Index. electron microscopy, 81 immunofluorescence microscopy, 80 light microscopy, 80 Amyloidosis clinical setting, 185 etiology/pathogenesis,

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1 A Acute antibody-mediated rejection (Acute AMR) clinical features, 203 clinicopathologic correlations, 206 pathogenesis, light microscopy, Acute cellular rejection (ACR) clinical setting, 199 pathogenesis, electron microscopy, 202 immunofluorescence microscopy, 202 light microscopy, Acute humoral rejection. See Acute antibody- mediated rejection (Acute AMR) Acute interstitial nephritis (AIN) clinical setting, 155 clinicopathologic correlations, 158 etiology/pathogenesis, , Acute tubular necrosis (ATN) ischemic pathogenesis, 170, toxic, 171 Afferent arterioles, 3, 5 African American Study of Kidney Disease (AASK) trial, 128 Alcoholic Bouin s solution, 9 Alport syndrome clinical setting, 79 etiology/pathogenesis, electron microscopy, light microscopy, 80 Amyloidosis clinical setting, 185 etiology/pathogenesis, electron microscopy, 187, light microscopy, Angiotensin-converting enzyme inhibitors (ACEI), 76 Anti-glomerular basement membrane antibody, 15 Anti-glomerular basement membrane disease, 109 clinicopathologic correlations, electron microscopy, , 111 light microscopy, Antineutrophil cytoplasmic autoantibody (ANCA) disease, 108 clinical setting, 112 clinicopathologic correlations, etiology/pathogenesis, 116, Anti-vascular endothelial derived growth factor (VEGF) agents, 140 Apoptosis, 170 Arcuate arteries, 3 Arterionephrosclerosis clinical setting, etiology/pathogenesis, 128 electron microscopy, 128 immunofluorescence, 127 light microscopy, A.B. Fogo et al., Fundamentals of Renal Pathology, DOI / , Springer-Verlag Berlin Heidelberg

2 226 B Banff system, 199 Basket-weaving appearance, GBM, 81 Bence Jones cast nephropathy clinical setting, 175 pathogenesis, immunohistochemistry and electron microscopy, 177 light microscopy, Bence Jones proteinuria, 176 Benign familial hematuria. See Thin basement membrane abnormality Bowman s space, 4 C Calcineurin inhibitor toxicity (CIT) clinical setting, 217 diagnosis, acute tubulopathy, arteriolopathy, thrombotic microangiopathy, 219 Calyces, 4 C3 glomerulonephritis clinical setting, 31 etiology/pathogenesis, 41 electron microscopy, 36 37, light microscopy, 34, 35 Cholesterol emboli, Chronic antibody-mediated rejection (Chronic AMR) clinical setting, diagnosis, 212 pathogenesis, electron microscopy, light microscopy, Chronic humoral rejection. See Chronic antibody-mediated rejection (Chronic AMR) Chronic interstitial nephritis clinical setting, 161 etiology/pathogenesis, gross findings, light microscopy, Chronic pyelonephritis, 164 Circumferential cellular interposition, 32 Columns of Bertin, 3 4 Cortex, 3 5 C1q nephropathy, 54 Crescents, 13 Cryoglobulinemic vasculitis, 109 Cryo-plugs, in capillary lumina, 39, 40 Cyclosporin A (CsA), 217 D Decompensated arterionephrosclerosis, 126 Dense deposit disease (DDD) clinicopathologic correlations, 41 etiology/pathogenesis, electron microscopy, 36, light microscopy, 34 Diabetic nephropathy clinical setting, 143 etiology/pathogenesis, 150 glomerular classification, 149 pathologic classification, electron microscopy, 148, light microscopy, Diffuse diabetic glomerulosclerosis, Diffuse lupus nephritis, Diffuse segmental lesions, 94 Distal tubule, 8, E Electron microscopy acute cellular rejection, 202 acute postinfectious glomerulonephritis, 65 Alport syndrome, 81 amyloidosis, 187, 188 anti-glomerular basement membrane disease, 110 Bence Jones cast nephropathy, 177 C3 glomerulonephritis, 36 37, 39

3 chronic antibody-mediated rejection, dense deposit disease, 36, 38 diabetic nephropathy, 148, 149 FSGS, 50 immunoglobulin A nephropathy and vasculitis, light and heavy-chain-deposition disease, membranous nephropathy, minimal change disease, 50 MPGN, scleroderma, thin basement membrane, 83 thrombotic microangiopathy, Endarteritis, Endocapillary proliferation, 62, 101 Exudative glomerulonephritis, 62 F Fibrillary glomerulonephritis clinical correlations, clinical setting, 191, Focal lupus nephritis, Focal segmental glomerulosclerosis (FSGS) clinical setting, 45 clinicopathologic correlations, C1q nephropathy, 54 etiology/pathogenesis, 50 electron microscopy, light microscopy, secondary, 55 Foot process effacement, 13, 25 chronic AMR, 210 FSGS, 51, 54 MCD, 50 MPGN, 36 G Giant cell arteritis, 108 Glomerular hyalinization, 12 Glomerular hyalinosis, 146 Glomerular scarring, 12 Goodpasture s syndrome. See Anti-glomerular basement membrane disease 227 H Heavy-chain-deposition disease. See Light-chain-deposition disease Hemolytic uremic syndrome (HUS) characterization, 135 clinicopathologic correlations, etiology/pathogenesis, electron microscopy, light microscopy, Henoch-Schönlein purpura. See Immunoglobulin A (IgA) nephropathy and vasculitis Humoral immunity, AIN, 157 Hyaline droplets, 13 Hyalinosis, 45, 47, 146 Hyperacute rejection, 206, 207 Hypertension arterionephrosclerosis, cholesterol emboli, scleroderma, I Immune complex vasculitis, 109 Immunofluorescence microscopy acute antibody-mediated rejection, acute cellular rejection, 202 acute postinfectious glomerulonephritis, Alport syndrome, 80 amyloidosis, 187 anti-glomerular basement membrane disease, 110, 111 C3 glomerulonephritis, 36 chronic antibody-mediated rejection, dense deposit disease, diabetic nephropathy, focal segmental glomerulosclerosis, 49 immunoglobulin A nephropathy and vasculitis, light and heavy-chain-deposition disease, 181 membranous nephropathy, 23, 24 MPGN, 34, 35 thin basement membrane, 83 thrombotic microangiopathy, 137

4 228 Immunoglobulin A (IgA) nephropathy and vasculitis definition, 69 etiology/pathogenesis, 74 electron microscopy, light microscopy, Immunotactoid glomerulopathy, Interferon-α therapy, 41 Interlobular arteries, 3 5 Interlobular veins, 3 Interstitial capillaries, 3 K Kawasaki disease, 108, 118 KDIGO guidelines, 76 Kimmelstiel Wilson (K W) nodules, 145 L Large-vessel vasculitis, Late graft loss, Light-chain cast nephropathy, 176. See also Bence Jones cast nephropathy Light-chain-deposition disease characterization, 179 clinical setting, 179 etiology/pathogenesis, 182 electron microscopy, light microscopy, 180 Light microscopy acute antibody-mediated rejection, acute cellular rejection, acute postinfectious glomerulonephritis, Alport syndrome, 80 amyloidosis, anti-glomerular basement membrane disease, Bence Jones cast nephropathy, C3 glomerulonephritis, 34, 35 chronic antibody-mediated rejection, dense deposit disease, 34 diabetic nephropathy, FSGS cellular variant, 49 classification schema, FSGS variants, 48 collapsing variant, 47, 48 glomerular tip lesion, 47, 49 glomerulosclerosis, 45, 46 hyalinosis, 45, 47 immunoglobulin A nephropathy and vasculitis, light and heavy-chain-deposition disease, 180 membranous nephropathy, minimal change disease, 45, 46 MPGN, scleroderma, 130, 131 thrombotic microangiopathy, Loop of Henle, 8 Lupus glomerulonephritis, 69 Lupus nephritis active and chronic glomerular lesions, 91 challenges, characterization, 89 clinicopathologic correlations, etiology/pathogenesis, ISN/RPS classification, 89, 90 advanced sclerosing lupus nephritis, 98 diffuse lupus nephritis, focal lupus nephritis, lupus podocytopathy, 98 membranous lupus nephritis, mesangial lupus nephritis, 91, 92 tubulointerstitial lesions, vascular lesions, Lupus podocytopathy, 98 M Malakoplakia, 164 Medium-vessel vasculitis, 108 Membranoproliferative glomerulonephritis (MPGN) characterization, 31 clinicopathologic correlations, 41 etiology/pathogenesis, electron microscopy, , 35 light microscopy, Membranous lupus nephritis, Membranous nephropathy clinical setting, 21 clinicopathologic correlations, 27 28

5 etiology/pathogenesis, electron microscopy, , 24 light microscopy, Mesangial cells, 7, 13 Mesangial lupus nephritis, 91, 92 Mesangiocapillary glomerulonephritis. See Membranoproliferative glomerulonephritis (MPGN) Michaelis-Gutmann bodies, 164 Microscopic polyangiitis (MPA), 108, 114 Minimal change disease (MCD) clinical setting, 45 etiology/pathogenesis, electron microscopy, 50 light microscopy, 45, 46 Monoclonal immunoglobulin deposition disease (MIDD), 150. See also Light-chain-deposition disease MPGN. See Membranoproliferative glomerulonephritis (MPGN) Myeloma cast nephropathy. See Bence Jones cast nephropathy N Nonreplacement phenomenon, 168, 169 O Onion-skin pattern, in scleroderma, 130, 131 Oxford classification system, IgA nephropathy, 75 P Pauci-immune crescentic glomerulonephritis, 113 Pedicles, 4 Podocyte foot processes, 65 Polyarteritis nodosa, 108, Polyomavirus clinical setting, 220 pathogenesis, 222 electron microscopy, immunohistochemistry, light microscopy, 220, 221 Postinfectious glomerulonephritis, acute clinical setting, clinicopathologic correlations, 67 etiology/pathogenesis, 66 electron microscopy, light microscopy, Progressive systemic sclerosis, Proliferative glomerulonephritis, 12 R Recurrent renal disease, Reflux nephropathy, 161, Renal allograft biopsies, 197, 198 Renal anatomy afferent arterioles, 3, 5 arcuate arteries, 3 Bowman s space, 4 collecting system, 4 cortex, 3 5 glomeruli, 4 6 interlobular arteries, 3, 4 interlobular veins, 3 loop of Henle, 8 medulla, 3 4 pathology glomeruli, interstitium, 14 tubules, tissue examination, 8 11 Renal diseases, pathogenic mechanisms in glomerular immunologic, nonimmunologic, 16 tubular and interstitial injury, 16 vasculature, Renal veins, 3 S Scleroderma, Sclerosis, 12 definition, 45 progressive systemic, Size-selective barrier, 8 Slit-pore diaphragm, 4 229

6 230 Small-vessel vasculitis, Staining characteristics, renal structures, 9 Streptococcal pyogenic exotoxin B (SpeB), 66 Systemic lupus erythematosus (SLE). See Lupus nephritis T Tacrolimus, 217 Takayasu arteritis, 108 Tamm-Horsfall protein (THP), Thin basement membrane abnormality clinical setting, electron microscopy, 83 etiology/pathogenesis, Thrombotic microangiopathies (TMA). See Hemolytic uremic syndrome (HUS); Thrombotic thrombocytopenic purpura (TTP) Thrombotic microangiopathy (TMA), 31, 219 Thrombotic thrombocytopenic purpura (TTP) characterization, 135 clinicopathologic correlations, etiology/pathogenesis, electron microscopy, immunofluorescence microscopy, 137 light microscopy, Toxic acute tubular necrosis, 171 Tram-track appearance, MPGN, 31 Transmural endarteritis, 201 Tubulointerstitial injury, 16 Tubulointerstitial lesions, Tubulointerstitial nephritis with uveitis (TINU) syndrome, 158 Tubuloreticular inclusions (TRIs), 97 U Uromodulin, V Verotoxin, W Wegener s granulomatosis, 108, 113, 115 Wire-loop lesions, 95, 97