Contents of Journal of the Romanian Society for Radiotherapy and Medical Oncology Volume XIV, 2008

Transcription

1 Ileana Matei, Felicia Constantina, Gabriel Matei: Malignant Chondroid Syringoma 241 Journal of Radiotherapy & Medical Oncology Contents of Journal of the Romanian Society for Radiotherapy and Medical Oncology Volume XIV, EDITORIAL G. Kacsó NUMBER 1 GENERAL ARTICLES 6 What is the Optimal Management of the Clinically Negative Neck for Patients with Head and Neck Squamous Cell Carcinomas? Voichiţa Bar 10 The Role of Inguinal Node Dissection in the Management of Vulvar Carcinoma Ovidiu Coza, Viorica Nagy, Claudia Ordeanu, Sorin Gavriş, Alin Rancea, Alexandru Trăilă, Adriana Tudosescu, Rareş Buiga, Nicolae Todor 13 Prostate Intensity Modulated Radiation Therapy (IMRT) in the 4D era Ştefan Both, Voichiţa Bar 18 Adenopathies with Unknown Primary: Therapeutic Implications Călin Căinap, Tudor E. Ciuleanu ORIGINAL STUDIES 21 Prognostic Value of Lymph Node Involvement in the Radio-Surgical Treatment in Laryngeal Carcinoma Elisabeta Ciuleanu, Valentin Cernea, Daniela Martin, Iolanda Sicoe, Emöke Palyi Kiss, Nicolae Todor, Dănuţ Gheorghiu, Octavian Chiş, Constantin Iencica, Marcel Cosgarea, Magdalena Chirilă, Liliana Resiga 28 The Prognostic Value of Lymph Node Status in Patients with Advanced Cervical Cancer Operated After Radio-Chemotherapy Viorica Nagy, Alexandru Trăilă, Alin Rancea, Ovidiu Coza, Claudia Ordeanu, Nicolae Todor, Nicolae Ghilezan 32 Three-dimensional Conformal Radiotherapy for Treatment of Localized Prostate Adenocarcinoma: the Ion Chiricuta Cancer Center Experience Ciprian Chira, Ovidiu Vereşezan, Ovidiu Bran, Victor Bogdan, Andra Fizeşan, Dan Dordai, Gabriel Kacsó 40 Low-Dose Rate Brachytherapy in the Treatment of Low-Risk Prostate Cancer: the European Institute of Oncology Experience A. Fodor, A. Vavassori, F. Cattani, C. Fodor, L. Santoro, V.D. Matei, B.A. Jereczek- Fossa, O. De Cobelli, R. Orecchia CASE REPORTS 50 Significance of Disease Stabilization for Survival and Quality of Life Benefits with Erlotinib in Relapsed Non-small-cell Lung Cancer Tudor E. Ciuleanu ONCOLOGICAL NEWS th Charles A. Coltman San Antonio Breast Cancer Symposium (SABCS). December 13-16, 2007, SanAntonio, Texas, USA Alexandru Eniu

2 242 Journal of Radiotherapy & Medical Oncology, December 2008 Vol. XIV No. 4: Important International Cancer Conferences 63 Guidance for Authors on the Preparation and Submission of Manuscripts to the Journal of Radiotherapy and Medical Oncology NUMBER 2 69 Curs postuniversitar Strategii terapeutice contemporane în oncologie reuniune post ASCO/ECCO/ASTRO Actualităţi în terapia moleculară ţintită a cancerului th Annual Congress of the Romanian Society for Radiotherapy and Medical Oncology and ESMO Course (Second announcement) 76 EDITORIAL Ioana Brie GENERAL ARTICLES 77 The Sentinel Node Navigation Radiotherapy (SNNRT) Ion-Christian Kiricuta, Bernd Schicker, Uwe Goetz ORIGINAL STUDIES 84 Epidemiology of Genitourinary Cancers in Romania, Ofelia Şuteu, Patricia Şuteu, Florian Nicula, Daniela Coza 96 Xeloda Based Combinations for Metastatic Colorectal Carcinoma: a Phase II Study Anca Mihailov, Flaviu Mureşan, Ovidiu Fabian, Răzvan Simescu, Traian Oniu, Mircea Cazacu 104 Concomitent Preoperative Chemoradiotherapy with Capecitabine in Locally Advanced Rectal Adenocarcinoma: a Phase II Study Alina-Simona Muntean, Adriana Mureşan, Anca Mihailov, Angela Parau, Lucian Lazăr, Alin Rancea, Viorica Nagy, Gabriel Kacso, Nicolae Ghilezan 111 Comparative Analysis of Adjuvant Treatment of Colorectal Cancer Patients Treated in Two Romanian Hospitals Răzvan-Ovidiu Curcă 117 Bisphosphonates in Metastatic Prostate Cancer Oana Marina, Gabriel Kacsó CASE REPORTS 121 Malignant Gastric Carcinoids Diagnostic and Classification Difficulties Flaviu Mureşan, Mircea Cazacu, Anca Mihailov, Iacob Domşa, Răzvan Simescu 126 Cytogenetic and Molecular Response after Dasatinib in Blastic Phase Chronic Myeloid Leukemia. Case Report Delia Dima, Andrei Cucuianu, Ljubomir Petrov ONCOLOGICAL NEWS 129 Report on the First World Congress of Brachytherapy, Boston 2008 Claudia Ordeanu 130 Important International Cancer Conferences 131 Guidance for Authors on the Preparation and Submission of Manuscripts to the Journal of Radiotherapy and Medical Oncology

3 Contents Volume XIV, EDITORIAL Gabriel Kacsó NUMBER 3 GENERAL ARTICLES 138 Key Signaling Pathways in Apoptosis Claudia Burz, Ioana Berindan Neagoe, Eleonora Dronca, Rareş Buiga 144 Present Trends in the Management of Locally Advanced Epithelial Ovarian Cancer Viorica Magdalena Nagy 151 Chemotherapy Results in Testicular Germ Cell Tumors Updates and Controversies Cristina Ligia Cebotaru 158 Clinical Management of Early Menopause in Young Women with Breast Cancer Dorina Larisa Ciule ORIGINAL STUDIES 163 Pancreatic Neuroendocrine Tumors Diagnostic and Therapeutic Opportunities in a General Surgery Department Mircea Cazacu, Nicolae Rednic, Doru Munteanu, Flaviu Mureşan, Iacob Domşa, Răzvan Simescu, Gabriel Petre, Alexandrina Mureşan 167 Photodynamic Effect of a Water Soluble Porphyrin Evaluated on Two Cancer Cell Lines Maria Perde-Schrepler, Piroska Virág, Eva Fischer-Fodor, Ioana Brie, Corina Tatomir, Olga Şoriţău, Ion Dan Postescu, Gabriela Cherecheş, Valentin Cernea, Simina Dreve CASE REPORTS 172 Three-Dimensional Conformal-Radiotherapy in Combined-Modality Treatment for Advanced Non-Small Cell Lung Cancer A Clinical Case Presentation Petronela Rusu, Nicolae Ghilezan 182 Primary Neuroendocrine Carcinoma of the Uterine Cervix. Report of Two Cases and Review of the Literature Ciprian Chira, Viorica Magdalena Nagy, Ovidiu Coza, Alin Rancea, Octavian Chiş, Cristina Cebotaru, Rareş Buiga, Mihaela Galatâr 190 Guidance for Authors on the Preparation and Submission of Manuscripts to the Journal of Radiotherapy and Medical Oncology NUMBER 3 Supplement 18 th Annual Congress of the Romanian Society for Radiotherapy and Medical Oncology and ESMO Course: Breast Cancer Management: an European Perspective 193 EDITORIAL Anton Cucuianu GENERAL ARTICLES NUMBER Operable Gastric Cancer Treatment Where are We and What is the Future? Călin Căinap, Gabriel Kacsó, Alina Marti, Anca Hodorog

4 244 Journal of Radiotherapy & Medical Oncology, December 2008 Vol. XIV No. 4: ORIGINAL STUDIES 199 Osteoblast Differentiation and Immunocytochemical Characterization of Human Mesenchymal Stem Cells Ciprian Tomuleasa, Olga Soriţău, Vasile Foriş, Valentin Lung-Illes, Ioana Brie, Piroska Virág, Eva Fischer-Fodor, Maria Perde-Schrepler, Corina Tatomir, Ion Dan Postescu, Gabriela Cherecheş, Doina Piciu 206 Predictive Value of HER Status for Pathological Response to Antracycline Based Neoadjuvant Chemotherapy in Hormone Receptor Negative Breast Cancer Renata Zahu, Sandu Istrate, Radu Tănăsescu, Carmen Popa, Nicolae Todor 211 Capecitabine (Xeloda) Efficacy, Safety and Clinical Benefit in Patients with Relapsed Metastatic Breast Cancer after Treatment with Anthracyclines and Taxans Dana Grecea, Carmen Vasiliniuc, Roxana Draghici, Luciana Neamţiu, Alin C. Rancea, Liliana Resiga, Dan I. Postescu, Viorica Nagy, Nicolae Ghilezan 217 A Phase II Study of Weekly versus 3 Weeks Docetaxel in Patients with Metastatic Breast Cancer Corina Idu, Daniela Grecea, Carmen Vasiliniuc, Luciana Neamţiu 221 Phyllodes Tumors and Primary Breast Sarcomas. The experience of Ion Chiricuţă Cancer Center, Cluj, between Zsolt Fekete, Daniela Martin, Cristina Vitoc, Valentin Cernea, Dan Eniu, Alin C. Rancea, Mihaela Galatâr, Nicolae Todor, Viorica Nagy CASE REPORTS 227 Unusual Massive Craniospinal Metastasis of a Treated Medulloblastoma Emilia Mihuţ, Dana Cernea, Ştefania Neamţu, Rodica Cosnarovici, Vasile Popiţa, Iolanda Hosu, Victor Bogdan 232 Incidental Diagnosis of a Sigmoid Tumour on PET-CT in a Thyroid Cancer Patient. A Case Report Cosmin Lisencu, Ioana Puşcaş, Doina Piciu Iolanda Hosu, Victor Bogdan 237 Malignant Chondroid Syringoma Case Report and Review of the Literature Ileana Matei, Felicia Constantina, Gabriel Matei 241 Contents of Journal of the Romanian Society for Radiotherapy and Medical Oncology, Vol. XIV, Index of Themes Index of Authors Guidance for Authors

5 Contents Volume XIV, Journal of Radiotherapy & Medical Oncology Index of Themes 2008 A. General 1. Epidemiology & Natural history 2. Biology of tumors. Radiobiology 3. Medical imaging 4. Pathalogic anatomy 5. Biostatistics 6. Management B. Clinical specialities 1. Head and neck cancer 2. Lung cancer 3. Gastrointestinal neoplasms 4. Breast cancer 5. Gynecologic neoplasms 6. Urogenital neoplasms 7. Lymphomas. Leukemia 8. Bone and soft tissue sarcomas 9. Tumors of the central nervous system 10. Thyroid cancer 11. Miscellaneous

6 246 Journal of Radiotherapy & Medical Oncology, December 2008 Vol. XIV No. 4: A. General A.1. Epidemiology & Natural History Epidemiology of Genitourinary Cancers in Romania, : A.2. Tumoral Biology & Radiobiology Key Signaling Pathways in Apoptosis: Osteoblast Differentiation and Immunocytochemical Characterization of Human Mesenchymal Stem Cells: Photodynamic Effect of a Water Soluble Porphyrin Evaluated on Two Cancer Cell Lines: The Sentinel Node Navigation Radiotherapy (SNNRT): B. Special Part B.1. ORL (Head and Neck Cancer) Prognostic Value of Lymph Node Involvement in the Radio-Surgical Treatment in Laryngeal Carcinoma: What is the Optimal Management of the Clinically Negative Neck for Patients with Head and Neck Squamous Cell Carcinomas?: 6-9 B.2. Lung cancer Significance of Disease Stabilization for Survival and Quality of Life Benefits with Erlotinib in Relapsed Non-small-cell Lung Cancer: Three-Dimensional Conformal-Radiotherapy in Combined-Modality Treatment for Advanced Non-Small Cell Lung Cancer A Clinical Case Presentation: B.3. Gastrointestinal neoplasms Comparative Analysis of Adjuvant Treatment of Colorectal Cancer Patients Treated in Two Romanian Hospitals: Concomitent Preoperative Chemoradiotherapy with Capecitabine in Locally Advanced Rectal Adenocarcinoma: a Phase II Study: Malignant Gastric Carcinoids Diagnostic and Classification Difficulties: Operable Gastric Cancer Treatment Where are we and what is the Future: Pancreatic Neuroendocrine Tumors Diagnostic and Therapeutic Opportunities in a General Surgery Department: Xeloda Based Combinations for Metastatic Colorectal Carcinoma: a Phase II Study: B.4. Breast cancer A Phase II Study of Weekly versus 3 Weeks Doutaxel in Patients with Ketostatic Breast Cancer: th Charles A. Coltman San Antonio Breast Cancer Symposium (SABCS). December 13-16, 2007, San Antonio, Texas, USA: Clinical Management of Early Menopause in Young Women with Breast Cancer: Phyllodes Tumors and Primary Breast Sarcomas. The Experience of Ion Chiricuta Cancer Center, Cluj, between : Predictive Value of HER Status for Pathological Response to Antracycline Based Neoadjuvant Chemotherapy in Houmane Receptor Negative Breast Cancer: B.5. Ginecologic neoplasms Present Trends in the Management of Locally Advanced Epithelial Ovarian Cancer: Primary Neuroendocrine Carcinoma of the Uterine Cervix. Report of Two Cases and Review of the Literature: The Prognostic Value of Lymph Node Status in Patients with Advanced Cervical Cancer Operated After Radio- Chemotherapy: The Role of Inguinal Node Dissection in the Management of Vulvar Carcinoma: B.6. Urogenital neoplasms Bisphosphonates in Metastatic Prostate Cancer: Chemotherapy Results in Testicular Germ Cell Tumors Updates and Controversies: Epidemiology of Genitourinary Cancers in Romania, : 84-95

7 Index of Themes Low-Dose Rate Brachytherapy in the Treatment of Low-Risk Prostate Cancer: the European Institute of Oncology Experience: Prostate Intensity Modulated Radiation Therapy (IMRT) in the 4D era: Three-dimensional Conformal Radiotherapy for Treatment of Localized Prostate Adenocarcinoma: the Ion Chiricuta Cancer Center Experience: B.7. Lymfomas. Leukemias Cytogenetic and Molecular Response after Dasatinib in Blastic Phase Chronic Myeloid Leukemia. Case Report: B.9. Tumors of the central nervous system Unusual Massive Craniospinal Metastasis of a Treated Meduloblastoma: B.10. Thyroid cancer Incidental Diagnosis of a Sigmoid Tumour on PET-CT in a Thyroid Cancer Patient. A case report: B.11. Miscellaneous Adenopathies with Unknown Primary: Therapeutic Implications: Malignant Chondroid Syringoma Case Report and Review of the Literature: Report of the First World Congress of Brachytherapy, Boston, 2003: 129 The Sentinel Node Navigation Radiotherapy (SNNRT): 77-83

8 248 Journal of Radiotherapy & Medical Oncology, September 2008 Vol. XIV No. 3: Journal of Radiotherapy & Medical Oncology Index of Authors 2008 B Bar Ad. V.: 6, 13 Berindan-Neagoe, I.: 138 Bogdan V.: 32, 227 Both Şt.: 13 Bran O.: 32 Brie I.: 76, 167, 199 Buiga R.: 10, 138, 182 Burz C.: 138 C Cattani F.: 40 Cazacu M.: 96, 121, 163 Căinap C.: 18, 195 Cebotaru C.L.: 151, 182 Cernea D.: 227 Cernea V.: 21, 167, 221 Cherecheş G.: 167, 199 Chira C.: 32, 182 Chirilă M.: 21 Chiş. O.: 21, 182 Ciule D.L.: 151 Ciuleanu E.: 21 Ciuleanu T.E.: 18, 50 Cosgarea, M.: 21 Constantina, F.: 237 Cosnarovici R.: 227 Coza D.: 84 Coza O.: 10, 28, 182 Cucuianu, A.: 126, 193 Curcă, R.: 111 D De Cobelli, O.: 40 Dima D.: 126 Domşa I.: 121, 163 Dordai, D.: 32 Drăghici, R.: 211 Dreve S.: 167 Dronca, E.: 138 E Eniu Al.: 54 Eniu, D.: 221 F Fabian O.: 96 Fekete Zs.: 221 Fischer-Fodor E.: 167, 199 Fizeşan A.: 32 Fodor A.: 40 Fodor C.: 40 Foriş V.: 199 G Galatâr M.: 182, 221 Gavriş, S.: 10 Gheorghiu, D.: 21 Ghilezan N.: 28, 104, 172, 211 Goetz U.: 77 Grecea D.: 211, 217 H Hodorog A.E.: 195 Hosu, I.: 227 I Iencica, Ctin: 21 Idu, C.: 217 Istrate, S.: 206 J Jereczek-Fossa, B.A.: 40 K Kacsó G.: 5, 32, 104, 117, 137, 195 Kiricuţă I. C.: 77 L Lazăr L.: 104 Lisencu C.: 232 Lung-Illes, V.: 199 M Marina O.: 117 Marti, A.: 195 Martin D.: 21, 221 Matei G.: 237 Matei I.: 237

9 Index of Authors Matei V.D.: 40 Mihailov A.: 96, 104, 121 Mihuţ, E.: 227 Muntean A.-S.: 104 Muntean D.: 163 Mureşan A.: 104, 163 Mureşan F.: 96, 121, 163 N Nagy V.: 10, 28, 104, 144, 172, 211, 221 Neamţiu L.: 211, 217 Neamţu Şt.: 227 Nicula F.: 84 O Oniu, T.: 96 Ordeanu, C.: 10, 28, 129 Orecchia, R.: 40 P Palyi Kiss, E.: 21 Parău, A.: 104 Perde-Schrepler M.: 167, 199 Petre, G.: 163 Petrov, L.: 126 Piciu, D.: 199, 232 Popa, C.: 206 Popiţa, V.: 227 Postescu I.D.: 167, 199, 211 Puşcaş, I.: 232 R Rancea A.C.: 10, 28, 104, 182, 211, 221 Rednic N.: 163 Resiga L.: 21, 211 Rusu P.: 172 S Santoro, L.: 40 Schicker, B: 77 Sicoe I.: 21 Simescu R.: 96, 121, 163 Soriţău O.: 167, 199 Ş Şuteu O.: 84 Şuteu P.: 84 T Tatomir C.: 167, 199 Tănăsescu R.: 206 Todor N.: 10, 21, 28, 206, 221 Tomuleasa, C.: 199 Trăilă A.: 10, 28 Tudosescu, A.: 10 V Vasiliniuc, C.: 211, 217 Vavassori A.: 40 Vereşezan O.: 32 Virág P.: 167, 199 Vitoc C.: 221 Z Zahu, R.: 206

10 250 Journal of Radiotherapy & Medical Oncology, September 2008 Vol. XIV No. 3: Journal of Radiotherapy & Medical Oncology Guidance for Authors on the Preparation and Submission of Manuscripts to the Journal of Radiotherapy and Medical Oncology Scope. The Journal of Radiotherapy and Medical Oncology (formerly Radioterapie & Oncologie Medicala) publishes papers, which are of a high standard and which contribute to the advancement of knowledge in the field of radiotherapy and medical oncology. The journal also publishes review articles, case reports and brief communications (including book reviews) on those specific topics. Review articles should report current and/or fundamental aspects in oncology; case reports should focus on diagnostic, therapeutic and post-therapeutic problems. Letters to the Editor, mentioning an opinion on an article previously published or referring to current points of interest, are welcome. Technical notes will also be accepted if on topics of professional interest. The website address of the Journal of Radiotherapy and Medical Oncology is The journal is published quarterly and papers are accepted for publication in the English language. Papers from contributors living abroad and from Romanian authors should be addressed to the editorial office: Gabriel Kacsó Editor in Chief, Journal of Radiotherapy and Medical Oncology, Republicii Street, Cluj-Napoca, Romania. Tel: (ext. 106) Fax: srrom@yahoo.com, gabi.kacso@gmail.com Please consider the following points before submission and make the appropriate declarations in your covering letter which should accompany your article: Redundant or duplicate publication. We ask you to confirm that your paper has not been published in its current form or a substantially similar form (in print or electronically, including on a web site), that it has not been accepted for publication by another journal, and that it is not under consideration by another publication. The International Committee of Medical Journal Editors (ICMJE) has provided details regarding duplicate or redundant publications ( In your covering letter to the editors, please mention any published work that concerns the same patients or subjects as the present paper. Conflicts of interest. We ask authors to state all possible conflicts of interest, including financial and other relationships. If you are sure that there is no conflict of interest, please state this also. The sources of funding should be acknowledged in your paper. Permission to reproduce previously published material. Please send us copies of permission to reproduce material (such as illustrations) from the copyright holder. Patient consent forms. The protection of a patient s right to privacy is essential. Please send copies of patient s consent forms on which patients or other subjects of your experiments clearly grant permission for the publication of photographs or other material that might identify them. If the consent form for your research does not specifically include this, please obtain it or remove the identifying material. Even if patient-identifying material is not included in your paper, all studies dealing with patients or normal volunteers (including case reports) need their (or in case of minors, their parents ) written informed consent. A statement must be included in the Methods section of your paper. Ethics Committee approval. You must state clearly in your submission in the Methods section that you conducted studies on human participants with the approval of the Hospital, or University Ethics Committee etc. Similarly, you must confirm that experiments involving animals adhered to ethical standards. Authorship. We ask that all authors sign the submission letter. We therefore ask all authors to confirm that they have read and approved the paper. We also ask all authors to confirm that they have met the criteria for authorship as established by the International Committee of Medical Journal Editors, believe that the paper represents honest work, and are able to verify the validity of the results reported. Error! Each paper must contain the following: Authors Disclosures of Potential Conflicts of Interest. (The authors indicated no potential conflicts of interest.) Author Contributions: - Conception and design: - Provision of study material or patients: - Collection and assembly of data: - Data analysis and interpretation: - Manuscript writing: - Final approval of manuscript: Authors s signature.

11 Guidance for Authors 251 Copyright assignment. Papers are accepted for publication on the understanding that exclusive copyright in the paper is assigned to the Journal of Radiotherapy and Medical Oncology. Submissions. All manuscripts submitted to the Journal of Radiotherapy and Medical Oncology are peer reviewed by two referees. The journal accepts electronic submission of manuscripts in Word format, whether on disk or CD-ROM or as attachments to electronic mail (manuscripts, figures and tables). Do not send them in PDF format. (Electronic submission saves time as well as postage costs, and allows the manuscript to be handled in electronic form throughout the editorial process). For those authors who have no option but to submit by mail, please send three copies of the article, plus an electronic version on disk or CD-ROM to Dr. Gabriel Kacso, Editor in Chief, Journal of Radiotherapy and Medical Oncology, Str. Republicii, Cluj-Napoca, Romania. Original articles should have a word count of up to 3000 words for original articles and 2000 words for case reports. Include the following where appropriate: subject consent forms; transfer of copyright form; permission to reproduce previously published material; checklist. Double spacing should be used throughout the manuscript, which should include the following sections, each starting on a separate page: title page, abstract and keywords, text, acknowledgements, references, individual tables and legends for figures. Margins should be not less than 3 cm. Pages should be numbered consecutively, beginning with the title page, and the Arabic numbers should be placed in the top right hand corner of each page. Presentation of papers Title page. The title page should carry the full title of the paper (no longer than 85 characters) and a short title to be used as a short running head (which should be so identified and should comprise maximum 45 characters). 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12 252 Journal of Radiotherapy & Medical Oncology, December 2008 Vol. XIV No. 4: Examples: Articles Lee YN, Wang KL, Lin MH, et al. Radical hysterectomy with pelvic lymph node dissection for treatment of cervical cancer: a clinical review of 954 cases. Gynecol Oncol, 1989;32: Mirimanoff RO, Wang CC, Doppke KP. Combined surgery and postoperative radiation therapy for advanced laryngeal and hypopharyngeal carcinomas. Int J Radiat Oncol Biol Phys 1985; 11: Book Ang KK, Garden AS. Radiotherapy for head and neck cancer, indications and techniques. Phyladelphia: Lippincott Williams and Wilkins, Philadelphia, 2006; Chapter in Books. Fyles A, Kirkbride P. Cervix uteri carcinoma. In: Hermanek G, Gospodarowicz MK, Henson DE: International Union Against Cancer, Prognostic factors in cancer. Springer, Berlin, 1995, Avoid abstracts as references or keep as few as possible. Personal communications and unpublished work should not feature in the reference list but should appear in parentheses in the text. Unpublished work accepted for publication but not yet released should be included in the reference list with the words in press in parentheses beside the name of the journal concerned. References should be verified by the author(s) against the original documents, although the accuracy of the references is always checked by the editorial office. Citations from this Journal are highly encouraged as this constitutes a major issue for establishing the impact factor of the Journal. Tables. Each table should be typed on a separate sheet in double spacing. Tables should not be submitted as photographs. Each table should be assigned a Roman numeral (e.g. Table III) and a brief title. Explanatory matter should be placed in footnotes. Explain in footnotes all non-standard abbreviations that are used in each table. 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Pre-submission Checklist It is hoped that this list will be useful during the final checking of an article prior to sending it to the Journal s Editor for review. one author designated as corresponding author: with address, full postal address, telephone and fax numbers; all necessary files have been uploaded; key words, running head; all figures and tables (including title, description, foot-notes); references are in the correct format for this Journal; all references mentioned in the reference list are cited in the text, and vice versa; permission has been obtained for use of copyrighted material from other sources. *These instructions comply with those formulated by the International Committee of Medical Journal Editors. See