Deputy Manager and Medical Assessor. Specialty Registrar in Histopathology. East Midlands Deanery (United Kingdom) Histopathology

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1 Curriculum vitae PERSONAL INFORMATION Ming-Yuan Tseng WORK EXPERIENCE October 2011 Present Deputy Manager and Medical Assessor Medicines and Healthcare Products Regulatory Agency (United Kingdom) Assessing and approving license for medicinal products, assessing and approving clinical trial authorisation August 2009 September 2011 Specialty Registrar in Histopathology East Midlands Deanery (United Kingdom) Histopathology October 2008 July 2009 Clinical Research Associate Randomised Double-blind Placebo-controlled Trials of Simvastatin in patients with subarachnoid haemorrhage: obtaining consent, taking blood samples, prescribing trial medications August 2007 September 2008 Specialist Registrar in Neurosurgery Addenbrooke's Hospital (United Kingdom) Clinical care of neurosurgical patients, including on-call, in-patient, out-patient clinic, theatre operations, accidents and emergency September 2002 April 2003 Specialist Registrar in Neurosurgery Newcastle General Hospital (United Kingdom) Clinical care of neurosurgical patients, including on-call, in-patient, out-patient clinic, theatre operations, Accidents and emergency July 1995 September 2001 Resident Doctor National Taiwan University Hospital, Taipei, Taiwan (China) Clinical care of surgical patients, including rota to all surgical specialities, on-call, in-patient, out-patient clinic, theatre operations, accidents and emergency September 1994 June 1995 Resident Doctor Municipal Taipei General Hospital, Taipei, Taiwan (China) Clinical care of surgical patients, including rota to all surgical specialities, on-call, in-patient, out-patient clinic, theatre operations, accidents and emergency July 1994 August 1994 Officer National Military Services, Taiwan (China) EDUCATION AND TRAINING October 1987 June 1994 Doctor of Medicine Kaohsiung Medical University Taiwan (China) Medicine in General 18/1/18 European Union, Page 1 / 5

2 October 2001 August 2002 MPhil in Neurosurgery A pilot clinical trial of hypertonic saline therapy in poor grade subarachnoid haemorrhage: obtaining consent, taking blood samples, prescribing trial medications, and performing bedside transcranial Doppler October 1999 September 2003 MSc in Epidemiology London School of Hygiene and Tropical Medicine (United Kingdom) Epidemiology: Principles and Practice October 2003 July 2007 PhD in Neurosurgery Randomised Double-blind Placebo-controlled Trials of Pravastatin and Erythropoietin in patients with subarachnoid haemorrhage: obtaining consent, taking blood samples, prescribing trial medications, and performing bedside transcranial Doppler September 2008 November 2012 MSc in Clinical Trials London School of Hygiene and Tropical Medicine (United Kingdom) Clinical Trials design, conduct, and management ADDITIONAL INFORMATION Expertise Neurology, Neurosurgery, surgery, epidemiology, clinical trials, histopathology, oncology, cardiovascular Publications Full Publications: 1. Tseng JH, Tseng MY, Liu AJ, Lin WH, Hu HU, Hsiao SH. Risk Factors for Chronic Subdural Hematoma after a Minor Head Injury in the Elderly: A population-based Study. BioMed Research International Tseng MY. Summary of evidence on immediate statins therapy following aneurysmal subarachnoid hemorrhage. Neurocrit Care 2011 Sep;15(2): Tseng MY, Hutchinson PJ, Kirkpatrick PJ. Interaction of neuroprotective and hematopoietic effects of acute erythropoietin therapy with age, sepsis, and statins following aneurysmal subarachnoid hemorrhage: post-hoc analysis of a randomized controlled trial. J Neurosurg 2010;112: Al-Rawi PG, Tseng MY, Richards HK, Nortje J, Timofeev I, Matta BF, Hutchinson PJ, Kirkpatrick PJ. Hypertonic saline in patients with poor grade subarachnoid haemorrhage improves cerebral blood flow, brain tissue oxygen and ph. Stroke 2010;41: Tseng MY, Hutchinson PJ, Richards H, Czosnyka M, Pickard JD, Erber WE, Brown S, Kirkpatrick PJ. Acute systemic erythropoietin therapy reduces delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a phase II randomized, double-blind, placebo-controlled trial. J Neurosurg 2009;111: Tseng JH, Kuo MF, Tu YK, Tseng MY. Lumbosacral spinal cord tethering in 46 patients: symptomatic factors affecting the outcome. Spine J 2008;8(4): Kirkpatrick PJ, Tseng MY, Hutchinson PJ. How SAFE is albumin for fluid resuscitation in critically ill patients with traumatic brain injury? Nat Clin Pract Neurol 2008;4(5): Tseng MY, Hutchinson PJ, Kirkpatrick PJ. Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: A prospective clinical study. Br J Neurosurg 2008;22(2): Tseng MY, Merchant E, Tseng JH. Effects of socioeconomic and geographical variations on survival for gliomas of the central nervous system. AANS neurosurgeon 2008;16: Tseng MY, Hutchinson PJ, Turner CL, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Biological effects of acute pravastatin treatment on patients after aneurysmal subarachnoid 18/1/18 European Union, Page 2 / 5

3 hemorrhage: a double-blind, placebo-controlled trial. J Neurosurg 2007;107: Tseng MY, Al-Rawi PG, Czosnyka M, Hutchinson PJ, Richards H, Pickard PJ, Kirkpatrick PJ. Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage. J Neurosurg 2007;107: Tseng MY, Hutchinson PJ, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute pravastatin treatment on intensity of rescue therapy, inpatient hospital stay and six-month outcome in patients after aneurysmal subarachnoid hemorrhage. Stroke 2007;38: Tseng JH, Tseng MY. Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study. Surgical Neurology. 2007;67: Tseng JH, Tseng MY. Survival analysis of 81 children with primary spinal gliomas: A populationbased study. Pediatric Neurosurg 2006;42: Tseng MY, Tseng JH, Merchant E. Comparison of effects of socio-economic and geographic variations on survival for adults and children with glioma. J Neurosurg (4 Suppl Pediatrics) 2006;105: Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage. Neurosurg Focus 2006;21:E Tseng JH, Merchant E, Tseng MY. Effects of socio-economic and geographic variations on survival for adult glioma in England and Wales. Surg Neurol : Tseng JH, Tseng MY. Brain abscess in 142 patients: factors influencing outcome and mortality. Surg Neurol 2006;65: Tseng JH, Tseng MY. Survival analysis of children with malignant primary brain tumors in England and Wales: a population-based study. Pediatric Neurosurg 2006;42: Al-Rawi PG, Zygun D, Tseng MY, Hutchinson PJ, Matta BF, Kirkpatrick PJ. Cerebral blood flow augmentation in patients with severe subarachnoid haemorrhage. Acta Neurochir 2005 suppl 95: Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomised placebo-controlled trial. Stroke 2005;36: Tseng MY, Tseng JH. Survival analysis for adult glioma in England and Wales: a population study. J Formos Med Assoc 2005;104: Xiao F, Tseng MY, Teng LJ, Tseng HM, Tsai JC. Brain abscess: clinical experience and analysis of 3 prognostic factors. Surg Neurol 2005;63: Tseng MY, Al-Rawi PG, Rasulo F, Pickard JD, Kirkpatrick PJ. Effect of hypertonic saline on cerebral blood flow in poor grade patients with subarachnoid haemorrhage. Stroke 2003;34: Tseng MY, Tseng JH. Thoracoscopic sympathectomy for palmar hyperhidrosis: effects on pulmonary function. J Clin Neurosci 2001;8: Tu YK, Tseng MY. Experience in surgical management of tumours involving the cavernous sinus. J Clin Neurosci 2000;7: Tseng MY, Tu YK, Shun CT. Primary central nervous system lymphoma - a retrospective study. J Clin Neurosci 1998;5: Case Reports 1. Mitchell P, Tseng MY, Mendelow AD. Decompressive craniectomy with lattice duraplasty. Acta Neurochir (Wien). 2004;146: Tseng JH, Tseng MY, Kuo MF, Tseng JL, Chang YL. The chronological changes of the magnetic resonance images in a case with a desmoplastic infantile ganglioglioma. Pediatric Neurosurgery 2002;36: Tseng MY, Tseng JH. Endoscopic retroperitoneal lumbar sympathectomy for plantar hyperhidrosis: case report. J Clin Neurosci 2001;8: Tseng MY, Tseng JH. Recurrent intracerebral hemorrhages in cerebral amyloid angiopathy. J Neurosurg Anesthes 2000;12: Tseng MY, Kao MC, Chiu CT. Isolated leptomeningeal tuberculoma: a case report. J Formos Med Assoc 1999;98: Projects 1. Determination of the cerebrospinal fluid level of beta-amyloid in patients with normal pressure 18/1/18 European Union, Page 3 / 5

4 hydrocephalus. 07/ /2009. Investigators: Pickard JD, Tseng MY, and GlaxoSmithKline. 2. Effects of systemic erythropoietin therapy on cerebral autoregulation and incidence of delayed ischemic deficits in patients with aneurysmal subarachnoid haemorrhage, a single-centered, randomized, double-blind, placebo-controlled, phase II study. (Cambridge Local Research Ethics Committee LREC No. 04/Q0108/87, EudraCT No ). 01/ /2007. Investigators: Tseng MY, Kirkpatrick PJ, Hutchinson PJ, Richards H. 3. Effects of oral statin therapy on cerebral autoregulation and the incidence of delayed ischemic deficits in patients with aneurysmal subarachnoid haemorrhage, a single-centered, randomized, double-blind, placebo-controlled, phase II study. (LREC No. 03/353). 01/10/ /02/2005. Investigators: Tseng MY, Kirkpatrick PJ, Hutchinson PJ, Richards H. 4. Effects of cerebral blood flow augmentation on brain oxygenation, metabolic condition and long term integrity following subarachnoid haemorrhage. (LERC No. 02/392). 01/10/ /2007. Investigators: PG Al-Rawi, Tseng MY, Kirkpatrick PJ, B Matta 5. The effect of intraventricular sodium nitroprusside on cerebral blood flow, as assessed by Xenon enhanced computerized tomography, in patients with poor grade aneurysmal subarachnoid haemorrhage, a single-centered, prospective, observational study. (LREC No.01/091). 01/10/ /08/2002. Investigators: Kirkpatrick PJ, PG Al-Rawi, Tseng MY, F Rasulo, B Matta 6. Comparison of cerebral blood flow effects of hypertonic saline and mannitol in patients with spontaneous subarachnoid haemorrhage, a single-centered, prospective, observational study. (LREC No. 01/354). 01/10/ /08/2002. Investigators: Tseng MY, Kirkpatrick PJ, PG Al-Rawi, F Rasulo, B Matta 7. Independent Data Monitoring Committee for EARLY DRAIN-Outcome after early lumbar CSF drainage in aneurysmal subarachnoid hemorrhage: a randomized controlled trial. Investigator: Stefan Wolf. Charité Center for Stroke Research Berlin 09/ SimvaSTatin in Aneurysmal Subarachnoid Haemorrhage (STASH), a Phase III, multi-center, international, double-blind, randomised, placebo-controlled study for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage by oral administration of Simvastatin 40mg daily. (EuraCT No , University of Cambridge & British Heart Foundation, UK), 01/ / Surgical Trial in Lobar Intracerebral Haemorrhage II (STICH II). University of Newcastle 01/ / Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage (CLEAR IVH): phase II, randomized, pharmacokinetic, dose finding, and dose frequency determination using r-tpa in intraventricular hemorrhage (FDA Orphan Products Grant Program. IND #: 8523, Johns Hopkins University, USA) Clazosentan to Overcome Neurological Ischemia and Infarction Occurring after Subarachnoid Hemorrhage-1 (CONSCIOUS-1): A Phase IIb, multi-center, international, double-blind, randomised, placebo-controlled, parallel-group, dose-finding study for prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage by intravenous administration of clazosentan, a selective endothelin A (ETa) receptor antagonist. (Actelion Pharmaceuticals Ltd, Allschwil, Switzerland), Memberships U.K. Royal College of Surgeons of England, Membership No Full registration, General Medical Council, London, U.K. (No ), 11/07/2005 Taiwan Taiwan Neurosurgical Society: Membership (No. 293) Taiwan Surgical Association: Membership (No ) Taipei Medical Association: Membership (No ) Other Relevant Information Awards, Prizes, & Distinctions 1. Brain Travel Grant ( 800), Wellcome Trust Centre for Neuroimaging 26/05/ Poster Award 2009 (Euro 250) from European Society of Clinical Investigation 03/04/ Travel Grant 2009 (Euro 800) from European Society of Clinical Investigation 01/04/2009, 26/03/ BUPA Foundation Award for the Best Emerging Medical Researcher ( 10,000), BUPA Foundation, 18/1/18 European Union, Page 4 / 5

5 London, UK 14/11/2007 ( 5. Aesculap Prize for Neurosurgical Research 2007 (5000 Euro), European Association of Neurological Surgeons, 24/02/ Prize awarded for the best oral presentation by the Society of British Neurological Surgeons, 6-8/09/ International Abstract Award, American Association of Neurological Surgeons, USA, 21-27/04/ Cone Pevehouse Award for Socioeconomic Studies in Neurosurgery, American Association of Neurological Surgeons, USA, 21-27/04/ Mention of Honor of Aesculap Prize for Neurosurgical Research 2006, European Association of Neurological Surgeons, 17/12/ Prize awarded for the best oral presentation by the Society of British Neurological Surgeons at Clinical Neurosciences 2005, UK, 7-9/09/ Poster Presentation Prize awarded by the EuroNeuro 2005, Cambridge UK, 1-4/09/ Travel Grants from St Catharine s College, University of Cambridge, UK, 2001, Top student of 176 graduate students in Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 18/06/ Top Student in Pathology, Kaohsiung Medical University, Kaohsiung, Taiwan, 24/05/ Award for the University Students Recreational Research from the National Scientific Council, the Executive Yuan, Taiwan, 20/05/ /1/18 European Union, Page 5 / 5