From micro GIST to GIST: How can it happen? (Why doesn t it happen?)
|
|
- Chastity Harvey
- 6 years ago
- Views:
Transcription
1 Brigham and Women s Hospital, Harvard Medical School From micro GIST to GIST: How can it happen? (Why doesn t it happen?) Jonathan A. Fletcher, M.D. Dept of Pathology Brigham and Women s Hospital Dana-Farber Cancer Institute Boston Dana-Farber/Harvard Cancer Center
2 microgist (<1cm) Found in 30% of the general population EG junction, spindle cell type Dr. Cher-Wei Liang
3 Why Study MicroGIST??? One of the most common benign tumors Only common benign tumor that results from TK genomic mutation Define events responsible for progression from TK-mutant ICC hyperplasia to microgist from microgist to clinical GIST Characterize barriers to malignant progression
4 P FAK PAK1 P Adhesion, motility GRB2 P SOS SHC Oncogenic KIT/PDGFRA DOK RAS-GAP P PI3K P JAK P RAS-GDP RAS-GTP AKT P STATs P P SAPK P MAPK P MEK1/2 BCLX L RAF BCLX L mtor BAD P P BAD ETV1 Mitochondria
5 Mutation Status in Small (<2cm) vs. Clinically-overt GISTs Genotype Small GISTs (N = 135) Overt GISTs (N = 101) P value Mutant 74% 84% KIT exon 11 46% 61% Drs. Sabrina Rossi, Roberta Maestro, Paolo dei Tos, AJSP, 2010
6 Relevant Risk Parameters for Primary GIST Including Molecular Data Parameters Lower risk Higher risk Surgery R0 R1, rupture Location Stomach Size < 5 cm > 5 cm Mitotic count < 5/50 HPFs > 5/50 HPFs Small bowel, rectal or other location Mutated gene KIT mutational type PDGFRA Duplication/ Insertion in exon 11 KIT Wildtype (non-pdgfr, non-kit) Deletion in exon 11 (esp. in codons W557 and K558); Duplication/insertion in exon 9 Wardelmann et al., Virchows Archiv 2007
7 Worrisome KIT mutations in benign microgists Exon 9 (4mm) Ex 11 del (3mm) Ex 11 homozygous (3mm) Dr. Cher-wei Liang
8 acgh Microdissect ion of tumor tissue WGA x 4 times Pool Cohybridization Result Microdissecti on of normal tissue WGA x 4 times Pool Cohybridization Cher-Wei Liang, MD
9 MicroGIST Genome Screen DELETIONS 1p 14q 22 GIST Genetic Progression KIT or PDGFRA mutation 14 22q 1p
10 FISH evaluation of chr 14 deletion in viable vs. hyalinized regions of microgists (N = 11) Cellular region Hyalinized region Chr 14 deletion evaluated in 200 cells from 11 microgists 5 of 11 microgists (45%) had chr 14 deletion present equally in cellular and hyalinized components
11 Pseudo-amplification of Biologically Crucial GIST Genes DOG1(ANO1, TMEM16A): RS 0.52 Cher-Wei Liang, MD
12
13 DOG1 Pseudo-amplification: exonic and intronic Courtesy of Cher-Wei Liang, MD
14 MicroGISTs and clinical GISTs share gene expression biomarkers Top 30 active-transcription regions in microgists Top 30 Neighbors Top 30 Genes Clinical GIST Non-GIST Sarcomas IGF2 (0.78), DOG1 (0.52), CD34 (0.50), SPRY4 (0.45), KIT (0.32), PRKCQ (0.27), PROM1 (0.29), ETV1 (0.24)
15 Despite KIT & PDGFRA mutations, and GIST biology : MicroGISTs struggle to grow B Calcification Hyalinization Dr. Cher-wei Liang
16 KIT exon 11 deletions in clinical GISTs vs. microgists Distribution of KIT E11 Deletion, clinical GISTs J Lasota & M Miettinen, Histopathology 2008 Distribution of KIT exon 11 deletion in 110 microgists (30, reference) collected from 6 series. CL Corless et al., AJP 2002 K Kawanowa et al., Hum P 2006 A Agaimy et al., AJSP 2007 A Agaimy et al., AJSP 2008 S Rossi et al., AJSP 2010 Distribution of KIT Ex11 deletions, microgists (34 cases from present series, and 76 cases from previously published series)
17 MicroGIST Mutations Expressed in KIT-negative GIST48B SCF (KIT-LG) dose response Cher-wei Liang
18 MicroGIST Mutations Expressed in KIT-negative GIST48B SCF (KIT-LG) dose response Cher-wei Liang
19 MicroGIST Mutations Expressed in KIT-negative GIST48B SCF (KIT-LG) dose response Cher-wei Liang
20 MicroGIST Mutations Expressed in KIT-negative GIST48B SCF (KIT-LG) dose response Cher-wei Liang
21 MicroGIST Mutations Expressed in KIT-negative GIST48B SCF (KIT-LG) time response Cher-wei Liang
22 KIT-ligand (SCF): strong expression in smooth muscle; weakto-no expression in microgist Green: Desmin Red: SCF Blue: DAPI
23
24 Dr. Jason Hornick MicroGISTs have infiltrative borders (90.7%) and smooth muscle markers (49%) RED = Desmin Brown = DOG1 GREEN = Desmin RED = DOG1 BLUE = DAPI
25 Dr. Cher-Wei Liang Some microgists are smooth muscledependent tumors
26 Cell cycle dysregulation in GIST Low-risk GIST (N = 16) TP53 MDM2 CDKN2A RB1 ATM None %mut % High-risk GIST (N = 24) TP53 MDM2 CDKN2A RB1 ATM None %mut %
27 Conclusions #1 MicroGISTs are on a biologic continuum with malignant GISTs But, they virtually never progress to malignancy And, they very often involute Certain KIT & PDGFRA mutations cannot sustain malignant progression
28 Conclusions #2 Progression from microgist to clinical problem Ligand-independence or autocrine/paracrine Further cell cycle dysregulation Other genetic hits (14q, 22q, 1p..)
29 Acknowledgements Brigham and Women s Hospital Department of Pathology Cher-wei Liang Yuexiang Wang Adrián Mariño Enríquez Stephen Swank Meijun Zhu Cheng-Han Lee Christopher D.M. Fletcher Jason Hornick Division of Surgical Oncology Chandrajit P. Raut Dana Farber Sarcoma Program George D. Demetri Andrew Wagner Memorial Sloan Kettering Cancer Center Cristina Antonescu Virginia and Daniel K.Ludwig Trust for Cancer Research, GIST Cancer Research Fund, The LifeRaft Group, National Institutes of Health (1P50CA127003). Treviso Angelo Paolo dei Tos Sabrina Rossi Aviano Roberta Maestro
Dystrophin Is a Tumor Suppressor in Human Cancers with Myogenic Programs
SUPPLEMENTARY INFORMATION Dystrophin Is a Tumor Suppressor in Human Cancers with Myogenic Programs Yuexiang Wang 1, Adrian Marino-Enriquez 1, Richard R. Bennett 2, Meijun Zhu 1, Yiping Shen 3,4, Grant
More informationOverview of New Drugs for GIST following resistance to standard TKIs (imatinib and sunitinib)
Overview of New Drugs for GIST following resistance to standard TKIs (imatinib and sunitinib) George D. Demetri, M.D. Center for Sarcoma and Bone Oncology Dana-Farber Cancer Institute Harvard Medical School
More informationNuevos avances en el tratamiento de los GIST
Nuevos avances en el tratamiento de los GIST Dr Javier Martin Broto Oncología Médica HospitalSon Espases Palma de Mallorca www.cotmes.com AGENDA Enfermedad localizada SSG AIO Enfermedad diseminada Sorafenib
More informationSupplementary Online Content
Supplementary Online Content Joensuu H, Wardelmann E, Sihto H, et al. Effect of KIT and PDGFRA mutations on survival in patients with gastrointestinal stromal tumors treated with adjuvant imatinib: an
More informationDisclosures 3/27/2017. Case 5. Clinical History. Disclosure of Relevant Financial Relationships
Hereditary Cancer Predisposition in Children Case 5 Cristina R. Antonescu, MD Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence
More informationGlivec en KIT: immuunhistochemie en mutatie analyse in gastro-intestinale stromacel tumoren. Judith V.M.G. Bovee Patholoog LUMC
Glivec en KIT: immuunhistochemie en mutatie analyse in gastro-intestinale stromacel tumoren Judith V.M.G. Bovee Patholoog LUMC Case 60 year old female Pain and discomfort upper abdomen MRI: tumor small
More informationC) The graph should look exactly like the graph on the left (Mut1 cells + Mating Pheromone for 3 hours at 25 degrees). The cells arrest in G1.
706-2000-Exam 4 Answer Key 1) The question asks you to explain peaks A and B in the top graph. The other two graphs were there to give you hints. The question did not ask for these other two graphs to
More informationMonday, 5 February 2018
Educational sessions for Junior audience Monday, 5 February 2018 09:30-11:00 Session 1 The diseases Chairs: Paolo. G Casali, IT; Paula Collini, IT 25 The natural history of STS & GIST Paolo. G Casali,
More informationInternational Journal of Scientific & Engineering Research, Volume 7, Issue 5, May ISSN Case Report Rare Case Of Small Bowel GIST
International Journal of Scientific & Engineering Research, Volume 7, Issue 5, May-2016 282 Case Report Rare Case Of Small Bowel GIST Shahaji G. Chavan, Sagar R. Ambre, Vinayak kshirsagar, Ashish Vashistha
More informationRESEARCH COMMUNICATION. Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology
DOI:http://dx.doi.org/10.7314/APJCP.2012.13.4.1389 RESEARCH COMMUNICATION Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology Xiu-Wei Sun & *,
More informationGastrointestinal stromal tumor with KIT mutation in neurofibromatosis type 1
J Korean Surg Soc 2011;81:276-280 http://dx.doi.org/10.4174/jkss.2011.81.4.276 CASE REPORT JKSS Journal of the Korean Surgical Society pissn 2233-7903 ㆍ eissn 2093-0488 Gastrointestinal stromal tumor with
More informationTemplate for Reporting Results of Biomarker Testing of Specimens From Patients With Gastrointestinal Stromal Tumors
Template for Reporting Results of Biomarker Testing of Specimens From Patients With Gastrointestinal Stromal Tumors Template web posting date: February 2015 Authors Meera Hameed, MD, FCAP Department of
More informationAffiliazione autori0. Riccardo Ricci Journal Club GIPAD, settore GIST Anatomia Patologica, Università Cattolica, Roma
GIST Manifesting as a Retroperitoneal Tumor: Clinicopathologic Immunohistochemical, and Molecular Genetic Study of 112 Cases American Journal of Surgical Pathology, 2017, 41:577-585 Miettinen M*; Felisiak-Golabek
More informationA) PUBLIC HEALTH B) PRESENTATION & DIAGNOSIS
GIST (Gastrointestinal stromal tumor) Updated MARCH 2017 by Dr. Doreen Ezeife, PGY-5 Resident, University of Calgary Reviewed by Dr. Jan-Willem Henning (Staff Medical Oncologist, University of Calgary)
More informationEvaluating and Reporting Gastrointestinal Stromal Tumors after Imatinib Mesylate Treatment
The Open Pathology Journal, 2009, 3, 53-57 53 Open Access Evaluating and Reporting Gastrointestinal Stromal Tumors after Imatinib Mesylate Treatment Katie L. Dennis * and Ivan Damjanov Department of Pathology
More informationSarcoma. Suzanne George, MD Dana-Farber/Brigham and Women s Cancer Center. Chandrajit P. Raut, MD, MSc Dana-Farber/Brigham and Women s Cancer Center
Sarcoma Suzanne George, MD Dana-Farber/Brigham and Women s Cancer Center Chandrajit P. Raut, MD, MSc Dana-Farber/Brigham and Women s Cancer Center July 21, 2016 Moderated by Shannon K. Ryan Conferences
More informationThe Genetics of Myoepithelial Tumors: salivary glands, soft tissue and bone
The Genetics of Myoepithelial Tumors: salivary glands, soft tissue and bone Cristina Antonescu, MD Memorial Sloan-Kettering Cancer Center, New York Nothing to declare Disclosure Spectrum of Myoepithelial
More informationMesenchymal neoplasms of the gastrointestinal tract what s new? Newton ACS Wong Department of Histopathology Bristol Royal Infirmary
Mesenchymal neoplasms of the gastrointestinal tract what s new? Newton ACS Wong Department of Histopathology Bristol Royal Infirmary Talk plan Summary from 2010 talk. What s happened since 2010. GISTs
More informationPathology of GIST and GIST mimics. Eva Wardelmann, Institute of Pathology, University Hospital Cologne, Germany
Pathology of GIST and GIST mimics Eva Wardelmann, Institute of Pathology, University Hospital Cologne, Germany Disclosure slide Honoraria, research and travel grants from Novartis Oncology Advisory Boards
More informationAbstract. Anatomic Pathology / c-kit and PDGFRA Mutations
Anatomic Pathology / c-kit and PDGFRA Mutations Detection of c-kit and PDGFRA Gene Mutations in Gastrointestinal Stromal Tumors Comparison of DHPLC and DNA Sequencing Methods Using a Single Population-Based
More informationLong Term Results in GIST Treatment
Long Term Results in GIST Treatment Dr. Laurentia Gales Prof. Dr. Rodica Anghel, Dr. Xenia Bacinschi Institute of Oncology Prof Dr Al Trestioreanu Bucharest 25 th RSRMO October 15-17 Sibiu Background Gastrointestinal
More informationACCME/Disclosures ALK FUSION-POSITIVE MESENCHYMAL TUMORS. Tumor types with ALK rearrangements. Anaplastic Lymphoma Kinase. Jason L.
Companion Meeting of the International Society of Bone and Soft Tissue Pathology The Evolving Concept of Mesenchymal Tumors ALK FUSION-POSITIVE MESENCHYMAL TUMORS Jason L. Hornick, MD, PhD March 13, 2016
More informationNext Generation Sequencing in Clinical Practice: Impact on Therapeutic Decision Making
Next Generation Sequencing in Clinical Practice: Impact on Therapeutic Decision Making November 20, 2014 Capturing Value in Next Generation Sequencing Symposium Douglas Johnson MD, MSCI Vanderbilt-Ingram
More informationCase: The patient is a 24 year- old female who was found to have multiple mural nodules within the antrum. Solid and cystic components were noted on
Case: The patient is a 24 year- old female who was found to have multiple mural nodules within the antrum. Solid and cystic components were noted on imaging. There is no significant past medical history.
More informationLate recurrences of gastrointestinal stromal tumours (GISTs) after 5 years of follow-up
DOI 10.1007/s12032-010-9806-7 ORIGINAL PAPER Late recurrences of gastrointestinal stromal tumours (GISTs) after 5 years of follow-up Margherita Nannini Guido Biasco Maria Caterina Pallotti Monica Di Battista
More informationDevelopments in small cell lung cancer G. Giaccone, MD PhD Chief, Medical Oncology Branch and Affiliates National Cancer Institute Bethesda MD USA
Developments in small cell lung cancer G. Giaccone, MD PhD Chief, Medical Oncology Branch and Affiliates National Cancer Institute Bethesda MD USA Geneva April 20, 2012 Neuroendocrine tumors of lung Typical
More informationUnderstanding Your GIST Pathology Report
Gastrointestinal Stromal Tumor Understanding Your GIST Pathology Report Jason L. Hornick, MD PhD Harvard Medical School Brigham and Women's Hospital Alexander J.F. Lazar, MD PhD Sarcoma Research Center
More informationClinicopathologic Spectrum of Gastrointestinal Stromal Tumours; Six Years Experience at King Hussein Medical Center
Clinicopathologic Spectrum of Gastrointestinal Stromal Tumours; Six Years Experience at King Hussein Medical Center Sahem T. Alqusous MD*, Osama J. Rabadi MD, MRCS*, Ala D. Al Omari MD*, Nabeeha N.Abbasi
More informationLooking Beyond the Standard-of- Care : The Clinical Trial Option
1 Looking Beyond the Standard-of- Care : The Clinical Trial Option Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program UF Health Cancer Center at Orlando Health Professor
More informationGastrointestinal Stromal Tumor Causes, Risk Factors, and Prevention
Gastrointestinal Stromal Tumor Causes, Risk Factors, and Prevention Risk Factors A risk factor is anything that affects your chance of getting a disease such as cancer. Learn more about the risk factors
More informationTherapeutic strategies for wild-type gastrointestinal stromal tumor: is it different from KIT or PDGFRA-mutated GISTs?
Editorial Therapeutic strategies for wild-type gastrointestinal stromal tumor: is it different from KIT or PDGFRA-mutated GISTs? Toshirou Nishida Department of Surgery, National Cancer Center Hospital,
More informationBiomarkers of Response to EGFR-TKIs EORTC-NCI-ASCO Meeting on Molecular Markers in Cancer November 17, 2007
Biomarkers of Response to EGFR-TKIs EORTC-NCI-ASCO Meeting on Molecular Markers in Cancer November 17, 2007 Bruce E. Johnson, MD Dana-Farber Cancer Institute, Brigham and Women s Hospital, and Harvard
More informationSignaling. Dr. Sujata Persad Katz Group Centre for Pharmacy & Health research
Signaling Dr. Sujata Persad 3-020 Katz Group Centre for Pharmacy & Health research E-mail:sujata.persad@ualberta.ca 1 Growth Factor Receptors and Other Signaling Pathways What we will cover today: How
More informationMolecular characterization and pathogenesis of gastrointestinal stromal tumor
Review Article Molecular characterization and pathogenesis of gastrointestinal stromal tumor Takeshi Niinuma 1, Hiromu Suzuki 1, Tamotsu Sugai 2 1 Department of Molecular Biology, Sapporo Medical University
More informationAvapritinib is Highly Active and Well-tolerated in Patients With Advanced GIST Driven by a Diverse Variety of Oncogenic Mutations in KIT and PDGFRA
Avapritinib is Highly Active and Well-tolerated in Patients With Advanced GIST Driven by a Diverse Variety of Oncogenic Mutations in KIT and PDGFRA Michael Heinrich, Margaret von Mehren, Robin L. Jones,
More informationC-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach
pissn : 2093-582X, eissn : 2093-5641 J Gastric Cancer 2015;15(4):290-294 http://dx.doi.org/10.5230/jgc.2015.15.4.290 Case Report C-Kit-Negative Gastrointestinal Stromal Tumor in the Stomach Ho Seok Seo,
More informationCENTRAL LABORATORY SERVICES
CENTRAL LABORATORY SERVICES Bridging the Gaps in Biomarker Development and Testing for Global Clinical Trials Biomarkers, Digital Pathology & the Central Lab Presentation Title Presenter Name July 16,
More informationA 9cm mass was excised from the jejunal wall and mesentery of a 33 year old woman.
A Few Observations on Gastrointestinal Stromal Tumors and Their Differential Diagnosis E. Montgomery A 9cm mass was excised from the jejunal wall and mesentery of a 33 year old woman. 1 2 3 CD117/c-kit
More informationJY Blay. New horizons 2011
Prevention of GIST resistance JY Blay Medical Oncology Chairman of the Soft Tissue and Bone Sarcoma Group of EORTC Chairman of the CONTICANET Network of Excellence 6th Framework Program of the European
More informationThe mutations that drive cancer. Paul Edwards. Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge
The mutations that drive cancer Paul Edwards Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge Previously on Cancer... hereditary predisposition Normal Cell Slightly
More informationEnzyme-coupled Receptors. Cell-surface receptors 1. Ion-channel-coupled receptors 2. G-protein-coupled receptors 3. Enzyme-coupled receptors
Enzyme-coupled Receptors Cell-surface receptors 1. Ion-channel-coupled receptors 2. G-protein-coupled receptors 3. Enzyme-coupled receptors Cell-surface receptors allow a flow of ions across the plasma
More informationChanging demographics of smoking and its effects during therapy
Changing demographics of smoking and its effects during therapy Egbert F. Smit MD PhD. Dept. Pulmonary Diseases, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands Smoking prevalence adults
More informationCancer and Oncogenes Bioscience in the 21 st Century. Linda Lowe-Krentz
Cancer and Oncogenes Bioscience in the 21 st Century Linda Lowe-Krentz December 1, 2010 Just a Few Numbers Becoming Cancer Genetic Defects Drugs Our friends and family 25 More mutations as 20 you get older
More informationCase Study - Informatics
bd@jubilantbiosys.com Case Study - Informatics www.jubilantbiosys.com Validating as a Prognostic marker and Therapeutic Target for Multiple Cancers Introduction Human genome projects and high throughput
More informationEXAMPLE. - Potentially responsive to PI3K/mTOR and MEK combination therapy or mtor/mek and PKC combination therapy. ratio (%)
Dr Kate Goodhealth Goodhealth Medical Clinic 123 Address Road SUBURBTOWN NSW 2000 Melanie Citizen Referring Doctor Your ref Address Dr John Medico 123 Main Street, SUBURBTOWN NSW 2000 Phone 02 9999 9999
More informationThe Clinical Approach to Wild Type GIST. Margaret von Mehren, MD Professor and Director of Sarcoma Oncology Fox Chase Cancer Center
The Clinical Approach to Wild Type GIST Margaret von Mehren, MD Professor and Director of Sarcoma Oncology Fox Chase Cancer Center Disclosure slide Scientific Advisor to Novartis, Pfizer, Merck Research
More informationKIT Inhibition in Advanced Melanoma: Rationale and Clinical i l Results
KIT Inhibition in Advanced Melanoma: Rationale and Clinical i l Results Richard D. Carvajal, M.D. Assistant Attending Physician Melanoma/Sarcoma Service Memorial Sloan-Kettering Cancer Center Disclosures
More informationEditorial The Significance of KIT (CD117) in Gastrointestinal Stromal Tumors
International Journal of Surgical Pathology 12(2):93 97, 2004 Editorial The Significance of KIT (CD117) in Gastrointestinal Stromal Tumors Jason L. Hornick, MD, PhD, and Christopher D. M. Fletcher, MD,
More informationKRAS: ONE ACTOR, MANY POTENTIAL ROLES IN DIAGNOSIS
UNIVERSITÀ DEGLI STUDI DI PALERMO Scuola di Specializzazione in Biochimica Clinica Direttore Prof. Marcello Ciaccio KRAS: ONE ACTOR, MANY POTENTIAL ROLES IN DIAGNOSIS Loredana Bruno KRAS gene Proto-oncogene
More informationThe Life Raft Group. Building Strategic Alliances
The Life Raft Group Building Strategic Alliances The Life Raft Group Our Mission Is Survival Keeping GIST Patients Alive By Ensuring That no one dies because they cannot access treatment That no one dies
More informationNature Medicine: doi: /nm.3559
Supplementary Note 1. A sample alteration report. Each alteration nominated by PHIAL is curated to answer specific fields that are intended to guide physician interpretation. Gene Alteration Patient ID
More informationMorphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment
The Korean Journal of Pathology 2009; 43: 368-73 DOI: 10.4132/KoreanJPathol.2009.43.4.368 Morphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment - Two Cases Report
More informationProtocol for the Examination of Specimens From Patients With Gastrointestinal Stromal Tumor (GIST)
Protocol for the Examination of Specimens From Patients With Gastrointestinal Stromal Tumor (GIST) Based on AJCC/UICC TNM, 7 th edition Protocol web posting date: December 2014 Procedures Biopsy Resection
More informationCase Report Massive Intra-Abdominal Imatinib-Resistant Gastrointestinal Stromal Tumor in a 21-Year-Old Male
Case Reports in Medicine Volume 2013, Article ID 373981, 5 pages http://dx.doi.org/10.1155/2013/373981 Case Report Massive Intra-Abdominal Imatinib-Resistant Gastrointestinal Stromal Tumor in a 21-Year-Old
More informationBest of ASCO 2014 Sarcoma
Best of ASCO 2014 Sarcoma Robin L Jones Seattle Cancer Care Alliance University of Washington Fred Hutchinson Cancer Research Center Presentation Outline Overview progress made in sarcoma Highlight 2 trials
More informationTitle: KIT codon 558 insertions in gastrointestinal stromal tumors (GISTs). Analysis of 17 rare KIT mutants.*
Elsevier Editorial System(tm) for Human Pathology Manuscript Draft Manuscript Number: YHUPA-D-07-00544R1 Title: KIT codon 558 insertions in gastrointestinal stromal tumors (GISTs). Analysis of 17 rare
More informationGenomic analysis of childhood High grade glial (HGG) brain tumors
Genomic analysis of childhood High grade glial (HGG) brain tumors Linda D Cooley Children s Mercy, Kansas City The Children s Mercy Hospital, 2017 Genomic analysis of childhood High grade glial (HGG) brain
More informationSubepithelial Lesions of the Gut: When Should I Worry?
Subepithelial Lesions of the Gut: When Should I Worry? President, ASGE Chairman, GI & Hepatology Scottsdale, AZ Faigel.douglas@mayo.edu Case 55 yo male with reflux EGD for Barrett s Screening SET, mucosal
More informationUpdate on new agents in Gastrointestinal Tumor (GIST)
Update on new agents in Gastrointestinal Tumor (GIST) Albiruni R Abdul Razak Medical Oncology Sarcoma Site Lead Princess Margaret Cancer Centre/Mount Sinai Hospital 21 st October 2017 1 Disclosure Research
More informationUNIVERSITY OF TORINO DEPARTMENT OF ONCOLOGY. Giorgio V. Scagliotti University of Torino Dipartment of Oncology
Giorgio V. Scagliotti University of Torino Dipartment of Oncology giorgio.scagliotti@unito.it Molecular landscape of MM not fully characterized to allow personalized treatment Recurrent genetic alterations
More informationDisclosure of Relevant Financial Relationships
Surgical Pathology Companion Meeting Case 5: Locally Recurrent Chest wall Mass Cristina Antonescu, MD Department of Pathology, Memorial Sloan Kettering Cancer Center Disclosure of Relevant Financial Relationships
More informationOncogenes and Tumor. supressors
Oncogenes and Tumor supressors From history to therapeutics Serge ROCHE Neoplastic transformation TUMOR SURESSOR ONCOGENE ONCOGENES History 1911 1960 1980 2001 Transforming retrovirus RSV v-src is an oncogene
More informationNET and GIST Molecular and Ancillary Studies
NET and GIST Molecular and Ancillary Studies Dr Gill has no conflicts of interest to disclose Anthony Gill MD FRCPA Pathologist PaLMS, Royal North Shore Hospital & Professor of Surgical Pathology University
More informationProtein tyrosine kinase signaling
rotein tyrosine kinase signaling Serge ROCHE CRBM CNRS/Montpellier University serge.roche@crbm.cnrs.fr rotein phosphorylation on Tyr A central mechanism to control cell communication in a multicellular
More informationCase Report Unusual Appearance of a Pendulated Gastric Tumor: Always Think of GIST
Case Reports in Surgery Volume 2012, Article ID 815941, 4 pages doi:10.1155/2012/815941 Case Report Unusual Appearance of a Pendulated Gastric Tumor: Always Think of GIST Kristel De Vogelaere, 1 Vanessa
More informationNEW FRONTIERS IN THE BIOLOGY OF LUNG CANCER: WHAT INFLUENCES DIAGNOSIS AND THERAPY?
NEW FRONTIERS IN THE BIOLOGY OF LUNG CANCER: WHAT INFLUENCES DIAGNOSIS AND THERAPY? STEVEN M. DUBINETT, MD CHIEF OF THE DIVISION OF PULMONARY AND CRITICAL CARE MEDICINE DIRECTOR, UCLA LUNG CANCER PROGRAM
More informationCorrelation of Imatinib Resistance with the Mutational Status of KIT and PDGFRA Genes in Gastrointestinal Stromal Tumors: a Meta-analysis
ORIGINAL PAPER Correlation of Imatinib Resistance with the Mutational Status of KIT and PDGFRA Genes in Gastrointestinal Stromal Tumors: a Meta-analysis Ju Han Lee,* Younghye Kim,* Jung Woo Choi, Young
More informationGenomic Medicine: What every pathologist needs to know
Genomic Medicine: What every pathologist needs to know Stephen P. Ethier, Ph.D. Professor, Department of Pathology and Laboratory Medicine, MUSC Director, MUSC Center for Genomic Medicine Genomics and
More informationA giant primary omental extragastrointestinal tumor: A case report
Mir et al. 1 CASE REPORT PEER REVIEWED OPEN ACCESS A giant primary omental extragastrointestinal tumor: A case report Ruquaya Mir, Vikram P. Singh, Sumaid Kaul ABSTRACT Extragastrointestinal stromal tumor
More informationWhole Genome and Transcriptome Analysis of Anaplastic Meningioma. Patrick Tarpey Cancer Genome Project Wellcome Trust Sanger Institute
Whole Genome and Transcriptome Analysis of Anaplastic Meningioma Patrick Tarpey Cancer Genome Project Wellcome Trust Sanger Institute Outline Anaplastic meningioma compared to other cancers Whole genomes
More informationClinical Trials. Phase II Studies. Connective Tissue Oncology Society. Jon Trent, MD, PhD
Clinical Trials Phase II Studies Jon Trent, MD, PhD Associate Professor Dept. of Sarcoma Medical Oncology The University of Texas, M. D. Anderson Cancer Center Connective Tissue Oncology Society GIST Overview
More informationKaryotype analysis reveals transloction of chromosome 22 to 9 in CML chronic myelogenous leukemia has fusion protein Bcr-Abl
Chapt. 18 Cancer Molecular Biology of Cancer Student Learning Outcomes: Describe cancer diseases in which cells no longer respond Describe how cancers come from genomic mutations (inherited or somatic)
More informationA View to the Future: The Development of Targeted Therapy for Melanoma. Michael Davies, M.D., Ph.D.
A View to the Future: Science to Survivorship Symposium September 26, 2009 The Development of Targeted Therapy for Melanoma Michael Davies, M.D., Ph.D. Assistant Professor, Melanoma Medical Oncology How
More informationSupplementary Figure 1. Copy Number Alterations TP53 Mutation Type. C-class TP53 WT. TP53 mut. Nature Genetics: doi: /ng.
Supplementary Figure a Copy Number Alterations in M-class b TP53 Mutation Type Recurrent Copy Number Alterations 8 6 4 2 TP53 WT TP53 mut TP53-mutated samples (%) 7 6 5 4 3 2 Missense Truncating M-class
More informationWhat really matters When and Why. Pathology of Uterine Mesenchymal Lesions. Nafisa Wilkinson London
What really matters When and Why Pathology of Uterine Mesenchymal Lesions Nafisa Wilkinson London Patient centred approach immunohistochemistry Histological diagnosis Next generation sequencing Genetic
More informationIntracellular signalling pathways activated by leptin by Gema FRUHBECK. Presentation by Amnesiacs Anonymous
Intracellular signalling pathways activated by leptin by Gema FRUHBECK Presentation by Amnesiacs Anonymous Introduction to Leptin By Ahrial Young Why is Leptin important? Pleiotropic = it controls the
More informationJNCCN Journal of the National Comprehensive Cancer Network
SUPPLEMENT JNCCN Volume 8 Supplement 2 Journal of the National Comprehensive Cancer Network NCCN Task Force Report: Update on the Management of Patients with Gastrointestinal Stromal Tumors George D. Demetri,
More informationSelecting the right patients for the right trials.
Selecting the right patients for the right trials. Paul Waring Professor of Pathology University of Melbourne June 21, 2011 RCPA Genetics short course Drug development challenges. Current model of drug
More informationIntroduction to Cancer Biology
Introduction to Cancer Biology Robin Hesketh Multiple choice questions (choose the one correct answer from the five choices) Which ONE of the following is a tumour suppressor? a. AKT b. APC c. BCL2 d.
More informationGastrointestinal stromal tumors (GIST)
Gastrointestinal stromal tumors (GIST) JY Blay Professor of Medicine GIST : standard of care Nosology : not a single disease Treatment of localized GIST Adjuvant treatment Treatment of advanced GIST First
More informationMichael T. Tetzlaff MD, PhD
Molecular alterations informing the diagnosis of melanocytic tumors Michael T. Tetzlaff MD, PhD Associate Professor Department of Pathology, Section of Dermatopathology Department of Translational and
More informationJon Trent, MD, PhD. Associate Professor Dept. of Sarcoma Medical Oncology The University of Texas, M. D. Anderson Cancer Center
Gastrointestinal Stromal Tumor GISTS 2010: After Standard of Care Jon Trent, MD, PhD Associate Professor Dept. of Sarcoma Medical Oncology The University of Texas, M. D. Anderson Cancer Center jtrent@mdanderson.org
More informationNext generation histopathological diagnosis for precision medicine in solid cancers
Next generation histopathological diagnosis for precision medicine in solid cancers from genomics to clinical application Aldo Scarpa ARC-NET Applied Research on Cancer Department of Pathology and Diagnostics
More informationWhat yield in the last decade about Molecular Diagnostics in Neuro
What yield in the last decade about Molecular Diagnostics in Neuro Oncology? Raphael Salles S.Medeiros Neuropathologist at HC FMUSP Clinical Research Project Manager at Oncology department at Hospital
More informationGastrointestinal Stromal Tumor Surgery and Adjuvant Therapy
Gastrointestinal Stromal Tumor Surgery and Adjuvant Therapy Valerie P. Grignol, MD a, Paula M. Termuhlen, MD b, * KEYWORDS GIST Gastrointestinal stromal tumor KIT PDGFRA Imatinib mesylate Gastrointestinal
More informationGynecologic Evening Specialty Conference. Karuna Garg, MD University of California San Francisco
Gynecologic Evening Specialty Conference Karuna Garg, MD University of California San Francisco Disclosure of Relevant Financial Relationships The USCAP requires that anyone in a position to influence
More informationGastrointestinal stromal tumor
Gastrointestinal stromal tumor 영남의대병리학교실 최준혁 Classification of gastrointestinal mesenchymal tumor Gastrointestinal stromal tumor(gist) Smooth muscle tumors : leiomyoma, leiomyosarcoma Neurogenic tumors
More informationTargeted Agent and Profiling Utilization Registry (TAPUR ) Study. February 2018
Targeted Agent and Profiling Utilization Registry (TAPUR ) Study February 2018 Precision Medicine Therapies designed to target the molecular alteration that aids cancer development 30 TARGET gene alterations
More informationCurrent and future applications of Molecular Pathology. Kathy Walsh Clinical Scientist NHS Lothian
Current and future applications of Molecular Pathology Kathy Walsh Clinical Scientist NHS Lothian Molecular Pathology in Solid tumours Cancer type Genes tested Purpose Associated treatments Non small cell
More informationStudying The Role Of DNA Mismatch Repair In Brain Cancer Malignancy
Kavya Puchhalapalli CALS Honors Project Report Spring 2017 Studying The Role Of DNA Mismatch Repair In Brain Cancer Malignancy Abstract Malignant brain tumors including medulloblastomas and primitive neuroectodermal
More informationProtocol for the Examination of Specimens From Patients With Gastrointestinal Stromal Tumor (GIST)
Protocol for the Examination of Specimens From Patients With Gastrointestinal Stromal Tumor (GIST) Based on AJCC/UICC TNM, 7 th edition Protocol web posting date: June 2012 Procedures Biopsy Resection
More informationAACR 101st Annual Meeting 2010, Washington D.C. Experimental and Molecular Therapeutics Section 29; Abstract #3855
Investigation of the Growth Inhibitory Activity of the MEK Inhibitor ARRY-162 in Combination with Everolimus in a Variety of KRas and PI3K Pathway Mutant Cancers Brian Tunquist, Tyler Risom, Debbie Anderson,
More informationRAS Genes. The ras superfamily of genes encodes small GTP binding proteins that are responsible for the regulation of many cellular processes.
۱ RAS Genes The ras superfamily of genes encodes small GTP binding proteins that are responsible for the regulation of many cellular processes. Oncogenic ras genes in human cells include H ras, N ras,
More informationSchool of Pathology and Laboratory Medicine: Current and New Research Interests
School of Pathology and Laboratory Medicine: Current and New Research Interests W/Professor Wendy Erber Current Research Interests Viral immunology and immunogenetics Bone pathology and cell signalling
More informationChapter 2 Melanoma Pathogenesis
Chapter 2 Melanoma Pathogenesis Jennifer A. Lo and David E. Fisher Abstract Melanoma is an aggressive and heterogeneous disease with respect to clinical behavior and underlying genomic lesions. Melanoma
More informationDisclosures Genomic testing in lung cancer
Disclosures Genomic testing in lung cancer No disclosures Objectives Understand how FISH and NGS provide complementary data for the evaluation of lung cancer Recognize the challenges of performing testing
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/17/3271 holds various files of this Leiden University dissertation. Author: Verbeke, Sofie Lieve Jozef Title: Primary vascular tumours of bone: towards a new
More informationMolecular Diagnosis of Soft Tissue Tumors: Avoid Pitfalls
Molecular Diagnosis of Soft Tissue Tumors: Avoid Pitfalls Cristina Antonescu, MD Department of Pathology Memorial Sloan-Kettering Cancer Center, New York Overview I. When should we rely on the help of
More informationA class of genes that normally suppress cell proliferation. p53 and Rb..ect. suppressor gene products can release cells. hyperproliferation.
Tumor Suppressor Genes A class of genes that normally suppress cell proliferation. p53 and Rb..ect Mutations that inactivate the tumor suppressor gene products can release cells from growth suppression
More information