Harvard Medical School

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1 Harvard Medical School Date Prepared: 10/21/2011 Name: Hesheng Liu Office Address: th St. Charlestown, MA Massachusetts General Hospital, Dept. of Radiology Athinoula A. Martinos Center for Biomedical Imaging Home Address: 375 Atlantic Ave. Marblehead, MA Work Phone: Work Work FAX: Place of Birth: Fujian Province, China Education Year Degree Field of Study Institution 1997 B.S. Biomedical Engineering Tsinghua University 2003 Ph.D. Biomedical Engineering Tsinghua University (Fusheng Yang) Postdoctoral Training Year(s) Title Specialty/Discipline Institution Research Associate Electrical Engineering Washington State University (Paul H. Schimpf) Research Fellow Radiology Massachusetts General Hospital (Steven M. Stufflebeam) Appointments at Hospitals/Affiliated Institutions Year(s) Position Title Department Institution Research Fellow Radiology Massachusetts General Hospital Research Fellow Radiology Harvard Medical School Instructor Radiology Harvard Medical School Assistant in Neuroscience Radiology Massachusetts General Hospital 1

2 Professional Societies Year(s) of Membership Society Name Member, IEEE Member, Society for Neuroscience Editorial Activities Ad hoc Reviewer Journal of Neuroscience Journal of Cognitive Neuroscience Neuroimage Brian and Language Epilepsia IEEE transations on Biomedical Engineering Journal of Neuroengineering and Rehabilitation Medical & Biological Engineering &Computing Computer Methods and Programs in Biomedicine Honors and Prizes Year Name of Honor/Prize Awarding Organization Achievement for which awarded 1995 Huang-tao Scholarship Tsinghua University Outstanding Academic Performance 1996 Award of Outstanding Student Tsinghua University Outstanding Academic Performance 1999 Winner of Young Researcher Chinese Soc. for Paper Competition Biomed. Engineering Winner of Paper Competition 2002 Award of the Best Research Team Tsinghua University Outstanding Research Performance Report of Funded and Unfunded Projects Funding Information Years Source PI Grant Direct Costs NINDS Hesheng Liu Mentored Quantitative Research 2016 Development Award (K25) $827,830 Local Invited Presentations Year Title of presentation Type of presentation Department and Institution where presented Sponsor/Source of compensation 2006 Brief Introduction to MEG/EEG Inverses Invited Lecture Brigham& Women s Hospital Dr. Alexandra Golby 2007 Functional Mapping on Normal Subjects Invited Lecture and Epilepsy Patients Brigham& Women s Hospital Dr. Alexandra Golby 2008 Functional Mapping Using fmri, fcmri, Lecture for BrainMap ieeg, and MEG/EEG 2

3 Massachusetts General Hospital Dr. Anastasia Yendiki 2008 Robust decoding of visual information Lecture for Systems Neuroscience from the human brain Harvard Medical School Dr. Gabriel Kreiman Local Teaching and Training Year Course Title Type of student/audience Location Level of Effort 2008 HST 563 Imaging Biophysics and Clinical Applications Harvard-MIT Graduate and undergraduate students of HST 3-hr lab experiment session National and International Invited Presentations and Courses Year Title of presentation or name of course Type of presentation/role(s) Location Sponsor/Source of compensation 2008 Fast decoding of visual information in ECoG Invited Lecture Tsinghua University, Beijing, China Dr. Bo Hong 2008 Pre-surgical Mapping using Resting State fmri Invited Lecture SanBo Hospital, Beijing, China Dr. Mingwang Zhu 2009 Functional Laterality in the Resting Brain Invited Lecture Xuanwu Hospital, Beijing, China Dr. Kuncheng Li 2009 Epileptic Foci Localization Based on fcmri Invited Lecture GuangAnMen Hospital, Beijing, China Dr. Jiliang Fang 2009 Functional Laterality in the Resting Brain Invited Lecture Chinese Medical University, Shenyang, China Dr. Ke Xu 2009 Intrinsic Functional Laterality in Human Brain Invited Lecture University of California, Berkeley, USA Dr. Robert Knight 2010 Hemispheric Interaction in Resting Brain Invited Lecture McGill University, Montreal, Canada Dr. Brenda Milner Technological and Other Scientific Innovations Innovation Epileptic EEG Screening System Description I developed the software toolbox for identifying epileptic spikes during long-term EEG monitoring. This software has been embedded in many EEG monitoring systems and used by multiple hospitals in China and abroad. 3

4 Publications Peer Reviewed Publications in print or other media 1. Liu H., Yang F., Preliminary screening of epileptiform waves in EEG, Chinese J. Biomed. Eng., Vol.20 No.2, pp , Liu H., Yang F., An improved automated epileptic EEG detection system, J. Tsinghua Univ. (Sci&Tech), Vol.42, No.3, pp , Liu H., Gao X., Yang F., Theory of Hidden Markov Modeling and its implementation, Foreign Med. Sci. (Biomed. Eng. Fascicle),Vol.25, No.6, pp , Liu H., Zhang T., Yang F., A multistage multimethod approach for automatic detection and classification of epileptiform EEG, IEEE trans. Biomed. Eng., Vol. 49, No.12, pp , Liu H., Yang F., Gao X., Studies on spatio-temporal pattern of 3-D EEG, Prog. Nat. Sci.(Chinese), Vol.13, No.4, pp.41-45, Liu H., Gao X., Yang F., A 3-Dimensional spatio-temporal EEG pattern analyzing system, Prog. Nat. Sci., Vol.11, No.13, pp , Dong G.,Liu H.,Yang F.,Bayford R., Yerworth R., Gao S.,Holder D., Yan W., The spatial resolution improvement of EIT images by GVSPM-FOCUSS, Physiol. Meas., Vol. 25, pp , Li Y., Gao X., Liu H., Gao S., Classification of single-trial electroencephalogram during finger movement, IEEE trans. Biomed. Eng., Vol. 51, No.6, pp Liu H., Gao X., Schimpf P., Yang F., Gao S., A recursive algorithm for the 3-dimensional imaging of brain electric activity: Shrinking LORETA-FOCUSS, IEEE trans. Biomed. Eng. Vol. 51, No.10, pp Dong G., Liu H., Bayford R., Yerworth R., Schimpf P., Holder D., Yan W., Spatial resolution improvement of 3D EIT images by Shrinking sloreta-focuss algorithm, Physiol. Meas., Vol.26, pp. s199-s208., Schimpf P., Liu H., Ramon C., Haueisen J., Spatial Refinement of Standardized Low Resolution Electromagnetic Tomography in an Anatomically Realistic EEG Model, IEEE trans. Biomed. Eng., Vol. 52, No. 5, pp Liu H., Schimpf P., Dong G., Gao X., Yang F., Gao S., Standardized Shrinking LORETA- FOCUSS (SSLOFO): A New Algorithm for Spatio-temporal EEG Source Reconstruction, IEEE trans. Biomed. Eng., Vol. 52, No. 10, pp , Liu H., Schimpf P., Efficient Localization of Synchronous EEG Source Activities Using a Modified RAP-MUSIC Algorithm, IEEE trans. Biomed. Eng., Vol. 53, No. 4, pp , Jia W., Kong N, Ma J., Liu H., GAO X., Gao S., Yang F., Detection of the short-term preseizure changes in EEG recordings using complexity and synchrony analysis, Prog. Nat. Sci., Vol.16, No.7, pp , Vandervert L., Schimpf P.,Liu H., How Working Memory and the Cerebellum Collaborate to Produce Creativity and Innovation, Creativ. Res. J., Vol. 19, No. 1, pp. 1-18, Schimpf P., Liu H., Localizing Sources of the P300 using ICA, SSLOFO, and Latency Mapping, J. Biomech. Biomed. Biophys. Eng., Vol. 2, No. 1, pp.1-11, Tanaka N., Hamalainen M.S., Ahlfors S.P., Liu H., Madsen J.R., Bourgeois B.F., Lee J.W., Dworetzky B.A., Belliveau J.W., Stufflebeam S.M., Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis, Neuroimage, Vol.50, No. 1, pp , Liu H., Buckner R.L., Talukdar T., Tanaka N., Madsen J.R., Stufflebeam S.M., Task-Free Presurgical Mapping Using fmri Intrinsic Activity, J. Neurosurg. Vol. 111, pp , Buckner R.L., Sepulcre J., Talukdar T., Krienen F., Liu H., Hedden T., Sperling R., Johnson K., Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, 4

5 and Relation to Alzheimer s Disease, J. Neurosci., Vol. 29 No. 6, pp , Liu. H., Agam Y., Madsen J.R., Kreiman G., Timing, timing, timing: Fast decoding of object information from intracranial field potentials in human visual cortex, Neuron, Vol. 62, pp , Wetterling F., Liehr M, Schimpf P., Liu H., and Haueisen J., The localization of focal heart activity via body surface potential measurements: tests in a heterogeneous torso phantom, Phys. Med. Biol. Vol. 54, pp , Tanaka N., Cole A.J., von Pechmann D., Wakeman D.G., Hämäläinen M.S., Liu H., Madsen J.R., Bourgeois B.F., Stufflebeam S.M., Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy. Epilep. Res. Vol. 85, No.2, pp , Liu H., Stufflebeam S.M., Sepulcre J., Hedden T., Buckner R.L., Evidence from Intrinsic Activity that Asymmetry of the Human Brain is Controlled by Multiple Factors, Proc. Natl. Acad. Sci. USA, Vol. 106, pp , Sepulcre J., Liu H.,, Talukdar T., Martincorena I., Yeo B.T. and Buckner R.L., The Organization of Local and Distant Functional Connectivity in the Human Brain, PLoS Comput. Biol., 6(6):e , Agam Y.,Liu H., Papanastassiou A., Buia C., Golby A., Madsen J.R., Kreiman G., Robust Selectivity to Two-object Images in Human Visual Cortex, Curr. Biol., 20(9):872-9, Liu H., Tanaka N., Stufflebeam S.M., Ahlfors S.P., Hamalainen M.S., Functional mapping with simultaneous MEG and EEG, J. Vis. Exp., Vol 40, pp. 1668, Sabuncu M.R.; Desikan R.S., Sepulcre J., Yeo B.T.T., Liu H., Schmansky N.J. Reuter M. Weiner M.W., Buckner R.L., Sperling R.A., Fischl B., The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease, Arch. Neurol. Vol 68, pp , Stufflebeam S.M., Liu H., Sepulcre J., Tanaka N., Madsen J.R., Buckner R.L., Localization of Focal Epileptic Discharges Using Functional Connectivity Magnetic Resonance Imaging, J. Neurosurg, Vol. 114, pp , Yeo B.T.T., Krienen F.M., Sepulcre J., Sabuncu M.R., Lashkari D., Hollinshead M., Roffman J.L., Smoller J.W., Zollei L., Polimeni J.R., Fischl B., Liu H., Buckner R.L. The organization of the human cerebral cortex estimated by functional connectivity, J Neurophysiol Vol 106, pp , Lu J.*, Liu H*. Zhang M. Wang D., Cao Y., Ma Q., Rong D., Wang X.,Buckner R.L., Li K., Focal Pontine Lesions Provide Evidence That Intrinsic Functional Connectivity Reflects Polysynaptic Anatomical Pathways, J Neurosci, 42(31): , 2011 (* equal contribution) Thesis Liu H. Spatio-temporal Analysis of EEG, Tsinghua University Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings: 1. Blumberg J., Singer J., Liu H., Agam Y., Madsen J.R., Kreiman G., Stationarity of the neural code for vision, Society for Neuroscience Annual Meeting, 2008, Washington DC, USA 2. Liu H., Hollinshead M., Buckner R.L., Brain Asymmetry Measured by Intrinsic Activity Predicts Task-Based Language Lateralization Society for Neuroscience Annual Meeting, 2010, San Diego, USA 3. Shafee R., Liu H., Sabuncu M.R., Thomas B.T.Y., Sepulcre J., Buckner R.L., Anatomical and Functional Asymmetry in the Cerebral Cortex Society for Neuroscience Annual Meeting, 2010, San Diego, USA 5

6 4. Holt D.J, Liu H., Coombs G., Goff D.C., Buckner R.L., Resting-state functional connectivity of the medial prefrontal cortex in schizophrenia and the delusion-prone, International Congress on Schizophrenia Research, 2010, Colorado Springs, USA Narrative Report (limit to 500 words) My work focuses on multi-modal imaging technology that combines information provided from electrical (MEG, EEG), hemodynamic (fmri, functional connectivity MRI - fcmri), and intracranial EEG. The majority of my time is spent on executing the patient-oriented research projects, including experimental design, data collection and analyses. I have conducted several studies on healthy individuals and patients with epilepsy to develop new imaging techniques that aim to better localize the language, memory, and motor systems. The findings were published on scientific journals including: Neuron, Proceedings of National Academy of Science USA, Journal of Neuroscience, Journal of Neurosurgery, etc. I will be funded by NIH through the K25 career development award in which I proposed to improve the pre-surgical mapping technology based on resting state fmri. I also started a project to study the inter-hemispheric interaction in healthy young subjects, older adults, and schizophrenia patients. Other ongoing projects include a longitudinal study on stroke patients in which I investigate the functional connectivity disruption and the recovery after stroke. My teaching efforts include teaching the lab course for HST 563, Imaging Biophysics and Clinical Applications, in which I designed the lab experiments on MEG data analysis. My past research has made contributions in answering several important questions in clinical and basic neuroscience research. My current research projects seek to develop new technologies that can improve, or even replace, traditional functional mapping approaches for epilepsy, tumor, and stroke patients. 6