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1 / 87 / / :.1.2 gharib_fa@yahoo.com : :.... :. : 0/1 0/2 1 1.( 94/74) :.. : /2/9 : 86/8/16 : 86/9/25 : 87/2/10 : 78 / 55

2 (Diabetes mellitus). (Sigma). (Merck) - (UV-VIS spectrophotometer). (Shimidzu) [8] Wu : ( 0/1 : : ( / /01). (ph=7/4. (Glycosylation).[1].[3 2].. (Thiobarbitoric acid).[5 4]... ( : 1 0/2 0/1 1 0/ (BA) [6] (Camellia siensis).[7]. (in vitro). / 78 / / 87 / 56

3 1 : ( / / 87 / / ( 90/74). ( 30/37) 0/2 0/1 : 1 0/1 > > 0/2 > > 1 > >.().(). 1 0/1. (p=0/387) 1 0/2.(p= 0/000) 20 (TCA). 0/5 0/5 0/3 0/ /05 TBA 0/ : (.. : (Mean ± SD) ± SPSS.. (Two way ANOVA). p<0/05 0/1). ( 1 0/2 TBA. 57

4 .1 p.value F (2,29) =425/403 F (2,29) =84/054 F (2,29) =0/983 p*=0/387 0/1 Mean ± SD 62/74±3/13 54/95±3/20 32/91±3/91 F (2,29) =202/629 0/2 Mean ± SD 82/22±1/27 70/92±2/91 31/86±3/98 F (2,29) =806/275 1 Mean ± SD 90/74±1/75 77/11±5/28 30/37±4/32 F (2,29) =604/581 p.value. 0/05 P.value * (Akgader) ( ) (Rosmarinus officinalis).[12] (Delers) [13] (Madhujith).[14] 2007 (Teucrium polium).[15]..[6] ) (. [9 8 7].[10]..[11] / / 87 / / 58

5 78 / / 87 / / 1. Tsuneki H, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic(ab/db) mice and on glucose methabolism in healthy humans.b M C Pharma 2004; 4: Marotta E, Lapolla A, Fedele D, et al. Accurate mass measurements by Fourier transform mass spectrometry in the study of advanced glycation end products/peptides. J Mass Spectrom 2003;38: Ahmed N, Dobler D, Dean M, Thornalley PJ. Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity. J Biol Chem 2005;280: Howard MJ, Smales CM. NMR analysis of synthetic human serum albumin α-helix 28 identifies structural distortion upon Amadori modification. J Biol Chem 2005;280: Ardestani A, Yazdanparast R. Antioxidant and free radical scavenging potential of Achillea santolina extracts. Food Chem 2007;104: Rizvi SI, Zaid MA, Anis R, Mishra N. Protective role tea catechins aganst oxidation-induced damage of type 2 diabetic erythrocytes. Clin Experi Pharmacol Physio 2005; 32: Sabarimuthu DQ, Raghu PS. Effects of (-)-epicatechin,a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart. Pharmacological Reports 2005;57: Wu CH, Yen GC. Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts. Journal of Agricultural and Food Chemistry 2005; 53: Wu LY, Juan CC, Ho L, Hsu YP, Hwang LS. Effect of green tea supplementation on insulin sensitivity in sprague-dawley rats. J Agric Food Chem 2004;52: Sabu MC, Smitha K, Kuttan R. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes.j Ethnopharmacol 2002; 83: Picerno P, Mencherini T, Lauro MR, Barbato F, Aquino R. Phenolic constituents and antioxidant properties of Xanthosoma violaceum leaves. Journal of Agricultural and Food Chemistry 2003; 51: Alhader AA, Hasan ZA, Agqel MB. Hyperglycemic and insulin release inhibitory effects on Rosmarinus Offecinalis. J Ethnopharmocol 2002;43(3): Delers F, Strecker G, Engler R. Glycosylation of chiken haptoglobin: Isolation and characterization of three molecular variants and study their distribution in hen plasma before and after terpen induced inflammation. Biochem Cell Biol 2004; 66 (3): [16].[17] 1 ).(2 1.[16] (3 1 ).[1].[10]. (in vivo). 59

6 and glucosemediated protein damage. J Agric Food Chem 2002; 50: Lo CY, Li S, Tan D, Pan MH, Sang S, Ho CT. Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions. Molecular Nutrition and Food Research 2006; 50: Madhujith T, Izydorczyk M, Shahidi, F. Antioxidant properties of pearled barley fractions. J Agric Food Chem. 2006; 54: Ardestani A, Yazdanparast R. Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. Food Chem Toxicol 2007; 45: Nakagawa T, Yokozawa T, Terasawa K, Shu S, Juneja LR. Protective activity of green tea against free radical- / / 78 / / 87 60