Table SI. Summary of a systematic review of light and laser

Transcription

1 1 Since this is a very extensive table, the format and content has not been edited by ActaDV. Table SI. Summary of a systematic review of light and laser Author, Year Picollo et al, 2014(1) Rosende et al, 2012(2) Hasegawa et al, 2011(3) Gleeson et al, 2011(4) Study No. of Clinical findings Previous Pretreatment / design patients Light specification Filter Pulse Interpulse (nm) duration delay Fluence rate/dose Interval case series 1 3 painful, firm, and vascularised nodules on ear Intralesional corticosteroid None IPL Up to 4; days Significant reduction of vascular component and consistency; pain disappearance case report 1 Popular Topical and Nd:YAG-Laser IPL Complete improvement; no erythematousviolaceous (1064nm) signs of recurrence after 2 plaques corticosteroids; years on elbows, knees, chloroquine (control of and dorsum of the the lesions on elbows nose and knees); MTX, allopurinol case report 1 Multiple 1-2 cm Topical Topical 20% 5-ALA PDT intense ; 14 days Improvement; no signs of small red-brown cryo pulsed light recurrence after 6 months indurated facial plaques case series 6 Papules, plaques, All cases with All cases with UVA - - Initial 0,2, Mean of 50; 3 patients with complete nodules, annular prednisolone (0.5 topical gel PUVA with daily Initial 2 times improvement, 3 patients lesions and lupus mg/kg) and topical (methoxypsoralen-8 dose weekly, with 50% improvement; pernio clobetasol propionate gel 0.005%); increments followed by benefit maintained at and tacrolimus 0.1%; 4 5 cases with of weekly intervals follow-up (4 months 3 cases with corticosteroid; some cases with mepacrine, doxycycline, allopurinol, and MTX prednisolone 0.5mg/kg; 1 case with prednisolone 0.2 mg/kg 2 cases with hydroxychloroquine and allopurinol J/cm 2 ; max. years) 3.7 J/cm 2

2 2 Penrose et al, case report 1 Multiple red-brown Topical,, Topical 20% 5-ALA PDT -blue light min and ; 14 days Some recurrence after 3 Hyperpigm 2011(5) papules coalescing and systemic illuminator 40s months entation and to confluence on corticosteroid (BLU-U) superficial nose desquamati on Patterson, 2009(6) case report 1 Reddish brown and Topical and Topical 5-ALA PDT non- 633 Fractionate 75 7; 6-8 weekly Clearly entirely Mild annular plaque with coherent light d dose improvement discomfort, induration at source (LED) regime* headache periphery and central tacrolimus 0.1%, atrophy on right azathioprine forehead Wilsmann-Theis et case series 2 large red- systemic Methyl PDT ; once a complete al, 2008(7) brown indurated aminolevulinate red light 630 8min and case 2: 38 week for 6 improvement; no relapse prickling tumor at the internal hydroxychloroquine; (Metvix ) (Aktilite ); case 2: 49s weeks, followed after 4 months sensation angle of the eye; case 2: systemic case 2: broad case 2: by once a month case 2: complete case 2:indurated, band light 20min for 2 months improvement; no relapse erythematous doxycycline (PhotoDyn case 2: 8; 14 after 6 months swelling of the right 501 ) days ear Author, Year Study No. of Clinical findings Previous Pretreatment / Light specification design patients Filter (nm) Pulse duration Interpulse delay Fluence rate/dose Interval Kondo et al, case report 1 Diffuse swelling Surgical excision, 10% ALA was PDT excimer ; (total of Reduction of swelling; no 2005(8) around flexor systemic injected into tendon dye laser 600 J/cm 2 ) recurrence at 2-years tendons of the MTX sheath (pulsed laser follow-up right middle light) finger, extended to the forearm Mahnke et al, case report 1 Multiple, painless, Topical UVA1 - Initial 20 50; 4 times Nearly all lesions 2004(9) red-brown, tacrolimus J/cm 2 for 3 weekly disappeared elevated, partially confluent papules 40 J/cm 2 for and plaques on the 12 sessions

3 3 Karrer et al, 2002(10) Graefe et al, 2001(11) whole body and 60 J/cm 2 for 35 sessions case report 1 Numerous painless, redbrown, slight elevated papules and plaques on legs and upper arms Topical,, and systemic corticosteroid; cryo; topical vitamin E; clofazimine, allopurinol, bathwater PUVA case report 1 Red-brown Surgical excision, colored plaque on topical corticosteroid forehead 3% ALA gel containing 40% dimethyl sulfoxide PDT noncoherent light source ; Initial 2 times/week, followed by weekly intervals Complete improvement UVA Initial 20 J/cm 2 for 2 50 J/cm 2 for 3 90 J/cm 2 for 5 sessions and 130 J/cm 2 for 15 sessions 25; 4 times weekly Lesion improved, leaving only a few markedly flattened papules; treatment with topical corticosteroid after UVA1 ; no relapse after 2 months Burning sensation, erythema and edema Author, Year Study No. of Clinical findings Previous Pretreatment / Laser specification design patients Filter (nm) Pulse duration Interpulse delay Fluence rate/dose Interval Emer et al, case report 1 Indurated red-to- Topical, oral, and NAFR (1550 nm, PDL ; 30 days Reduction in lesions size; 2014(12) violaceous nodules 70mJ); improvement maintained on the nose corticosteroids; oral Prophylactic for 6 months of follow-up (Lupus pernio) hydroqui and allopurinol Roos et al, case report 1 Grossly defined Topical corticosteroid After 4 weeks of PDL Complete improvement 2009(13) nodules on back PDL beginning: after a follow-up of 28 systemic months

4 4 corticosteroid by iridocyclitis and necrobiosis lipoidica Holzmann et al, case report 1 Isolated Surgical excision, PDL (2 to 4 pulses Clinical remission; no 2008(14) inflammatory, amoxicillin, topical per session); 6 recurrence after 12-month erythematous, and, weeks follow-up ulcerated plaque on the left buccal tacrolimus 0.1% cheek O Donoghue and case series 3 case1: lupus Case 3: prednisolone CO2 Laser Residual lesional tissue and cases 1: Barlow, 2005(15) pernio; 5mg (systemic (paint mode) wound base was present in subtle case 2: violaceous oral, and sarcoidosis) cases 1 and 3 (treated with hypopigme nodule on the Cases 1 and 3: ntation nasal bridge and cyclosporine, MTX; triamcinolone); cases 1 and diffuse nasal tip case 2: ; triamcinolone 2: well controlled; case 3: swelling and case 3: acetonide partial recurrence after 2 erythema; years by declined systemic case 3: lupus oral, and treatment pernio MTX, cryo. Ekbäck and Molin, case report 1 Bluish-red slightly Topical and PDL ; (10 Lesions were less reddish 2004(16) infiltrated plaques sessions in 3 and thinner; limited effect on left cheek years) hydroxychloroquine PDL YAG Laser ; 7 months Complete improvement; no Slight recurrence after 3 years erythema and swelling of treated skin Grema et al, case report 1 Scarred tissue and PDL ; 4-6 weeks No response after (17) reddish-brown months; pruritus remained livid nodal lesions unaffected with irregular margins on elbow and knees

5 5 PDL Q-switched ruby laser nanosec 10 4; 4-6 weeks Complete improvement; no recurrence Author, Year Study No. of Clinical findings Previous Pretreatment / design patients Laser specification Filter Pulse Interpulse (nm) duration delay Fluence rate/ Dose Interval Cliff et al, 1999(18) case report 1 Violaceous eruption over the nose (lupus pernio) Topical corticosteroid; cryo PDL 585 ( shots pro session) ; 6 weeks Considerable cosmetic improvement Stack et al, 1996(19) case report 1 Nodular skin lesions on trunk, extremities, and nasal alar rims, columella, philtrum and upper lip (lupus pernio) Intralesional hydroxychloroquine Intralesional corticosteroid CO2-Laser 1 Complete improvement, no recurrence after 24 months Goodman and case report 1 Stable, diffuse, Intralesional PDL ; 6-7 months 75% improvement 6 Alpern, 1992(20) violaceous corticosteroids months after second erythema with session; return of majority multiple of erythema and papules granulomatous after 15 months (before the papules on the third session) nose References Table I: 1. Piccolo D, Di Marcantonio D, Crisman G, Cannarozzo G, Sannino M, Chiricozzi A, et al. Unconventional use of intense pulsed light. Biomed Res Int 2014; Rosende L, del Pozo J, de Andres A, Perez Varela L. Intense pulsed light for lupus pernio. Actas Dermosifiliogr 2012; 103: Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S. Photodynamic using intense pulsed light for cutaneous sarcoidosis. J Dermatol 2012; 39: Gleeson CM, Morar N, Staveley I, Bunker CB. Treatment of cutaneous sarcoid with topical gel psoralen and ultraviolet A. Br J Dermatol 2011; 164: Penrose C, Mercer SE, Shim-Chang H. Photodynamic for the treatment of cutaneous sarcoidosis. J Am Acad Dermatol 2011; 65: Patterson C. Successful treatment of cutaneous sarcoid by photodynamic with minimal discomfort using a fractionated dosing regime. Photodermatol Photoimmunol Photomed 2009; 25: Wilsmann-Theis D, Bieber T, Novak N. Photodynamic as an alternative treatment for cutaneous sarcoidosis. Dermatology 2008; 217: Kondo C, Watanabe D, Nakaseko H, Morishita M, Tsuboi T, Tamada Y, et al. Photodynamic for recurrent sarcoid flexor tenosynovitis of the finger. J Am Acad Dermatol 2006; 55:

6 6 9. Mahnke N, Medve-Koenigs K, Berneburg M, Ruzicka T, Neumann NJ. Cutaneous sarcoidosis treated with medium-dose UVA1. J Am Acad Dermatol 2004; 50: Karrer S, Abels C, Wimmershoff MB, Landthaler M, Szeimies RM. Successful treatment of cutaneous sarcoidosis using topical photodynamic. Arch Dermatol 2002; 138: Graefe T, Konrad H, Barta U, Wollina U, Elsner P. Successful ultraviolet A1 treatment of cutaneous sarcoidosis. Br J Dermatol 2001; 145: Emer J, Uslu U, Waldorf H. Improvement in lupus pernio with the successive use of pulsed dye laser and nonablative fractional resurfacing. Dermatol Surg 2014; 40: Roos S, Raulin C, Ockenfels HM, Karsai S. Successful treatment of cutaneous sarcoidosis lesions with the flashlamp pumped pulsed dye laser: a case report. Dermatol Surg 2009; 35: Holzmann RD, Astner S, Forschner T, Sterry G. Scar sarcoidosis in a child: case report of successful treatment with the pulsed dye laser. Dermatol Surg 2008; 34: O'Donoghue NB, Barlow RJ. Laser remodelling of nodular nasal lupus pernio. Clin Exp Dermatol 2006; 31: Ekback M, Molin L. Effective laser treatment in a case of lupus pernio. Acta Derm Venereol 2005; 85: Grema H, Greve B, Raulin C. Scar sarcoidosis-treatment with the Q-switched ruby laser. Lasers Surg Med 2002; 30: Cliff S, Felix RH, Singh L, Harland CC. The successful treatment of lupus pernio with the flashlamp pulsed dye laser. J Cutan Laser Ther 1999; 1: Stack BC, Jr., Hall PJ, Goodman AL, Perez IR. CO2 laser excision of lupus pernio of the face. Am J Otolaryngol 1996; 17: Goodman MM, Alpern K. Treatment of lupus pernio with the flashlamp pulsed dye laser. Lasers Surg Med 1992; 12: