Use of PSI on CS instruments
|
|
|
- Stuart Hood
- 5 years ago
- Views:
Transcription
1 Johan Claes, Version 01, 1 st September 2016 User day hemostasis 2016 Use of PSI on CS instruments Restricted Siemens Healthcare GmbH, 2016
2 Hemostasis Lab Challenges Preanalytical problems in Haemostasis Patient ID Collecting blood needle, catheters, discard tube, order of draw Anticoagulant, tube composition Sample mixing Sample transport Sample storage Sample processing Sample quality checks - haemolysis, filling Hemolyzed sample sample In most cases errors are directly related to specimen collection! 54 % Others Others Incorrect sample Insufficient sample Source: Lippi et al (2006), Lippi et al (2008) Page 2 Restricted Siemens Healthcare GmbH, 2016
3 Preanalytical Sample Integrity (PSI) Checks Probe 1 Probe Upper 575 level Absorbance! Lipemia Hemolysis Icterous 1 st volume check Lower level 2 nd volume check Wavelength (nm) Hemolytic Correct first time Preanalysis Analysis Results Page 3 Restricted Siemens Healthcare GmbH, 2016
4 Preanalytical Sample Integrity (PSI) Checks Page 4 Restricted Siemens Healthcare GmbH, 2016
5 HIL - Frequency of samples rejection Example of Haemolysis Plasma Haemoglobin 15 g/l 6 g/l 1 g/l control Page 5 Restricted Siemens Healthcare GmbH, 2016
6 Preanalytical Sample Integrity (PSI) Checks Page 6 Restricted Siemens Healthcare GmbH, 2016
7 HIL - What level of haemolysis is routinely encountered? 59 consecutive haemolysed samples rejected for visible haemolysis* n Low Hb concentration are more frequent , Plasma Hb g/l *Example from systems validations in the UK (Sheffield Teaching Hospitals ) Page 7 Restricted Siemens Healthcare GmbH, 2016
8 Diference H/lsed - clear APTT (sec) HIL - Effect of Haemolysis Is the effect greater at higher levels of haemolysis? Patient samples APTT -20,0 1,0 2,0 3,0 4,0 5,0 6,0 7,0 8,0 9,0 10,0 Plasma Hb (g/l) Slight hemolysis have an higher impact? Page 8 Restricted Siemens Healthcare GmbH, 2016
9 APPT Tests Hemostasis Lab Challenges Preanalytical Risks to Diagnostic Accuracy Increasing levels of hemolysis are associated with shorter APTT results 1 Such a shift can cause abnormal samples to produce normal results Reference interval of APTT Test on STA Compact System: Reference interval of APTT Test on Sysmex CS-2100i System: Controls (CS-2100i) Heparin (CS-2100i) Controls (STA Compact) Heparin (STA Compact) The green and blue lines/symbols describe the effect of increasing levels of hemolysis on control blood samples, while the orange and maroon lines/symbols describe the effect on the same samples spiked with unfractionated heparin (0.15 IU/ml) Data on file, Siemens Healthcare Diagnostics 1. The Effects of Hemolysis and Primary Tube Under-filling on Several Hemostasis Assays; Automatic Detection by the Sysmex CS-2100i System. De Haan, Hoogendoorn, et al Level of hemolysis (free Hb; mg/dl) Page 9 Restricted Siemens Healthcare GmbH, 2016
10 HIL - Effect of Haemolysis 6 normal subjects Vacutainer 0.109M trisodium citrate (3.2%) Whole blood frozen Lysed cells added to plasma from same subject 12 different mixtures prepared Mean plasma haemoglobin 0 20 g/l (10-15% haemolysis) REAGENTS: PT reagent APTT reagent Second APTT reagent TT reagent Fib (Clauss reagent) D-Dimer reagent Page 10 Restricted Siemens Healthcare GmbH, 2016
11 APTT (sec) HIL - Effect of Haemolysis Artificial Haemolysis APTT reagent - CS series Influence of Hemolysis on APTT results is patient dependent. 18 <2 g/l 2.5g/l 4.5g/l 6g/l 7.8g/l 9.5g/l 10.8g/l 12.8g/l Plasma Haemoglobin 15g/l 17g/l 19.7g/l 20.7g/l Page 11 Restricted Siemens Healthcare GmbH, 2016
12 APTT (sec) HIL - Effect of Haemolysis Artifical haemolysis second APTT reagent - CS series Influence of Hemolysis on APTT results is patient and/or reagent dependent. 24 <2 g/l 2.5g/l 4.5g/l 6g/l 7.8g/l 9.5g/l 10.8g/l 12.8g/l Plasma Haemoglobin 15g/l 17g/l 19.7g/l 20.7g/l Page 12 Restricted Siemens Healthcare GmbH, 2016
13 HIL - Effect of Haemolysis Samples falsely raised above DDimer above the VTE cutoff (0.5 µg/ml) Haemolysed DDimer (µg/ml) Clear DDimer (µg/ml) Plasma Hb (g/l) HIL check Potentially unnecessary ultrasounds COST? Page 13 Restricted Siemens Healthcare GmbH, 2016
14 Underfilling Tubes Case Report Effect of under filling the tube First sample PT 104 seconds (properly filled 1 ml sample) Second sample (no treatment) PT 14 secs (properly filled 5ml sample)? Artefact? Wrong patient Page 14 Restricted Siemens Healthcare GmbH, 2016
15 Underfilling Tubes Case Report Effect of under filling the tube Third sample PT 14 seconds First sample - mixed 0.5 ml blood with 0.5ml anticoagulant in a 5 ml tube - this mix was added to a paediatric (1 ml) tube with further 0.1 ml anticoagulant CITRATE excess prolonged PT from 14 sec to 104 seconds Page 15 Restricted Siemens Healthcare GmbH, 2016
16 APTT Time (s) Underfilling Tubes APTT / CA1500 (Mean of 20 normals) It is admitted that a threshold of 80% filling is the ultimate lower limit. (Ray et al., 1991) % Filled Underfilling of the tube can have a significative impact on APTT time Page 16 Restricted Siemens Healthcare GmbH, 2016
17 HIL recommandations from recent studies Test Specific assessment of effects of haemolysis on citrated blood samplels using Sysmex CS series analysers Issued from the collaboration between Sysmex and Royal Hallamshire Hospital Scheffield UK On CS series analysers with Siemens reagents To asses test specific thresholds for effects of haemolysis on coagulation tests. Page 17 Restricted Siemens Healthcare GmbH, 2016
18 HIL recommandations from recent studies Page 18 Restricted Siemens Healthcare GmbH, 2016
19 HIL recommandations from recent studies Page 19 Restricted Siemens Healthcare GmbH, 2016
20 HIL recommandations from recent studies Page 20 Restricted Siemens Healthcare GmbH, 2016
21 HIL recommandations from recent studies Page 21 Restricted Siemens Healthcare GmbH, 2016
22 HIL recommandations from recent studies Page 22 Restricted Siemens Healthcare GmbH, 2016
23 HIL recommandations from recent studies Assay PT INN PT THS Parameter sec INR D-Fib sec INR D-Fib Acceptance Criteria *+-15% Recommandations Hb at Flag level Level 4 or Level 5 without D- Fib 240 mg/dl *+-15% Level mg/dl APTT FS sec *+/- 15% Level 1 40 mg/dl APTT FSL sec *+/- 15% Level 1 40 mg/dl Fbg g/l *+/- 15% Level mg/dl Thrombin Time sec *+/- 15% Level mg/dl AT % *+/- 10% Level mg/dl PC % *+/- 10% Level mg/dl FXIII % *+/- 15% Level 1 40 mg/dl D-Dimer mg/l *+/- 15% Level 1 40 mg/dl Page 23 Restricted Siemens Healthcare GmbH, 2016
24 HIL recommandations from recent studies Summary The level of haemoglobin causing >15% changes was different in spiked samples compared to genuine patient samples for some tests. D-Dimer, FXIII and APTT were more tolerant of haemolysis in spiked samples. Taking all data into account the following flag levels were required to ensure 15% change in results (10% for AT, PC) with equivalent plasma Hb in brackets. Page 24 Restricted Siemens Healthcare GmbH, 2016
25 HIL recommandations from recent studies Summary Level 5 (>300 mg/dl) - PT (Thromborel S), Clauss Fbg, Thrombin Time; Level 4 ( mg/dl) - PT (lnnovin), Protein C; Level 3 ( mg/dl) - Antithrombin Level 1 ( mg/dl) - APTT (Actin FS, Actin FSL), FXIII, D-Dimer. Page 25 Restricted Siemens Healthcare GmbH, 2016
26 Preanalytical Sample Integrity (PSI) Checks Onboard Reducing Preanalytical Risk Preanalytical Sample Integrity (PSI ) checks Multiwavelength analysis Autoverification Direct LIS connection Patients and physicians Preanalysis Analysis Review Results Accurate diagnosis Page 26 Restricted Siemens Healthcare GmbH, 2016
27 Now s our time to inspire the future of healthcare together Engineering success. Pioneering healthcare. Restricted Siemens Healthcare GmbH, 2016
Use of PSI on CS instruments
Johan Claes, Version 01, 1 st September 2016 User day hemostasis 2016 Use of PSI on CS instruments Restricted Siemens Healthcare GmbH, 2016 Hemostasis Lab Challenges Preanalytical problems in Haemostasis
Generate Knowledge Pre-Analytical Variables in the Coagulation Lab: Why Does It Matter?
Generate Knowledge Pre-Analytical Variables in the Coagulation Lab: Why Does It Matter? Paul Riley, PhD, MBA Pre-Analytical Variables: Objectives 1. Define Pre-Analytical variables 2. Explain how blood
Y. ZHAO, G. LV SUMMARY
International Journal of Laboratory Hematology ORIGINAL ARTICLE The Official journal of the International Society for Laboratory Hematology INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY Influence of temperature
Determination of APTT factor sensitivity the misguiding guideline
International Journal of Laboratory Hematology ORIGINAL ARTICLE The Official journal of the International Society for Laboratory Hematology INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY Determination
Presented by Marcelo Cardona, MT(ASCP) Johns Hopkins University
Presented by Marcelo Cardona, MT(ASCP) Johns Hopkins University Alert or critical values represent those assay results that require prompt, rapid clinical attention to avert significant study-participant
Worldwide Report Coagulation Lot Exp 31 Oct 2018
April 0 Worldwide Report Coagulation Lot 780 Exp Oct 08 Activated Partial Thromboplastin Time (APTT) Diagnostica Stago C.K. Prest Seconds 0.7 0.89.8 9 0.7 0.89.8 9 8.8..7 8.8..7 9.90 0.97.0 9.90 0.97.0
The study has been approved by Ethics Commission. Informed consent has been given by all participants.
Evaluation of new 9NC Coagulation Tubes Background: Venous blood with sodium citrate is the most commonly obtained examination sample for coagulation determinations. The additive functions as an anticoagulant
Individual Lab Report Ci-Trol Nov,2016. Abnormal Fibrinogen (mg/dl) Abnormal Fbg Control - Lot# LFC Your Lab
Individual Lab Report Ci-Trol Nov,2016 ST VINCENT MEDICAL CENTER LABORATORY(LAB# 7300 ) 2131 WEST THIRD STREET LOS ANGELES CA USA 90057 Abnormal Fibrinogen (mg/dl) Abnormal Fbg Control - Lot# LFC SYSMEX
Laboratory management of haemolysed samples results of an RCPAQAP survey. Penny Petinos
Laboratory management of haemolysed samples results of an RCPAQAP survey Penny Petinos Agenda Background to KIMMS survey on haemolysis Results of the 2010 and 2014 surveys Outcomes/decisions 2 Background
Evaluation Report. Eurolyser PT (INR) test kit (ST0180) on CUBE and smart analysers
Evaluation Report Eurolyser PT test kit (ST0180) on CUBE and smart analysers Locations Location 1: Eurolyser Diagnostica GmbH Operator: Simone Wieser Date: 30.06.2015 Specimens The specimens used for analysis
HEMOCHRON. Whole Blood Coagulation Systems
HEMOCHRON Whole Blood Coagulation Systems Citrated Activated Partial Thromboplastin Time (APTT) Cuvette Correlation Protocol for HEMOCHRON Microcoagulation Instruments MSIG:131 10/06 Dear Medical Professional:
The information contained here may be very important to your practice. Please take a moment to review this document.
September 2017 Dear Healthcare Provider, The information contained here may be very important to your practice. Please take a moment to review this document. TEST BULLETIN T-SPOT TB TESTING Please see
Insights on the Quality of Coagulation Testing
Insights on the Quality of Coagulation Testing Piet Meijer ECAT Foundation The Netherlands No conflicts of interest HAEMOSTATIC BALANCE BLEEDING HAEMOSTATIC BALANCE THROMBOSIS HAEMOSTATIC BALANCE Thrombosis
Internal Quality Control in the Haemostasis laboratory. Dr Steve Kitchen Sheffield Haemophilia and Thrombosis centre & UK NEQAS Blood Coagulation
Internal Quality Control in the Haemostasis laboratory Dr Steve Kitchen Sheffield Haemophilia and Thrombosis centre & UK NEQAS Blood Coagulation Why do we need Quality control? Philadelphia Enquirer Aug
Internal Quality Control in the Haemostasis laboratory. Dr Steve Kitchen Sheffield Haemophilia and Thrombosis centre & UK NEQAS Blood Coagulation
Internal Quality Control in the Haemostasis laboratory Dr Steve Kitchen Sheffield Haemophilia and Thrombosis centre & UK NEQAS Blood Coagulation Disclosures None What is Quality Control? In a medical laboratory
P re-analytical conditions are very important in laboratory assessment of hemostatic and coagulation systems
OPEN SUBJECT AREAS: PRE-CLINICAL STUDIES PROTEASES BIOCHEMICAL ASSAYS BIOPHYSICAL CHEMISTRY Received 19 November 2013 Accepted 8 January 2014 Published 27 January 2014 Correspondence and requests for materials
Point of Care Testing in Coagulation
Point of Care Testing in Coagulation Dr Steve Kitchen Scientific Director,UK NEQAS Blood Coagulation Head Scientist Coagulation Laboratory, Royal Hallamshire Hospital Sheffield UK POCT in Haemostasis Patient
Coping with Analytical Interferences
Coping with Analytical Interferences (Handling Icteric, Hemolytic and Lipaemic Samples) Graham Jones Department of Chemical Pathology St Vincent s Hospital, Sydney Surabaya Indonesia 2016 Acknowledgements
Comparison of Samples Obtained From 3.2% Sodium Citrate Glass and Two 3.2% Sodium Citrate Plastic Blood Collection Tubes Used in Coagulation Testing
Coagulation and Transfusion Medicine / GLASS VS PLASTIC IN HEMOSTASIS TESTING Comparison of Samples Obtained From 3.2% Sodium Citrate Glass and Two 3.2% Sodium Citrate Plastic Blood Collection Tubes Used
MEASUREMENT OF ANTICOAGULANT EFFECTS OF NEW ORAL ANTICOAGULANTS PRACTICAL ASPECTS
MEASUREMENT OF ANTICOAGULANT EFFECTS OF NEW ORAL ANTICOAGULANTS PRACTICAL ASPECTS Désirée Coen Herak Department of Laboratory Diagnostics University Hospital Centre Zagreb WARFARIN ERA Warfarin monopoly
Alere INRatio 2 METHOD AND SAMPLE COLLECTION
Alere INRatio 2 METHOD AND SAMPLE COLLECTION 1. PURPOSE AND SCOPE The purpose of this document is to describe the procedure for performing an INR test using the Alere INRatio2 analyser. The INRatio2 meter
Effects of preanalytical frozen storage time and temperature on screening coagulation tests and factors VIII and IX activity
www.nature.com/scientificreports Received: 8 February 2017 Accepted: 30 August 2017 Published: xx xx xxxx OPEN Effects of preanalytical frozen storage time and temperature on screening coagulation tests
Coagulation BEFORE Surgery
Coagulation BEFORE Surgery Lorenzo ALBERIO Médecin chef Hématologie générale et Hémostase Service et Laboratoire centrale d Hématologie CHUV, Lausanne Outline 1. Pre-op testing 2. Ongoing anticoagulation
Mouse HBsAg(Hepatitis B Virus Surface Antigen) ELISA Kit
Mouse HBsAg(Hepatitis B Virus Surface Antigen) ELISA Kit Catalogue No.: EM0002 Size: 96T Reactivity: Mouse Application: This immunoassay kit allows for the qualitative determination of HBsAg in Mouse serum
Hemolyzed Samples Should be Processed for Coagulation Studies: The Study of Hemolysis Effects on Coagulation Parameters
Original Article Hemolyzed Samples Should be Processed for Coagulation Studies: The Study of Hemolysis Effects on Coagulation Parameters Arora S, Kolte S, Dhupia JS Department of Pathology, VMMC and Safdarjang
Sample Quality Assurance
Sample Quality Assurance Phlebotomy Association of Ireland AGM 2012 Julie Riordan BSc, HDip Arts, MSc, F.A.M.L.S. Talk Outline Quality Assurance (QA) Preanalytical Variables (PAVs) & Errors (PAEs) Effects
Beyond Clotting Time Clot Waveform Analysis (CWA)
Beyond Clotting Time Clot Waveform Analysis (CWA) DR CHUEN WEN TAN CONSULTANT DEPARTMENT OF HAEMATOLOGY SINGAPORE GENERAL HOSPITAL FELLOW ANZAC RESEARCH INSTITUTE HAEMATOLOGY, CONCORD HOSPITAL Outline
Downloaded from journal.qums.ac.ir at 6: on Monday September 3rd 2018
The Journal of Qazvin Univ. of Med. Sci. No. 31, Summer 2004 - - * Assessment of mutual impact of different sodium citrate concentrations and minimum specimen volume on the result of routine coagulation
Hematology & Coagulation Practicum Objectives CLS - 647
Hematology & Coagulation Practicum Objectives CLS - 647 The following objectives are to be completed by the student for successful completion of this clinical rotation. The objectives within the psychomotor
Polymer Technology Systems, Inc. CardioChek PA Comparison Study
Polymer Technology Systems, Inc. CardioChek PA Comparison Study Evaluation Protocol: Accuracy Precision Clinical Correlation PTS Panels Lipid Panel Test Strips For Use in Comparisons to a Reference Laboratory
PICT ANTICOAGULANT MONITORING 1. PEFAKIT PICT. Clotting Assay. PEFAKIT PiCT. PEFAKIT PICT Calibrators UFH. PEFAKIT PICT Controls UFH
1 2 3 4 PEFAKIT PiCT PEFAKIT PICT Calibrators UFH PEFAKIT PICT Controls UFH PEFAKIT PICT Calibrators LMWH Clotting Assay PICT 1. PEFAKIT PICT Package size 8-505-01 kit 80 3 vials of PiCT Activator (2mL)
Patient Preparation Unique patient preparation requirements are listed under each test in the Test Directory.
Specimen Collection Lab results are only as good as the specimen provided. Patient preparation, venipuncture technique, specimen handling, and transportation can all affect the quantity of results. Health
prevent its recurrence. The FDA is reviewing possible deficiencies in the manufacturer s reagent package labeling.
science [coagulation and hematology] Laboratory Variables That May Affect Test Results in Prothrombin Times (PT)/International Normalized Ratios (INR) David L. McGlasson, MS, CLS/NCA, H, ASCP 59th Clinical
Collection of Blood Specimens by Venipuncture for Plasma-Based Coagulation Assays Necessity of a Discard Tube
Coagulation and Transfusion Medicine / Discard Tube Unnecessary for Coagulation Assays Collection of Blood Specimens by Venipuncture for Plasma-Based Coagulation Assays Necessity of a Discard Tube Maarten
Hemolysis and Pre-analytical Variables. Kathleen Finnegan, MS MT(ASCP)SH CM
Thursday April 6, 2017 C23 Hemolysis and Pre-analytical Variables Kathleen Finnegan, MS MT(ASCP)SH CM Clinical Associate Professor and Program Director of the Phlebotomy Training Program, Dept. of Clinical
Blood Collection Additives
Blood Collection Additives Blood collection tubes and other collection devices often contain one or more additives. There are a number of different types of additives, and each has a specific function.
EARLY ONLINE RELEASE
EARLY ONLINE RELEASE Note: This article was posted on the Archives Web site as an Early Online Release. Early Online Release articles have been peer reviewed, copyedited, and reviewed by the authors. Additional
Lab Guide Hematology Section Lab Guide
Lab Guide - 2018 Hematology Section Lab Guide Activated Partial Thromboplastin Time (APTT) One tube 2.7 ml citrated blood sample filled up to the mark on the tube label. (Light blue top tube, citrated
Scoring System for Detecting Spurious Hemolysis in Anticoagulated Blood Specimens
Original Article Laboratory Informatics Ann Lab Med 2015;35:341-347 http://dx.doi.org/10.3343/alm.2015.35.3.341 ISSN 2234-3806 eissn 2234-3814 Scoring System for Detecting Spurious Hemolysis in Anticoagulated
A. SAP is the D-Lab's name for a specific set of serum biochemical tests.
Understanding CBC, SAP, UA/Laura J. Steadman, DVM I. CBC - Complete Blood Count A. Three major types of cells are counted 1. Red Blood Cells 2. White Blood Cells 3. Platelets B. Cells are counted at the
QMS TACROLIMUS APPLICATION BECKMAN COULTER AU480 /AU680 /AU5800
QMS TACROLIMUS APPLICATION BECKMAN COULTER AU480 /AU680 /AU5800 Beckman Coulter Reagent REF A53727 The QMS Tacrolimus Immunoassay is intended for the quantitative determination of tacrolimus in human whole
Stability of prothrombin time and activated partial thromboplastin time tests under different storage conditions
Clinica Chimica Acta 300 (2000) 13 21 www.elsevier.com/ locate/ clinchim Stability of prothrombin time and activated partial thromboplastin time tests under different storage conditions L.V. Rao *, A.O.
General approach to the investigation of haemostasis. Jan Gert Nel Dept. of Haematology University of Pretoria 2013
General approach to the investigation of haemostasis Jan Gert Nel Dept. of Haematology University of Pretoria 2013 Clinical reasons to investigate haemostasis Investigating a clinically suspected bleeding
HBeAg and HBeAg Ab ELISA Kit
HBeAg and HBeAg Ab ELISA Kit Catalog Number KA0290 96 assays Version: 17 Intended for research use only www.abnova.com Table of Contents Introduction... 3 Intended Use... 3 Principle of the Assay... 3
The effect of the direct oral anticoagulants (DOACs) on haemostasis tests.
The effect of the direct oral anticoagulants (DOACs) on haemostasis tests. Emmanuel J Favaloro, Haematology, ICPMR, Pathology West, Sydney Centres for Thrombosis and Haemostasis, Westmead Hospital (with
Quantitative Measurement of Cardiac Biomarkers
Cardiac Biomarker Analyzer Quantitative Measurement of Cardiac Biomarkers Troponin I, Myoglobin, CK-MB, D-Dimer, NTproBNP, hscrp Results in 17 minutes Direct measurement from whole blood samples 6 parallel
Evaluation of VACUETTE Urine CCM Tubes for Urine Strip Testing
Evaluation of VACUETTE Urine CCM Tubes for Urine Strip Testing Background The VACUETTE Urine is for the collection, transport and storage of urine samples for urine culture and urinalysis in the laboratory.
Test Bulletin. Save time, money, resources, and precious blood by NOT collecting extra specimens just in case
Test Bulletin October 2018 Save time, money, resources, and precious blood by NOT collecting extra specimens just in case ACL Laboratories has seen an increase in the number of specimens submitted without
New Anticoagulants: Laboratory Monitoring?? Dr Steve Kitchen Sheffield Haemostasis and Thrombosis centre UK
New Anticoagulants: Laboratory Monitoring?? Dr Steve Kitchen Sheffield Haemostasis and Thrombosis centre UK Ideal Anticoagulant (Hirsh et al 2004) High efficacy to safety ratio Predictable dose response
The APC of Coag Back to Basics Troubleshooting
The APC of Coag Back to Basics Troubleshooting Connie Solano Supervising Scientist Pathology Queensland Princess Alexandra Hospital Brisbane Sarah Just Senior Hospital Scientist SEALS Prince of Wales Hospital
HEMOSTASIS Quality Time saving Economy Practicability Quality assurance Precision
Quality Time saving Economy Practicability Quality assurance Precision exclusive distributor of for France, Netherlands, Belgium and Luxembourg List of frozen reagents In 1992, Precision BioLogic began
Point of Care Testing (POCT)
Accounting for Pre-analytical Variables in POCT L.V. Rao, PhD Senior Clinical Laboratory Director Associate Professor, Pathology UMass Memorial Medical Center (Worcester, MA) Senior Scientific Director
Coagulation, Haemostasis and interpretation of Coagulation tests
Coagulation, Haemostasis and interpretation of Coagulation tests Learning Outcomes Indicate the normal ranges for routine clotting screen and explain what each measurement means Recognise how to detect
Exendin-4 (Exenatide) ELISA Kit
Exendin-4 (Exenatide) ELISA Kit Catalog: DEIABL227 For the quantitative determination of Exendin-4 in serum or plasma using competitive ELISA method For Research Use Only. Protocol Provided for Informational
QuickVet Diagnostic System
QuickVet Diagnostic System Package insert for QuickVet PT/aPTT Coag Combo Test Version: January 4, 2017 Introduction The QuickVet PT/aPTT Coag Combo test cartridge is a quantitative coagulation test intended
C56-A Hemolysis, Icterus, and Lipemia/Turbidity Indices as Indicators of Interference in Clinical Laboratory Analysis; Approved Guideline
C56-A Hemolysis, Icterus, and Lipemia/Turbidity Indices as Indicators of Interference in Clinical Laboratory Analysis; Approved Guideline Presented by: Merle B. Smith, MBA, MS, MT(ASCP) Siemens Healthcare
January Testing Delays and Spurious Results Caused by Improper Specimen Collection
January 2011 Testing Delays and Spurious Results Caused by Improper Specimen Collection Lauren Anthony, MD, MT(ASCP)SBB Medical Director, Allina Medical Laboratories Collecting a specimen may seem routine,
LOGO. Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University & Thai Society of Clinical Pathology
LOGO Improvement of Coagulation Lab Practice in Thailand via Thailand NEQAS for Blood Coagulation : 4-year Experience Nisarat Opartkiattikul MD,PhD Panutsaya Tientadakul, MD. Department of Clinical Pathology,
CLINICAL LABORATORY SERVICES
10. SPECIMEN ACCEPTANCE/ REJECTION 10.1. General guidelines Complete the request form legibly, using a ball point pen, and completely; include a contact number. Samples which are inadequately identified
Introduction to coagulation and laboratory tests
Introduction to coagulation and laboratory tests Marc Jacquemin Special Haemostasis Laboratory Center for Molecular and Vascular Biology University of Leuven Coagulation in a blood vessel: fibrin stabilises
Clinical Study Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism
International Endocrinology Volume 2012, Article ID 156854, 4 pages doi:10.1155/2012/156854 Clinical Study Procoagulant and Anticoagulant Factors in Childhood Hypothyroidism Nevin Kilic, 1 Yildiz Dallar,
Fibrinogen, Ddimer and Factor XIII testing Data from UK NEQAS (Blood Coagulation) Disclosure. Factor XIII. UK NEQAS data
Fibrioge, Ddimer ad Factor XIII testig Data from UK NEQAS (Blood Coagulatio) Steve Kitche UK NEQAS (Blood Coagulatio & Sheffield Haemophilia ad Thrombosis Cetre) Disclosure Relevat Fiacial Relatioship(s)
The PATH to better cardiac care starts here
The PATH to better cardiac care starts here #1 for precision among point-of-care analyzers * Affordable, core-lab quality results in under 17 minutes Test menu: Troponin I, NTproBNP, CK-MB, D-Dimer, hscrp
DOAC and NOAC are terms for a novel class of directly acting oral anticoagulant drugs including Rivaroxaban, Apixaban, Edoxaban, and Dabigatran.
Guideline for Patients on Direct Oral Anticoagulant Therapy Requiring Urgent Surgery for Hip Fracture Trust Ref:C10/2017 1. Introduction This guideline is for the clinical management of patients on direct
CoQ10(Coenzyme Q10) ELISA Kit
CoQ10(Coenzyme Q10) ELISA Kit Catalogue No.: EU0196 Size: 48T/96T Reactivity: Universal Detection Range: 0.781-50ng/ml Sensitivity:
Behzad Poopak, DCLS PhD
Behzad Poopak, DCLS PhD Test Report Name Age Critical Low HEMATOLOGY Activated Partial Thromboplastin Time, Plasma Critical High - 150 sec Units Fibrinogen 60 - mg/dl INR (International Normalizing
Plasma Hemoglobin Determination: Two Manual Methods Compared. An Honors Thesis (HONRS 499) Anne M. Emerick. Sharlene Strahl. Beech Grove, Indiana
Plasma Hemoglobin Determination: Two Manual Methods Compared An Honors Thesis (HONRS 499) by Anne M. Emerick Sharlene Strahl St. Francis Hospital and Health Centers Beech Grove, Indiana Dr. Nancy Behforouz
DRI METHAQUALONE APPLICATION BECKMAN COULTER AU5800
DRI METHAQUALONE APPLICATION BECKMAN COULTER AU5800 Catalog No. 0514, 0515 Homogeneous Enzyme Immunoassay for the Qualitative and Semiquantitative Determination of Methaqualone Levels in Urine For In Vitro
Delta Hb: A Potential Novel Parameter For Quality Monitoring Of Red Cell Concentrates
Delta : A Potential Novel Parameter For Quality Monitoring Of Red Cell Concentrates L. George, A. Meli, L. Willmott, R. Blanco, S. F. Garner, R. Cardigan Component Development Laboratory, NHSBT, Cambridge
Human Alpha 1 microglobulin ELISA Kit
Human Alpha 1 microglobulin ELISA Kit Catalogue No.: EH4144 Size: 48T/96T Reactivity: Human Range:0.625-40ng/ml Sensitivity:
Quantitative Measurement of Emergency Biomarkers in Parallel
Point-of-Care Immunoassay Analyzer Quantitative Measurement of Emergency Biomarkers in Parallel Troponin I, Myoglobin, CK-MB, D-Dimer, NTproBNP, hscrp Results in 17 minutes Direct measurement from whole
Hemostasis Test Validation, Performance and Reference Intervals
Hemostasis Test Validation, Performance and Reference Intervals Richard A. Marlar, Ph.D. Pathology and Laboratory Medicine Oklahoma City VA Medical Center University of Oklahoma Health Sciences Center
6 semanas de embarazo. Critical pt inr levels. Inicio / Embarazo / 6 semanas de embarazo
Inicio / Embarazo / 6 semanas de embarazo 6 semanas de embarazo Critical pt inr levels INR is the result of the patient PT/mean normal PT, exponentially equalized by the ISI. INR levels above 4.9 are considered
NOACS/DOACS*: COAGULATION TESTS
NOACS/DOACS*: COAGULATION TESTS OBJECTIVES: To describe the effect of the newer direct oral anticoagulants (DOACs) on laboratory coagulation tests which are widely available: prothrombin time (PT), international
History of the Vacutainer Tube. Coagulant Blood Tests
History of the Vacutainer Tube The different tubes are known as a vacutainer and were developed by Joseph Kleiner in 1947. The vacutainer is currently being manufactured by Becton, Dickinson and Company
CEDIA OPIATE APPLICATION BECKMAN COULTER AU5800
CEDIA OPIATE APPLICATION BECKMAN COULTER AU5800 Catalog No. 100089, 100098, 1661248 Intended for the qualitative and semiquantitative determination of opiates in human urine For In Vitro Diagnostic and
How Good is your INR? The Use of Certified Plasmas in PT/INR Testing. INR System. How Good is your INR? Outline
How Good is your INR? The Use of Certified Plasmas in PT/INR Testing Dot Adcock, MD Esoterix Coagulation Mayo/NASCOLA Coagulation Testing Quality Conference April 25, 2007 How Good is your INR? The Use
Postanalytical phase
Postanalytical phase Test request POSTANALYTICAL Result interpretation PHASE Result Sampling Black box: the lab And the RESULT is created The technician approves the result; it is transferred to the lab
Influenza A IgG ELISA
Influenza A IgG ELISA For the qualitative determination of IgG-class antibodies against Influenza A virus in human serum or plasma (citrate, heparin). For Research Use Only. Not For Use In Diagnostic Procedures.
TRANSFUSION GUIDELINES FOR CARDIOTHORACIC UNIT 2006
TRANSFUSION GUIDELINES FOR CARDIOTHORACIC UNIT 2006 CTU blood product transfusion guidelines 2006 1 Summary of guidelines RED CELLS (10-15ml/kg) This applies to ward patients / icu patients who are stable.
MASSIVE TRANSFUSION DR.K.HITESH KUMAR FINAL YEAR PG DEPT. OF TRANSFUSION MEDICINE
MASSIVE TRANSFUSION DR.K.HITESH KUMAR FINAL YEAR PG DEPT. OF TRANSFUSION MEDICINE CONTENTS Definition Indications Transfusion trigger Massive transfusion protocol Complications DEFINITION Massive transfusion:
Guidance for management of bleeding in patients taking the new oral anticoagulant drugs: rivaroxaban, dabigatran or apixaban
Guidance for management of bleeding in patients taking the new oral anticoagulant drugs: rivaroxaban, dabigatran or apixaban Purpose The aim of this guidance is to outline the management of patients presenting
TUD Sdn Bhd ( V)
Instruction for Use of TUD Evacuated Blood Collection Tubes Direction for Use of TUD Evacuated Blood Collection Tube Product name: TUD Evacuated blood collection tube I. Application: It is used for collection,
Multiple Choice Questions and Answers
Barger both02.tex V3-07/08/2015 7:05 P.M. Page 1 Multiple Choice Questions and Answers Chapter 1 Getting Started with Clinical Pathology 1. Which component of the microscope should be adjusted when evaluating
DEEP VEIN THROMBOSIS (DVT): TREATMENT
DEEP VEIN THROMBOSIS (DVT): TREATMENT OBJECTIVE: To provide an evidence-based approach to treatment of patients presenting with deep vein thrombosis (DVT). BACKGROUND: An estimated 45,000 patients in Canada
ACTICLOT dpt REF 824. IVD C i 2 l. Dilute Prothrombin Time Test for the Determination of Lupus Anticoagulants (LA) (CPT Code No.
Sekisui Diagnostics, LLC 500 West Avenue, Stamford, CT 06902 M Tel. (203) 602-7777 Fax (203) 602-2221 INTENDED USE The ACTICLOT dpt is intended for the qualitative determination of Lupus Anticoagulants
COLLECTION TUBES FOR PHLEBOTOMY
COLLECTION TUBES FOR PHLEBOTOMY Red Top None Blood clots, and the serum is separated by centrifugation Chemistries, Immunology and Serology, Blood Bank (Crossmatch) Gold Top None Serum separator tube (SST)
The Rapid D-Dimer Test is a chromatographic immunoassay for the qualitative detection of D-Dimer in human whole blood and plasma.
D-Dimer Rapid Test Cat. No.:DTS589 Pkg.Size: Intended use The Rapid D-Dimer Test is a chromatographic immunoassay for the qualitative detection of D-Dimer in human whole blood and plasma. General Description
EDUCATIONAL COMMENTARY DISSEMINATED INTRAVASCULAR COAGULATION
EDUCATIONAL COMMENTARY DISSEMINATED INTRAVASCULAR COAGULATION Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE
Mission Hb accurately detects both
Mission Digital Hb-Testing System: Save Cost by testing 2- Parameters with Single Strip real time ie: i.e: Hemoglobin & Hematocrit-[PCV]. Presented By : Remedy Healthcare Private Limited, New Delhi, [INDIA].
Applicable To Employees of Gundersen Boscobel Area Hospital Laboratory and Gundersen Palmer Lutheran Hospital and Clinics Laboratory.
Subject Creatinine COBAS C311 Index Number Lab-8814 Section Laboratory Subsection Regional/Affiliates Location Category Departmental Contact Tilleraas, Betty Last Revised 1/17/2018 References Required
Managing Coagulopathy in Intensive Care Setting
Managing Coagulopathy in Intensive Care Setting Dr Rock LEUNG Associate Consultant Division of Haematology, Department of Pathology & Clinical Biochemistry Queen Mary Hospital Normal Haemostasis Primary
Hepatitis A virus IgM ELISA Kit
Hepatitis A virus IgM ELISA Kit Catalog Number KA0285 96 assays Version: 04 Intended for research use only www.abnova.com Table of Contents Introduction... 3 Intended Use... 3 Background... 3 Principle
Routine, Every 2 hours, Starting today, If temperature greater than 38.5 C initiate Evaluation for Possible Sepsis Physician Order #829
Height Weight Allergies General Vital Signs [X] Frequent vital signs Indication: Q15 minutes x (# of occurrences): 4 Q30 minutes x (# of occurrences): 4 Q1 hour x (# of occurrences): Q2 hours x (# of occurrences):
Collect and label sample according to standard protocols. Gently invert tube 8-10 times immediately after draw. DO NOT SHAKE. Do not centrifuge.
Complete Blood Count CPT Code: CBC with Differential: 85025 CBC without Differential: 85027 Order Code: CBC with Differential: C915 Includes: White blood cell, Red blood cell, Hematocrit, Hemoglobin, MCV,
Cover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/37409 holds various files of this Leiden University dissertation Author: Engbers, Marissa Title: Conventional and age-specific risk factors for venous thrombosis
Gentian Canine CRP Immunoassay Application Note for Abbott Architect * c4000
v2-jan214 Gentian Canine CRP Immunoassay Application Note for Abbott Architect * c4 Intended Use The canine CRP immunoassay on Abbott's Architect c4 is an in vitro diagnostic test for quantitative determination
TITLE: Whole Blood Glucose Monitoring Using the Nova StatStrip Meter
Page 4 of 14 IV. Performance of Quality Control A. Purpose: To detect any errors due to system failures or operator performance B. Frequency: Levels 1 and 3 controls are run every 24 hours of use. C. Quality
Quality Control for Point-of-Care Testing
Quality Control for Point-of-Care Testing James H. Nichols, PhD, DABCC, FACB Professor of Pathology, Microbiology and Immunology Medical Director of Clinical Chemistry and Point-of-Care Testing Vanderbilt
Evaluation of VACUETTE CAT Serum Fast Separator Blood Collection Tube for Routine Chemistry Analytes in Comparison to VACUTAINER RST Tube
Evaluation of VACUETTE CAT Serum Fast Separator Blood Collection Tube for Routine Chemistry Analytes in Comparison to VACUTAINER RST Tube Background: Greiner-Bio-One, Austria has been selling plastic evacuated