Angioplasty Summit TCTAP Technical Aspects of Overview in CTO-PCI Toyohashi Heart Center Takahiko Suzuki, M.D
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1 Angioplasty Summit TCTAP 2010 Technical Aspects of Overview in CTO-PCI Toyohashi Heart Center Takahiko Suzuki, M.D
2 Introduction CTO-PCI has been technically and technologically evolved over the past two decades; thereby resulted in the expansion of indications. In technical perspective, the development of various techniques including parallel wiring, IVUS guided wiring, as well as retrograde wiring technique was introduced. In technological perspective, new guidewires were introduced and significantly improved the success rate of CTO-PCIs. The advent of the drug-eluting stent has been improved the long-term patency rate. Toyohashi Heart Center
3 Objective The aim of this presentation is to introduce current overview CTO-PCI including the operator technique, equipment, and outcomes. Toyohashi Heart Center
4 Devices CTO wires Microcatheters Balloon catheters
5 Development of CTO wires ACS Standard USCI Steerable Miracle Conquest Magic SHOOTING FielderFC X-tream Toyohashi Heart Center
6 1. The superior performance of the device Current CTO guidewires Spring coil wire Neo s Miracle R (Getz Brothers) Neo s Conquest (Getz Brothers) AthleteGT Magic R (Japan Life Line) Zeon CTO wire R (Zeon Medical) Hydrophilic coated wire Wizard (Nihon Lifeline) Fielder bros (Asahi Intec) X-treme (Asahi Intec) Choice PT R (Boston Scientific) Toyohashi Heart Center
7 Neo s Miracle R The concepts of the wire u u u Thicker Spring Coil Thicker Core Wire Shorter Length of Spring Coil u u u Better Torque Greater Strength NoWire Trapping Variations of Stiffness to Match Lesion Characteristics Miracle 3 Stainless Core Wire mm Radiopaque Spring Coil ACS HI-TORQUE STD. TM Teflon Coating mm Radiopaque 300mm Spring Coil Toyohashi Heart Center
8 Spring coil wires Miracle Wire Diameter Tip Radiopaque / cm Platinum Tip Stiffness Coating (Dis./ Prox.) Silicon Coating Coil Teflon Coating 3.0,4.5,6.0,12.0g Silicon / Teflon Magic Wire Diameter Tip Radiopaque / cm Gold Tip Tip Stiffness Coating (Dis./ Prox.) Hydrophilic Coating Coil Teflon Coating 4.5,9.0,18.0g Hydrophilic / Teflon ZEON CTO NEW! Wire Diameter / Tip Stiffness Tip Radiopaque 12cm Platinum Coating (Dis./ Prox.) Hydrophilic Coating Coil Teflon Coating 4.5,9.0,15.0g Hydrophilic / Teflon Toyohashi Heart Center
9 X-treme Tip Stiffness 0.8g Tip Diameter 0.009~0.014 PTFE Coating Stainless Steel Core 16cm Polymer Sleeve & Hydrophilic Coating 16cm Radio-opaque spring coil cm 1cm Fielder FC Tip Stiffness 0.8g Tip Diameter Stainless Steel Core 11cm Spring Coil 3cm Radio-opaque Coil PTFE Coating cm Polymer Sleeve & Hydrophilic Coating Fielder Tip Stiffness 1.0g Tip Diameter Stainless Steel Core 12cm Spring Coil 3cm Radio-opaque Coil PTFE Coating cm Polymer Sleeve & Hydrophilic Coating
10 Wizard Basic Information Specification 1g O.D: / 4cm O.D: / 12.5cm 3g O.D: / 4cm O.D: / 12.5cm Model Tip Stiffness Radiopaque Coating 全長 WIZARD 1 1g 16.5cm 17cm Hydrophilic 178cm WIZARD 3 3g 16.5cm 17cm Hydrophilic 178cm
11 Microcatheters Toyohashi Heart Center
12 Microcatheters Transit 2 (Cordis) Excelsior (Boston Scientific) Good Master (Goodman) Finecross MG (Terumo) Ichibanyari (Kaneka) Tornus (Asahi Intec) Corsair (Asahi Intec) Toyohashi Heart Center
13 Micro catheters Transit 2 (Cordis) Excelsior (Boston Scientific) Toyohashi Heart Center
14 Micro catheters Good Master (Goodman) Finecross MG (Terumo) Toyohashi Heart Center
15 Micro catheters Ichibanyari (Kaneka) Length 1350mm Tapered 150mm Sleeve 300mm 75mm 0.Dφ0.71 I.Dφ0.46 Tornus (Asahi Intecc) Toyohashi Heart Center
16 Channel Dilator Corsair
17 Basic structure is same as Tornus device.
18 Corsair Marker coil 10.86mm (2.6Fr) 20.82mm (2.5Fr) 30.86mm (2.6Fr) l l l l Tapered Soft Tip 20cm Screw Head Structure Hydrophilic Polymer Coating PTFE Inner Layer
19 Balloon Catheters Toyohashi Heart Center
20 Balloon Catheters for CTO-PCIs 1.00mm FALCON 1.25mm Tazuna 1.25mm Sprinter LEGEND 1.3mm Lacrosse 1.5mm 1.5mm Maverick Voyager
21 Operator Techniques Single technique Parallel wiring technique IVUS guide wiring technique Retrograde wiring technique
22 Development of CTO Techniques Single wire Parallel wire IVUS guided Retrograde (CART) Toyohashi Heart Center
23 Advanced CTO technique-1 Parallel Wire (Contact wire Technique)
24 Parallel (contact) wire technique is effective when the stiffer guidewire go into subintima and make a false lumen.
25 CCT 2010 Case 19 T CCT 2010 Live Case Demonstration Toyohashi Heart Center 70 s. male Target Lesion: mid LAD (CTO) Diagnosis: OMI, AP Prior intervention: STENT (ost RCA AMI) Cypher STENT (prox. RCA) TAXUS Coronary risk factor: HT, Current smoking EuroSCORE: 5 SYNTAX Score: 36 Final CAG findings: LVEF: 46% CAG: mid LAD 100%, LM 50%, prox. LCX 75%, mid LCX 90%, prox RCA 90%(AMI)-> 0%(Cypher+TAXUS)
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29 Advanced CTO technique-2 IVUS Guided Wiring Crossing Technique
30 How to IVUS Guide Wire Crossing Technique 1. Advance the guidewire into the subintimal space 2. Subintimal space is enlarged with a 1.5mm balloon catheter along with the guidewire 3. IVUS catheter is advanced into the subintimal space. Stiff guidewire is advanced into the true lumen. 4. Wire manipulation under IVUS imaging
31 Advanced CTO technique-3 Retrograde Technique
32 Concept of CART TM technique (Controlled Antegrade and Retrograde subintimal Tracking) make connection between antegrade and retrograde subintimal space utilizing behavior of subintimal dissection. antegrade wire automatically gets into distal true lumen.
33 Bilateral Approach for CTO lesion
34 What is the major limitation of primitive CART? Retrograde wire usually gets into plaque, not into subintima at proximal part of distal CTO end so that retrograde balloon is inflated at intra-plaque. If antegrade wire is advanced into subintima at the site of retrograde balloon dilation, it is difficult to direct the antegrade wire to the true distal lumen, similar to a difficult situation in the antegrade approach.
35 PCI-CTO Toyohashi Experience ~2009
36 Doctors in THC
37 Number of CTO-PCI N=1136 (n)
38 Lesion Characteristics ( 99-09, n=1577) Target vessel RCA 621 (39.4%) LAD 473 (30.1%) LCX 334 (21.2%) LMT 8 (0.5%) Branch 138 (8.8%) Bypass graft 2 (0.13%) Prior PCI 424 (26.9%) In-stent occlusion 171 (10.8%) Bending> (12.3%) Calcified lesion 555 (35.2%) Significant side branch 231 (14.6%)
39 Crossing Guide Wire (2009, n=118) Failure 3% Others 3% Miracle 33% X-treme 27% FielderFC 15% Wizard 4% Pilot 4% Conquest 11%
40 Toyohashi experience CTO-PCI ( 04 vs. 09) Crossed guide wires 100% 17.5% 7.0% 80% 15.0% 47.4% 60% 40% 67.5% 45.6% Spring coil floppy wire Plastic jacket wire Spring coil CTO wire 20% 0% (n=120) (n=114)
41 Crossing Techniques (2009, n=118) CART 12% Failure 3% Retrograde 8% Single wire 59% IVUS guide 7% Parallel wire 11%
42 Toyohas CTO-PCI ( 04 vs. 09) Toyohashi experience hi Successful guide wire technique by year 100% 80% 60% 40% 20% 2% experien 11% 2% 11% 23% 12% 23% 4% 8% 23% 8% 8% ce 10% 11% CTO-PCI 65% ( 04 vs. 07) 65% 56% 61% CART technique Retrograde approach IVUS guided Parallel wire technique Single wire technique 0% (n=120) (n=142) (n=114) Toyohashi Heart Center
43 Initial Success Rate 86.9% (988/1136) (%) % (83/113) 79.0% (94/119) 84.2% (117/139) 86.3% (145/168) 92.4% (157/170) 92.2% (142/154) 91.6% (142/155) 91.5% (108/118)
44 Toyohashi experience CTO-PCI ( 04 vs. 09) Success rate of guide wire crossing 100% 80% 60% 40% 86.3% (120/139) 96.6% (114/118) 20% 0% Toyohashi Heart Center
45 Complications Major complications Death in hospital 8 (0.5%) Emergency CABG 4 (0.3%) Q-MI 5 (0.3%) Minor complications Cardiac tamponade 14 (0.9%) Aortic dissection 5 (0.3%) Acute occlusion 12 (0.8%) Subacute occlusion 4 (0.3%) Side branch compromise 50 (3.2%) Coronary perforation Type-I 145 (9.2%) Type-II 13 (0.8%)
46 Angiographic Follow Up BMS era DES era (Jan. 03-Sep. 04) (Jan. 07-Dec. 8) No. of CTOs Initial success 183 (80.6%) 279(90.9%) No. of CAG F/U 139 (76.0%) 163 (58.4%) No. of restenosis 54 (38.8%) 37 (22.7%) No. of reocclusion 23 (16.5%) 12 (7.4%) 77 (55.3%) 49 (30.1%) No. of TLR 60 (43.1%) 41 (25.1%) Clinical restenosis 29.5% 17.6% Clinical TLR 32.8% 14.7% Mean F/U period 7.1±4.4(mos.) 9.3±4.9(mos.)
47 Summary l The success rate of CTO-PCI in Toyohashi Heart Center is very high with low restenosis and reocclusion rates. l With expert technique as well as appropriate device selections, CTO-PCI is not inferior to CABG.
48 Summary Over the past two decades, CTO-PCI has dramatically evolved in both technical and technological aspects. The advent of drug-eluting stents has also improved the long-term patency rate of CTO- PCI. Therefore, the role of vascular interventionists further expanded. Toyohashi Heart Center
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