Reduction of In Vivo Oxidation induced by Lipid Absorption by Phospholipid Polymer Grafting on Orthopedic Bearings
|
|
- Coleen McKinney
- 5 years ago
- Views:
Transcription
1 Reduction of In Vivo Oxidation induced by Lipid Absorption by Phospholipid Polymer Grafting on Orthopedic Bearings Masayuki Kyomoto, Ph.D. 1,2, Toru Moro, M.D., Ph.D. 1, Shihori Yamane, MSc 1,2, Kenichi Watanabe, BS 1,2, Sakae Tanaka, M.D., Ph.D. 1, Kazuhiko Ishihara, Ph.D The University of Tokyo, Tokyo, Japan, 2 KYOCERA Medical Corporation, Osaka, Japan. Disclosures: M. Kyomoto: None. T. Moro: None. S. Yamane: None. K. Watanabe: None. S. Tanaka: None. K. Ishihara: None. Introduction: To decrease wear particle production and eliminate periprosthetic osteolysis, we developed an articular cartilage-based technology that allows surface modification of acetabular liners used in artificial hip joints by using phospholipid polymer grafting, such as poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) for cross-linked polyethylene (CLPE) [1]. Modifying bearing surfaces of an artificial joint with a hydrophilic layer has reported to increase lubrication similar to that for articular cartilage under physiological conditions. Our previous study on the tribological and biological effects of PMPC revealed that such grafting decreases wear particle production and bone resorptive responses [2]. However, wear-resistance is only one of several important indicators of clinical performance of acetabular liners. As well as wear-resistance, oxidation resistance is an important indicator of the clinical performance of acetabular liners. Free radicals during gamma-ray irradiation limit the longevity of artificial hip joints. In vivo oxidation of the CLPE liner occurs, not only by annealing, but also by melting; CLPE absorbs lipids from the synovial fluid in vivo, which accelerates oxidative degradation; however, although the clinical impact of this degradation is unclear, in vivo oxidation is regarded undesirable. Stabilization of residual free radicals with an antioxidant such as vitamin E (VE) is necessary as an additional or alternative process. In the present study, we prepared a highly hydrophilic nanometer-scale surface by grafting a PMPC onto the surface of an antioxidative CLPE substrate, modified by VE blending (CLPE(VE)). Our ultimate goal was to manipulate the surface and substrate of the CLPE liner applied to life-long orthopedic bearings such that the surface not only had high wear resistance, but also had high oxidative resistance [3]. In this study, we investigated (1) the effect of the grafted PMPC layer on the lipid absorption of CLPE and CLPE(VE) samples, and (2) the effect of PMPC layer on oxidative resistance. Methods: A bar stock of 0.1 mass% VE-blended polyethylene (GUR1020E resin) was irradiated with gamma-rays (high dose [HD]; 100 kgy) and annealed at 120 C for 12 h in N 2 gas, to facilitate cross-linking (HD-CLPE(VE)). For the control, a bar stock of polyethylene without any additives (GUR1020 resin) was irradiated with gamma-rays (50 kgy) and annealed at 120 C for 7.5 h in N 2 gas, to facilitate cross-linking (CLPE). The CLPE and HD-CLPE(VE) samples were then machined from the bar stocks and were immersed in aqueous MPC solution. Photo-induced graft polymerization of MPC was performed on the CLPE and HD-CLPE(VE) surfaces by using UV irradiation (intensity, 5 mw/cm 2 ) at 60 C for 90 min. All samples were sterilized using gamma-rays (dose, 25 kgy). Lipid absorption and oxidative properties of the 4 samples (untreated CLPE, PMPC-grafted CLPE, untreated HD-CLPE(VE), and PMPC-grafted HD-CLPE(VE) were investigated. The residual-free radical concentrations in the samples were analyzed using electron spin resonance (ESR). Squalene absorption,
2 after squalene soaking at 120 C for 2 h, was evaluated by Fourier transform-infrared spectroscopy (FT- IR). Squalene index was calculated as the ratio of the peak area at 1145 cm -1 to that at 1895 cm -1. Oxidative stability (oxidation-induction time) was evaluated by differential scanning calorimetry according to ASTM D3895. The oxidative degradation of samples subjected to accelerated aging by exposure to 80 C in air for 21 d was evaluated using FT-IR according to ASTM F2102. Results: In ESR spectra, multiple peaks corresponding to alkyl or allyl radicals were observed in all samples (Fig.1A). The small detectable peaks corresponding to tocopheroxyl radicals were observed only in the untreated and PMPC-grafted HD-CLPE(VE) samples. The residual free-radical concentrations after gamma-ray sterilization did not differ significantly between samples (Fig. 1B). Squalene indices of the PMPC-grafted samples were lower than those of the untreated samples (Fig. 2). Oxidative-induction times were significantly longer in the untreated and PMPC-grafted HD-CLPE(VE) samples than in the untreated and PMPC-grafted CLPE samples (Fig. 3A). Oxidative-induction times of the untreated and PMPC-grafted HD-CLPE(VE) samples were shorter after squalene absorption than those before absorption. In the absence of squalene absorption, oxidative-induction times did not differ significantly between untreated and PMPC-grafted samples. In contrast, after squalene absorption, the oxidative-induction times of PMPC-grafted HD- CLPE(VE) samples was significantly longer than those of the untreated HD-CLPE(VE) samples. Thus, oxidation indices of the accelerated-aged untreated and PMPC-grafted HD-CLPE(VE) samples were significantly lower (almost zero) than those of the untreated CLPE and PMPC-grafted CLPE samples, despite squalene absorption (Fig. 3B). Compared with untreated CLPE, the increased oxidation index after squalene absorption was prevented in PMPC-grafted CLPE. Discussion: Here, we investigated the effects of surface modification with a phospholipid polymer on oxidative resistance of CLPE or HD-CLPE(VE). The PMPC-grafted HD-CLPE(VE) samples had extremely high oxidation resistance, even though the residual-free radical levels were detectable. Even after PMPC grafting, the HD-CLPE(VE) substrate maintained high oxidation resistance. Indeed, VE is an extremely efficient radical scavenger. Interestingly, PMPC-grafted samples were resistant to squalene absorption, probably because of the presence of the PMPC layer: MPC is a methacrylate monomer that has a phospholipid polar group in its side chain and is highly hydrophilic, while PMPC is water-soluble. Therefore, we believe that the presence of a water-fluid film and hydrated PMPC layer is the primary mechanism underlying the high oxidation resistance; water molecules in the hydration layers reduce lipid absorption, thus reducing adhesive interaction or interpenetration. The secondary mechanism is attributed to the suppressed diffusion of squalene into the PMPC layer because squalene is an insoluble molecule in the methacrylate monomer. In conclusion, the PMPC layer grafted on the CLPE or HD-CLPE(VE) surface prevented squalene absorption and its accelerated oxidation degradation. These results provide preliminary evidence that surface modification affected the extent of oxidative stability. This suggests that the PMPC-grafted surface and VE-blended substrate may be a promising approach for longevity of artificial hip joints. Significance: Our in vitro findings indicate some improvements in the oxidation resistance of CLPE acetabular cups in total hip arthroplasty.
3
4
5 ORS 2015 Annual Meeting Poster No: 1807
The information contained in this document is intended for healthcare professionals only.
The information contained in this document is intended for healthcare professionals only. Trident Poly Acetabular System Trident PSL HA Acetabular Shell with X3 Poly insert Trident Hemispherical Acetabular
More informationMassachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2.782J/3.961J/BEH.
Massachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2.782J/3.961J/BEH.451J/HST524J WEAR AND CORROSION M. Spector, Ph.D. WEAR PROCESSES
More informationCPGAN #002. FTIR Quantification of Absorbed Radiation Dose in Polyethylene
1.1 Introduction Ultra-high molecular weight polyethylene (UHMWPE) is the current material of choice for bearing surface applications in total joint arthroplasty. In an effort to enhance the wear properties
More informationWear Properties of UHMWPE in CHARITE Artificial Inter-vertebral Disc
Mechanics of Contact and Lubrication, MTM G230 Department of Mechanical & Industrial Enineering Northeastern University Spring 2006 Wear Properties of UHMWPE in CHARITE Artificial Inter-vertebral Disc
More informationFIXATION FIRST WEAR REDUCTION OXIDATIVE STABILITY MECHANICAL INTEGRITY PROVEN TECHNOLOGY
FIXATION FIRST WEAR REDUCTION OXIDATIVE STABILITY MECHANICAL INTEGRITY PROVEN TECHNOLOGY Fixation First FIXATION FIRST 1958 Charnley Hip Over 1,000,000 implanted 1 96.2 percent survivorship at 32 years
More informationUHMWPE LONGEVITY: INFLUENCES OF THE ORTHOPAEDIC TRIAD
UHMWPE LONGEVITY: INFLUENCES OF THE ORTHOPAEDIC TRIAD AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS 66th Annual Meeting February 4-9, 1999 Anaheim, California COMMITTEE ON BIOMEDICAL ENGINEERING COMMITTEE ON
More informationMicroSeal Total Hip Acetabular System. Like Nothing Else
MicroSeal Total Hip Acetabular System Like Nothing Else Like Nothing Else Unique Patented Sealing and Locking Design The MicroSeal design features: Locking/Sealing mechanisms work together to minimize
More informationA Novel Technique for Assessing Antioxidant Concentration in Retrieved UHMWPE
Clin Orthop Relat Res (2017) 475:1356 1365 DOI 10.1007/s11999-016-4939-4 Clinical Orthopaedics and Related Research A Publication of The Association of Bone and Joint Surgeons SYMPOSIUM: ADVANCES IN POLYETHYLENE
More informationThe information contained in this document is intended for healthcare professionals only.
The information contained in this document is intended for healthcare professionals only. Trident Hemispherical Acetabular Shell Trident PSL HA Acetabular Shell Featuring: The Trident Acetabular System
More informationEvaluation of wetting and dispersing additives for the use in waterborne anticorrosive paints. Düsseldorf, , Martin Muth
Evaluation of wetting and dispersing additives for the use in waterborne anticorrosive paints Düsseldorf, 12.09.2013, Martin Muth Content 1. Introduction 2. Functionality and chemistry of wetting and dispersing
More informationCatherine Bladen, John Fisher, Eileen Ingham, Joanne Tipper University of Leeds, UK
Institute of Medical & Biological Engineering Reduced inflammatory potential of Antioxidant Ultra High Molecular Weight Polyethylene containing Vitamin E May Lead to Improved Longevity in Total Joint Replacement
More information3.1 Background. Preformulation Studies
Preformulation Studies 3.1 Background Delivery of any drug requires a suitable dosage form to get optimum therapeutic effects. The development of such dosage forms fundamental properties of the drug molecule
More informationMARATHON Cross-Linked Polyethylene
MARATHON Cross-Linked Polyethylene Fixation First... 1 Wear Reduction... 2 Oxidative Stability... 3 Mechanical Integrity... 4 Proven Technology...5-6 References... 7 Fixation First FIXATION FIRST Prodigy
More informationUlllted States Patent [19] [11] Patent Number: 4,997,881
Ulllted States Patent [19] [11] Patent Number: 4,997,881 Patel et a1. [45] Date of Patent: Mar. 5, 1991 [54] POLY(ALKYL VINYL ETHER)POLYOLEFIN [56] References Cited COPOLYMERS U.S. PATENT DOCUMENTS [75]
More informationPyroCarbon Implants Durability + Biocompatibility
PyroCarbon Implants Durability + Biocompatibility What is PyroCarbon? PyroCarbon is a specific form of carbon that has been tailored for durability and biocompatibility. PyroCarbon exhibits favorable wear
More informationActive Articulation E1
Active Articulation E1 Dual Mobility Hip System Design Rationale Knees Hips Extremities Cement and Accessories PMI Trauma Technology Active Articulation E1 Dual Mobility Hip System Dual Mobility: Not a
More informationMelt-Grafting of Maleimides Having Hindered Phenol Group onto Polypropylene
Melt-Grafting of Maleimides Having Hindered Phenol Group onto Polypropylene Bull. Korean Chem. Soc. 2003, Vol. 24, No. 12 1809 Melt-Grafting of Maleimides Having Hindered Phenol Group onto Polypropylene
More informationArComXL Polyethylene: A New Way to Process Highly Crosslinked Polyethylene
TM ArComXL Polyethylene: A New Way to Process Highly Crosslinked Polyethylene Several years ago, our competitors introduced highly crosslinked polyethylene (HXLP). Biomet chose not to follow that path.
More informationCan wetting and dispersing additives improve the durability of coatings?
Can wetting and dispersing additives improve the durability of coatings? János Hajas BYK-Chemie, Wesel, Germany Topics: WETTING AND DISPERSING ADDITIVE, DURABILITY, CORROSION RESISTANCE 1. Abstracts There
More informationZimmer Longevity Highly Cross-linked Polyethylene. Clinical Value Dossier - APAC
Zimmer Longevity Highly Cross-linked Polyethylene Clinical Value Dossier - APAC Table of Contents 1 Executive Summary...................................................... 1 2 Burden of Illness........................................................
More informationA 15-years experience in analyses of UHMWPE prosthetic components: state of the art and future perspectives.
A 15-years experience in analyses of UHMWPE prosthetic components: state of the art and future perspectives. P. Bracco, E.M. Brach del Prever*, V. Brunella, M. Zanetti, L. Costa Università di Torino Dipartimento
More informationACETABULAR CUP SURGICAL TECHNIQUE
ACETABULAR CUP SURGICAL TECHNIQUE ACETABULAR CUP DEVICE INDICATIONS FOR USE The ICONACY I-Hip total hip replacement is indicated for the following conditions: 1. A severely painful and/or disabled hip
More informationEVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data
EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In
More information4. Monitoring of dissolution induced changes in film coat
4. Monitoring of dissolution induced changes in film coat composition 4.1 Introduction As membrane controlled drug delivery coatings are subjected to changes in coating composition, it is necessary to
More informationPseudo tumor a cystic or solid mass (MRI or ultrasound) 1% of MOM pts develop pseudo tumors by 5 years 17 pts, all female, Pandit et al (JBJS, 2008)
Pseudo tumor a cystic or solid mass (MRI or ultrasound) 1% of MOM pts develop pseudo tumors by 5 years 17 pts, all female, Pandit et al (JBJS, 2008) 8% at 5yrs FU indicated by preliminary study from same
More information4 Development of an ESR online-method for the monitoring of in vitro fat digestion
4 Development of an ESR online-method for the monitoring of in vitro fat digestion 4.1 Introduction When regarding the oral administration of lipid-based nanocapsules, gastrointestinal digestion will play
More informationOptimal Differentiation of Tissue Types Using Combined Mid and Near Infrared Spectroscopy
Optimal Differentiation of Tissue Types Using Combined Mid and Near Infrared Spectroscopy Mugdha V. Padalkar, M.S. 1, Cushla M. McGoverin, Ph.D. 1, Uday P. Palukuru, M.S. 1, Nicholas J. Caccese 1, Padraig
More informationSystematic Review of Clinical Outcome using Titanium Fiber Mesh Porous Ingrowth Surfaces
Systematic Review of Clinical Outcome using Titanium Fiber Mesh Porous Ingrowth Surfaces Timothy L. Tan, BS 1, Brenna C. Moeljadi, BS 2, Edward Ebramzadeh, PhD 3, Patricia Campbell, PhD 3, Sophia Nicole
More informationDATE: 21 November 2012 CONTEXT AND POLICY ISSUES
TITLE: Vitamin E Infused Polyethylene Liners, Conventional Polyethylene Liners, and Cross-Linked Polyethylene Liners for Knee Articular Resurfacing in Adults: A Review of Clinical and Cost-Effectiveness
More informationA NEW APPROACH TO BEARING SURFACES FOR TOTAL HIP ARTHROPLASTY
A NEW APPROACH TO BEARING SURFACES FOR TOTAL HIP ARTHROPLASTY by Timothy McTighe, Exec. Dir., JISRF, Chagrin Falls, Ohio Ying Ko, Ph.D., Cincinnati, Ohio Russell B. Bennett, Ph.D., Cincinnati, Ohio James
More informationARTICLE IN PRESS. Surface Oxidized Zirconium Total Hip Arthroplasty Head Damage Due to Closed Reduction. Effects on Polyethylene Wear
The Journal of Arthroplasty Vol. 00 No. 0 2008 Surface Oxidized Zirconium Total Hip Arthroplasty Head Damage Due to Closed Reduction Effects on Polyethylene Wear William L. Jaffe, MD,* Eric J. Strauss,
More informationOXIDATIVE STRESS STUDIES ON LIPID MODEL MEMBRANES
OXIDATIVE STRESS STUDIES ON LIPID MODEL MEMBRANES MARCELA ELISABETA BARBINTA-PATRASCU *, LAURA TUGULEA * * Faculty of Physics, University of Bucharest, Romania Received December 21, 2004 The liposomes
More informationChapter 2 The Chemistry of Life Part 2
Chapter 2 The Chemistry of Life Part 2 Carbohydrates are Polymers of Monosaccharides Three different ways to represent a monosaccharide Carbohydrates Carbohydrates are sugars and starches and provide
More informationProtection of DPPC phospholipid liposomal membrane against radiation oxidative damage by antioxidants
Protection of DPPC phospholipid liposomal membrane against radiation oxidative damage by antioxidants D. L. Marathe, B. N. Pandey and K. P. Mishra Radiation Biology Division, Bhabha Atomic Research Centre,
More informationCHAPTER 5 CHARACTERIZATION OF ZINC OXIDE NANO- PARTICLES
88 CHAPTER 5 CHARACTERIZATION OF ZINC OXIDE NANO- PARTICLES 5.1 INTRODUCTION This chapter deals with the characterization of ZnO nano-particles using FTIR, XRD, PSA & SEM. The results analysis and interpretations
More informationPeggers Super Summaries: THR and Revision Concepts
Total Hip replacement: ARTICUALTIONS Ceramic on polyethylene Ceramic on ceramic for young Metal on metal (resurfacing) Metal (cobalt chrome) on polyethylene WEAR Wear debris similar to bacteria o < 10
More informationRadicals. Structure and Stability of Radicals. Radicals are formed from covalent bonds by adding energy in the form of heat (Δ) or light (hν).
Radicals Chapter 15 A small but significant group of reactions involve radical intermediates. A radical is a reactive intermediate with a single unpaired electron, formed by homolysis of a covalent bond.
More informationWATERBASED RADIATION-CURABLE POLYURETHANE ACRYLATE COATINGS
WATERBASED RADIATI-CURABLE PLYURETAE ACRYLATE CATIGS by Y. eischkel*, K. Menzel+, E. Beck+, K.. Sass&, C. A. Glotfelter, F. Masson#, C. Decker#, and R. Schwalm*, BASF AG, *Polymer Research Laboratory,
More information5 Application of the ESR online-method for the monitoring of nanocapsule digestion
5 Application of the ESR online-method for the monitoring of nanocapsule digestion 5.1 Introduction The oral use of nanocapsules has received considerable attention in recent years because the bioavailability
More informationAuthor(s) Hatano, Hiroyuki; Ganno, Shigetake;
Electron Spin Resonance Studies on Title Inactivation by Direct Action of Ga Issue on Physical, Chemical and Bio Radiation, IV) Author(s) Hatano, Hiroyuki; Ganno, Shigetake; Citation Bulletin of the Institute
More informationWhite Paper: Monitoring Polar Compounds in Fryer Oil
White Paper: Monitoring Polar Compounds in Fryer Oil Nowadays, deep-frying foods is one of the most widespread culinary and industrial cooking techniques in the world. But with an emphasis on healthy eating
More informationAdditives for polyolefines: chemistry involved and innovative effects
Additives for polyolefines: chemistry involved and innovative effects Abstract Because many synthetic resins suffer from photo degradation, the investigation of ways to inhibit or at least retard this
More informationby fluorescence and Fourier-transform infrared spectroscopy
The effect of terpenoid esters on membrane structure investigated by fluorescence and Fourier-transform infrared spectroscopy Mariia Nesterkina 1,2, *, Sergii Smola 3, and Iryna Kravchenko 1,2 1 dessa
More informationLipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study)
Lipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study) Presented by Dr. AHMED ATEF DONIA, PH. D., Lecturer of Pharmaceutical Technology, Faculty of Pharmacy, Tanta
More informationBIO-BASED POLYETHYLENE/ RICE STARCH COMPOSITE
BIO-BASED POLYETHYLENE/ RICE STARCH COMPOSITE Sathaphorn O-suwankul a, Kittima Bootdee a, Manit Nititanakul* a a The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, Thailand Keywords
More informationChapter 11 Nutrition: Food for Thought
Chapter 11 Nutrition: Food for Thought Do you think about the food that goes into your body and how it affects you? How can you interpret the various nutrition information found in the press? What are
More informationASTM Committee F04 Tuesday 05/19/2015 Grand Ballroom F Platinum 9
ASTM Committee F04 Tuesday 05/19/2015 Grand Ballroom F Platinum 9 8:00 AM 8:00 AM 10:00 AM 10:00 AM F04 Attendees are invited to an ASTM Training Session on Responsibilities for Subcommittee Chairman,
More informationExperimental Prediction of Contact Area in Hip Replacement and Hemi- Arthroplasty
Experimental Prediction of Contact Area in Hip Replacement and Hemi- Arthroplasty Qianqian Wang, John Fisher, Sophie Williams. Institute of Medical and Biological Engineering, School of Mechanical Engineering,
More informationSurface evaluation of orthopedic hip implants marketed in Brazil
Surface evaluation of orthopedic hip implants marketed in Brazil M.M.Souza 1, R.M. Trommer 2, M.M.Maru 2, C.R.M.Roesler 3, W.S.Barros 1, M.S. Dutra 3 1 Dimensional Metrology Laboratory, Inmetro. Brazil;
More informationEffect of Femoral Head Size to Contact Stress at Pure Titanium Femoral Ball Head Outer Surface of Hip Joint Implant
Effect of Femoral Head Size to Contact Stress at Pure Titanium Femoral Ball Head Outer Surface of Hip Joint Implant Agung Setyo Darmawan, Waluyo Adi Siswanto, Haryanti Samekto Faculty of Mechanical and
More informationWhat is superhydrophobicity? How it is defined? What is oleophobicity?
Avijit Baidya 12.11.2016 What is superhydrophobicity? How it is defined? What is oleophobicity? Introduction : Hydrophobic and amphiphobic surfaces have been studied in great depth over the past couple
More informationCase report: Pain L THR [ post THR 2 years; with history of trivial fall] Your Diagnosis?
Case report: Pain L THR [ post THR 2 years; with history of trivial fall] Your Diagnosis? Diagnosis: Ceramic head fracture In the 1970 s, Boutin implemented ceramic in modern total hip arthroplasty (THA).
More informationInternational Journal of Pharma Sciences and Scientific Research
Research Article International Journal of Pharma Sciences and Scientific Research ISSN 2471-6782 Open Access Formulation, development and evaluation of rivaroxaban tablets by using solubility enhancement
More informationOrganic Chemistry Diversity of Carbon Compounds
Organic Chemistry Diversity of Carbon Compounds Hydrocarbons The Alkanes The Alkenes The Alkynes Naming Hydrocarbons Cyclic Hydrocarbons Alkyl Groups Aromatic Hydrocarbons Naming Complex Hydrocarbons Chemical
More informationTitle. YOON, Seokjoo; MARUYAMA, Yutaka; KA FUJITA, Shoichi. Author(s) Issue Date /jjvr
Title Application of FT-IR and ESR spectr study of CCl_4-induced peroxidation Author(s) YOON, Seokjoo; MARUYAMA, Yutaka; KA FUJITA, Shoichi Citation Japanese Journal of Veterinary Rese Issue Date 2000-02-29
More informationAdditives for waterborne coatings
Additives for waterborne coatings Wernfried Heilen 1 Introduction 2 Wetting- and dispersing additives 2.1 Modes of action 2.1.1 Pigment wetting 2.1.2 Grinding 2.1.3 Stabilisation 2.1.3.1 Electrostatic
More informationRadiation Dosimeters for Foods. Ashish Anand Department of Biological and Agricultural Engineering Texas A&M University
Radiation Dosimeters for Foods Ashish Anand Department of Biological and Agricultural Engineering Texas A&M University Introduction Interest in food irradiation technology is increasing world-wide. Some
More informationChemical Surface Transformation 1
Chemical Surface Transformation 1 Chemical reactions at Si H surfaces (inorganic and organic) can generate very thin films (sub nm thickness up to µm): inorganic layer formation by: thermal conversion:
More informationTECHNICAL DATASHEET POUR TYPE ACRYLIC RESIN PDFTPT-082
TCHNICAL DATASHT POUR TYP ACRYLIC RSIN 1 PRODUCT OVRVIW Methacrylate polymers have enjoyed great popularity in dentistry because they are easily processed by using relatively simple techniques; they have
More informationASTM Committee F04 Tuesday 11/13/2012
ASTM Committee F04 Tuesday 11/13/2012 Centennial Regency Ballroom Ballroom III V 7:00 AM 7:00 AM 8:00 AM 8:00 AM 10:00 AM 10:00 AM 11:00 AM 11:00 AM F04 Celebration of Committee F04's 50th Anniversary
More informationMatthew G. Hobbs, Peter Dufresne Jr. 1 1 EPT, th Avenue S.E. Calgary, AB, Canada
Varnish Mitigation: Relative Effectiveness of Non-Deposit-Forming Next Generation Lubricants vs. the Use of Varnish-Removal Filters with their Conventional Counterparts Matthew G. Hobbs, Peter Dufresne
More informationThe Synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. The modified starch nanoparticles were
CHAPTER 4 Hydrophobic grafted and crosslinked starch nano particles for drug delivery The Synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. The modified
More informationBone Apatite Composition Of Osteonecrotic Trabecular Bone From The Femoral Head Of Immature Pigs
Bone Apatite Composition Of Osteonecrotic Trabecular Bone From The Femoral Head Of Immature Pigs Olumide O. Aruwajoye 1,2, Harry KW Kim, MD 1, Pranesh B. Aswath, PhD 2. 1 Texas Scottish Rite Hospital,
More informationExeter. Designed for Anatomic Restoration. Clinical Evidence Education
Exeter Designed for Anatomic Restoration Clinical Evidence Education Anatomic Restoration Exeter re-creating biomechanics In hip replacement, the smallest adjustment can make a big difference. Stryker
More informationCHAPTER 10 IMPROVING LIGHT FASTNESS OF REACTIVE DYED COTTON FABRIC WITH COMBINED APPLICATION OF ULTRAVIOLET ABSORBERS AND ANTIOXIDANTS
166 CHAPTER 10 IMPROVING LIGHT FASTNESS OF REACTIVE DYED COTTON FABRIC WITH COMBINED APPLICATION OF ULTRAVIOLET ABSORBERS AND ANTIOXIDANTS 10.1 INTRODUCTION In the light fastness of dyes the impact of
More informationY FILMS DOSIMETR Nederland België / Belgique
DOSIMETRY FILMS GAFCHROMIC Dosimetry Films The Self-developing Dosimetry Films that Allow You to Go Filmless Do away with the cost and headache of calibrating and maintaining a processor Do away with hazardous
More informationEvaluation of bond to Enigma High Impact Denture Base
page 13 Evaluation of bond to Enigma High Impact Denture Base 1 Assignment Evaluation of the bonding strength between each layer of artificial tooth material and denture base resin at the site of fracture
More information2. Block Copolymers. 2.1 Micelle and gel formation in amphiphilic block copolymers. 2.2 Phase behavior in the bulk. 2.3 Structures in thin films
2. Block Copolymers 2.1 Micelle and gel formation in amphiphilic block copolymers 2.2 Phase behavior in the bulk 2.3 Structures in thin films I.W. Hamley, Block Copolymers in Solution. Wiley 2005. 1 Block
More informationSynthesis and Evaluation of Esterified Estolide
Chapter 5 Synthesis and Evaluation of Esterified Estolide 5.1 Introduction Coconut oil has a very high congelation temperature precluding its use as base oil for industrial lubricants in temperate and
More informationCement Polished Tapered Stems of 12/14 Taper. 96 mm 98 mm 104 mm 110 mm 116 mm 122 mm 128 mm. Ceramic Femoral Head. Outer Diameter
Design Philosophy Cementless Stems of 12/14 Taper Stem Length Neck shaft Angle STEM-N3 STEM-N4 STEM-N5 STEM-N6 STEM-N7 STEM-N8 STEM-N9 123 mm 125 mm 130 mm 135 mm 140 mm 145 mm 150 mm 132 Cement Polished
More informationCAUTION Federal law (USA) restricts this device to sale, by or on the order of a physician.
CAUTION Federal law (USA) restricts this device to sale, by or on the order of a physician. ENGLISH Mpact 3D Metal Implants and Augments 3D Metal INSTRUCTION FOR USE Important notice: the device(s) can
More informationSP2 Report. Part 3: Epoxy Coating Specification
SP2 Report On Part 3: Epoxy Coating Specification Author: Marjorie Valix Chief Investigator: Marjorie Valix 1 Table of Contents 1. INTRODUCTION... 2 2. RESULTS... 4 2.1 EFFECT OF LOI... 6 2.2 EFFECT OF
More informationINFLUENCE OF ADDITIVES IN SPINNING DOPE AND SPIN BATH TEMPERATURES ON STRUCTURE AND PROPERTIES OF ACRYLONITRILE TERPOLYMER FIBERS
INFLUENCE OF ADDITIVES IN SPINNING DOPE AND SPIN BATH TEMPERATURES ON STRUCTURE AND PROPERTIES OF ACRYLONITRILE TERPOLYMER FIBERS by M. SURYA KUMARI DEPARTMENT OF TEXTILE TECHNOLOGY Submitted in fulfilment
More informationFABRICATION OF POLYMERIC FILMS AND COATINGS ON NICKEL-TITANIUM SHAPE MEMORY ALLOY AND THEIR BIOMEDICAL APPLICATIONS
FABRICATION OF POLYMERIC FILMS AND COATINGS ON NICKEL-TITANIUM SHAPE MEMORY ALLOY AND THEIR BIOMEDICAL APPLICATIONS LI PENGHUI DOCTOR OF PHILOSOPHY CITY UNIVERSITY OF HONG KONG AUGUST 2014 CITY UNIVERSITY
More informationPREPARATION OF MONTMORILLONITE- POLYACRYLAMIDE INTERCALATION COMPOUNDS AND THE WATER ABSORBING PROPERTY
Clay Science 7, 243-251 (1989) PREPARATION OF MONTMORILLONITE- POLYACRYLAMIDE INTERCALATION COMPOUNDS AND THE WATER ABSORBING PROPERTY MAKOTO OGAWA, KAZUYUKI KURODA and CHUZO KATO Department of Applied
More informationModel for measurement of water layer thickness under lipid bilayers by surface plasmon resonance
Model for measurement of water layer thickness under lipid bilayers by surface plasmon resonance Koyo Watanabe Unit of Measurement Technology, CEMIS-OULU, University of Oulu, PO Box 51, 87101 Kajaani,
More informationSENTRY TM POLYOX Water Soluble Resins
SENTRY TM POLYOX Water Soluble Resins Technical Information on Stability Introduction Key Points Antioxidants SENTRY POLYOX WSR resins consist of a family of high molecular weight polyethers with nominal
More informationCan Wetting and Dispersing Additives Improve the Durability of Coatings? János Hajas. Technical support manager Coating additives
Lehet-e nedvesitö-és diszpergálószerekkel a festékek tartósságát javítani? Wetting, Dispersion and Stabilization of Titanium Dioxide in Organic Coatings Can Wetting and Dispersing Additives Improve the
More informationContinuous Granulation Using a Twin-Screw Extruder. Lin Zhu, Ph.D. Manufacture Science and Technology AbbVie June, 2016
Continuous Granulation Using a Twin-Screw Extruder Lin Zhu, Ph.D. Manufacture Science and Technology AbbVie June, 2016 What is a twin screw extruder and how to use it for continuous granulation? Dry feed:
More informationGreat Lakes Generation
Great Lakes Generation Jack Boilerman 20338 Progress Dr. Strongsville, OH 44149 216-251-2510 Machine No: 19-1-3007 Fluid Type: Phosphate Ester Machine Type: EHC Hydraulic System Sample Source: Unit 1 EHC
More informationStudy on Synthesis of Maleic Anhydride Grafted Starch Jian-Jiang SHANG1, a*, Li-Na JIANG1,b, De-Qiang LI2,c and Xiao-Yan ZHU1,d
Proceedings of the 3rd International Conference on Material Engineering and Application (ICMEA 2016) Study on Synthesis of Maleic Anhydride Grafted Starch Jian-Jiang SHANG1, a*, Li-Na JIANG1,b, De-Qiang
More informationG7 ACETABULAR SYSTEM. beautifully. efficient.
G7 ACETABULAR SYSTEM beautifully efficient. HERITAGE MEETS MODERN DESIGN SIMPLICITY, EFFICIENCY AND PERFORMANCE The G7 System is a multi-bearing acetabular platform delivering simplicity, efficiency and
More informationSulzer Orthopedics Joint & Fracture Care
Sulzer Orthopedics Joint & Fracture Care Natural-Knee Family Anatomic design for superior clinical results. Natural-Knee Natural-Knee Family: A solution for every knee. Asymmetric design increases coverage
More informationDocument No Rev. B Pg. 1 of 5 Approvals / Date Title: INSTRUCTIONS FOR USE DJO SURGICAL MODULAR REVISION HIP SYSTEM AND ACETABULAR CAGE
Document No. 0400-0205 Rev. B Pg. 1 of 5 Approvals / Date Title: INSTRUCTIONS FOR USE DJO SURGICAL MODULAR REVISION HIP SYSTEM AND ACETABULAR CAGE Revision ECO Date ECO Summary of Changes Deann Rector
More informationLecture No (3) Latex
Lecture No (3) Latex Rubber Latex The latex is a mixture of compounds consists of special structures called laticifers, which have many compositions for different types, but typically contains water, sugars,
More informationIn vitro Accelerated Aging of Composites and a Sealant
In vitro Accelerated Aging of Composites and a Sealant J. M. POWERS, P.L. FAN, and M. MARCOTTE School ofdentistry, University of Michigan, Ann Arbor, Michigan 48109 The in vitro accelerated aging of conventional
More informationBone Bangalore
Dr Suresh Annamalai MBBS, MRCS(Edn), FRCS( Tr & Orth)(Edn), FEBOT(European Board), Young Hip and Knee Fellowship(Harrogate, UK) Consultant Arthroplasty and Arthroscopic Surgeon Manipal Hospital, Whitefield,
More informationEffects of Film Variety on the Amountsof Carboxylic Acids from Electron Beam Irradiated Polyethylene Film
Agric. Biol. Chem., 48 (8), 2003-2008, 1984 2003 Effects of Film Variety on the Amountsof Carboxylic Acids from Electron Beam Irradiated Polyethylene Film Keiko Azuma, Yoshikazu Tanaka, Hirotaka Tsunoda,*
More informationFORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam
More informationEffect of Surface-Treated ZnO on Mechanical and Morphological Properties of High Density Polyethylene/ZnO Nanocomposites
Paper Code: pp011 TIChE International Conference 2011 Effect of Surface-Treated ZnO on Mechanical and Morphological Properties of High Density Polyethylene/ZnO Nanocomposites Pannida Kijkobchai *, Sirirat
More informationEffects of Diet, Packaging and Irradiation on Protein Oxidation, Lipid Oxidation of Raw Broiler Thigh Meat
AS 659 ASL R26 203 Effects of Diet, Packaging and Irradiation on Protein Oxidation, Lipid Oxidation of Raw Broiler Thigh Meat Shan Xiao Iowa State University Wan Gang Zhang Iowa State University Eun Joo
More informationCERAMIC-ON-METAL. References: Cat No: version 2
CERAMIC-ON-METAL References: 1. Beaule, P. E., et al. Jumbo femoral head for the treatment of recurrent dislocation following total hip replacement. J.Bone Joint Surg (2002). 84-A: 256-63. 2. Jolles, B.
More informationTime (min) Supplementary Figure 1: Gas decomposition products of irradiated DMC.
200000 C 2 CH 3 CH 3 DMC 180000 160000 140000 Intensity 120000 100000 80000 60000 40000 C 2 H 6 CH 3 CH 2 CH 3 CH 3 CCH 3 EMC DEC 20000 C 3 H 8 HCCH 3 5 10 15 20 25 Time (min) Supplementary Figure 1: Gas
More informationTest Bank for Lehninger Principles of Biochemistry 5th Edition by Nelson
Test Bank for Lehninger Principles of Biochemistry 5th Edition by Nelson Link download full: http://testbankair.com/download/test-bank-forlehninger-principles-of-biochemistry-5th-edition-by-nelson/ Chapter
More informationRegulatory role of mesenchymal stem cells in osteoclast differentiation. , Masahiro Kondo and Yoshiya Tanaka 1, )
217 Mini Review Regulatory role of mesenchymal stem cells in osteoclast differentiation Koichi Oshita 1, 2), Kunihiro Yamaoka 1) 1, 2), Masahiro Kondo and Yoshiya Tanaka 1, ) 1) The First Department of
More informationList of Figure. Figure 1.1. Selective pathways for the metabolism of arachidonic acid
List of Figure Figure 1.1. Selective pathways for the metabolism of arachidonic acid Figure 1.2. Arachidonic acid transformation to ω and ω-1 hydroxylase 14 19 reaction mediated by cytochrome P450 enzyme
More informationInfluence of Preparation Conditions on the Physical Properties of Zein Films
Influence of Preparation Conditions on the Physical Properties of Zein Films Tomoyuki Yoshino a, Seiichiro Isobe b, *, and Takaaki Maekawa c a Agricultural Sciences, University of Tsukuba, Tsukuba, Ibaraki
More informationNMR spectroscopy of saccharide-doped PAGAT dosimeters
University of Wollongong Research Online Faculty of Engineering and Information Sciences - Papers: Part A Faculty of Engineering and Information Sciences 2015 NMR spectroscopy of saccharide-doped PAGAT
More informationFabrication of Nanofiltration Membrane from Polysulfone Ultrafiltration Membrane Via Photo Polymerization
Fabrication of Nanofiltration Membrane from Polysulfone Ultrafiltration Membrane Via Photo Polymerization A. Akbari 1*, M. Homayoonfal 1 Nanoscience and Nanotechnology Institute, University of Kashan,
More information3.1.3 Lipids. Source: AQA Spec
alevelbiology.co.uk SPECIFICATION Triglycerides and phospholipids are two groups of lipid. Triglycerides are formed by the condensation of one molecule of glycerol and three molecules of fatty acid. A
More information