CLINICAL CHEMISTRY REAGENTS MANUFACTURER

Transcription

1 CLINICAL CHEMISTRY REAGENTS MANUFACTURER

2 LR Liquid Reagents Method CCS137 ALBUMIN BCG LR Bromocresol Green - Colorimetric Endpoint R1 6x50 ml + STD CCS054 ALKALINE PHOSPHATASE LR DGKC optimized - Colorimetric Kinetic R1 5x40 ml + R2 1x50 ml CCS424 AMYLASE LR CNPG3 - Colorimetric Kinetic R1 5x10 ml CCS416 BILIRUBIN DIRECT LR Jendrassik/Grof modified - Colorimetric Endpoint R1 5x40 ml + R2 1x50 ml CCS417 BILIRUBIN TOTAL LR Jendrassik/Grof modified - Colorimetric Endpoint R1 5x40 ml + R2 1x50 ml CCS431 CALCIUM ARSENAZO III LR Arsenazo (III) - Colorimetric Endpoint R1 6x50 ml + STD CCS410 CALCIUM CPC LR Ortocresolphatelein - Colorimetric Endpoint R1 3x50 ml + R2 3x50 ml + STD CCS432 CHLORIDE LR Mercuric Thyocianate - Colorimetric Endpoint R1 6x50 ml + STD CCS088 CHOLESTEROL HDL DIRECT LR PVS/PEGME coupled - Enzymatic Fixed Time R1 1x60 ml + R2 1x20 ml CCS043 CHOLESTEROL HDL PEG 6000 LR Peg Precipitant Endpoint R1 2X50 ml + STD CCS246 CHOLESTEROL LDL DIRECT LR PVS/PEGME coupled - Enzymatic Fixed Time R1 1x60 ml + R2 1x20 ml CCS425 CHOLESTEROL TOTAL LR CHOD-PAP - Enzymatic Colorimetric Endpoint R1 6X50 ml + STD CCS020 CHOLINESTERASE LR DGKC Butirylthiocoline - Colorimetric Kinetic R1 1x40 ml + R2 1x10 ml CCS014 CK-Nac LR DGKC/IFCC optimized - Kinetic UV R1 1x40 ml + R2 1x10 ml CCS168 COPPER Direct Colorimetric - Endpoint R1 4x30 ml + STD CCS400 CREATININE ENZYMATIC LR Advanced Trinder coupled Enzymatic - Fixed Time R1 4x30 ml + R2 1x40 ml + STD CCS408 CREATININE LR (Picric Ac.) Jaffè - Colorimetric Fixed Time R1 3x50 ml + R2 3x50 ml + STD CCS426 GAMMA GT LR SZASZ Carboxy - Colorimetric Kinetic R1 5x40 ml + R2 1x50 ml CCS427 GLUCOSE LR GOD/POD - Enzymatic Colorimetric Endpoint R1 6X50 ml + STD CCS409 GLYCATED HEMOGLOBIN LR R1 1x30 ml + R2 1x10 ml CCS420 GOT/AST LR IFCC optimized - Kinetic UV R1 5x40 ml + R2 1x50 ml CCS421 GPT/ALT LR IFCC optimized - Kinetic UV R1 5x40 ml + R2 1x50 ml CCS390 HOMOCYSTEINE LR Enzymatic UV - Fixed Time R1 1x30 ml + R2 1x5 ml + CTRL CCS412 IRON CAB LR Chromazurol B - Colorimetric Endpoint R1 4x50 ml + STD CCS266 IRON FERENE LR FERENE S - Colorimetric Endpoint R1 4x40 ml + R2 4x10 ml + STD CCS055 LDH LR SCE optimized - Kinetic UV R1 1x40 ml + R2 1x10 ml CCS128 LIPASE LR Colorimetric Kinetic R1 4x10 ml + CAL CCS226 MAGNESIUM LR Xylidyl Blue - Colorimetric Endpoint R1 4x50 ml + STD CCS436 MAGNESIUM ENZYMATIC UV LR Enzymatic - Fixed Time UV R1 4x40 ml + R2 4x10 ml + STD CCS291 MICROALBUMIN LR Turbidimetric - Fixed Time UV R1 1x45 ml + R2 1x5 ml + CAL CCS031 PHOSPHOROUS LR Blue Molybdate - Endpoint UV R1 4x50 ml + STD CCS272 POTASSIUM LR R1 1X80 ml + STD CCS395 SODIUM ENZYMATIC LR Enzymatic - Fixed Time R1 1x40 ml + R2 1x20 ml + STD CCS214 TOTAL PROTEIN LR Biuret - Colorimetric Endpoint R1 5x100 ml + STD CCS429 TRIGLYCERIDES LR GPO/PAP - Enzymatic Colorimetric Endpoint R1 6x50 ml + STD CCS423 UREA UV LR UREASE/GLDH - Fixed Time UV R1 5x40 ml + R2 1x50 ml + STD CCS422 URIC ACID LR Uricase POD/PAP - Enzymatic Colorimetric E.P. R1 5x40 ml + R2 1x50 ml + STD CCS268 URIC ACID LR Mono Uricase POD/PAP - Enzymatic Colorimetric E.P. R1 5x50 ml + STD CCS070 URINE TOTAL PROTEIN LR Pyrogallol Red - Colorimetric Endpoint R1 4x50 ml + STD CCS165 ZINC LR Nitro-PAPS - Colorimetric Endpoint R1 4x30 ml + STD

3 Controls & Calibrator for Clinical Chemistry Type CCS430 MULTICAL Serum Lyophilized for Clinical Chemistry 3x3 ml CCS091 CONTROL HUMAN Serum NORMAL Lyophilized for Clinical Chemistry 6x5 ml CCS245 CONTROL HUMAN Serum PATH Lyophilized for Clinical Chemistry 6x5 ml CCS404 HbA1c SET CALIBRATOR Lyophilized 5 concentrations 5x1 ml CCS405 HbA1c CONTROL SET 2 LEVELS Lyophilized 2 levels 2x1 ml CCS402 HOMOCYSTEINE CALIBRATOR Liquid 2 levels 2x1 ml CCS403 HOMOCYSTEINE CONTROLS Liquid 3 levels 3x0,5 ml CCS183 CCS064 CCS255 washing Solutions for Clinical Chemistry CONCENTRATE SURFACTANT CUVETTES CLEANING SOLUTION CUVETTES CLEANING SOLUTION EXTRA 2x50 ml 1 Lt 1 Lt Chemicals Standards for Clinical Chemistry Type CCS012 CALCIUM STD CCS017 CHLORIDE STD CCS192 CHOLESTEROL HDL PEG STD CCS024 CREATININE STD CCS034 GLUCOSE/UREA STD CCS056 IRON FERENE STD CCS275 MAGNESIUM STD CCS057 PHOSPHOROUS STD CCS188 POTASSIUM/SODIUM STD CCS207 TOTAL PROTEIN/ALBUMIN STD CCS276 TRIGLYCERIDES STD CCS003 URIC ACID STD

4 Turbidimetry Liquid Reagents for Plasmaproteins turbidimetric quantitative determination by Antisera reaction Method TUS022 ALPHA ANTITRYPSIN TUS152 ALPHA GLYCOPROTEIN ACID TUS021 ALPHA MACROGLOBULIN TUS153 ANTITHROMBIN III TUS019 APOLIPOPROTEIN A1 (APO A1) TUS012 APOLIPOPROTEIN B (APO B) TUS120 C3 FACTOR TUS122 C4 FACTOR TUS023 CERULOPLASMIN TUS114 FIBRINOGEN TUS154 IMMUNOGLOBULIN A - IgA TUS155 IMMUNOGLOBULIN G - IgG TUS156 IMMUNOGLOBULIN M - gm TUS026 K LIGHT CHAINS (FREE plus BOUND) TUS027 LAMBDA LIGHT CHAINS (FREE plus BOUND) TUS025 LIPOPROTEIN (A) - LP(A) CCS291 MICROALBUMIN LR Turbidimetric - Fixed Time R1 1x45 ml + R2 1x5 ml + CAL TUS162 PCR Turbidimetric - Fixed Time R1 1x45 ml + R2 1x5 ml TUS024 PREALBUMIN TUS157 TRANSFERRIN LatexTurbidimetry Liquid Reagents for Plasmaproteins quantitative determination by latex agglutination Method TUS093 ASO TURBILATEX R1 1x64ml + R2 1x16ml TUS092 PCR TURBILATEX R1 1x64ml + R2 1x16ml TUS129 RF TURBILATEX R1 1x64ml + R2 1x16ml TUS161 ASO TURBILATEX High Performance R1 1x45ml + R2 TUS163 PCR TURBILATEX High Performance R1 1x45ml + R2 TUS160 RF TURBILATEX High Performance R1 1x45ml + R2

5 Controls & Calibrator for Immunochemistry Type TUS164 FIBRINOGEN CALIBRATOR Lyophilized 1 concentration 3x0,5 ml TUS165 FIBRINOGEN CONTROLS 2 LEVELS Lyophilized 2 levels 2x1,5ml + 2x0,7ml TUS115 PLASMAPROTEINS CALIBRATOR Liquid 5 concentrations 5x1ml TUS166 PLASMAPROTEINS CONTROL Normal 2x3ml TUS167 PLASMAPROTEINS CONTROL Path 2x3ml TUS142 MICROALBUMIN CALIBRATOR TUS143 MICROALBUMIN CONTROL TUS003 ASO CALIBRATOR TUS001 PCR CALIBRATOR TUS002 RF CALIBRATOR TUS112 ASO/PCR/RF CONTROL LOW Lyophilized 1 level TUS116 ASO/PCR/RF CONTROL HIGH Lyophilized 1 level IDR - Radial Immuniondifussion 15 Wells Plates for determination of proteins Type SRS078 Α1-ACID GLICOPROTEIN SRS099 APOLIPOPROTEIN A1 SRS100 APOLIPOPROTEIN B SRS101 ANTITHROMBIN III SRS102 C3 SRS103 C4 SRS104 KAPPA FREE & BOUND On urine SRS105 LAMBDA FREE & BOUND On urine SRS010 FIBRINOGEN SRS007 IgA SRS008 IgG SRS009 IgM SRS106 MULTIPLATE IgA-IgG-igM 3x5 Test SRS006 TRANSFERRIN

6 Rapid Test on Slide Rheumatoid Serodiagnostic for qualitative and semi-quantitative determination by agglutination reaction Method SRS002 SRS003 SRS001 SRS005 ASO Latex (with controls) PCR Latex (with controls) RF Latex (with controls) WAALER ROSE R1 + CTRL (100 Tests) R1 + CTRL (100 Tests) R1 + CTRL (100 Tests) R1 + CTRL (100 Tests) Syphilis Serodiagnostic for qualitative and semi-quantitative determination by agglutination reaction Method SRS024 SRS055 SRS097 RPR CARBON TPHA VDRL 150 Tests 100 Tests 250 Tests Febrile Serodiagnostic for qualitative and semi-quantitative determination by agglutination reaction Method SRS020 SRS085 SRS082 SRS019 SRS021 SRS083 SRS046 SRS022 SRS053 SRS023 SRS084 Brucella Bengal Rose Brucella Totale Salmonella Paratyphi A Total Salmonella Paratyphi AH Salmonella Paratyphi AO Salmonella Paratyphi B Total Salmonella Paratyphi BH Salmonella Paratyphi BO Salmonella Typhi H Salmonella Typhi O Salmonella Typhi Total

7 Liquid Reagents for monitoring of intrinsic and extrinsic system factor of coagulation process Method EMS002 EMS003 EMS109 EMS141 EMS142 EMS143 EMS144 aptt LR FIBRINOGEN PT DILUENT IMIDAZOLE BUFFER DILUENT KAOLIN CLEANER SOLUTION Activated partial thromboplastin Time Clauss Test Prothrombin Time For use with Fibrinogen For use with Fibrinogen For use with Fibrinogen 2x4ml 4x2ml 4x5ml 4x50ml 4x50ml 8x1ml 2x100ml Controls & Calibrator for monitoring of intrinsic and extrinsic system factor of coagulation process Method EMS137 EMS138 EMS139 EMS140 COAGULATION CALIBRATOR COAGULATION LOW CONTROL COAGULATION NORMAL CONTROL COAGULATION PATH CONTROL Calibrator Control lev I Control lev II Control lev III 6x1ml 6x1ml 6x1ml 6x1ml EMS024 EMS005 EMS006 EMS007 Blood Grouping monoclonal antisera for blood typing ANTI A ANTI B ANTI AB ANTI D IgG/IgM 10 ml 10 ml 10 ml 10 ml

8 Ready to use colture media BAS200 BAS201 BAS203 BAS204 BAS205 BAS206 BAS207 BAS208 BAS209 BAS210 BAS211 BAS212 BAS213 BAS214 BAS215 BAS216 BAS217 BAS218 BAS219 BAS220 BAS221 BAS222 BAS223 BAS224 BAS225 BAS226 BAS227 AZIDE DEXTROSE BROTH BACILLUSCEREUS AGAR BASE (PEMBA) BAIRD PARKER AGAR BILE ESCULIN AZIDE AGAR BISMUTH SULFITE AGAR BRILLIANT GREEN AGAR CAMPYLOBACTER AGAR BASE CAMPYLOBACTER BLOOD FREE BASE (ccda BOLTON) C-EC AGAR - Chromogenic Medium CETRIMIDE PSEUDONOMAS AGAR COLUMBIA BLOOD AGAR DEXTROSE TRYPTONE AGAR DEXTROSE TRYPTONE BROTH EC-X-GLUC AGAR (E.COLI) - Chromogenic Medium EC BROTH HEKTOEN ENTERIC AGAR KF STREPTOCOCCUS AGAR LACOTSE BROTH LAURYL SULFATE BROTH LEGIONELLA SELECTIVE AGAR (BCYE) LEGIONELLA SELECTIVE MEDIUM (GVPC) LEGIONELLA SELECTIVE MEDIUM (MWY) LISTERIA SELECTIVE AGAR - Aloa - Chromogenic Medium LISTERIA SELECTIVE AGAR OXFORD m CP AGAR (CLOSTRIDIUM PERFINGENS) m ENDO AGAR LES m FAECAL COLIFORM AGAR Medium for selective determination of enterococci in water Selective medium for isolation and enumeration of B.Cereus Selective medium for determination and enumeration of coagulase-positive staphylococci in food (ISO ), pharmaceutical and cosmetics samples Medium for selective isolation of enterococci in water Selective medium for isolation of Salmonella spp., in particular Salmonella typhi in food and clinical samples Selective medium for the isolation of Salmonella spp., in particular of Salmonella typhi for clinical sample Base medium for determination of Campylobacter Selective medium with supplement Bolton, without blood, for isolation of Campylobacter (ISO 10272) Selective medium, Chromogenic and fluorogenic for simultaneous determination of E.Coli (blue-green colonies fluorescent) and total coliforms blue-green colonies) Medium for selection and identification of Pseudonomas aeruginosa. For determination of Ps. Aeruginosa in not-sterile pharmaceutical products in accordance with harmonized methods EP, USP, JP Medium with 5% of defibrinated sheep blood for general use Medium for counting spores of thermophilic and mesophilic bacteria (type Bacillus) in food samples Medium for cultivation of fastidious microorganisms and for determination of gas product by enteric bacilli Medium for E.Coli determination by chromogenic method especially in water(unichim 1185); E.Coli develops blue-green colonies Medium for isolation and enumeration of faecal and not faecal coliforms in water, wastewater, shellfish and food samples Selective and differential medium for the isolation of gram negative enterobacteria and in particular for isolation of Salmonella and Shigella. Also Known as HE or HEA Selective medium for the isolation and enumeration of enterococci in food samples, water, waste water and drink Medium for detection of Coliforms and Salmonella in water, food samples, dairy and pharmaceuticals products Medium for the detection of coliforms in water, waste water and food. Also known as Lauryl Tryptose Broth and abbreviated as LTB and LSB Selective medium for isolation of Legionella (ISO 11731) Selective medium for isolation of Legionella (ISO 11731) Selective medium for isolation of Legionella (ISO 11731) Selective medium for isolation of Listeria spp. And identification of L.monocytogenes (ISO 11290) Selective medium for isolation of Listeria spp. (ISO 11290) Selective medium for isolation and presumptive identification of Clostridium perfrigens in water Medium of growth and enumeration of coliforms in water by membrane filtration method Medium for growth and enumeration of fecal coliform by membrane filtration method

9 BAS228 BAS229 BAS230 BAS231 BAS232 BAS233 BAS234 BAS235 BAS236 BAS237 BAS238 BAS239 BAS240 BAS241 BAS242 BAS243 BAS244 BAS245 BAS246 BAS247 BAS248 BAS249 BAS250 BAS251 BAS252 BAS253 BAS254 BAS255 BAS256 BAS257 BAS258 BAS259 BAS260 BAS261 BAS262 MAC CONKEY AGAR MAC CONKEY BROTH MALT EXTRACT AGAR MANNITOL SALT AGAR MRS AGAR (Lactobacilli) MUELLER HINTON BROTH NUTRIENT AGAR NUTRIENT BROTH PLATE COUNT AGAR POTATO DEXTROSE AGAR POTATO DEXTROSE BROTH PSEUDONOMAS CN AGAR PSEUDONOMAS SELECTIVE AGAR RAPPAPORT VASSILIADIS (RV) BROTH ROSE BENGAL AGAR + CHLORAMPHENICOL R2A AGAR SABOURAUD DEXTROSE AGAR SABOURAUD DEXTROSE AGAR + CHLORAMPHENICOL SALMONELLA SHIGELLA AGAR (SSA) SALMONELLA AGAR CHROMOGENIC MEDIUM SELENITE BROTH SLANETZ BARTLEY AGAR SULPHITE POLIMIXIN SULFADIAZIDE (SPS) AGAR THIOGLYCOLLATE AGAR TTC TERGITOL 7 AGAR TOMATO JUICE AGAR TRYPTIC SOY AGAR TRYPTIC SOY BROTH TBX (Tryptone Bile X-Glucuronide AGAR) - Chromogenic Medium TSC (Tryptose Sulfite Cycloserine) AGAR VIOLET RED BILE AGAR VIOLET RED BILE AGAR W MUG WL DIFFERENTIAL AGAR WL NUTRIENT AGAR XLD AGAR Selective medium for isolation and differentiation of lactose fermenting Entrobatteri in food samples, dairy, water, pharmaceutical and biological samples Selective medium for growth of coliforms in food samples and in water Medium for growth, isolation and enumeration of yeasts and molds in food samples Medium the isolation and differentiation of Staphylococci Medium for growth and enumeration of Lactobacillus spp in food and dairy products Medium for testing of antimicrobial testing of microorganism Medium for growth of non-fastidious microorganism (ISO 8523, 6579,10273) Medium for growth of non-fastidious microorganism Medium for enumeration of aerobic bacteria in water, foods and dairy products Medium for isolation, cultivation and enumeration of yeast and molds from food and dairy samples Medium for isolation and cultivation of yeast and molds from food and dairy samples Medium for the isolation of Pseudonomas (EN 12780, 16266) Like CETRIMIDE PSEUDONOMAS AGAR Selective broth for enrichment of Salmonella Medium with chloramphenicol for enumeration of yeast and molds in foods Medium for total count of heterotrophic bacteria in the water Medium for growth and isolation of yeast and molds Selective medium with chloramphenicol for isolation of yeast and molds Selective and differential medium for Salmonella and Shigella Selective and differential medium for determination of Salmonella spp Medium for enrichment of Salmonella spp. In clinical and food samples Selective medium for enterococci with membrane filtration method Selective medium for isolation and enumeration of Clostridium perfringens Medium for growth of microorganism in sterility tests in product containing mercury preservatives. Suitable when you want to get an early and clear growth Selective medium for isolation and enumeration of coliforms in the water with membrane filtration method (ISO ) Medium for growth and enumeration of Lactobacillus spp. Medium for growth of a various microorganism and total enumeration bacterial with EP, USP, JP method Medium for growth of a various microorganism. Conform with EP, USP, JP method Chromogenic selective medium for detection of E.Coli in food (ISO 16649). E.Coli developed blue-green in colonies Selective medium for isolation of Clostridium perfrigens (ISO 7937, 15213) Medium for isolation and enumeration of coliforms in food samples Fluorogenic medium for detection and enumeration of coliforms and E.Coli in food samples. Also known as VRBA with MUG Medium for determination of the microbial flora in fermentation processes. Also Known as Wallerstein Laboratory Differential Medium Medium for determination of the microbial flora in fermentation processes. Also known as Wallerstein Laboratory Medium Medium for isolation and differentiation of enteric gram-negative bacilli, in particular Shigella and Salmonella

10 ELS030 ELS018 ELS002 ELS026 ELS036 Solutions for Electrophoresis 10X CONCENTRATE HIPPURATE BUFFER for Serum Proteins TRIS /GLYCINE BUFFER FOR HEMOGLOBIN PONCEAU S ECOLOGICAL 20X CONCENTRATE DESTAINING SERUM PROTEINS CLEARING SOLUTION 250 ml 1000 ml 1000 ml 250 ml 1000 ml ELS043 ELS001 ELS042 ELS047 ELS044 ELS031 ELS042 ELS032 ELS033 ELS036 ELS037 ELS038 ELS039 ELS040 ELS041 Stripes for Electrophoresis CELLOGEL WET MEMBRANE 5,7X13 cm (for manual use) CELLOGEL WET MEMBRANE 5,7X14 cm (for manual use) CELLOGEL WET MEMBRANE 5,7X14,5 cm (for manual use) DRY MEMBRANE 3X7,6 cm DRY MEMBRANE 6,7X8,9 cm DRY MEMBRANE 7,6X6,0 cm DRY MEMBRANE 7,6X6,0 cm (for manual use) DRY MEMBRANE 7,6X6,2 cm DRY MEMBRANE 7,6X3,0 cm DRY MEMBRANE 7,6X18,0 cm DRY MEMBRANE 7,6X21,0 cm DRY MEMBRANE 7,8X22,7 cm DRY MEMBRANE 8,0X12,5 cm DRY MEMBRANE 9,4X7,6 cm (for manual use) DRY MEMBRANE 25,0X8,0 cm 30 pc 25pc ELS024 ELS028 ELS034 ELS035 ELS045 ELS022 Kits &Controls for Electrophoresis ELECTROPHORETIC KIT FOR AUTOMATIC INSTRUMENTS ELECTROPHORETIC KIT FOR AUTOMATIC INSTRUMENTS ELECTROPHORETIC KIT FOR AUTOMATIC INSTRUMENTS ELECTROPHORETIC KIT FOR AUTOMATIC INSTRUMENTS ELECTROPHORETIC KIT FOR AUTOMATIC INSTRUMENTS ELECTROPHORESIS SERUM CONTROL 400 Tests 200 Tests 384 Tests 192 Tests 648 Tests 3x5 ml

11 Flame Photometry Standard Solutions CCS257 CCS258 CCS256 CCS061 CCS090 CCS095 Na/K standard (serum) 140/5 MEq/L Na/K standard (urine) 100/100 meq/l LITHIUM standard (Na/K/Li) 140/5/1,5 meq/l LITHIUM concentrated solution 1500 meq/l POTASSIUM concentrated solution 150 meq/l ENZYMATIC CLEANING SOLUTION 4X10ml 4X10ml 4X10ml 4X10ml 4X10ml 4X50ml Rapid Test on Cards One Step CDS010 CDS015 CDS008 CDS067 CDS028 CDS074 CDS082 CDS100 CDS058 FECAL OCCULT BLOOD HCG serum/urine HELICOBACTER PYLORI serum antibodies HELICOBACTER PYLORI fecal antibodies MICROALBUMIN MONONUCLEOSIS (IgM) MULTIDRUGS 7-PANELS STREPTOCOCCUS A STREPTOCOCCUS B 25 Test 50 Test 10 Test 10 Test 10 Test 20 Test 10 Test 30 Test 20 Test Consumables PCN003 PCN008 PCN002 EMS071 CRN008 CRN003 BI-DISTILLED WATER <0.1 µs BI-DISTILLED WATER <0.1 µs BI-DISTILLED WATER <0.1 µs SODIUM CITRATE 3,8% THERMAL PAPER mm 58 x mt 30 THERMAL PAPER mm 110 x mt 30 5 Lt 10 Lt 20 Lt 250 ml 10 Rolls 6 Rolls UPON REQUEST: Hematology Reagents - Disposable Labware ***ALL PRODUCTS ARE AVAILABLE IN OEM AND BULK PACKAGING***

12 For over 35 years a point of reference for laboratory analysis, today Sanymed become a manufacturer of its own line of reagents for Clinical Chemistry repositioning its place on the market, from the previous and exclusive commercial role, it is now also open to manufacturing, thus becoming a reference not only to the end user, but also for those engaged in resale specialist. Sanymed s.a.s. - ITALY Pescara - P.zza Pierangeli 41/42 Phone: Fax: info@sanymed.it -