Case Report Tracheomalacia Treatment Using a Large-Diameter, Custom-Made Airway Stent in a Case with Mounier-Kuhn Syndrome
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1 Case Reports in Pulmonology, Article ID , 4 pages Case Report Tracheomalacia Treatment Using a Large-Diameter, Custom-Made Airway Stent in a Case with Mounier-Kuhn Syndrome Cengiz Özdemir, 1 Sinem Nedime Sökücü, 1 Levent Karasulu, 1 Sedat AltJn, 1 and Levent Dalar 2 1 YedikuleChestDiseaseandThoracicSurgeryResearchandTrainingHospital,34760Istanbul,Turkey 2 Department of Pulmonary Medicine, School of Medicine, Istanbul Bilim University, Istanbul, Turkey Correspondence should be addressed to Sinem Nedime Sökücü; sinemtimur@yahoo.com Received 24 June 2014; Revised 22 August 2014; Accepted 29 August 2014; Published 8 September 2014 Academic Editor: Akif Turna Copyright 2014 Cengiz Özdemir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mounier-Kuhn Syndrome (MKS) is a rare congenital disease that presents with abnormal enlargement in the central airways. In MKS, tracheomegaly is accompanied by difficulty in expelling recurrent lung infections and bronchiectasia. We presented a patient with MKS where commercially made stents were inadequate for stabilization and a custom-made, self-expandable metallic stent with a diameter of 28 mm and length of 100 mm was used. Chest pain that was thought to develop due to the stent and that disappeared after stent removal may be considered the main complication leading to stent removal. Continuous positive airway pressure therapy (CPAP) therapy was planned for the control of symptoms, which re-emerged after stent removal. This case is presented as an example that complications developing due to the stent as well as patient noncompliance may lead to stent removal, even when useful results are obtained from treatment of MKS. 1. Introduction Mounier-Kuhn Syndrome (MKS) is a rare congenital disease that presents with abnormal enlargement in the central airways [1]. Enlargement in the central airways continues to the distal end of the trachea and main bronchus and the airways return to normal size after the fourth to fifth branching [2]. In MKS, tracheomegaly is accompanied by difficulty in expelling recurrent lung infections and bronchiectasia [3, 4]. In the involved airway segment, there is collapse at varying degrees at expiration and the disorder is among the congenital causes of tracheobronchomalacia (TBM) [5]. In cases where symptoms cannot be controlled with the treatment of infections and comorbid diseases, stent placement in the airways and surgical treatment (tracheobronchoplasty) options may also yield useful results [6]. In the present report, the placement of a large, custommade tracheal stent and treatment outcome are discussed. 2. Case Report A 58-year-old male patient presented with complaints of dyspnea on exertion, cough, sputum production, and snoring for the last 7 years. The patient stated that he was admitted to the hospital several times within the last 2 years due to the progressionofthesesymptoms.healsoreceivedtreatment for the diagnoses of hypertension, hypothyroiditis, and type II diabetes and used several types of inhaler treatment for dyspnea. Physical examination revealed that he was obese with a body mass index (BMI) of 41.8 and his respiratory sounds were rough with a long expiration time. However, examinations of his other systems were normal. His whole blood count, biochemical analysis, and thyroid function tests were unremarkable. On chest X-ray, enlargement in the transverse diameter of the trachea was detected; the spirometric test results are shown in Table 1.Arterial blood gas analysis in ambient air was also unremarkable. His thorax
2 2 Case Reports in Pulmonology Table 1: Spirometric evaluation results before and after stent insertion. Before stent insertion After stent insertion FEV 1 in liters (%) 1.43 (44.6%) 2.95 (111.7%) FVC in liters (%) 2.92 (72.3%) 3.54 (114%) FEV 1 /FVC FEV 1 : forced expiratory volume in 1 s; FVC: forced vital capacity. tomography is shown in Figure 1. Bronchoscopyrevealedan enlarged transverse diameter of the trachea starting from the entrance and severe collapse was observed with respiration. The diameter of the trachea was measured to be 35 mm at the largest dimension. Enlargement and collapse continued in the right and left main bronchus. The diameter of the airways was normal at the distal end of the main bronchus. Polysomnography was also planned with the presumptive diagnosis of obstructive sleep apnea syndrome. Stent placement was planned for airway stabilization. Because the diameter of the trachea increased excessively, it was not preferred to use stents with the largest diameter of 22 mm because of the high risk of migration. A custom-made, self-expandable metallic stent with a diameter of 28 mm and a length of 100 mm was ordered. The stent (Silmet; Novatech, La Ciotat, France) was produced within 3 weeks. Under general anesthesia, the stent was placed in the trachea using a rigid bronchoscope (Figures 2(a) and 2(b)). Following the procedure, airway stability was improved in the trachea. The patient was transferred to the hospital ward after staying for 24 h postoperatively in the intensive care unit. There was marked improvement in symptoms. The spirometry results before stent placement and at the first-month control visit are summarized in Table 1 and bronchoscopic view is given in Figure 2(c). At the fourth-month control visit, the patient demanded that the stent be removed due to chest pain and inability toproducesputum,whichheattributedtothestent.his cardiological examination was normal and the patient stated that he did not benefit from the treatment administered for the palliation of pain. Improvement in dyspnea and exercise capacity was still maintained. In bronchoscopy, minimal secretion was observed in the stent and the stent was observed to prevent collapse markedly during expiration. Although the patient was strongly advised about the benefit of the stent, he was not persuaded and the stent was removed under general anesthesia. After the removal of the stent, the patient was still symptomatic. At the control visit, his BMI had increase up to 43.6 and polysomnography revealed an apnea-hypopnea index (AHI) of However, the patient could not tolerate a nasal or an oronasal mask and stated that he could not accept this alternative treatment either. 3. Discussion MKS was originally defined by Mounier-Kuhn [7]. The enlargement of the airways is accompanied by collapse in expiration, resulting in symptoms. Criteria have been defined to measure dilation by tomography [8]. A diameter of the trachea over 30 mm, right main bronchus over 20 mm, and the left main bronchus over 18 mm is considered dilation. The aim of treatment is to control symptoms by improving malacia. Therefore, treatment opt ions such as airway stabilization by stent placement and surgical methods are recommended in addition to the treatment of accompanying conditions. In TBM cases, airway stabilization using a stent or surgical methods is becoming more common at many centers [9 11]. Thiscasewasreferredforevaluationuponcontinuationof symptoms despite medical treatment administered for COPD and TBM accompanying MKS. In bronchoscopy, dilation and malacia were found in a large airway segment involving thetracheaandmainbronchusthatrequiredevaluationfor alternative treatment options other than medical treatment. In the present case, the tracheal segment with malacia was successfully stabilized with a custom-made stent. Although a stent is not used for the main bronchus, collapsibility of the main bronchus is partly prevented by the change in the respiration mechanics with the effect of maintenance of the tracheal lumen patency, stabilization, and also change of the tracheobronchial tree angulation. Because no complication was noted in the followup, improvement was found in his symptoms and respiratory function tests and stent placement inthesegmentswithmalaciainthemainbronchiwasnot considered. In TBM, airway stabilization is necessary for symptom control and prevention of complications such as frequent respiratory tract infections and the development of bronchiectasia. Using stents for airway stabilization is useful for symptom control in patients who cannot undergo surgical intervention [11]. In patients with MKS accompanied by severe TBM, experience regarding the success of airway stabilization is limited. Odell et al. reported that although MKS cases showed substantial improvement in quality of life, dyspnea scores, and symptoms after stent placement and tracheobronchoplasty, no significant change was found in forced expiratory volume in 1 s (FEV 1 )values[6]. In the present case, the FEV 1 value was found to increase by 1500 ml after stent placement and this improvement was maintained at the four-month followup. The most important problem that will be encountered in stent placement in cases with MKS is the lack of sufficiently largestentsrequiredforexcessivedilationintheairway. Odell et al. reported that, in cases with MKS, migration was prevented by placing a silicon Y type stent in the airway [6]. However, in the present case, it was impossible to produce adequate stabilization in the airway with a Y stent because the trachea was dilated throughout its entire length with severe malacia. Considering that the stents that are currently available commercially would be inadequate for stabilization in this patient, a custom-made, self-expandable metallic stent with a diameter of 28 mm and length of 100 mm was used (Silmet; Novatech). Surgery is the first line treatment in TBM. Stent application can help symptom palliation in patients in which surgery cannot be applied or refuse surgery [11]. Besides a stent is beneficial both for symptom control via airway stabilization and for the determination of patients who will
3 Case Reports in Pulmonology 3 Figure 1: Thoracic computed tomography: in the airway segment starting from the proximal end of the trachea and extending to the main bronchi, an increase in the transverse diameter, a decrease in the anterior-posterior diameter, and diverticular irregularities in the level of the carina are observed. (a) (b) (c) Figure 2: Pictures of stent during the rigid bronchoscopy procedure. Increase in trachea transverse diameter and severe malacia (a), trachea after stent placement (b), control visit at 1st month (c).
4 4 Case Reports in Pulmonology benefit from surgical intervention [11]. Because our case refused the surgical treatment option, stent placement was attempted for symptom palliation. Thus far, to the best of our knowledge, only one case report exists in which a custom-made large stent was used for tracheal dilation and malacia [12]. In a case with tracheomegalyassociatedwithmarfansyndrome,dueto malacia in the lower third segment of the trachea and main bronchi, a self-expandable, custom-made metallic stent with a diameter of 28 mm and a length of 69 mm was placed in the trachea and an 18-mm-diameter silicon stent was placed in theleftandrightmainbronchi.symptomimprovementwas maintained during 2 years of followup. In airway stents, the formation of granulation tissue, mucostasis, infection, and migration are common complications [6, 12]; in some cases, it may be necessary to remove the stent for management of these complications. Probable complications that could develop in these patients and stent fractures could end up by the removal of the stent. For this reason, surgery should be kept in mind as a first line treatment in patients with TBM for both long term symptom palliation and not facing stent related complications. In the present case, no serious complication was observed except for chest pain attributed to the stent. Chest pain that was thought to develop due to the stent and that disappeared after stent removal may be considered the main complication leading to stent removal. Pressure exerted by the stent on a thinned tracheal wall was considered to be the main cause of retrosternal pain. In cases with TBM, noninvasive positive pressure may help to decrease pulmonary resistance and respiratory work load and improve expiratory flow with airway stabilization and symptom control [5]. In the present case, continuous positive airway pressure therapy (CPAP), therapy was planned forthecontrolofsymptoms,whichreemergedafterstent removal, as well as for the treatment of obstructive sleep apnea syndrome. Because the patient did not accept CPAP either, its long-term effect on symptom palliation could not be evaluated. 4. Conclusion In cases with severe TBM accompanied by MKS-associated tracheobronchomegalia, using large-diameter stents instead of conventional stents may be beneficial for airway stabilization and, hence, symptom control. Airway stabilization with stent can be the only option beside probable complications in cases in which traditional surgery cannot be applied. However, it should be considered that complications developing due to the stent as well as patient noncompliance may lead to stent removal, even when useful results are obtained from treatment. Acknowledgment The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: ych2mk. References [1] G. L. Adani, J. Baccarani, D. Lorenzin et al., Renal transplantation in a patient affected by Mounier-Kuhn syndrome, Transplantation Proceedings,vol.37,no.10,pp ,2005. [2] B.Menon,A.Malik,A.Chugh,andB.Vashishat, Radiological appearances in a rare case of tracheomegaly, tracheal diverticulosis, bronchomegaly and bronchiectasis, Indian Chest Diseases & Allied Sciences,vol.47,no.1,pp.39 41,2005. [3] M. Schwartz and L. Rossoff, Tracheobronchomegaly, Chest, vol. 106, no. 5, pp , [4] M. S. Shin, R. M. Jackson, and K.-J. Ho, Tracheobronchomegaly (Mounier-Kuhn Syndrome): CT diagnosis, The American Roentgenology, vol. 150, no. 4, pp , [5] K. A. Carden, P. M. Boiselle, D. A. Waltz, and A. Ernst, Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review, Chest,vol.127,no.3,pp , [6] D.D.Odell,A.Shah,S.P.Gangadharanetal., Airwaystenting and tracheobronchoplasty improve respiratory symptoms in Mounier-Kuhn syndrome, Chest, vol. 140, no. 4, pp , [7] P. Mounier-Kuhn, Dilatation de la trachee: constations radiographiques et bronchoscopiques, Lyon Médical, vol. 150, pp , [8] L. C. Lazzarini-de-Oliveira, C. A. Costa de Barros Franco, C. L. GomesdeSalles,andJ.DeOliveiraA.C., A38-year-oldman with tracheomegaly, tracheal diverticulosis, and bronchiectasis, Chest,vol.120,no.3,pp ,2001. [9] A.Ernst,A.Majid,D.Feller-Kopmanetal., Airwaystabilization with silicone stents for treating adult tracheobronchomalacia: a prospective observational study, Chest, vol. 132, no. 2, pp , [10] D. Sommer and V. Forte, Advances in the management of major airway collapse: the use of airway stents, Otolaryngologic Clinics of North America,vol.33,no.1,pp ,2000. [11] A. Majid, J. Guerrero, S. Gangadharan et al., Tracheobronchoplasty for severe tracheobronchomalacia: a prospective outcome analysis, Chest,vol.134,no.4,pp ,2008. [12] H. Dutau, A. Cavailles, I. Fernandez-Navamuel, and D. P. Breen, Tracheal compression in a patient with Marfan s syndromeassociated tracheomegaly treated by an XXL stent: the largest diameter airway stent ever placed in a previously undescribed airway condition, Respiration, vol. 77, no. 1, pp , Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.
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