Medical Science Is Tentative: The Role of Research

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1 Medical Science Is Tentative: The Role of Research Keith C. Norris, MD, PhD(c) Executive VP for Research and Health Affairs and Immediate President- Charles Drew University Assistant Dean for Translational Science - UCLA

2 What Do I Know For Certain? Do I really know what I think I know or have I just taken the beliefs and opinions of others? Adayashanti

3 Science has finally figured out a way to create life out of nothing God is sitting in Heaven when a scientist says to Him, "Lord, we don't need you anymore. Science has finally figured out a way to create life out of nothing. "Oh, is that so? Tell me...," replies God. "Well," says the scientist, "we can take dirt and form it into the likeness of You and breathe life into it, thus creating man. "God says, "Well, that's interesting. Show Me. "So the scientist bends down to the earth and starts to mold the soil. "Oh no, no, no...," interrupts God. "Get your own dirt."

4 Medical Science Is Tentative Uncertain Conditional Contingent on or dependent on other things

5 If we knew what we were doing, it wouldn't be called research. - Einstein

6 Why Research? Evaluate new approaches to improving health & health care systems To Improve the HEALTH of our Community

7 Definition: Health Health, from the Anglo-Saxon word hale meaning whole The English holy is based on the root whole? Health = Whole = Holy Condition of being sound in body, mind, or spirit

8 Medical Science Is Tentative BC) ( Considered the founder of medicine - author of the medical text, the Edwin Smith papyrus - contains anatomical observations, ailments, physical exams, treatments, and prognosis Hippocrates (460 BC- 370 BC) -referred to as the father of Western medicine -established medicine as a discipline and profession distinct from other fields Sir William Osler, M.D., ( ) -Possibly the greatest icon of modern medicine. - His text The Principles and Practice of Medicine focus on history & physical exam

9 It is much more important to know what sort of a patient has a disease, than what sort of disease a patient has. -William Osler

10 How Tentative Is Medical Science CPR: As Easy As A- B- C Cardiopulmonary Resuscitation: Easy As A- B- C Airway Breathing Circulation Research American Heart Association 2005 American Heart Association 2010

11 How Tentative Is Medical Science - Diabetes Research Research

12 Four humors of Hippocratic medicine: black bile, yellow bile, phlegm, and blood. Research 12 Blood letting Research Transfusion

13 The First Documented Case of Cancer The oldest documented case of cancer is from ancient Egypt (1500 bc). A papyrus documented 8 cases of tumors occurring on the breast. Hippocrates believed that an excess of black bile in any given site in the body caused cancer. This was the general thought of the cause of cancer for the next 1400 years. 13

14 Even Breast Cancer Screening is Tentative U.S. Preventive Services Task Force mammogram not needed until age 50 (Nov 2009) Two recent studies showed screening for Breast Cancer at age 40 reduces mortality by 10-26%. (September 2010) Hellquist BN, et al. Effectiveness of population-based service screening with mammography for women ages 40 to 49 years: evaluation of the Swedish Mammography Screening in Young Women (SCRY) cohort. Cancer Sep 29. [Epub ahead of print] The impact of a national program to provide free mammograms to low-income, uninsured women on breast cancer mortality rates.howard 14 DH, Ekwueme DU, Gardner JG, Tangka FK, Li C, Miller JW.Cancer Oct 1;116(19):

15 Medical Science Is Tentative Uncertain Conditional Contingent (on or upon) Dependent The Field of Cancer is also Tentative Art or Practice Science Research

16 What is Research? Any systematic investigation, including research development, testing and evaluation, designed to develop or contribute to knowledge. Search and search again re-search

17 Common Types of Research Quality of Life Screening Prevention Treatment Observational many people are not aware of this Interventional

18 Examples of Results from Different Types of Research? Seatbelts Parachutes Penicillin Aspirin Cancer Prevention Cancer Treatments

19 Summary Medical Science Is Tentative Life Is Tentative Research helps to make it less tentative Research help us understand Cancer

20 Thank You Cancer Specialists Community Leaders Cancer Patients and Their Families

21 When you have exhausted all possibilities, Remember this you haven't. - Author Unknown

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