Presented by Ron Parker August 2017

Transcription

1 Presented by Ron Parker August 2017

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3 MY DIABETIC FRIEND Has had type 2 diabetes for many years Very obese Uses cane to walk Can t walk more than a few hundred feet due to leg pain Major diabetic neuropathy Loves carbs more than life

4 GOALS Encourage people to be proactive about health to avoid unpleasant surprises Share my experience to help others Provide my experimental data Provide a source of information and encouragement Serve as a resource to others wanting to try

5 DISCLAIMERS I m not a doctor (nor a lawyer) Your mileage or calorage may vary If necessary, consult a physician before taking my advice (But don t be surprised if they don t know anything about what I m going to talk about) Nothing is easy but commitment and effort will usually be rewarded More than one variable was changed at the same time

6 DISCLAIMERS Many diets work Some work better than others Genetics has a role Diets are like religions to many people and they will kill you for not believing the same as they do

7 MY QUALIFICATIONS Not a doctor Someone interested in science Curious Always asking Why? Tried a few weight loss strategies that didn t work or didn t work well Learned some interesting things and why they worked for me

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9 MAHB I praise you because I am fearfully and wonderfully made; your works are wonderful, I know that full well. Psalm 139:14 Fearful == with great reverence, heart-felt interest and respect Found over 160 Youtube videos on biochemistry just on the Khan Academy channel

10 NONALCOHOLIC STEATOHEPATITIS AWARENESS (NASH) WEEK Not much information about this topic Your liver (or the liver of a loved one) may be in trouble and you don t know it A lot of misinformation Copious scientific evidence does not support the popular viewpoints A lot of money is being made by people and products who aren t really helping us

11 WHY YOU SHOULD LOVE YOUR LIVER The liver plays a central role in all metabolic processes in the body. Your liver: Filters toxins from blood Synthesizes proteins your body requires to function Manufactures biochemicals needed for digestion Helps regulate glycogen storage and blood glucose levels Disposes of old red blood cells Plus over 500 other functions You can t live without it, literally There isn t a machine that can replace it (no dialysis machine for liver)

12 FIBROSIS AND CIRRHOSIS Fibrosis Buildup of scar tissue resulting from ongoing inflammation and liver cell death Risk factors include fatty liver (NASH, high triglycerides) and insulin resistance Symptoms typically none without testing Cirrhosis Permanent scarring of liver tissue Severe impairment of liver function Increased risk of liver cancer End stage of chronic liver disease Treatment is liver transplant

13 LIVER ENZYMES AND OTHER TESTS Liver enzymes Like cardiac enzymes, released when damage occurs AST (SGOT) Present in other cells in the body, not just liver Acute or recent damage ALT (SGPT) Acute or recent damage More specific to the liver Albumin Protein made in the liver Low albumin indicates chronic liver injury Prothrombin Time (PT) and INR Shows acute and chronic injury Measures time for blood to clot Liver makes most of the proteins required for blood clotting Most sensitive test for liver disease

14 SIGNS YOUR LIVER ISN T HAPPY Before diagnosis of type 2 diabetes there is a long, silent scream from the liver. Often no symptoms Elevated liver enzymes Fatigue Risk factors High triglycerides High fasting blood glucose

15 HOW THIS STARTED FOR ME 2012 Complain to doctor about fatigue 2013 Continue complaining about fatigue, blood tests show high triglycerides and elevated liver enzymes 2015 Diagnosed with moderate sleep apnea May 2016 Referred to gastroenterologist for evaluation following blood tests indicating high insulin, elevated liver enzymes September 2016 Ultrasounds and biopsy indicate liver fibrosis, referred to liver specialist in Houston where people go to get new livers

16 MY TIMELINE Date ALT (10-60) Triglycerides (35-160) Fasting Glucose (65-120) Insulin ( ) Explanation 1/16/ ALT high due to strenuous exercise and too many NSAIDS. Others due to eating too much. 2/21/ Ditto 9/4/ Wow! 12/18/ Normal range but high end 3/5/ Too many Dr. Peppers 5/27/ Referred to gastroenterologist 9/14/16 Liver biopsy, ultrasound and lab tests indicated advanced fibrosis. Referred to BSLMC Hepatology Clinic in Houston

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18 May/26/ 1995 Jun/03/ 1996 Jan/01/1997 Jun/12/ 1998 Jan/01/1999 Jan/22/ 2000 Oct/03/ 2001 Jan/01/2002 Jan/01/2003 Oct/30/ 2004 Jan/01/2005 Jan/01/2006 Jan/01/2007 Jan/01/2008 Jan/01/2009 Jan/01/2010 Jan/01/2011 Dec/19/ 2012 Jan/01/2013 jan/01/2014 Jan/01/2015 Jan/05/ 2016 Jan/16/ 2017 Jan/24/ 2017 Feb/09/ 2017 May/26/ 2017 Jun/08/ 2017 Jun/12/ 2017 Jul/02/ 2017 Jul/05/ 2017 Jul/06/ 2017 Jul/14/ 2017 Jul/20/ 2017 Jul/28/ 2017 Aug/01/ 2017 Aug/04/ MY WEIGHT STORY

19 THE CALORIE BALANCE PARADOX Over a period of about 20 years, I gained about 40 pounds This is an average of 2 pounds per year Given that it takes 3,500 excess calories to result in gaining 1 pound, this equals 7,000 excess calories per year 7,000 calories per year / 365 days = 19 calories per day Conclusion: I should have eaten one less bite of food per day and I wouldn t have gained weight

20 THE LAZY DOOFUS THEORY Medical advice for weight loss: eat less, exercise more Assumption: you continue gaining weight or don t lose it so you are a lazy doofus sloth who needs to eat less, exercise more

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25 BODY FUEL STORAGE Glycogen stores carbohydrates Mostly stored in liver and muscles 480g typically stored X 4 kcal/g = 1,920 kcal (~1 day) Protein Stored primarily in muscles 6,000g typically stored X 4 kcal/g = 24,000 kcal (~ 12 days) Fats Stored in adipose tissue and liver (even if you are thin ) 12,000g stored X 9 kcal/g = 108,000 kcal (~54 days) Equal to 90,000g of glycogen (due to water content of carbs)

26 INSULIN RESISTANCE Eating carbohydrates causes your body to release insulin Insulin tells your body to store the sugar somewhere, anywhere, to get it out of your bloodstream Too much glucose is toxic in your bloodstream Insulin prevents your body from burning fat Constant exposure to insulin makes your body less sensitive to insulin

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28 WHAT I TRIED IN THE PAST Calorie math Exercising consistently throughout all the below Low fat Lower total calories (<1,700 per day) Reduced carbohydrates More exercise More exercise plus lower total calories Some progress while training for Bearathon in 2015

29 WHAT I TRIED THIS TIME BASED ON THE SCIENCE Low carb, high fat (LCHF) Low carb = 20 grams or less of carbs per day High fat = all the fat I want to eat Ate until I was full Didn t eat when I was full Tried skipping a few meals Just enough exercise to maintain cardiovascular fitness and muscle tone

30 MY WEIGHT STORY

31 WHAT THIS IS AND ISN T Atkins? Nutrisystem? Keto? Paleo? Quick Weight Loss Center? Jenny Craig?

32 KETONES Ketones <> ketoacidosis One of the two primary fuel sources The clean fuel for your body Produced in the liver from the BREAKDOWN OF FATS!!! Formed in quantity only when: There is not enough glucose in the body for energy needs Insulin levels are low Burned by all the cells in your body, including your brain Beta-hydroxybutyrate can be measured in blood with meter Taking ketone supplements <> making your own inside your body

33 WHAT I EAT Image from dietdoctor.com

34 WHAT I EAT Image from dietdoctor.com

35 WHAT I EAT

36 LOWEST CARB DRINKS Image from dietdoctor.com

37 WHAT I DON T EAT Image from dietdoctor.com

38 WHAT I DON T EAT Image from from dietdoctor.com

39 BENEFITS Rapid weight loss Virtually no hunger Improved athletic performance Increased maximum heart rate during exercise Increased speed during runs Greatly reduced joint pain Reduced fatigue levels after runs Improved mental state Reduced digestive issues More energy and productivity New recipes to try

40 CHALLENGES Adjustment to new food paradigm Getting enough fat into meals Weight loss plateaus Eating out or outside my control Carb nostalgia Impact on family

41 EXPERIMENTAL DATA Blood glucose Ketones Weight

42 FASTING BLOOD GLUCOSE

43 RECOMMENDATIONS If you are overweight, learn about NASH and NAFLD If your tests indicate a possible problem, ask for follow-up testing to determine nature of problem Take action based on information, if warranted Be proactive - don t expect your doctor to manage your overall health Get hepatitis vaccinations

44 HELPFUL YOUTUBE VIDEOS Gary Taubes-Low carb, high fat versus other diet strategies:

45 HELPFUL YOUTUBE VIDEOS Body fuel systems: Liver function tests: Liver function:

46 HELPFUL WEB SITES Dietdoctor.com No ads, $10 per month fee after 30 day trial Tons of recipes Large amount of free material Large number of free videos to get you started Intensivedietarymanagement.com Additional detail on science behind low carb as well as possible issues Detailed information about insulin resistance

47 HELPFUL AUTHORS AND SPEAKERS Gary Taubes Overall science and history of low fat versus low carb theories Several good books and videos on Youtube (search for his name) Jason Fung Insulin resistance and how to overcome it Intermittent fasting to fix insulin resistance Intensivedietarymanagement.com web site Several good videos on Youtube (search for his name)

48 NEXT STEPS Lose More Weight My goal is to get under 190 pounds by January = 27 pounds must go Continue testing to determine how my body works Labor Day to Thanksgiving Challenge Start Tuesday after Labor Day Back to < 20g of carbs per day, high fat Try more intermittent fasting if necessary Thanksgiving week is next rest period

49 THE MIRACLE MAN