DOWNLOAD OR READ : LIPOPOLYSACCHARIDE ENDOTOXIN INDUCES IL 18 VIA CD14 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO PDF EBOOK EPUB MOBI

Size: px
Start display at page:

Download "DOWNLOAD OR READ : LIPOPOLYSACCHARIDE ENDOTOXIN INDUCES IL 18 VIA CD14 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO PDF EBOOK EPUB MOBI"

Transcription

1 DOWNLOAD OR READ : LIPOPOLYSACCHARIDE ENDOTOXIN INDUCES IL 18 VIA CD14 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO PDF EBOOK EPUB MOBI Page 1

2 Page 2

3 lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro lipopolysaccharide endotoxin induces il pdf lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Discovery. The toxic activity of LPS was first discovered and termed "endotoxin" by Richard Friedrich Johannes Pfeiffer, who distinguished between exotoxins, which he classified as a toxin that is released by bacteria into the surrounding environment, and endotoxins, which he considered to be a toxin kept "within" the bacterial cell and released only after destruction of the bacterial cell wall. Lipopolysaccharide - Wikipedia lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock (PDF) Central role for type I interferons and Tyk2 in lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Bacterial lipopolysaccharide induces a dose-dependent activation of rat neuroglia and cholinergic cell loss Bacterial lipopolysaccharide induces a dose-dependent lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro MyD88 is a general adaptor protein that plays an important role in the Toll/IL-1 receptor family signalings. Recently, Toll-like receptors 2 and 4 (TLR2 and TLR4) have been suggested to be the signaling receptors for lipopolysaccharide (LPS). Unresponsiveness of MyD88-Deficient Mice to Endotoxin lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro 2 LAL Update March 1998 TECHNICAL REPORT The influence of endotoxin upon cytokine production by single cell types in vitrohas been widely reported.endotoxin has been cited as the most potent stimulus for tumor necrosis factor (TNF) production. 17 Effects upon transcription have been noted18,19,20,21 and it has been suggested that the primary regulation of stimulation may occur at LALUpdate lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Systemic exposure to LPS from Porphyromonas gingivalis induces AD-like phenotypes.. Cathepsin B is critical for inducing microglia-mediated neuroinflammation. â Cathepsin B is critical for inducing microglia-dependent Aβ accumulation in neurons. Cathepsin B plays a critical role in inducing Alzheimerâ s lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro The Association for Academic Surgery is widely recognized as an inclusive surgical organization. The impetus of the membership remains research-based academic surgery, and to promote the shared vision of research and academic pursuits through the exchange of ideas between senior surgical residents, junior faculty and established academic surgical professors. Journal of Surgical Research Home Page lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro The Protein Purification Facility is a learning station and a resource of information and assistance available to researches and students as well as biotech and pharmaceutical companies interested in protein purification. Page 3

4 The Protein Purification Facility lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Air pollution leads to well-documented cardiovascular and respiratory problems 1,2, brain cancer, and neurological disorders including strokes, Alzheimerâ s, and Parkinsonâ s disease 3,4,5,6,7... Coarse particulate matter (PM 2.5â 10 ) in Los Angeles lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.it is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and... Tumor necrosis factor alpha - Wikipedia lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Seminars in Immunology 16 (2004) 3â 9 TLR signaling pathways Kiyoshi Takeda, Shizuo Akira∠Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, TLR signaling pathways - Columbia University lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro Christoph Mueller, University of Bern, Pathology Department, Faculty Member. Studies Tumor Immunology, Cell Signaling, and Inflammation. Christoph Mueller University of Bern - Academia.edu lipopolysaccharide endotoxin induces il 18 via cd14 in human peripheral blood mononuclear cells in vitro PA induces inflammation in the heart through MD2. We first determined whether PA induces innate immune responses in the cardiac tissue and whether MD2 is involved in this process. Page 4

5 Page 5

DOWNLOAD OR READ : TUMOR BIOLOGY REGULATION OF CELL GROWTH DIFFERENTIATION AND GENETICS IN CANCER PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : TUMOR BIOLOGY REGULATION OF CELL GROWTH DIFFERENTIATION AND GENETICS IN CANCER PDF EBOOK EPUB MOBI DOWNLOAD OR READ : TUMOR BIOLOGY REGULATION OF CELL GROWTH DIFFERENTIATION AND GENETICS IN CANCER PDF EBOOK EPUB MOBI Page 1 Page 2 tumor biology regulation of cell growth differentiation and genetics

More information

11/25/2017. THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS BARRIER DEFENSES INNATE IMMUNITY OF VERTEBRATES

11/25/2017. THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS BARRIER DEFENSES INNATE IMMUNITY OF VERTEBRATES THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS Exoskeleton made of chitin forms the first barrier to pathogens Digestive system is protected by a chitin-based barrier and lysozyme,

More information

Immunology lecture: 14. Cytokines: Main source: Fibroblast, but actually it can be produced by other types of cells

Immunology lecture: 14. Cytokines: Main source: Fibroblast, but actually it can be produced by other types of cells Immunology lecture: 14 Cytokines: 1)Interferons"IFN" : 2 types Type 1 : IFN-Alpha : Main source: Macrophages IFN-Beta: Main source: Fibroblast, but actually it can be produced by other types of cells **There

More information

Under the Radar Screen: How Bugs Trick Our Immune Defenses

Under the Radar Screen: How Bugs Trick Our Immune Defenses Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 3: Toll-like receptors (TLRs) Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research Introduction to Toll-like

More information

How the Innate Immune System Profiles Pathogens

How the Innate Immune System Profiles Pathogens How the Innate Immune System Profiles Pathogens Receptors on macrophages, neutrophils, dendritic cells for bacteria and viruses Broad specificity - Two main groups of bacteria: gram positive, gram-negative

More information

Innate Immunity & Inflammation

Innate Immunity & Inflammation Innate Immunity & Inflammation The innate immune system is an evolutionally conserved mechanism that provides an early and effective response against invading microbial pathogens. It relies on a limited

More information

Overview of the Immune System

Overview of the Immune System Overview of the Immune System Immune System Innate (Nonspecific) Adaptive (Specific) Cellular Components Humoral Components Cell-Mediated Humoral (Ab) Antigens Definitions Immunogen Antigen (Ag) Hapten

More information

immunity defenses invertebrates vertebrates chapter 48 Animal defenses --

immunity defenses invertebrates vertebrates chapter 48 Animal defenses -- defenses Animal defenses -- immunity chapter 48 invertebrates coelomocytes, amoebocytes, hemocytes sponges, cnidarians, etc. annelids basophilic amoebocytes, acidophilic granulocytes arthropod immune systems

More information

Innate Immunity. Natural or native immunity

Innate Immunity. Natural or native immunity Innate Immunity 1 Innate Immunity Natural or native immunity 2 When microbes enter in the body 3 Secondly, it also stimulates the adaptive immune system 4 Immunologic memory 5 Components of Innate Immunity

More information

Innate immune regulation of T-helper (Th) cell homeostasis in the intestine

Innate immune regulation of T-helper (Th) cell homeostasis in the intestine Innate immune regulation of T-helper (Th) cell homeostasis in the intestine Masayuki Fukata, MD, Ph.D. Research Scientist II Division of Gastroenterology, Department of Medicine, F. Widjaja Foundation,

More information

Innate immunity. Abul K. Abbas University of California San Francisco. FOCiS

Innate immunity. Abul K. Abbas University of California San Francisco. FOCiS 1 Innate immunity Abul K. Abbas University of California San Francisco FOCiS 2 Lecture outline Components of innate immunity Recognition of microbes and dead cells Toll Like Receptors NOD Like Receptors/Inflammasome

More information

2. Innate immunity 2013

2. Innate immunity 2013 1 Innate Immune Responses 3 Innate immunity Abul K. Abbas University of California San Francisco The initial responses to: 1. Microbes: essential early mechanisms to prevent, control, or eliminate infection;

More information

Innate Immunity. Natural or native immunity

Innate Immunity. Natural or native immunity Innate Immunity 1 Innate Immunity Natural or native immunity 2 When microbes enter in the body 3 Secondly, it also stimulates the adaptive immune system 4 Immunologic memory 5 Components of Innate Immunity

More information

Innate Immunity. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples Chapter 3. Antimicrobial peptide psoriasin

Innate Immunity. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples Chapter 3. Antimicrobial peptide psoriasin Know Differences and Provide Examples Chapter * Innate Immunity * kin and Epithelial Barriers * Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive

More information

Chapter 16 Innate Immunity: Nonspecific Defenses of the Host

Chapter 16 Innate Immunity: Nonspecific Defenses of the Host Module 10 Chapter 16 Innate Immunity: Nonspecific Defenses of the Host The concept of immunity Immunity: ability to protect against from microbes and their o Aka, Susceptibility: vulnerability or lack

More information

INNATE IMMUNITY Non-Specific Immune Response. Physiology Unit 3

INNATE IMMUNITY Non-Specific Immune Response. Physiology Unit 3 INNATE IMMUNITY Non-Specific Immune Response Physiology Unit 3 Protection Against Infection The body has several defenses to protect itself from getting an infection Skin Mucus membranes Serous membranes

More information

The Lymphatic System. Innate Immunity

The Lymphatic System. Innate Immunity The Lymphatic System Innate Immunity 1 Types of Immunity Innate (non-specific) immunity Adaptive (specific) immunity The human body has several different ways that it defends itself against infection by

More information

TD-BF01: Innate immunity to microorganisms

TD-BF01: Innate immunity to microorganisms TD-BF01: Innate immunity to microorganisms I. Toll receptors (adapted from Takeuchi, O. et al. (1999) Immunity 11:443; Kawai, T. et al. (1999) Immunity 11:115; Hemmi, H. et al. (2000) Nature 408:740; Muzio,

More information

Chapter 24 The Immune System

Chapter 24 The Immune System Chapter 24 The Immune System The Immune System Layered defense system The skin and chemical barriers The innate and adaptive immune systems Immunity The body s ability to recognize and destroy specific

More information

Chapter 35 Active Reading Guide The Immune System

Chapter 35 Active Reading Guide The Immune System Name: AP Biology Mr. Croft Chapter 35 Active Reading Guide The Immune System Section 1 Phagocytosis plays an important role in the immune systems of both invertebrates and vertebrates. Review the process

More information

Cytokines (II) Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel:

Cytokines (II) Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel: Cytokines (II) Dr. Aws Alshamsan Department of Pharmaceu5cs Office: AA87 Tel: 4677363 aalshamsan@ksu.edu.sa Learning Objectives By the end of this lecture you will be able to: 1 Understand the physiological

More information

The TNF & TNF receptor superfamillies

The TNF & TNF receptor superfamillies TNF Luca Tordella The TNF & TNF receptor superfamillies R.M.Locksley et al.,the TNF and TNF receptor superfamilies: integrating mammalian biology, Cell, 104:487,2001 Late 1800s: Dr William Coley at the

More information

Basis of Immunology and

Basis of Immunology and Basis of Immunology and Immunophysiopathology of Infectious Diseases Jointly organized by Institut Pasteur in Ho Chi Minh City and Institut Pasteur with kind support from ANRS & Université Pierre et Marie

More information

CYTOKINES. Based on: Cellular and Molecular Immunology, 4 th ed.,abbas A.K., Lichtman A.H. and Pober J.S. Sounders company; Philadelphia, 2010.

CYTOKINES. Based on: Cellular and Molecular Immunology, 4 th ed.,abbas A.K., Lichtman A.H. and Pober J.S. Sounders company; Philadelphia, 2010. CYTOKINES Based on: Cellular and Molecular Immunology, 4 th ed.,abbas A.K., Lichtman A.H. and Pober J.S. Sounders company; Philadelphia, 2010. 1 What are cytokines? Glycoproteins (15 25 kda): Interleukins

More information

Accepted Manuscript. Innate immune cells regulate oncoimmunity and cancer development. Ai-Ping Bai, Yuan Guo

Accepted Manuscript. Innate immune cells regulate oncoimmunity and cancer development. Ai-Ping Bai, Yuan Guo Accepted Manuscript Innate immune cells regulate oncoimmunity and cancer development Ai-Ping Bai, Yuan Guo PII: S0016-5085(18)34974-6 DOI: 10.1053/j.gastro.2018.08.057 Reference: YGAST 62119 To appear

More information

Toll-like Receptor Signaling

Toll-like Receptor Signaling Toll-like Receptor Signaling 1 Professor of Medicine University of Massachusetts Medical School, Worcester, MA, USA Why do we need innate immunity? Pathogens multiply very fast We literally swim in viruses

More information

Lecture on Innate Immunity and Inflammation

Lecture on Innate Immunity and Inflammation Lecture on Innate Immunity and Inflammation Evolutionary View Epithelial barriers to infection Four main types of innate recognition molecules:tlrs, CLRs, NLRs, RLRs NF-κB, the master transcriptional regulator

More information

1. TLR. TLR Toll-like receptors. Toll Toll-like receptor, TLR TLR TLR TLR. type I TLR TLR. Toll

1. TLR. TLR Toll-like receptors. Toll Toll-like receptor, TLR TLR TLR TLR. type I TLR TLR. Toll 54pp.145 152 2004 1. TLR T B TLR Toll-like receptors TLR TLR I IFN TLR T B B T Toll NF- B 1996 565-0871 3-1 TEL 06-6879-8303 FAX 06-6879-8305 E-mail uemattsu@biken.osaka-u.ac.jp Toll Toll-like receptor,

More information

Animal Models to Understand Immunity

Animal Models to Understand Immunity Animal Models to Understand Immunity Hussein El Saghire hesaghir@sckcen.be Innate Adaptive immunity Immunity MAPK and NF-kB TLR pathways receptors Fast Slow Non-specific Specific NOD-like receptors T-cell

More information

Commensal Bacteria, Toll-like Receptors and Intestinal Injury. Journal Club December 16, 2004

Commensal Bacteria, Toll-like Receptors and Intestinal Injury. Journal Club December 16, 2004 Commensal Bacteria, Toll-like Receptors and Intestinal Injury Journal Club December 16, 2004 Gut-Commensal Interactions Nutrient metabolism Tissue development Resistance to colonization with pathogens

More information

Overview of the immune system

Overview of the immune system Overview of the immune system Immune system Innate (nonspecific) 1 st line of defense Adaptive (specific) 2 nd line of defense Cellular components Humoral components Cellular components Humoral components

More information

Immune Surveillance. Immune Surveillance. Immune Surveillance. Neutrophil granulocytes Macrophages. M-cells

Immune Surveillance. Immune Surveillance. Immune Surveillance. Neutrophil granulocytes Macrophages. M-cells he immune system is everywhere Some organs have developed strategies towards the immune system to keep it out or to put it under control Immune privileged organs: Brain Eye estis hyroid gland Humoral immunity

More information

Chapter 10 (pages ): Differentiation and Functions of CD4+ Effector T Cells Prepared by Kristen Dazy, MD, Scripps Clinic Medical Group

Chapter 10 (pages ): Differentiation and Functions of CD4+ Effector T Cells Prepared by Kristen Dazy, MD, Scripps Clinic Medical Group FIT Board Review Corner September 2015 Welcome to the FIT Board Review Corner, prepared by Andrew Nickels, MD, and Sarah Spriet, DO, senior and junior representatives of ACAAI's Fellows-In-Training (FITs)

More information

Writing Effective Grant Proposals

Writing Effective Grant Proposals WritingEffectiveGrantProposals SUPPLEMENTALHANDOUT EXERCISES (toaccompanypowerpointslidepresentation) PamelaDerish ScientificPublicationsManager DepartmentofSurgery,UCSF tel415.885 7686 Pamela.Derish@ucsfmedctr.org

More information

Lines of defense. Innate Immunity. Immunity. First line of defense: Skin and mucous membranes 11/20/2016. Chapter 16 BIO 220

Lines of defense. Innate Immunity. Immunity. First line of defense: Skin and mucous membranes 11/20/2016. Chapter 16 BIO 220 Lines of defense Innate Immunity Chapter 16 BIO 220 Immunity The ability to ward off disease caused by microbes or their products and to protect against environmental agents such as pollen, chemicals,

More information

1. The scavenger receptor, CD36, functions as a coreceptor for which TLR? a. TLR ½ b. TLR 3 c. TLR 4 d. TLR 2/6

1. The scavenger receptor, CD36, functions as a coreceptor for which TLR? a. TLR ½ b. TLR 3 c. TLR 4 d. TLR 2/6 Allergy and Immunology Review Corner: Cellular and Molecular Immunology, 8th Edition By Abul K. Abbas, MBBS, Andrew H. H. Lichtman, MD, PhD and Shiv Pillai, MBBS, PhD. Chapter 4 (pages 62-74): Innate Immunity

More information

There are 2 major lines of defense: Non-specific (Innate Immunity) and. Specific. (Adaptive Immunity) Photo of macrophage cell

There are 2 major lines of defense: Non-specific (Innate Immunity) and. Specific. (Adaptive Immunity) Photo of macrophage cell There are 2 major lines of defense: Non-specific (Innate Immunity) and Specific (Adaptive Immunity) Photo of macrophage cell Development of the Immune System ery pl neu mφ nk CD8 + CTL CD4 + thy TH1 mye

More information

生命科学基础 (21)- 动物的免疫器官. The Immune System. KE, Yuehai 柯越海. Zhejiang University, School of Basic Medical Sciences (BMS-ZJU) 浙江大学基础医学院

生命科学基础 (21)- 动物的免疫器官. The Immune System. KE, Yuehai 柯越海. Zhejiang University, School of Basic Medical Sciences (BMS-ZJU) 浙江大学基础医学院 生命科学基础 (21)- 动物的免疫器官 The Immune System KE, Yuehai 柯越海 Zhejiang University, School of Basic Medical Sciences (BMS-ZJU) 浙江大学基础医学院 Outlines The Immune System 1. Innate immunity 2. Adaptive immunity 3. Immune

More information

Immune System. Presented by Kazzandra Anton, Rhea Chung, Lea Sado, and Raymond Tanaka

Immune System. Presented by Kazzandra Anton, Rhea Chung, Lea Sado, and Raymond Tanaka Immune System Presented by Kazzandra Anton, Rhea Chung, Lea Sado, and Raymond Tanaka Content Standards 35.1 In innate immunity, recognition and response rely on traits common to groups of pathogens 35.2

More information

PATHOGENICITY OF MICROORGANISMS

PATHOGENICITY OF MICROORGANISMS PATHOGENICITY OF MICROORGANISMS Some microorganisms are : 1- Harmless microorganism, as normal flora 2- Harmfull microorganism, as pathogenic. A pathogenic microorganism is defined as one that causes or

More information

Structure and Function of Antigen Recognition Molecules

Structure and Function of Antigen Recognition Molecules MICR2209 Structure and Function of Antigen Recognition Molecules Dr Allison Imrie allison.imrie@uwa.edu.au 1 Synopsis: In this lecture we will examine the major receptors used by cells of the innate and

More information

Defense mechanism against pathogens

Defense mechanism against pathogens Defense mechanism against pathogens Immune System What is immune system? Cells and organs within an animal s body that contribute to immune defenses against pathogens ( ) Bacteria -Major entry points ;open

More information

محاضرة مناعت مدرس المادة :ا.م. هدى عبدالهادي علي النصراوي Immunity to Infectious Diseases

محاضرة مناعت مدرس المادة :ا.م. هدى عبدالهادي علي النصراوي Immunity to Infectious Diseases محاضرة مناعت مدرس المادة :ا.م. هدى عبدالهادي علي النصراوي Immunity to Infectious Diseases Immunity to infection depends on a combination of innate mechanisms (phagocytosis, complement, etc.) and antigen

More information

Innate Immunity. Lines of defense. Immunity. Innate vs. adaptive immunity 11/24/2017

Innate Immunity. Lines of defense. Immunity. Innate vs. adaptive immunity 11/24/2017 Immunity Innate Immunity Chapter 16 BIO 220 The ability to ward off disease caused by microbes or their products and to protect against environmental agents such as pollen, chemicals, and pet dander Innate

More information

Microbial Mechanisms of Pathogenicity & Innate Immunity: Nonspecific Defenses of the Host

Microbial Mechanisms of Pathogenicity & Innate Immunity: Nonspecific Defenses of the Host Microbial Mechanisms of Pathogenicity & Innate Immunity: Nonspecific Defenses of the Host Microbial Mechanisms of Pathogenicity Pathogenicity: Virulence: The extent of pathogenicity. - function of: - infectivity

More information

Lecture on Innate Immunity and Inflammation. Innate Immunity: An Evolutionary View

Lecture on Innate Immunity and Inflammation. Innate Immunity: An Evolutionary View Lecture on Innate Immunity and Inflammation Evolutionary View Epithelial barriers to infection Four main types of innate recognition molecules:tlrs, CLRs, NLRs, RLRs NF-κB, the master transcriptional regulator

More information

Immunology Part II. Innate Immunity. 18. April 2018, Ruhr-Universität Bochum Marcus Peters,

Immunology Part II. Innate Immunity. 18. April 2018, Ruhr-Universität Bochum Marcus Peters, Immunology Part II Innate Immunity 18. April 2018, Ruhr-Universität Bochum Marcus Peters, marcus.peters@rub.de Conserved structures of pathogens PAMPs are detected by Pattern Recognition Receptors PRRs

More information

ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS. Choompone Sakonwasun, MD (Hons), FRCPT

ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS. Choompone Sakonwasun, MD (Hons), FRCPT ACTIVATION AND EFFECTOR FUNCTIONS OF CELL-MEDIATED IMMUNITY AND NK CELLS Choompone Sakonwasun, MD (Hons), FRCPT Types of Adaptive Immunity Types of T Cell-mediated Immune Reactions CTLs = cytotoxic T lymphocytes

More information

Innate Immunity. Chapter 3. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples. Antimicrobial peptide psoriasin

Innate Immunity. Chapter 3. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples. Antimicrobial peptide psoriasin Chapter Know Differences and Provide Examples Innate Immunity kin and Epithelial Barriers Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive Immunity

More information

Medical Virology Immunology. Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University

Medical Virology Immunology. Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Medical Virology Immunology Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Human blood cells Phases of immune responses Microbe Naïve

More information

ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY

ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY The recognition of specific antigen by naïve T cell induces its own activation and effector phases. T helper cells recognize peptide antigens through

More information

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 13 Effector Responses: Cell- and Antibody-Mediated Immunity Copyright 2013 by W. H.

More information

Components of the innate immune system

Components of the innate immune system Components of the innate immune system Before our discussion about innate immunity Differences between innate and adaptive systems: Innate immune system = natural = native -Germline: prepared before exposure

More information

Immune response to infection

Immune response to infection Immune response to infection Dr. Sandra Nitsche (Sandra.Nitsche@rub.de ) 20.06.2018 1 Course of acute infection Typical acute infection that is cleared by an adaptive immune reaction 1. invasion of pathogen

More information

Cutaneous Immunology: Innate Immune Responses. Skin Biology Lecture Series

Cutaneous Immunology: Innate Immune Responses. Skin Biology Lecture Series Cutaneous Immunology: Innate Immune Responses Skin Biology Lecture Series The Immune Response: Innate and Adaptive Components Source: Wolff, Goldsmith, Katz, Gilchrest, Paller, Leffell. Fitzpatrick s Dermatology

More information

The Immune System. These are classified as the Innate and Adaptive Immune Responses. Innate Immunity

The Immune System. These are classified as the Innate and Adaptive Immune Responses. Innate Immunity The Immune System Biological mechanisms that defend an organism must be 1. triggered by a stimulus upon injury or pathogen attack 2. able to counteract the injury or invasion 3. able to recognise foreign

More information

Natural Defense Mechanisms

Natural Defense Mechanisms Color code: Important in red Extra in blue For team error adjustments, click here Natural Defense Mechanisms Objectives To know First (non-specific immunity) and second (adaptive immunity) lines of defense

More information

Innate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016

Innate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016 Innate Immunity Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016 Objectives: Explain how innate immune system recognizes foreign substances

More information

All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity

All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity 1 2 3 4 5 6 7 8 9 The Immune System All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity Figure 43.2 In innate immunity, recognition and

More information

The Skinny of the Immune System

The Skinny of the Immune System The Skinny of the Immune System Robert Hostoffer, DO, FACOP, FAAP Associate Professor of Pediatrics Case Western Reserve University, Cleveland, Ohio Overview 1. Immune system of the skin 2. Immune Players

More information

Bruce A. Beutler and Jules A. Hoffmann. Ralph M. Steinman

Bruce A. Beutler and Jules A. Hoffmann. Ralph M. Steinman PRESS RELEASE 20-0-03 The Nobel Assembly at Karolinska Institutet has today decided that The 20 Nobel Prize in Physiology or Medicine shall be divided, with one half jointly to Bruce A. Beutler and Jules

More information

ANATOMY OF THE IMMUNE SYSTEM

ANATOMY OF THE IMMUNE SYSTEM Immunity Learning objectives Explain what triggers an immune response and where in the body the immune response occurs. Understand how the immune system handles exogenous and endogenous antigen differently.

More information

Innate Immunity: Nonspecific Defenses of the Host

Innate Immunity: Nonspecific Defenses of the Host PowerPoint Lecture Presentations prepared by Bradley W. Christian, McLennan Community College C H A P T E R 16 Innate Immunity: Nonspecific Defenses of the Host Host Response to Disease Resistance- ability

More information

Adaptive Immunity: Specific Defenses of the Host

Adaptive Immunity: Specific Defenses of the Host 17 Adaptive Immunity: Specific Defenses of the Host SLOs Differentiate between innate and adaptive immunity, and humoral and cellular immunity. Define antigen, epitope, and hapten. Explain the function

More information

Immunity. Chapter 38 Part 1

Immunity. Chapter 38 Part 1 Immunity Chapter 38 Part 1 Impacts, Issues Frankie s Last Wish Infection with a common, sexually transmitted virus (HPV) causes most cervical cancers including the one that killed Frankie McCullogh 38.1

More information

DOWNLOAD OR READ : JOURNAL OF THE ANNUAL SESSION OF THE RHODE ISLAND EPISCOPAL CONVENTION VOLUME 112 PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : JOURNAL OF THE ANNUAL SESSION OF THE RHODE ISLAND EPISCOPAL CONVENTION VOLUME 112 PDF EBOOK EPUB MOBI DOWNLOAD OR READ : JOURNAL OF THE ANNUAL SESSION OF THE RHODE ISLAND EPISCOPAL CONVENTION VOLUME 112 PDF EBOOK EPUB MOBI Page 1 Page 2 journal of the annual session of the rhode island episcopal convention

More information

Cytokines modulate the functional activities of individual cells and tissues both under normal and pathologic conditions Interleukins,

Cytokines modulate the functional activities of individual cells and tissues both under normal and pathologic conditions Interleukins, Cytokines http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter22/animation the_immune_response.html Cytokines modulate the functional activities of individual cells and tissues both under

More information

Clinical Basis of the Immune Response and the Complement Cascade

Clinical Basis of the Immune Response and the Complement Cascade Clinical Basis of the Immune Response and the Complement Cascade Bryan L. Martin, DO, MMAS, FACAAI, FAAAAI, FACOI, FACP Emeritus Professor of Medicine and Pediatrics President, American College of Allergy,

More information

Disease causing organisms Resistance Immunity

Disease causing organisms Resistance Immunity Part 1 Disease causing organisms Resistance Immunity Bacteria Most common pathogens Anthrax Cholera Staphylococcus epidermidis bacteria Bacterial diseases Tuberculosis Cholera Bubonic Plague Tetanus Effects

More information

Chapter 13: Cytokines

Chapter 13: Cytokines Chapter 13: Cytokines Definition: secreted, low-molecular-weight proteins that regulate the nature, intensity and duration of the immune response by exerting a variety of effects on lymphocytes and/or

More information

Central Nervous System Diseases and Inflammation

Central Nervous System Diseases and Inflammation Central Nervous System Diseases and Inflammation Thomas E. Lane Monica Carson Conni Bergmann Tony Wyss-Coray Editors Central Nervous System Diseases and Inflammation Thomas E. Lane Center for Immunology

More information

Immunity. Acquired immunity differs from innate immunity in specificity & memory from 1 st exposure

Immunity. Acquired immunity differs from innate immunity in specificity & memory from 1 st exposure Immunity (1) Non specific (innate) immunity (2) Specific (acquired) immunity Characters: (1) Non specific: does not need special recognition of the foreign cell. (2) Innate: does not need previous exposure.

More information

The Immune System: The Mind Body Connection. Presented by Margaret Kemeny, Ph.D. Department of Psychiatry, University of California, San Francisco

The Immune System: The Mind Body Connection. Presented by Margaret Kemeny, Ph.D. Department of Psychiatry, University of California, San Francisco The Immune System: The Mind Body Connection Presented by Margaret Kemeny, Ph.D. Department of Psychiatry, University of California, San Francisco Psychoneuroimmunology Investigation of the bidirectional

More information

Innate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 July 2017

Innate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 July 2017 Innate Immunity Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 July 2017 Objectives: Explain how innate immune system recognizes foreign substances

More information

DOWNLOAD OR READ : THYMOCYTE ACTIVATION BY CYTOKINES DIRECT ASSESSMENT OF G0 G1 TRANSITION BY FLOW CYTOMETRY PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : THYMOCYTE ACTIVATION BY CYTOKINES DIRECT ASSESSMENT OF G0 G1 TRANSITION BY FLOW CYTOMETRY PDF EBOOK EPUB MOBI DOWNLOAD OR READ : THYMOCYTE ACTIVATION BY CYTOKINES DIRECT ASSESSMENT OF G0 G1 TRANSITION BY FLOW CYTOMETRY PDF EBOOK EPUB MOBI Page 1 Page 2 thymocyte activation by cytokines direct assessment of g0

More information

4b. Innate (nonspecific) Immunity

4b. Innate (nonspecific) Immunity 4b. Innate (nonspecific) Immunity Chapter 16: Innate (nonspecific) Immunity! Some terms:! Susceptibility: Lack of immunity to a disease.! Immunity: Ability to ward off disease.! Innate immunity: Defenses

More information

Attribution: University of Michigan Medical School, Department of Microbiology and Immunology

Attribution: University of Michigan Medical School, Department of Microbiology and Immunology Attribution: University of Michigan Medical School, Department of Microbiology and Immunology License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

More information

Immunology Lecture- 1

Immunology Lecture- 1 Immunology Lecture- 1 Immunology and Immune System Immunology: Study of the components and function of the immune system Immune System a network collected from cells, tissues organs and soluble factors

More information

DOWNLOAD OR READ : VEGETABLES DISEASE DIAGNOSIS AND BIOMANAGEMENT PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : VEGETABLES DISEASE DIAGNOSIS AND BIOMANAGEMENT PDF EBOOK EPUB MOBI DOWNLOAD OR READ : VEGETABLES DISEASE DIAGNOSIS AND BIOMANAGEMENT PDF EBOOK EPUB MOBI Page 1 Page 2 vegetables disease diagnosis and biomanagement vegetables disease diagnosis and pdf vegetables disease

More information

Ch 12. Host Defenses I: Nonspecific Defenses

Ch 12. Host Defenses I: Nonspecific Defenses Ch 12 Host Defenses I: Nonspecific Defenses SLOs Differentiate between innate and adaptive immunity. Define and explain PRRs and PAMPs Differentiate physical from chemical factors, and list examples of

More information

Effector T Cells and

Effector T Cells and 1 Effector T Cells and Cytokines Andrew Lichtman, MD PhD Brigham and Women's Hospital Harvard Medical School 2 Lecture outline Cytokines Subsets of CD4+ T cells: definitions, functions, development New

More information

MONTGOMERY COUNTY COMMUNITY COLLEGE Department of Science LECTURE OUTLINE CHAPTERS 16, 17, 18 AND 19

MONTGOMERY COUNTY COMMUNITY COLLEGE Department of Science LECTURE OUTLINE CHAPTERS 16, 17, 18 AND 19 MONTGOMERY COUNTY COMMUNITY COLLEGE Department of Science LECTURE OUTLINE CHAPTERS 16, 17, 18 AND 19 CHAPTER 16: NONSPECIFIC DEFENSES OF THE HOST I. THE FIRST LINE OF DEFENSE A. Mechanical Barriers (Physical

More information

Cell-Derived Inflammatory Mediators

Cell-Derived Inflammatory Mediators Cell-Derived Inflammatory Mediators Introduction about chemical mediators in inflammation Mediators may be Cellular mediators cell-produced or cell-secreted derived from circulating inactive precursors,

More information

LYMPHOCYTE ACTIVATION CHEMICAL IMMUNOLOGY AND ALLERGY VOL 59 V 59 DIRK ZAJONC - LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY

LYMPHOCYTE ACTIVATION CHEMICAL IMMUNOLOGY AND ALLERGY VOL 59 V 59 DIRK ZAJONC - LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY LYMPHOCYTE ACTIVATION CHEMICAL IMMUNOLOGY PDF (PDF) KUBY - IMMUNOLOGY.PDF??????????? - ACADEMIA.EDU DIRK ZAJONC - LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY 1 / 5 2 / 5 3 / 5 lymphocyte activation chemical

More information

2 - Adaptive Immunity

2 - Adaptive Immunity 2 - Adaptive Immunity The Division of the Immune System - Macrophages are in the tissues, neutrophils migrate through the blood stream - There s a release of a chemical signal which attracts all the cells

More information

Introduction to Immune System

Introduction to Immune System Introduction to Immune System Learning outcome You will be able to understand, at a fundamental level, the STRUCTURES and FUNCTIONS of cell surface and soluble molecules involved in recognition of foreign

More information

Where are we heading?

Where are we heading? Unit 5: Where are we heading? Unit 5: Introduction Unit 1: Why should we care about infectious diseases? Unit 2: What does it mean to have an infectious disease? Unit 3: When does a microbe become a pathogen?

More information

Innate Immunity. Bởi: OpenStaxCollege

Innate Immunity. Bởi: OpenStaxCollege Innate Immunity Bởi: OpenStaxCollege The vertebrate, including human, immune system is a complex multilayered system for defending against external and internal threats to the integrity of the body. The

More information

Innate Immunity II. Integration. Lindsay Nicholson Advanced Immunology L2

Innate Immunity II. Integration. Lindsay Nicholson Advanced Immunology L2 Innate Immunity II Integration Lindsay Nicholson Advanced Immunology L2 l.nicholson@bristol.ac.uk Lecture 1 Defining Innate Immunity Recognition and effector mechanisms (I) Lecture 2 Recognition and effector

More information

Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD

Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD ? Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD Christian S Lobsiger & Don W Cleveland (2007) Nature Neuroscience 10, 1355-1360 Astrocytes: interlinked gatekeepers of glutamate astrocytes

More information

The Innate Immune Response

The Innate Immune Response The Innate Immune Response FUNCTIONS OF THE IMMUNE SYSTEM: Recognize, destroy and clear a diversity of pathogens. Initiate tissue and wound healing processes. Recognize and clear damaged self components.

More information

Concept of Inflammation Definition? Cardinal Signs? Name of Scientists?

Concept of Inflammation Definition? Cardinal Signs? Name of Scientists? INFLAMMATION DR. M. TARIQ JAVED PROFESSOR DEPARTMENT OF PATHOLOGY FACULTY OF VETERINARY SCIENCE UNIVERSITY OF AGRICULTURE, FAISALABAD. LEARNING OBJECTIVES Definition of inflammation Overview of cells and

More information

Time course of immune response

Time course of immune response Time course of immune response Route of entry Route of entry (cont.) Steps in infection Barriers to infection Mf receptors Facilitate engulfment Glucan, mannose Scavenger CD11b/CD18 Allows immediate response

More information

1. Specificity: specific activity for each type of pathogens. Immunity is directed against a particular pathogen or foreign substance.

1. Specificity: specific activity for each type of pathogens. Immunity is directed against a particular pathogen or foreign substance. L13: Acquired or adaptive (specific) immunity The resistance, which absent at the time of first exposure to a pathogen, but develops after being exposed to the pathogen is called acquired immunity. It

More information

The New Era of Wellness. The Science of Inflammation. Inflammation and Interdisciplinary Care. The Immune System. Periodontal Biofilms + - 3/11/2014

The New Era of Wellness. The Science of Inflammation. Inflammation and Interdisciplinary Care. The Immune System. Periodontal Biofilms + - 3/11/2014 The New Era of Wellness The Science and Application of the Mouth-Body Connection Inflammation and Interdisciplinary Care Lee Ostler DDS The Immune System The Science of Inflammation The Concept of Immunity

More information

Question 1. Kupffer cells, microglial cells and osteoclasts are all examples of what type of immune system cell?

Question 1. Kupffer cells, microglial cells and osteoclasts are all examples of what type of immune system cell? Abbas Chapter 2: Sarah Spriet February 8, 2015 Question 1. Kupffer cells, microglial cells and osteoclasts are all examples of what type of immune system cell? a. Dendritic cells b. Macrophages c. Monocytes

More information

Microbial Mechanisms of Pathogenicity

Microbial Mechanisms of Pathogenicity Microbial Mechanisms of Pathogenicity Portals of Entry Mucous membranes Conjunctiva Respiratory tract: Droplet inhalation of moisture and dust particles. Most common portal of entry. GI tract: food, water,

More information

7/6/2009. The study of the immune system and of diseases that occur as a result of inappropriate or inadequate actions of the immune system.

7/6/2009. The study of the immune system and of diseases that occur as a result of inappropriate or inadequate actions of the immune system. Diseases of Immunity 2009 CL Davis General Pathology Paul W. Snyder, DVM, PhD Purdue University Acknowledgements Pathologic Basis of Veterinary Disease, 4 th Ed Veterinary Immunology, An Introduction 8

More information