Adolfo Garcia-Sastre, New York, USA

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1 Program Overview Sunday, September 21, Registration OPENING Welcome note by the organizers Opening lecture: Interactions of the influenza virus NS1 with the host. Adolfo Garcia-Sastre, New York, USA Reception at the meeting site (food and drinks) Monday, September 22, Session 1: HOST GENETICS OF INFECTIONS Chair: Peter Stäheli 9.00 Keynote lecture: Virus and host genetics of infectious disease severity Paul Kellam, Cambridge, United Kingdom 9.30 Genetic background influences the antiviral activity of Mx1 gene to influenza virus infection in mice Dai-Lun Shin, Braunschweig, Germany Severely reduced influenza A virus resistance of wild-derived CAST/EiJ mice due to two amino acid changes in the interferon-induced Mx1 resistance factor Cindy Nürnberger, Freiburg, Germany Analysis of the host response to influenza A virus infection in the Collaborative Cross founder strains Sarah R. Leist, Braunschweig, Germany Coffee break Session 2: VIRUS HOST CELL INTERACTION Chair: Stephan Ludwig Downregulation of the Na,K-ATPase in the alveolar epithelium after Influenza A infection is dependant on the kinases CaMKKb and AMPK Christin Becker, Gießen, Germany 1

2 The tetraspanin proteins, CD81 and CD9, promote efficient influenza A virus budding through interactions with HA and NA Yuhong Liang, New York, USA Influenza Virus-induced Caspase-dependent Enlargement of Nuclear Pores Coincides with Nuclear Export of Viral Ribonucleoprotein Complexes Stephan Pleschka, Gießen, Germany Type I interferon signalling is inhibited upon influenza A virus and Staphylococcus aureus co-infection Christina Ehrhardt, Münster, Germany Lunch & Poster viewing Session 3: INNATE IMMUNITY Chair: Martin Schwemmle 14:00 Keynote lecture: Innate immune sensing by RIG-I-like receptors and escape strategies of influenza virus Michaela Gack, Boston, USA 14:30 DDX6 RNA Helicase is a novel RIG-I regulator that enhances RIG-I mediated IFN ß production Rocio Davina Nunez, Berlin, Germany Flu s first defense against IFN: Viral suppressors of type I IFN response are prepackaged in influenza A virus virions Swantje Liedmann, Münster, Germany Comparison of the antiviral activity of M. spretus Mx1 and M. musculus A2G Mx1 against influenza A virus. Judith Verhelst, Gent, Belgium Coffee break Session 4: VIRAL REPLICATION STRATEGIES I FROM ENTRY TO BUDDING Chair: Klaus Schughart Mechanism of influenza virus uncoating Yohei Yamauchi, Zürich, Switzerland Single-molecule studies of promoter binding by the influenza RNA polymerase Nicole Robb, Oxford, United Kingdom 2

3 Recruitment of RED-SMU1 complex by influenza A virus RNA polymerase to control viral mrnasplicing Guillaume Fournier, Paris, France The nuclear export protein of H5N1 Influenza A Viruses recruits M1 to the viral ribonucleoprotein to mediate nuclear export. Linda Brunotte, Freiburg, Germany Plasticity in the nucleoprotein of Influenza A virus to escape the antiviral Mx protein David Riegger, Freiburg, Germany Alterations of membrane curvature during influenza virus budding Jeremy Rossman, Kent, United Kingdom Conference dinner at the Schloßgarten-Restaurant 3

4 Tuesday, September 23, Session 5: VACCINES & ANTIVIRALS Chair: Stephan Ludwig 9.00 Keynote lecture: Anti-inflammatory drugs for infectious diseases - a case for influenza Mauro Teixeira, Belo Horizonte, Brazil 9.30 Sponsors talk: CiFlu, development of a novel subunit influenza vaccine candidate based on the ciliate performance expression system. Marcus Hartmann (Cilian AG), Münster, Germany Improvement of protection elicited by live attenuated influenza vaccines via mucosal TLR-3 ligation. Jose Vicente Perez-Giron, Hamburg, Germany Novel small molecules inhibitors of influenza A and B viruses targeting the PA-PB1 subunits interaction of the viral polymerase. Arianna Loregian, Padova, Italy Coffee break Session 6: VIRAL REPLICATION STRATEGIES II - THE VIRAL NS1 PROTEIN Chair: Stephan Pleschka 11:00 Influenza A/NS1 mediated inhibition of the signaling integrator c-abl results in excessive lung homeostasis deregulation, lung damage and mortality Eike R. Hrincius, Memphis, USA Avian influenza NS1 protein inhibits innate responses in vitro, but is unable to suppress an in vivo cytokine storm. Konrad Bradley, London, Germany Quantitative proteomic analysis of the Influenza A virus protein NS1 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor Hans Haecker, Memphis, USA 4

5 Lunch & Poster viewing Session 7: PATHOGENESIS Chair: Roland Zell Keynote lecture: Novel Influenza A (H7N9) Virus: Origin Host Jump and Drug-Resistance George G. Gao, Beijing, China H5N1 and H7N9 Viruses Induce Impaired IFN-mediated Antiviral State by Different Mechanisms Pamela Österlund, Helsinki, Finland The PA-X protein modulates virus pathogenicity in chick embryos independently of host cell shut off function Saira Hussain, Edinburgh, Scotland Activation of Influenza Virus Hemagglutinin by a L.pneumophila Protease Annika Arendt, Marburg, Germany 15:30 15:45 WRAP-UP LECTURE: WHAT S NEW WHAT S EXCITING? Peter Stäheli, Freiburg, Germany DISCUSSION AND CLOSING REMARKS 5

Patricia Fitzgerald-Bocarsly

FLU Patricia Fitzgerald-Bocarsly October 23, 2008 Orthomyxoviruses Orthomyxo virus (ortho = true or correct ) Negative-sense RNA virus (complementary to mrna) Five different genera Influenza A, B, C Thogotovirus