MarineOmega. Support Cardiovascular, Brain and Immune Health. Menyokong Kesihatan Kardiovaskular, Otak dan Imun. English / Bahasa Melayu

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1 MarineOmega Support Cardiovascular, Brain and Immune Health Menyokong Kesihatan Kardiovaskular, Otak dan Imun For every bottle purchased, US$0.25 will be donated to the Southeast Asia Children s Heart Fund. Contributions to the fund are used to save children with congenital heart diseases in Thailand, the Philippines, Malaysia, Indonesia, Singapore and Vietnam. Dengan pembelian setiap botol, US$0.25 akan didermakan kepada Tabung Kesihatan Jantung Kanak- Kanak Asia Tenggara (SEA CHF). Sumbangan daripada dana ini adalah menyelamatkan kanak-kanak yang mempunyai masalah jantung di Thailand, Filipina, Malaysia, Indonesia, Singapura dan Vietnam. English / Bahasa Melayu

2 ESSENTIAL NUTRIENT - OMEGA-3 FATTY ACIDS NUTRIEN YANG PENTING - ASID LEMAK OMEGA-3 Omega-3 fatty acids such as Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) are essential nutrients and cannot be synthesized by the body, but must be obtained directly from foods or dietary supplements. Essential fatty acids are necessary for normal growth, healthy skin, circulation, nerves, and metabolism. A study published in the American Journal Clinical Nutrition demonstrated that every time we eat a meal, one that is high in fat and low in fruits and vegetables, our body will experience a surge in inflammation leading to the production of free radicals. This is mainly due to changing lifestyles and westernized dietary habits, most city dwellers consume large amounts of plant oils, such as corn oil and sunflower oil, which have a high concentration of omega-6 fatty acids. Although omega-6 fatty acids are essential nutrients, an imbalance of omega-6 and omega-3 fatty acid ratio contributes to a pro-inflammatory condition in the body. Asid lemak Omega-3 adalah nutrien penting dan tidak dapat disintesis oleh tubuh. Ianya hanya boleh didapati terus daripada makanan atau suplemen. Asid lemak diperlukan untuk tumbesaran normal, kulit yang sihat, peredaran darah, sistem saraf dan metabolisme tubuh. Kajian yang diterbitkan oleh Jurnal Nutrisi Klinikal Amerika menjelaskan bahawa setiap kali kita makan makanan yang tinggi kandungan lemak serta kurang makan sayur-sayuran dan buah-buahan, tubuh kita akan mengalami inflamasi yang mengakibatkan penghasilan radikal bebas. Perubahan gaya hidup dan tabiat pemakanan ala-kebaratan mengakibatkan kebanyakan penduduk yang tinggal di bandar mengamalkan pengambilan minyak tumbuh-tumbuhan seperti minyak jagung dan minyak bunga matahari dalam kuantiti yang tinggi. Minyak sebegini mengandungi konsentrasi asid lemak omega-6 yang tinggi. Walaupun asid lemak omega-6 adalah nutrien yang diperlukan oleh tubuh, ketidakseimbangan nisbah di antara asid lemak omega-6 dan omega-3 mempengaruhi keadaan pro-inflamasi di dalam tubuh. Source Sumber: Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P. Increase in intranuclear NF-kB and decrease in lkb in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. American Journal of Clinical Nutrition.2004;79(4): THE FATTY ACID IMBALANCE KETIDAKSEIMBANGAN ASID LEMAK + - Omega-6 Omega-3 Inflammation Inflamasi Cancer Kanser Heart disease Penyakit jantung Eczema Ekzema Dermatitis Dermatitis Arthritis Artritis Allergies Alahan ROS generation (AUC) Penghasilan ROS Control Terkawal 38% High Fat Diet Diet tinggi lemak Mononuclear cells Sel mononuklear Control Terkawal 49% High Fat Diet Diet tinggi lemak Polymorphonuclear leukocytes Leukosit polimorfonuklear Change in NF-kB binding activity (%) Perubahan terhadap aktiviti pencantuman NF-KB (%) High fat diet Diet tinggi lemak Control Terkawal Time/Hour Masa/Jam STUDY SHOWS that consuming meals that are high in fat and low in fruits and vegetables content increase Reactive Oxygen Species (free radicals) generation by mononuclear cells and polymorphonuclear leukocytes up to 40% and 50% respectively. KAJIAN menunjukkan bahawa pengambilan hidangan yang tinggi kandungan lemak dan kurang dengan buah-buahan dan sayur-sayuran akan meningkatkan penghasilan Spesis Oksigen Reaktif (radikal bebas) melalui sel-sel mononuklear dan leukosit polimorfonuklear sehingga 40% dan 50%. STUDY SHOWS that after consuming meal with high fat and low fruits and vegetables content for 2 hours, the activity of inflammation promoters increases by more than 100%. It promotes chronic inflammation which is relevant to chronic hypertension, obesity and atherosclerosis. KAJIAN menunjukkan bahawa selepas mengambil makanan yang tinggi kandungan lemak dan rendah kandungan buah-buahan dan sayur-sayuran selama 2 jam, aktiviti perangsang inflamasi telah meningkat melebihi 100%. Ini mengakibatkan inflamasi kronik yang berkait rapat dengan hipertensi, kronik obesiti dan atherosclerosis. The American Heart Association recommends to decrease the usage of omega-6 fatty acids dominant in vegetable oils to avoid health problems caused by excessive intake of omega-6 fatty acids. In addition increasing intakes of omega-3 fatty acids provides anti-inflammatory properties to keep the balance in order to reduce risk of chronic diseases. Persatuan Jantung Amerika menyarankan supaya penggunaan minyak sayuran yang tinggi kandungan omega-6 dikurangkan untuk mencegah inflamasi. Dengan cara meningkatkan pengambilan asid lemak omega-3, tubuh akan dibekalkan dengan komponen antikeradangan yang mampu menyeimbangkan kondisi kesihatan tubuh agar terhindar daripada risiko jangkitan penyakit kronik.

3 SCIENTIFIC SUPPORT SOKONGAN SAINTIFIK Researchers in the recent years have confirmed that omega-3 fatty acids have indispensable beneficial effects on cardiovascular health, brain development, joint and skin health. Baru-baru ini, para penyelidik telah berjaya membuktikan bahawa asid lemak omega-3 memberikan kesan positif terhadap kesihatan kardiovaskular, perkembangan otak, sendi dan kesihatan kulit. Cardiovascular Health Kesihatan Kardiovaskular Clinical studies showed that omega-3 fatty acids and krill oil were significantly effective in lowering blood pressure, reducing the growth rate of atherosclerotic plaque, reducing low density lipoprotein (LDL), triglyceride level and increase in high density lipoprotein (HDL). Kajian klinikal telah menunjukkan bahawa asid lemak omega-3 dan minyak krill berkesan untuk menurunkan tekanan darah, mengurangkan kadar pertumbuhan plak atherosklerotik, mengurangkan lipoprotein berkepadatan rendah (LDL), menurunkan paras trigliserida dan meningkatkan lipoprotein berkepadatan tinggi (HDL). Source Sumber: JSS Medical Research, Inc. Evaluation of the effects of Neptune Krill Oil on the management of hyperlipidemia. June 7, The American Heart Association stated that epidemiological and clinical studies have shown that omega-3 fatty acids reduced the risk of cardiovascular disease (CVD). Healthy people, even those at high risk of CVD and patients with pre-existing CVD can benefit from omega-3 fatty acids. Persatuan Jantung Amerika menyatakan bahawa kajian klinikal dan epidemiologikal membuktikan bahawa asid lemak omega-3 berupaya mengurangkan risiko penyakit kardiovaskular (CVD). Mereka yang sihat, tetapi berisiko tinggi menghidapi CVD dan juga pesakit yang sedang menghidapi CVD, bermanfaat daripada asid lemak omega-3. Source Sumber: Kris-Etherton PM, Harris WS, Appel LJ. American Heart Association Scientific Statement: Fish consumption, fish oil, omega-3 fatty acids, and Cardiovascular Disease. Circulation 2002;106: Joint Health Kesihatan Sendi According to 13 double-blind placebo-controlled studies, Omega-3 fatty acids in fish oil can help reduce the symptoms of rheumatoid arthritis. Berdasarkan 13 kajian dwi-buta kawalan-plasebo yang telah dijalankan, asid lemak omega-3 daripada minyak ikan boleh membantu mengurangkan simptom artritis reumatoid. Source Sumber: Shapiro, J.A., et al. Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology, 1996 May, 7(3) A study showed that consumption of broiled or baked fish with two or more servings per week was associated with up to 43 percent decreased risk of rheumatoid arthritis. Kajian menunjukkan bahawa pengambilan ikan yang dipanggang atau dibakar sebanyak dua atau lebih sajian seminggu berkaitan dengan penurunan risiko menghidapi artritis reumatoid sebanyak 43 peratus. Source Sumber: Volker D, Fitzgerald P, Major G, Garg M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol Oct;27(10): Brain Health Kesihatan Otak Omega-3 fatty acids are associated with decreased risk of dementia and alzheimer s disease. Asid lemak omega-3 berkaitan dengan penurunan risiko menghidapi penyakit dementia (hilang ingatan) dan Alzheimer. Source Sumber: Haag M. Essential fatty acids and the brain. Can J Psychiatry 2003;48: Phospholipids are important in forming nerve membranes, and in protecting nerve membranes from toxic injury and free radical attacks. Phospholipid penting dalam pembentukan membran saraf dan melindunginya daripada kecederaan toksik dan serangan radikal bebas. Source Sumber: Hirata, F, Axelrod, J. Phospholipid methylation and biological signal transmission. Science 1980;209: Amaducci, L, Crook, TH, Lippi, A, et al. Use of phosphatidylserine in Alzheimer s Disease. Ann NY Acad Sci 1991;640: Skin Health Kesihatan Kulit Evidence suggested that omega-3 fatty acids and krill oil might be effective in protecting against UV-induces photoaging, skin damage and cancers. Terdapat bukti yang menunjukkan bahawa asid lemak omega-3 dan minyak krill berkemungkinan efektif dalam melindungi kulit daripada kesan UV yang mengakibatkan fotopenuaan, kerosakan kulit dan kanser. Source Sumber: Rhodes LE, Shahbakhti H, Azurdia RM, et al. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers. Carcinogenesis 2003;24: JSS Medical Research, Inc. Evaluation of the effects of Neptune Krill Oil on UV Induced Skin Cancer

4 MarineOmega OMEGA-3 FATTY ACIDS SUPPLEMENT WITH KRILL OIL SUPLEMEN OMEGA-3 DENGAN MINYAK KRILL Pharmanex MarineOmega is an omega-3 fatty acids dietary supplement that combines ultra pure fish oils with the highest grade krill oil from the pristine marine waters of Antarctica developed to help promote wellness and longevity. Pharmanex MarineOmega merupakan suplemen pemakanan omega-3 yang menggabungkan minyak ikan ultra tulen dengan minyak krill gred tertinggi daripada lautan marin Antartika yang dirumus untuk membantu memperbaiki dan mengekalkan tahap kesihatan secara keseluruhan. BENEFITS OF Marine Omega Kebaikan Produk Supports cardiovascular health Promotes brain function Modulates inflammation response Improves joint function and mobility Promotes healthy skin condition Menyokong kesihatan kardiovaskular Merangsang fungsi otak Menyeimbangkan keradangan Membaikpulih fungsi sendi dan pergerakan Menggalakkan kesihatan kulit 6S QUALITY PROCESS PROCESS KUALITI 6S Pharmanex uses proprietary technology in its manufacturing processes to maintain tight quality controls through all stages of product development. The key to consistent quality is the Pharmanex 6S Quality Process, the basis of the company s pharmaceutical approach to product development. The attention to detail, strict scientific testing, and commitment to quality ensure that every Pharmanex product is absolutely safe and effective. Ultra-pure source of fresh fish oil and krill oil are tested free of toxins, pollutants and heavy metals by Pharmanex 6S Quality Process. Pharmanex menggunakan teknologi proprietari dalam proses pembuatan untuk mengekalkan kawalan kualiti yang ketat melalui semua peringkat pembangunan produk. Kunci kepada kualiti yang konsisten adalah Proses Kualiti Pharmanex 6S, asas pendekatan syarikat farmaseutikal untuk pembangunan produk. Kepekaan yang terperinci, ujian-ujian saintifik yang ketat dan komitmen terhadap kualiti memastikan semua produk Phamanex adalah selamat dan efektif. Minyak ikan segar daripada sumber ultra-tulen dan minyak krill telah diuji dan diperakui bebas daripada toksin merbahaya, pencemar dan logam berat oleh Proses Kualiti Pharmanex 6S.

5 ACTIVE INGREDIENTS BAHAN-BAHAN AKTIF Krill Oil Minyak Krill Krill oil in MarineOmega is harvested from the pristine waters of Antarctica that provides highly bioactive EPA and DHA in a unique phospholipids form that contains the powerful antioxidant, astaxanthin, a unique flavonoid. Krill or Euphasia superba, are small shrimp or prawn-like crustaceans found in oceans off the West Coast of Vancouver Island, Russia, Ukraine, Antarctica, and Japan. Has a high concentration of EPA and DHA in a unique phospholipid form that passes through the harsh digestive system with DHA intact. Unique phospholipid structure passes through the blood-brain barrier with ease, making it a logically beneficial and bio-available source not found in other fish oil products. Contains the antioxidant, carotenoid astaxanthin which has been shown to be up to 550 times more powerful than vitamin E (Shimidzu 1996; Di Mascio 1990), and a unique flavonoid (yet unnamed)-the first flavonoid to be extracted from a non-plant or algae source that provides additional antioxidant. Krill oil offers an ideal ratio of Omega-3 to Omega-6 fatty acids at 15:1 to help compensate for modern diets which severely favor the Omega-6 type. Minyak krill daripada MarineOmega diperolehi daripada lautan dingin Antartika. Ia membekalkan EPA dan DHA yang berbioaktif dalam bentuk phospholipid dimana ia mengandungi astaxanthin, sejenis antioksidan yang kuat dan flavonoid yang unik. Krill atau Euphasia superba, adalah udang kecil atau haiwan laut bercengkerang seperti udang yang ditemui di sekitar lautan Pantai Barat Kepulauan Vancouver, Rusia, Ukraine, Antartika dan Jepun. Mengandungi konsentrasi EPA dan DHA yang tinggi dalam bentuk phospholipid unik yang berupaya melalui sistem penghadaman yang sukar tanpa menjejaskan keberkesanannya. Struktur phospholipidnya yang unik bergerak dengan mudah melepasi penghalang darah ke otak, menjadikannya lebih berkhasiat dan sumber bio-dapatan yang tidak terdapat pada mana-mana produk minyak ikan yang lain. Mengandungi antioksidan, karotenoid astaxanthin yang telah terbukti hebat sehingga 550 kali lebih berkuasa daripada vitamin E (Shimidzu 1996; Di Mascio 1990), dan flavonoid unik (belum diberi nama) flavonoid pertama yang diperolehi daripada sumber bukan-tumbuhan atau alga yang membekalkan antioksidan tambahan. Minyak krill membekalkan ratio ideal bagi asid lemak Omega-3 ke Omega-6 paa 15:1 untuk membantu mengimbangkan diet moden yang teruk memihak kepada jenis Omega-6. Fish Oil Minyak Ikan Fish oil in MarineOmega is derived from the flesh of four different types of fishes; such as sardine, salmon, mackerel, anchovy which are obtained from deep water providing marine lipid concentrate and omega-3 fatty acids, both EPA and DHA. Minyak ikan yang terkandung di dalam MarineOmega didapati daripada isi empat jenis ikan laut dalam; iaitu sardin, salmon, makerel dan ikan bilis yang kaya dengan konsentrasi lipid marin dan asid lemak omega-3,

6 COMPETITIVE ADVANTAGE OF MarineOmega KELEBIHAN KOMPETITIF MarineOmega 1. Potent source of EPA and DHA omega-3 fatty acids. 2. Contains krill oil that has 40% of a unique phospholipid form that passes the harsh digestive system and blood-brain barrier with DHA intact while most fish oil sources do not provide any phospholipids. 3. High in phospholipid for forming and protecting nerve and cell membranes. 4. Krill oil contains carotenoid astaxanthin, a powerful antioxidant. 5. Krill oil contains a unique flavanoid, the first flavanoid extracted from a non-plant or algae source. 6. Natural lemon oil to provide pleasant aroma. 7. Contains vitamin E to preserve product freshness and also provides nutritional benefits. 8. Aids the absorption of LifePak and g3, thus improving our Skin Carotenoid Score. 1. Sumber poten asid lemak omega-3 EPA dan DHA. 2. Minyak krill yang mengandungi 40% keunikan komponen phospholipid yang berupaya melalui sistem penghadaman yang sukar dan mengekalkan kandungan DHAnya apabila melepasi penghalang darah ke otak, manakala kebanyakan sumber minyak ikan tidak membekalkan sebarang phospholipid. 3. Kaya dengan phospholipid bagi pembentukan dan perlindungan saraf dan membran sel. 4. Minyak krill mengandungi karotenoid astaxanthin, sejenis antioksidan yang kuat. 5. Minyak krill mengandungi flavanoid unik yang merupakan flavonoid pertama terhasil daripada bahan bukan tumbuhan atau sumber alga. 6. Minyak lemon semulajadi menghasilkan aroma yang menyenangkan. 7. Mengandungi vitamin E untuk mengekalkan kesegaran produk dan membekalkan kebaikan nutrisi secara optimum. 8. Membantu proses penyerapan LifePak dan g3, dan seterusnya menambahbaik Skor Karotenoid Kulit. BUILD YOUR FOUNDATION OF NUTRITION WITH LifePak, g3 SUPERFRUIT BLEND AND MarineOmega BINALAH ASAS NUTRISI ANDA DENGAN LifePak, g3 SUPERFRUIT BLEND DAN MarineOmega MarineOmega and g3 Superfruit Blend are designed as companion products to LifePak for a complete dietary supplement foundation. LifePak provides optimal levels of essential vitamins, minerals and antioxidants; g3 Superfruit Blend offers Lipocarotenes that aids the nutrient absorption; and MarineOmega provides the macronutrient, omega-3 fatty acids, which are most lacking from our diet. When used together, LifePak, g3 Superfruit Blend and MarineOmega provide optimal levels of essential micronutrients and macronutrients necessary for wellness, typically lacking in most diets. As a conclusion, omega-3 fatty acids could be useful in the prevention of different pathologies, such as cardiovascular, psychiatric, neurological, dermatological and rheumatological disorders. A number of studies suggest that antioxidants can prevent the oxidation of various macromolecules, such as DNA, proteins and lipids. The ideal use of antioxidants should be a prophylactic and continue treatment before aging. MarineOmega dan g3 Superfruit Blend dipasangkan dengan Lifepak sebagai asas suplemen pemakanan yang lengkap. LifePak membekalkan vitamin, mineral dan antioksidan pada tahap yang optimum; g3 Superfruit Blend membekalkan Lipocarotenes untuk membantu penyerapan nutrien; dan MarineOmega membekalkan makronutrien, iaitu asid lemak omega-3 yang seringkali kekurangan dalam diet seharian. Apabila kesemuanya diambil bersama, LifePak, g3 Superfruit Blend dan MarineOmega membekalkan mikronutrien dan makronutrien pada tahap optimum yang diperlukan untuk mencapai kesihatan yang unggul. Kesimpulannya, asid lemak omega-3 sangat berguna dalam pencegahan pelbagai ketidakseimbangan patologi yang berbeza seperti kardiovaskular, psikiatrik, neurologikal, dermalogikal dan reumatologikal. Kajian dan penyelidikan telah merumuskan bahawa antioksidan berupaya mencegah pelbagai jenis oksidasi peringkat makromolekul, seperti DNA, protein dan lipid. Cara penggunaan antioksidan yang tepat adalah secara propilaktik dan rawatan berterusan sebelum penuaan.

7 FREQUENTLY ASKED QUESTIONS SOALAN-SOALAN LAZIM Q1. A1. What are the differences between MarineOmega and typical fish oils? Apakah perbezaan antara MarineOmega dengan minyak ikan jenama lain? MarineOmega contains krill oil. It provides phopholipid form DHA and EPA omega-3 fatty acids which are important for forming, protecting nerve membrane and promoting brain development. MarineOmega is the only supplement in Pharmanex that combines the benefits of omega-3 fatty acids with the unique benefits found in krill oil. MarineOmega mengandungi minyak krill. Ia membekalkan asid lemak omega-3 DHA dan EPA dalam bentuk phospholipid yang penting bagi pembentukan dan perlindungan membran saraf, serta menyokong perkembangan otak. MarineOmega adalah satu-satunya suplemen yang menggabungkan kelebihan omega-3 dengan menyokong khasiat unik yang terdapat di dalam minyak krill. Q2. A2. Can children take MarineOmega? Adakah MarineOmega selamat untuk kanak-kanak? MarineOmega provides high contents of essential fatty acids, EPA and DHA which are important in physical and brain development of children. Children aged 6-11 can take one (1) softgel daily and aged 12 or above can take two (2) softgels daily. If children cannot swallow the softgels, parent can break the softgels and put the fish oil into food and drinks. MarineOmega membekalkan kandungan asid lemak, EPA dan DHA yang tinggi, di mana ianya penting untuk perkembangan otak dan fizikal kanak-kanak. Kanak-kanak berusia 6 hingga 11 tahun boleh mengambil satu (1) gel lembut setiap hari dan dua (2) gel lembut bagi mereka yang melebihi 12 tahun. Jika kanak-kanak mengalami kesukaran menelan, ibubapa boleh memecahkannya dan mencampur kandungan minyak ikan tersebut ke dalam makanan dan minuman.

8 Product Suitability Kesesuaian Produk Recommended Dosage Cadangan Pengambilan Contents Kandungan MarineOmega is recommended for anyone who wishes to balance their essential fatty acids nutrition and to add omega-3 fatty acids to their diet. MarineOmega disarankan kepada mereka yang ingin menyeimbangkan kandungan nutrisi asid lemak dan menambah kandungan asid lemak omega-3 ke dalam diet seharian. This product is formulated to be taken with LifePak and g3 Superfruit Blend. As a dietary supplement, take two (2) to four (4) softgels daily with meals. Produk ini diformulasi untuk diambil bersama dengan LifePak dan g3 Superfruit Blend. Sebagai suplemen pemakanan, ambil dua (2) hingga empat (4) gel lembut setiap hari bersama makanan. 120 softgels/ bottle 120 gel lembut/ botol To know more about Nu Skin products, please contact our authorized distributors. Sila hubungi pengedar-pengedar berdaftar untuk mengetahui produk Nu Skin dengan lebih lanjut. Nu Skin (Malaysia) Sdn Bhd ( V) License No. AJL Lot 01-05, Level 1, PNB Darby Park Retail, No. 10, Jalan Binjai, Kuala Lumpur Tel: Fax: NuSkin Pharmanex (B) Sdn Bhd D2, Blk D, Lot 11620, Jalan Gadong Bandar Seri Begawan BE1718 Brunei Darussalam Tel: Fax: /15