in clinical behaviour especially in response
Challenges of new discoveries of clinical applications into the management of cancer patients
Challenges of new discoveries of clinical applications into the management of cancer patients Tomáš Zima, Veronika Mikulová Institute of Clinical Biochemistry and Laboratory Diagnostics, General University
Morphological and Molecular Typing of breast Cancer
Morphological and Molecular Typing of breast Cancer Ian Ellis Molecular Medical Sciences, University of Nottingham Department of Histopathology, Nottingham University Hospitals NHS Trust Histological
THE 21-GENE RECURRENCE SCORE: BEATSON WEST OF SCOTLAND CANCER CENTRE EXPERIENCE. Dr Husam Marashi 03/02/2017
THE 21-GENE RECURRENCE SCORE: BEATSON WEST OF SCOTLAND CANCER CENTRE EXPERIENCE Dr Husam Marashi 03/02/2017 THE 21-GENE RECURRENCE SCORE: BEATSON WEST OF SCOTLAND CANCER TODAY S TALK: CENTRE EXPERIENCE
The Current Status and the Future Prospects of Multigene testing in Europe
The Current Status and the Future Prospects of Multigene testing in Europe Emiel J. Rutgers The Netherlands Cancer Institute Antoni Van Leeuwenhoek Hospital Amsterdam St. Gallen Recommendations 2009 =
Genomic platforms in breast cancer
Genomic platforms in breast cancer Prof. Miguel Martín Instituto de Investigación Sanitaria Hospital Gregorio Marañón Universidad Complutense Madrid mmartin@geicam.org Disclosure Dr. Martin has received
Carcinome du sein Biologie moléculaire. Thomas McKee Service de Pathologie Clinique Genève
Carcinome du sein Biologie moléculaire Thomas McKee Service de Pathologie Clinique Genève Pathology Diagnostic Prognostic information Predictive information The information provided depends on the available
Evolving Practices in Breast Cancer Management
Evolving Practices in Breast Cancer Management The Georgia Tumor Registrars Association 2016 Priscilla R. Strom, MD, FACS Objectives 1. understand newer indications for neoadjuvant treatment 2. understand
My Personalized Breast Cancer Worksheet
My Personalized Breast Cancer Worksheet KNOW For Early-Stage Breast Cancer. No Questions. Only Results. No two tumors are alike. What are the characteristics of your breast cancer and how will that effect
Current Status of Biomarkers (including DNA Tumor Markers and Immunohistochemistry in the Laboratory Diagnosis of Tumors)
Current Status of Biomarkers (including DNA Tumor Markers and Immunohistochemistry in the Laboratory Diagnosis of Tumors) Kael Mikesell, DO McKay-Dee Hospital May 14, 2015 Outline Update to DNA Testing
Advances in Breast Cancer
Advances in Breast Cancer Developed in collaboration Learning Objectives Upon completion, participants should be able to: Apply genomic medicine to treatment decisions for patients with HR+/HER2- early
Precision Genetic Testing in Cancer Treatment and Prognosis
Precision Genetic Testing in Cancer Treatment and Prognosis Deborah Cragun, PhD, MS, CGC Genetic Counseling Graduate Program Director University of South Florida Case #1 Diana is a 47 year old cancer patient
Breast Cancer Basics. Clinical Oncology for Public Health Professionals. Ben Ho Park, MD, PhD
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this
Breast Cancer Treatment
Breast Cancer Treatment Treatment 2 aspects 1. Treatment of the breast itself: Local Treatment 2. Treatment of the whole body = Systemic treatment Local Treatment Surgery +/- Radiation Usually: a. Breast
A Day in the Life of a Breast Cancer Doctor: Integrating Omics to Optimize Patient Outcomes. March 17-18, 2015 New York, NY
A Day in the Life of a Breast Cancer Doctor: Integrating Omics to Optimize Patient Outcomes March 17-18, 2015 New York, NY A Day in the Life of a Breast Cancer Doctor: Integrating Omics to Optimize Patient
What is the Oncotype DX test?
Patient & Family Guide 2018 What is the Oncotype DX test? www.nscancercare.ca What is the Oncotype DX test? Information for women diagnosed with early-stage breast cancer What is the Oncotype DX test?
GENOMIC TESTS FOR BREAST CANCER: FACT, MYTH, AND EVERYTHING IN BETWEEN
GENOMIC TESTS FOR BREAST CANCER: FACT, MYTH, AND EVERYTHING IN BETWEEN Adam Brufsky, MD, PhD Professor of Medicine Associate Chief, Hematology-Oncology Associate Director, Clinical Investigation University
Breast Cancer: Current Approaches to Diagnosis and Treatment
Breast Cancer: Current Approaches to Diagnosis and Treatment Barbara L. Smith, MD, Ph.D. Massachusetts General Hospital Division of Surgical Oncology No Disclosures Incidence of Breast Cancer USA 2018
Cancer Biomarkers, Clinical Trials, and New Treatment Options. Joseph A. Sparano, MD
Cancer Biomarkers, Clinical Trials, and New Treatment Options Joseph A. Sparano, MD Professor of Medicine & Women s s Health Albert Einstein College of Medicine Associate Chairman, Dept. of Medical Oncology
Breast Cancer. Dr. Andres Wiernik 2017
Breast Cancer Dr. Andres Wiernik 2017 Agenda: The Facts! (Epidemiology/Risk Factors) Biological Classification/Phenotypes of Breast Cancer Treatment approach Local Systemic Agenda: The Facts! (Epidemiology/Risk
Should novel molecular therapies replace old knowledge of clinical tumor biology?
Should novel molecular therapies replace old knowledge of clinical tumor biology? Danai Daliani, M.D. Director, 1 st Oncology Clinic Euroclinic of Athens Cancer Treatments Localized disease Surgery XRT
Quiz. b. 4 High grade c. 9 Unknown
Quiz 1. 10/11/12 CT scan abdomen/pelvis: Metastatic liver disease with probable primary colon malignancy. 10/17/12 Colonoscopy with polypectomy: Adenocarcinoma of sigmoid colon measuring at least 6 mm
Genomic Profiling in Early Stage Breast Cancer. James V. Pellicane, MD, FACS Director of Breast Oncology Bon Secours Cancer Institute Richmond, VA
Genomic Profiling in Early Stage Breast Cancer James V. Pellicane, MD, FACS Director of Breast Oncology Bon Secours Cancer Institute Richmond, VA 1 Disclosures Speakers Bureau Agendia Focal Therapeutics
Case Study Oncotype DX Breast Cancer Assay
Case Study Oncotype DX Breast Cancer Assay Steven Shak, MD Chief Medical Officer, Genomic Health IOM Workshop on the Review of Omics-Based Tests November 16, 2010 Trastuzumab For Herceptest Positive Breast
Intro to Cancer Therapeutics
An Intro to Cancer Therapeutics Christopher R. Chitambar, MD Professor of Medicine Division of Hematology & Oncology Froedtert and Medical College of Wisconsin Clinical Cancer Center cchitamb@mcw.edu Intro
Bradley M Turner MD, MPH, MHA. Assistant Professor University of Rochester Department of Pathology and Laboratory Medicine
Bradley M Turner MD, MPH, MHA Assistant Professor University of Rochester Department of Pathology and Laboratory Medicine My real job!!! I have nothing to disclose although Oncotype Dx year end revenues
Manejo do câncer de mama RH+ na adjuvância: o que há de novo?
II Simpósio Internacional de Câncer de Mama para o Oncologista Clínico Manejo do câncer de mama RH+ na adjuvância: o que há de novo? INGRID A. MAYER, MD, MSCI Assistant Professor of Medicine Director,
Kimberly Rohan ANP-BC, AOCN Nurse Practitioner Edward Cancer Center
Kimberly Rohan ANP-BC, AOCN Nurse Practitioner Edward Cancer Center Objective The nurse will be able to explain biomarkers and their implications to patient s prescribed treatment plan Biomarkers Use in
Breast Imaging: Multidisciplinary Approach. Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina
Breast Imaging: Multidisciplinary Approach Madelene Lewis, MD Assistant Professor Associate Program Director Medical University of South Carolina No Disclosures Objectives Discuss a multidisciplinary breast
Targeted Medicine and Molecular Therapeutics. Angus McIntyre, M.D. Medical Oncologist, Addison Gilbert Hospital and Beverly Hospital October 6, 2009
Targeted Medicine and Molecular Therapeutics Angus McIntyre, M.D. Medical Oncologist, Addison Gilbert Hospital and Beverly Hospital October 6, 2009 Approaches to Cancer Prevention Screening and early diagnosis
ISPOR 4 th Asia Pacific Conference IP2 Gilberto de Lima Lopes
Health Economic Considerations for Personalized Medicine in Asia: Using Genomic Profiling to Guide Treatment Decisions in Early Breast Cancer Gilberto de Lima Lopes, Jr., M.D., M.B.A Assistant Director
New Drug development and Personalized Therapy in The Era of Molecular Medicine
New Drug development and Personalized Therapy in The Era of Molecular Medicine Ramesh K. Ramanathan MD Virginia G. Piper Cancer Center Translational Genomics Research Institute Scottsdale, AZ Clinical
Adjuvant Systemic Therapy in Early Stage Breast Cancer
Adjuvant Systemic Therapy in Early Stage Breast Cancer Julie R. Gralow, M.D. Director, Breast Medical Oncology Jill Bennett Endowed Professor of Breast Cancer Professor, Global Health University of Washington
Breast Cancer Heterogeneity
Breast Cancer Heterogeneity Session 2: 8:15 AM 9:00 AM Molecular Subsets and Molecular Diagnostics in Breast Cancer ER + subtypes ER-negative subtypes Lisa A. Carey, MD University of North Carolina Lineberger
Breast Cancer Scanning the Horizon
Breast Cancer Scanning the Horizon Prof Fran Boyle BCNA Summit Sydney 2013 Feature Interview: Dr Fran Boyle :: Sunday Nights - ABC www.abc.net.au/sundaynights/stories/s1544975.htm Familial breast cancer
Adjuvant Systemic Therapy In Early Brest Cancer
Ductal Carcinoma In-situ and Early Breast Cancer Symposium With International Contributions Adjuvant Systemic Therapy In Early Brest Cancer Vicente Valero, M.D., F.A.C.P. Professor of Medicine and Deputy
A View to the Future: The Development of Targeted Therapy for Melanoma. Michael Davies, M.D., Ph.D.
A View to the Future: Science to Survivorship Symposium September 26, 2009 The Development of Targeted Therapy for Melanoma Michael Davies, M.D., Ph.D. Assistant Professor, Melanoma Medical Oncology How
SYSTEMIC THERAPY OPTIONS FOR BREAST CANCER IN 2014
SYSTEMIC THERAPY OPTIONS FOR BREAST Oncology Day 2014 CANCER IN 2014 Dr. Katherine Enright, M.D., M.P.H., F.R.C.P.(C) Katherine.enright@Trilliumhealthpartners.ca OBJECTIVES 1. Outline an approach to the
What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine
What is Cancer? Petra Ketterl, MD Medical Oncology and Functional Medicine What is Cancer? Layman s terms: cancer starts when cells grow out of control (in any place in the body) and crowd out normal cells
4/13/2010. Silverman, Buchanan Breast, 2003
Tailoring Breast Cancer Treatment: Has Personalized Medicine Arrived? Judith Luce, M.D. San Francisco General Hospital Avon Comprehensive Breast Care Center Outline First, treatment of DCIS Sorting risk
Systemic Treatment of Breast Cancer. Hormone Therapy and Chemotherapy, Curative and Palliative
Systemic Treatment of Breast Cancer Hormone Therapy and Chemotherapy, Curative and Palliative Systemic Therapy Invasive breast cancers Two forms Curative Palliative Curative Systemic Therapy Adjuvant Therapy
NSABP Pivotal Breast Cancer Clinical Trials: Historical Perspective, Recent Results and Future Directions
1 1 NSABP Pivotal Breast Cancer Clinical Trials: Historical Perspective, Recent Results and Future Directions Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program UF Health
Barriers to Understanding
Behind the Scenes: The Critical Importance of Cancer Cell Pathology and the Pathologist Sherry T. Emery, M.D., Chief of Pathology Northeast Health System Barriers to Understanding Questions for 2010 What
Hereditary Breast and Ovarian Cancer Rebecca Sutphen, MD, FACMG
Hereditary Breast and Ovarian Cancer 2015 Rebecca Sutphen, MD, FACMG Among a consecutive series of 11,159 women requesting BRCA testing over one year, 3874 responded to a mailed survey. Most respondents
Making Understanding Molecular Profiles Less Painful. Presenter Disclosure Information
Welcome to Master Class for Oncologists Miami, FL December 18, 2009 Session 1: 1:00 PM - 1:45 PM Towards Personalized Medicine in Breast Cancer: Understanding Molecular Subtypes and the Role of Diagnostics
Explaining Personalized Medicine in Cancer and Some Tips for a Healthier Life. Petra Ketterl, MD Integrative Medicine and Cancer Care
Explaining Personalized Medicine in Cancer and Some Tips for a Healthier Life Petra Ketterl, MD Integrative Medicine and Cancer Care Personalized Medicine in General A type of medical care in which treatment
Cancer Program Report 2014
Cancer Program Report 2014 Queen of the Valley Hospital St Joseph Health Queen of the Valley Hospital - 2014 Site Table Site Total Class Sex Group Cases Analytic NonAn M F 0 I II ALL SITES 661 494 167
The Intermountain Oncology Clinical Program: Present and Future
The Intermountain Oncology Clinical Program: Present and Future William T. Sause, MD Director of Radiation Oncology; Intermountain Healthcare; Murray, Utah Objectives: Define current status of the Cancer
Key Ouestions. to ask your medical oncology team after being diagnosed with breast cancer
Key Ouestions to ask your medical oncology team after being diagnosed with breast cancer tips to make your visit with the physician a success: Bring this list of questions, a pen and paper to write down
Clinical options for mutations of BRCA 1/2 genes. Ioannis Th. Natsiopoulos Breast surgeon
Clinical options for mutations of BRCA 1/2 genes Ioannis Th. Natsiopoulos Breast surgeon The detection of a BRCA mutation is not diagnosis of a disease; it is genetic information and risk assessment Indications
6/22/2017 TARGETING THE TARGETS IN 2017 TARGETING THE TARGETS IN 2017
TARGETING THE TARGETS IN 2017 Primary Care Focus Symposium July 1, 2017 Grace Wang MD I do not have any relevant financial relationships to disclose at this time TARGETING THE TARGETS IN 2017 What are
Contemporary Classification of Breast Cancer
Contemporary Classification of Breast Cancer Laura C. Collins, M.D. Vice Chair of Anatomic Pathology Professor of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School Boston, MA Outline
Evolution of Pathology
1 Traditional pathology Molecular pathology 2 Evolution of Pathology Gross Pathology Cellular Pathology Morphologic Pathology Molecular/Predictive Pathology Antonio Benivieni (1443-1502): First autopsy
The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer
The Neoadjuvant Model as a Translational Tool for Drug and Biomarker Development in Breast Cancer Laura Spring, MD Breast Medical Oncology Massachusetts General Hospital Primary Mentor: Dr. Aditya Bardia
Personalized Medicine: Lung Biopsy and Tumor
Personalized Medicine: Lung Biopsy and Tumor Mutation Testing Elizabeth H. Moore, MD Personalized Medicine: Lung Biopsy and Tumor Mutation Testing Genomic testing has resulted in a paradigm shift in the
WHAT IS A GENE? CHROMOSOME DNA PROTEIN. A gene is made up of DNA. It carries instructions to make proteins.
WHAT IS A GENE? CHROMOSOME E GEN DNA A gene is made up of DNA. It carries instructions to make proteins. The proteins have specific jobs that help your body work normally. PROTEIN 1 WHAT HAPPENS WHEN THERE
UK Interdisciplinary Breast Cancer Symposium. Should lobular phenotype be considered when deciding treatment? Michael J Kerin
UK Interdisciplinary Breast Cancer Symposium Should lobular phenotype be considered when deciding treatment? Michael J Kerin Professor of Surgery National University of Ireland, Galway and Galway University
Oncology 101. Cancer Basics
Oncology 101 Cancer Basics What Will You Learn? What is Cancer and How Does It Develop? Cancer Diagnosis and Staging Cancer Treatment What is Cancer? Cancer is a group of more than 100 different diseases
BRCA mutation carrier patient: How to manage?
BRCA mutation carrier patient: How to manage? Clinical Case Presentation Katarzyna Sosińska-Mielcarek Department of Oncology and Radiotherapy University Clinical Center Gdansk, Poland esmo.org DISCLOSURE
Educator Navigation Guide
Decoding Breast Cancer Virtual Lab Educator Navigation Guide Decoding Cancer Nav Guide 2 Introduction In this virtual lab, students test tissue samples from different patients with breast cancer in order
Andreas Wicki. University Hospital Basel Switzerland
Andreas Wicki University Hospital Basel Switzerland Disclosures Funding of research projects: Piqur Therapeutics Consultancy: Actelion Pharmaceuticals Predictive Biomarkers for Targeted Therapy in Oncology
Tumor Markers Yesterday, Today & Tomorrow. Steven E. Zimmerman M.D. Vice President & Chief Medical Director
Tumor Markers Yesterday, Today & Tomorrow Steven E. Zimmerman M.D. Vice President & Chief Medical Director Tumor Marker - Definition Substances produced by cancer cells or other cells in response to cancer
Breast Cancer Update 2018 The Latest in Diagnosis and Treatment SARATH K, PALAKODETI, DO, FAACS GENERAL, BREAST, AND COSMETIC SURGEON TOLEDO CLINIC
Breast Cancer Update 2018 The Latest in Diagnosis and Treatment SARATH K, PALAKODETI, DO, FAACS GENERAL, BREAST, AND COSMETIC SURGEON TOLEDO CLINIC Objectives Identify breast lesions and masses, and know
Development of Circulating Tumor DNA
Development of Circulating Tumor DNA Title of presentation Arial Bold 30pt in White Biomarkers Secondary title 22pt using Arial Next in White Generation Sequencing Brian Dougherty PhD, MBA Translational
Supplementary Tables. Supplementary Figures
Supplementary Files for Zehir, Benayed et al. Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients Supplementary Tables Supplementary Table 1: Sample
Breast Cancer: Who Gets It? Who Survives? The Latest Information
Breast Cancer: Who Gets It? Who Survives? The Latest Information James J. Stark, MD, FACP Medical Director, Cancer Program and Director of Palliative Care Maryview Medical Center Professor of Medicine
Breast cancer: Molecular STAGING classification and testing. Korourian A : AP,CP ; MD,PHD(Molecular medicine)
Breast cancer: Molecular STAGING classification and testing Korourian A : AP,CP ; MD,PHD(Molecular medicine) Breast Cancer Theory: Halsted Operative breast cancer is a local-regional disease The positive
Anaplastic A term used to describe cancer cells that divide rapidly and have little or no resemblance to normal cells.
Oncology Terminology A Adenocarcinoma A cancerous tumor that arises in or resembles glandular tissue. Adjunct agent In cancer therapy, a drug or substance used in addition to the primary therapy. Adjuvant
Genetic Panel Testing and Implications for Cancer Care
Genetic Panel Testing and Implications for Cancer Care Dana Zakalik, M.D. Nancy and James Grosfeld Cancer Genetics Center Professor, OUWB Medical School MCC Board of Directors Meeting September 28, 2016
Molecular biology of colorectal cancer
Molecular biology of colorectal cancer Phil Quirke Yorkshire Cancer Research Centenary Professor of Pathology University of Leeds, UK Rapid pace of molecular change Sequencing changes 2012 1,000 genomes
WHAT IS A GENE? CHROMOSOME DNA PROTEIN. A gene is made up of DNA. It carries instructions to make proteins.
WHAT IS A GENE? CHROMOSOME GENE DNA A gene is made up of DNA. It carries instructions to make proteins. The proteins have specific jobs that help your body work normally. PROTEIN 1 WHAT HAPPENS WHEN THERE
The Genetics of Breast and Ovarian Cancer Prof. Piri L. Welcsh
The Genetics of Breast Piri L. Welcsh, PhD Research Assistant Professor University of Washington School of Medicine Division of Medical Genetics 1 Genetics of cancer All cancers arise from genetic and
Treatment Options for Breast Cancer in Low- and Middle-Income Countries: Adjuvant and Metastatic Systemic Therapy
Women s Empowerment Cancer Advocacy Network (WE CAN) Conference Bucharest, Romania October 2015 Treatment Options for Breast Cancer in Low- and Middle-Income Countries: Adjuvant and Metastatic Systemic
Personalized Treatment of DCIS
Global Breast Cancer Conference 2016 [The Shilla Hotel, Jeju] Symposium 1 : DCIS - What s New? (14:40-15:50) Personalized Treatment of DCIS 2016. 4. 28. Breast Division, Department of Surgery Sungkyunkwan