Ceracare AC45. Harmony of All Ceramides Powerful All-in-one Moisturiser

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1 Ceracare AC45 Harmony of All Ceramides Powerful All-in-one Moisturiser Made by NFC Sales Team Published date : Dec

2 What is Ceramide? What is Ceramide? 1. Powerful Moisturizing Factor Important for maintaining moisture of skin as it is one of the main component of horny layer. 50% of Intercellular lipids is Ceramide 2. Skin Barrier Prevents evaporation of water located between each corneous cell. Keeps moisture of skin and protect from external stimulus. Lack of Ceramide? Accelerating the water evaporation of skin. Accelerating skin aging from dryness. Causing skin troubles such as chronic dryness, reduction of skin elasticity and causing wrinkle and pimple. Sensitive to external stimulus which cause skin troubles such as acne. Lowers the function of skin barrier

3 Synergy Effect from Various Ceramides Various kinds of Ceramide Our skin contains various kinds of Ceramide Each Ceramide has different functions and makes cooperative effect. Gives powerful moisturizing benefit for synergy effect from various Ceramide and increases bio-availability of Ceramide NP by more than 45%. <Change of Ceramide distribution based on the condition of skin healthiness> Ceramide EOP (1) Ceramide NS (2) Ceramide NP (3) Ceramide AS (5) <Skin structure diagram and Ceramide > Ceramide AP (6)

4 Various Ceramides of the Skin < Analysis of different kind of Ceramide components in real skin> 30 Ceramide Contents (%) Ceramide EOP (1) Ceramide NS (2) Ceramide NP (3) Ceramide AS (5) Ceramide AP (6) Mostly, existence of various ceramide structures the skin and gives moisturizing function to skin. Healthy Person 1 (Caucasian) Healthy Person 2 (Asian) Unhealthy person (Atopy) <Refer: M Janssens et al(2011) Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema, Journal of Investigative Dermatology (2011) 131, > Is there a way to apply all of these functional Ceramide to cosmetics?

5 Development of Ceracare AC45 Ceracare AC45 development background 1. World-First complex of ceramide. Real skin contains various kind of ceramide. Each ceramide co-operate each other. Contains all of commercialized Ceramide products. 2. Moisture of Biomimetic structure. Skin contain various phospholipid components (Ceramides, Cholesterol, Phosphatidyl Choline etc.). Powerful moisturizer which is similar with real skin lipids. Ceramide EOP (1) Makes skin barrier. Prevents oxidation of skin. Prevents atopy. Ceracare AC45 Cholesterol Important component of skin cell membrane Ceramide NS (2) Increase of skin moisture absorptance and maintenance Ceramide AS (5) Prevents atopy. Strengthen skin cell membrane transfer Ceramide NP (3) Ceramide AP (6) Structures phospholipid components and Multilamellar and increases the osmosis moisturizing effect Prevents atopy. Restore and maintain skin barrier Vitalize moisture between cells <Refer: Soft Matter, 2011,7, DOI: /C1SM05134B Received 26 Jan 2011, Accepted 08 Jul 2011 First published online 09 Aug 2011, BJYP Mar 2009 Maria et al.>

6 Properties of Ceracare AC45 Ceramides applied for Ceracare AC45 INCI Name Function Content (%) Ceramide EOP (Ceramide 1) Ceramide NS (Ceramide 2) Ceramide NP (Ceramide 3) Ceramide AS (Ceramide 5) Ceramide AP (Ceramide 6) Makes skin barrier. Prevents oxidation of skin. Prevents atopy. Increase of skin moisture absorption and maintenance. Structures phospholipid components and Multilamellar and increases the osmosis moisturizing effect. Prevents atopy. Prevents atopy. Strengthen skin cell membrane. Restore and maintain skin barrier. Vitalize moisture between cells. Sphingolipids (Ceramides) Total : 45 % Cholesterol Important component of skin cell membrane. Cf) Ceramide 4 is not applied for commercialized product yet. All-in-one Ceramide Complex which contains 5 kinds of ceramide

7 Synergy effect of mixed Ceramides 0.90 in-vitro Test for water-loss as the composition of Ceramide W a t e r L o s s ( g ) #L01 #L02 #L03 #L04 #L05 #L06 #L07 #L08 #L09 #L10 LCC2 LCCP Blank No. Content of Main ingredients No. Content of Main ingredients Total content of Ceramide is the same: 0.4%. NFC s technique is applied or not. 01 Ceramide 3 (40%) (=NFC s Ceracare H40 applied) 07 NFC technology (Ceramide 3 (20%), Ceramide 6 (20%)) 02 Pure Ceramide 3 (no NFC technology) 08 NFC technology (Ceramide 5 (20%), Ceramide 6 (20%)) 03 NFC technology (Ceramide 2 (20%), Ceramide 3 (20%)) NFC technology (Ceramide 2 (20%), Ceramide 5 (20%)) 05 NFC technology (Ceramide 2 (20%), Ceramide 6 (20%)) 10 NFC technology (Ceramide 2 (10%), 3 (28.5%), 5(1%), 6(0.5%), Cholesterol (1%)) NFC technology (Ceramide 2 (10%), 3 (28.5%), 5(1%), 6(0.5%), Cholesterol (1%), Phytosphingosine(1%), N-Acetyl Phytosphingosine(1%)) 06 NFC technology (Ceramide 3 (20%), Ceramide 5 (20%)) LCCP Liquid Crystal Emulsion (without Ceramide)

8 Benefits of Ceracare AC World-First Ceramide complex. Contains high content of existing Ceramide. Synergy effect of each Ceramide. 04. Outstanding Stability Able to apply in all types of formula since it is waterdispersible. No Stability problem such as recrystallization in the cosmetics. 03. Luxurious Skin-feel 02. Skin friendly moisturizer Very good skin suitability since it is similar to skin structure. Powerful Moisturizing function according to synergy effect of Ceramides. Luxurious skin feel of Ceramide Gives very soft end feeling and elastic texture after absorption into skin

9 Stability Data of Ceracare AC45 *Ceracare AC 45 1% solution stability test 0 days 30 days 60 days 90 days Microscope photo X400 (Olympus, BX41) Very stable in all temperature.

10 Applying Direction ( Direction 1 ) Hydration 1) Put Ceracare AC45 into water. If the water phase contains some kinds of polyol, the hydration step would be easier. Ceracare AC45 Homogenizer Heating 2) Heat it to 75 while mixing gradually. 3) At 75, agitate it for 10 mins(h/m 5000rpm). 4) If it becomes a clear milky color, the hydration step is succeeded. 5) After checking whether the hydration be done well, add other ingredients into the water phase to solute or emulsify or just cool down it. Purified Water Hot Plate Caution: If the temperature of the water is too high when you put Ceracare, the hydration would not be done well, so some micro particles would be shown. The benefits of Hydration 1. Better sticky feel to skin. 2. Better moisturizing effect. ( Direction 2 ) Dissolving in Polyol 1) Put Ceracare AC45 into Polyol(Dipropylene glycol, 1,3-Butylene glycol, Propylene glycol, Glycerin) and heat to 70~80 to solve them transparently. Ceracare AC45 Homogenizer Heating 2) Put the above 1) polyol base into the water heated to 70~80 and agitate it for 5 mins (H/M 5000rpm). Polyol 3) After checking whether the hydration be done well, add other ingredients into the water phase to solute or emulsify or just cool down it. Hot Plate The benefits of Polyol dissolving 1. Easy to use 2. Quickly dispersed into water Other Water or Oil Phase

11 Guide Formula [Ceramide Premium Cheese Cream] Phase Trade Name Con.(%) INCI Name Maker A B C Purified Water Purified Water - Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS, Ceramide AP, Ceracare AC Cholesterol, Hydrogenated lecithin, Glyceryl stearate, Sucrose distearate, NFC Dipropylene glycol Picocare SE 2.00 Hydrogenated Lecithin, Myristic Acid, Stearic Acid, Behenic Acid, Stearyl Alcohol, Behenyl Alcohol NFC Kelterol-F 0.10 Xanthan Gum CP Kelco Glycerin 5.00 Glycerin KAO Turmericgel 1.00 Lactobacillus Ferment, Curcuma Longa (Turmeric) Root Extract, Butylene Glycol, 1.2-Hexanediol NFC NF-Fucoidangel 2.00 Biosaccharide Gum-1, 1,2-Hexanediol NFC 1,3-B.G Butylene Glycol KAO Stearic Acid 1.00 Stearic Acid Emery Lanette O 1.00 Cetearyl Alcohol BASF Simulsol Glyceryl Stearate, PEG-100 Stearate Seppic Montanov Arachidyl Alcohol, Behenyl Alcohol, Arachidyl Glucoside Seppic NF-Ester EHS 5.00 Ethylhexyl Stearate NFC NF-HPIB Hydrogenated Polyisobutene NFC Aqua Solution Dimethicone, Dimethicone/PEG-10/15 Crosspolymer, Lauryl PEG-9 Pol ydimethylsiloxy ethyl Dimethicone, Dimethicone/Vinyl Dimethicone C rosspolymer, Cyclopentasiloxane NFC NF-Silkysome TF 2.00 Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer NFC Cosmol Diisostearyl Malate Nissin OilliO Vaseline 3.00 Petrolatum Merku Vitamin E Acetate 0.50 Tocopheryl Acetate BASF D Simulgel NS 1.00 Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolyme r, Squalane, Polysorbate 60 Seppic E Hydrolite 6 O ,2-Hexanediol Symrise Heating. 80 Heating. 80 Heating. Hydration, H/M 2000rpm, 20 min. Mixing, H/M 3000rpm, Paddle 25rpm, 10 min. Emulsifying, H/M 3500rpm, Paddle 25rpm, 10 min. Mixing, H/M 3000rpm, 5 min. 45, Mixing, H/M 3000rpm, 5 min. Vacuuming, Cooling, Paddle 15rpm. Filtering and Finish

12 Guide Formula [Ceramide Fluid Essence] Phase Trade Name Con.(%) INCI Name Maker A Purified Water Purified Water - Ceracare AC Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS, Ceramide AP, Cholesterol, Hydrogenated lecithin, Glyceryl stearate, Sucrose distearate, Dipropylene glycol 1,3-B.G Butlyene Glycol KAO Keltrol F 0.10 Xanthan Gum CP Kelco NF-Fucoidangel 2.00 Biosaccharide Gum-1, 1,2-Hexanediol NFC NFC 60 Heating. Mixing, H/M 3000rpm, Paddle 25rpm, 20 min. Turmericgel 1.00 Lactobacillus Ferment, Curcuma Longa (Turmeric) Root Extract, Butylene Glycol, 1.2-Hexanediol NFC B NF-Elasome E Dimethicone/Vinyl Dimethicone Crosspolymer, Cy clopentasiloxane, Hydrogenated Lecithin, 1,2-Hexa nediol, Water NFC 45 Mixing, H/M 2500rpm, 5 min. C Hydrolite 6 O ,2-Hexanediol Symrise 25 Mixing, H/M 2500rpm, 5 min. Vacuuming, Cooling, Paddle 15rpm. Filtering and Finish

13 THANK YOU Main Office : 인천연수구갯벌로 145번길 15-6 (15-6 Gaetbeol-ro 145beon-gil, Yeonsu-gu, Incheon City) Contact Number : Tel (82) / Fax (82) Contact Person : 영업부송재근과장 (Eric of Sales Department) nfc_song@naver.com Homepage :

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