Syncope: Causes and Treatment
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- Frederick Banks
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1 March 01, 2006 By Avery Hayes, MD [1] and Mahendr S. Kochar, MD, MS [2] Because the causes of syncope are numerous and the diagnostic tests have low yield, this disorder is often difficult to evaluate. Here we describe a practical approach to the workup that can help you rapidly identify serious underlying pathology. We also discuss treatment of the most common causes of syncope. Syncope is responsible for 1% to 6% of hospital admissions and up to 3% of visits to the emergency department (ED).1 This sudden, brief loss of consciousness results from a decrease in or cessation of cerebral blood flow and is followed by spontaneous recovery.2 The causes range from benign to life-threatening. Because the causes of syncope are numerous and the diagnostic tests have low yield, this disorder is often difficult to evaluate. Here we describe a practical approach to the workup that can help you rapidly identify serious underlying pathology. We also discuss treatment of the most common causes of syncope. EPIDEMIOLOGY In a population-based study by Soteriades and colleagues, patients were observed for an average of 17 years. During that time, 822 reported at least 1 episode of syncope; the overall incidence of a first report of syncope was 6.2 per 1000 person-years. The incidence increased with age, especially after age 70 (the incidence in persons aged 70 to 79 years was 11.1 per 1000 person-years). The age-adjusted incidences for men and women were equal. TYPES OF SYNCOPE The more common types of syncope can be grouped into the following categories, on the basis of the underlying mechanism of cerebral hypoperfusion: Neurally mediated syncope. Syncope resulting from orthostatic hypotension. Cardiac syncope. Syncope of unknown cause. In the study by Soteriades and associates,3 the most frequently encountered types of syncope were vasovagal (the most common type of neurally mediated syncope) (21.2%), cardiac (9.5%), and syncope of unknown cause (36%). In another study, which included 650 patients, structural heart disease was identified as the cause of syncope in 11% of patients, arrhythmias in 7%, orthostatic hypotension in 24%, and a vasovagal mechanism in 37%.4 In younger patients without structural heart disease, syncope is most likely to be vasovagal.4 Table 1 Common causes of orthostatic hypotension Autonomic failure Primary Page 1 of 8
2 Shy-Drager syndrome Pure autonomic failure (Bradbury-Eggleston syndrome) Secondary Diabetes mellitus Uremia Amyloidosis Parkinson disease with autonomic failure Drugs Diuretics Tricyclic antidepressants ß-Blockers Angiotensin-converting enzyme inhibitors Calcium channel blockers Phenothiazines Nitrates Hypovolemic disorders Diarrhea Vomiting GI hemorrhage Neurally mediated syncope. In this type of syncope, transient loss of consciousness results from a temporary failure of the autonomic nervous system to maintain an adequate heart rate and blood pressure. Included in this category are neurocardiogenic syncope (the vasovagal faint); syncope resulting from "situational" triggers, such as emotional stress, micturition, coughing, or anticipation of pain; and syncope caused by carotid sinus syndrome.1 Neurocardiogenic, or vasovagal, syncope is characterized by reflexive vasodilatation and bradycardia.1 Patients may experience predominantly vasodilatation (vasodepressor response), predominantly bradycardia (cardioinhibitory response), or both. Neurocardiogenic syncope may be preceded by fatigue, weakness, diaphoresis, nausea, abdominal discomfort, visual field changes, paresthesias, or feelings of depersonalization.1 Cardiac syncope. This may be associated with organic heart disease (eg, aortic stenosis, hypertrophic cardiomyopathy, myocardial infarction, pulmonary embolism). It can also result from tachyarrhythmias (eg, ventricular tachycardia, torsade de pointes, supraventricular tachycardia) or bradyarrhythmias (eg, sinus node disease, second- or third-degree heart block, drug-induced bradycardia). Syncope resulting from orthostatic hypotension. Orthostatic hypotension is generally defined as a reduction in systolic blood pressure of at least 20 mm Hg or a reduction in diastolic blood pressure of at least 10 mm Hg within 3 minutes of standing. Smaller decrements in blood pressure may be significant if they are associated with symptoms. Orthostatic hypotension results when the Page 2 of 8
3 autonomic nervous system fails to overcome orthostatic stress or when circulating volume is decreased because of volume depletion. Table 1 lists the more common causes of orthostatic hypotension. EVALUATION Ruling out other causes of transient loss of consciousness. Syncope must be distinguished from other conditions (such as seizure, transient ischemic attack, and hypoglycemia) that cause a transient loss of consciousness. These conditions can be excluded on the basis of the history, physical examination, and measurement of blood glucose levels. Table 2 includes clues in the history that suggest conditions other than syncope as the cause of a transient loss of consciousness. Initial evaluation. History taking, physical examination, and electrocardiography are the starting points for establishing the cause of syncope. In a prospective study, the cause was strongly suspected after the initial evaluation in 69% of patients. The history and physical findings alone led to the diagnosis in 38% of patients.4 Extensive laboratory testing has not been shown to provide additional diagnostic benefit. History taking. Table 2 lists typical elements in the history associated with various types of syncope. Physical examination. Include in the examination cardiac auscultation, palpation and auscultation of carotid arteries for evidence of carotid stenosis, measurement of orthostatic blood pressure, and measurement of blood pressure and pulse in both arms. Cardiac auscultation may identify murmurs consistent with aortic stenosis, mitral stenosis, or hypertrophic cardiomyopathy. Pay particular attention to palpation of the carotid arteries and auscultation for bruits. Avoid carotid sinus massage in patients with a history of stroke and in those in whom bruits are detected (because of the risk of plaque breakage and embolization). Significant differences in the blood pressure or pulse of the 2 arms may indicate subclavian steal or aortic dissection. Measure orthostatic blood pressure in all patients. In a prospective study,4 standardized measurement of orthostatic changes in the ED identified orthostatic hypotension as the probable cause of syncope in 24% of patients. Of those, orthostatic hypotension was drug-related in 58%, the result of hypovolemia in 22%, and postprandial in 12%; 28% had idiopathic hypotension. Electrocardiography. This has been shown to reveal the cause of syncope on presentation in 5% of patients.4 Arrhythmias were identified as the cause of syncope in most of these patients. Although electrocardiography has a low yield, the test is relatively inexpensive and can be instrumental in identifying underlying structural heart disease. Detection of such abnormalities as first-degree heart block, bundle-branch block, and sinus bradycardia may point to bradycardia as the cause of syncope. Previous myocardial infarction or pronounced left ventricular hypertrophy in hypertrophic cardiomyopathy may be associated with ventricular tachycardia.5 If the initial evaluation fails to yield the cause of syncope, it can be used to guide further diagnostic testing. Neurologic imaging is generally not indicated unless focal neurologic signs are present.2,5,6 Table 2 Clues in the history that suggest the cause of a transient loss of consciousness (TLOC) Salient historical features Suspected cause of TLOC Prolonged standing, pain, fear, or panic Vasovagal attack Occurs immediately after cough, micturition, defecation, etc Situational syncope Page 3 of 8
4 Nausea and vomiting, diarrhea, diuretic use Orthostatic hypotension History of coronary artery disease or congestive heart failure, sudden onset of syncope with no prodrome Arrhythmia Syncope on exertion, chest pain Structural heart disease or pulmonary embolism Urinary incontinence, prolonged confusion Seizure Headache, vertigo, dysarthria, diplopia Transient ischemic attack or stroke Risk stratification. By the time patients present to the ED after an episode of syncope, they are often asymptomatic. Some of these patients are nonetheless at increased risk for morbidity and mortality. Cardiac syncope is associated with significantly greater mortality than other types of syncope. In one study, mortality rates in patients with syncope that resulted from underlying arrhythmia or ischemia were double those in patients with syncope from any cause.3 Multivariate-adjusted hazard ratios among patients with syncope from any cause were 1.31 for death from any cause, 1.27 for myocardial infarction or death from coronary heart disease, and 1.06 for fatal and nonfatal stroke. The corresponding hazard ratios among patients with cardiac syncope were 2.01, 2.66, and 2.01, respectively. Syncope of unknown cause was associated with an increased risk of death from any cause. Patients with vasovagal, orthostatic, or medication-induced syncope were at no higher risk for death from any cause, myocardial infarction, or coronary heart disease than were patients without syncope.3 Thus, a main goal is to identify patients at higher risk for arrhythmias and sudden cardiac death who require hospital admission for evaluation and management. The following were shown to be significant risk factors for arrhythmia or death at 1 year6: Abnormal ECG (defined as ventricular tachycardia of 3 beats or more, sinus pause of 2 seconds or longer, symptomatic sinus bradycardia or supraventricular tachycardia, atrial fibrillation, third-degree heart block, or Mobitz type II heart block). Age greater than 45 years. History of ventricular arrhythmia. History of congestive heart failure. In patients with no risk factors, the incidence of major arrhythmia ranged from 3.3% to 5.5%. In patients with 3 or 4 risk factors, the incidence ranged from 45.5% to 63.0%. One-year mortality rates ranged from 1.1% to 1.8% in patients with no risk factors to 27.3% to 37% in patients with 3 or 4 risk factors. Page 4 of 8
5 Table 3 lists additional indications for hospitalization. Table 3 Indications for hospital admission History of myocardial infarction, heart failure, or ventricular arrhythmia Symptoms that suggest arrhythmia palpitations Physical examination findings valvular heart disease ECG findings that suggest ischemia, eg, bundle-branch block and arrhythmia (eg, bradycardia Moderate to severe orthostatic Older age (60 y or older) Data from Linzer M et al. Ann Intern Med Additional testing. In patients in whom the initial evaluation fails to definitively identify the cause of syncope, further evaluation may be indicated. Arrhythmias. Suspect arrhythmias in older patients and in those with heart disease. Ambulatory ECG monitoring using an event recorder or mobile outpatient telemetry is indicated in such patients. In patients at high risk for ventricular arrhythmia, consultation with a cardiologist is indicated. The cardiologist can perform an electrophysiologic study to detect ventricular tachycardia, sinus node dysfunction, atrioventricular block, or other arrhythmia.7 Structural heart disease. Order an echocardiogram to assess patients with heart murmurs consistent with obstructive lesions. Echocardiographic findings that may be diagnostic of the cause of syncope include: Mean aortic gradient greater than 50 mm Hg or valve area of less than 0.9 cm (indicative of severe aortic stenosis). Evidence of hypertrophic cardiomyopathy with outflow tract obstruction. Mean pulmonary arterial pressure greater than 30 mm Hg (indicative of severe pulmonary hypertension). Left atrial myxoma. Thrombus. Even if echocardiography in patients with unexplained syncope does not reveal any unsuspected cardiac abnormalities that might be the cause of the syncope, it can help identify those patients with documented or suspected cardiovascular disease who have systolic dysfunction (left ventricular ejection fraction, 40% or greater) and are thus at higher risk for ventricular arrhythmia.8 In patients at high risk for the development of coronary artery disease, order cardiac stress testing to rule out ischemia. Neurocardiogenic syncope. A tilt-table test is used to detect neurocardiogenic syncope.2 Such tests have a sensitivity of 67% to 83% and a specificity of 75% to 100%. Tilt-table testing need not be Page 5 of 8
6 performed in most patients whose symptoms suggest vasovagal syncope. Indications for testing include: Recurrent syncope of unexplained cause. Presence of structural heart disease in conjunction with exclusion of cardiac causes of syncope. Single episode of syncope in a patient with a high-risk occupation or hobby (eg, flying an airplane, operating heavy machinery, or driving a commercial vehicle). Syncope associated with significant injury.9,10 TREATMENT Neurocardiogenic syncope. When neurocardiogenic syncope occurs infrequently and in a patient who does not have a high-risk occupation or hobby, nonpharmacologic treatment is usually sufficient. This includes instructing the patient to avoid predisposing conditions and to lie down at the onset of any prodromal symptoms. Isometric contractions of the extremities to augment venous return may also be helpful. Increasing the intake of sodium and fluid may decrease the risk of syncope recurrence.11 Patients who experience debilitating symptoms or significant injury and those who are involved in high-risk occupations need prophylactic therapy. Numerous interventions are available (Table 4); however, the data from randomized controlled trials (RCTs) are limited and sometimes conflicting. Fludrocortisone (a mineralocorticoid that promotes sodium retention and raises blood pressure) and midodrine (an alpha sympathomimetic agent that causes vasoconstriction) are the 2 mainstays of drug treatment. b-blockers are used by some experts as first-line agents to treat neurocardiogenic syncope. They are purported to act by blocking the initial increase in adrenergic tone and its negative inotropic effects, thereby inhibiting the activation of left ventricular mechanoreceptors. Few randomized, double-blind, placebo-controlled studies support their use.12 In one RCT, etilefrine, an a-agonist and potent vasoconstrictor, was not shown to be effective in preventing episodes of vasovagal syncope.13 In another RCT, the response to paroxetine was significant after 1 month of follow-up.14 Dual-chamber pacemaker implantation may be an option for select patients with refractory vasovagal syncope of the predominantly cardioinhibitory type. In the North American Vasovagal Pacemaker Study (VPS), 54 patients with a lifetime history of 6 or more episodes of syncope and tilt-table-induced syncope or presyncope were randomly assigned to receive a dual-chamber pacemaker or no intervention. The risk of syncope was 85.4% lower in the group that received pacemakers than in the group that did not receive pacemakers.15 These results were later corroborated by a prospective, controlled, multicenter study of 42 patients with a history of recurrent syncope and a positive cardioinhibitory response to tilt-table testing. The patients were randomly assigned to receive a DDI pacemaker or no intervention and were observed for a minimum of 1 year. Syncope recurred in 1 patient (5%) in the pacemaker group after 15 months and in 14 patients (61%) after 5 months in the group that did not receive pacemakers (P =.0006).16 Because these studies were not blind, their power was limited. A blind, placebo-controlled study by Connolly and colleagues17 found that pacemakers were not helpful as first-line therapy in patients with vasovagal syncope. However, pacemakers continue to be used in patients with refractory syncope. Orthostatic hypotension. Patients with acute orthostatic hypotension require intravascular volume replacement. Medications known to cause or exacerbate orthostatic hypotension should be avoided. Patients with autonomic dysfunction may benefit from salt supplementation and elastic support stockings. Fludrocortisone has been used as a first-line agent; midodrine is also usually beneficial. Cardiac syncope. Management of structural heart disease and refractory arrhythmias is the province of the cardiologist. Patients with significant arrhythmias who are unresponsive to antiarrhythmic medications require an implantable cardioverter-defibrillator, a pacemaker, or both. Table 4 Therapies for neurocardiogenic syncope Treatment Use or dosage Page 6 of 8
7 Lifestyle changes Fluid intake 2 L/d Salt intake 2.7 g/d of sodium (equivalent to 7 g/d of table salt) Physical maneuvers Isometric contractions Fludrocortisone mg qd Midodrine mg tid Selective serotonin reuptake For example, paroxetine, 20 mg qd Drugs inhibitors* Permanent cardiac pacemaker* DDD mode Page 7 of 8
8 *These treatments were shown to be effective in at least 1 randomized controlled trial. Adapted from Grubb B. N Engl J Med References: REFERENCES: 1.Kapoor W. Syncope. N Engl J Med. 2000;343: Goldschlager N, Epstein A, Grubb B, et al. Etiologic considerations in the patient with syncope and an apparently normal heart. Arch Intern Med. 2003;163: Soteriades ES, Evans JC, Larson MG, et al. Incidence and prognosis of syncope. N Engl J Med. 2002;347: Sarasin FP, Louis-Simonet M, Carballo D, et al. Prospective evaluation of patients with syncope: a population-based study. Am J Med. 2001;111: Linzer M, Yang E, Estes M III, et al. Diagnosing syncope, part 1. Ann Intern Med. 1997;126: Martin TP, Hanusa BH, Kapoor WN. Risk stratification of patients with syncope. Ann Emerg Med. 1997;29: Krahn AD, Klein GJ, Raymond Y, Skanes A. Randomized assessment of syncope trial: conventional diagnostic testing versus a prolonged monitoring strategy. Circulation. 2001;104: Sarasin FP, Junod AF, Carballo D, et al. Role of echocardiography in the evaluation of syncope: a prospective study. Heart. 2002;88: Benditt D, Ferguson D, Grubb B, et al. American College of Cardiology Expert Consensus Document. Tilt table for assessing syncope. J Am Coll Cardiol. 1996;28: Kapoor W. Using a tilt-table to evaluate syncope. Am J Med Sci. 1999;317: Grubb B. Neurocardiogenic syncope. N Engl J Med. 2005;352: Madrid AH, Ortega J, Rebollo JG, et al. Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic population: a prospective, double-blind, randomized and placebo-controlled study. J Am Coll Cardiol. 2001;37: Raviele A, Brignole M, Sutton R, et al. Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope. Circulation. 1999; 99: Di Girolamo E, Di Iorio C, Sabatini P, et al. Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol. 1999;33: Connolly S, Sheldon R, Roberts R, Gent M. The North American Vasovagal Pacemaker Study (VPS). J Am Coll Cardiol. 1999;33: Sutton R, Brignole M, Menozzi C, et al. Dual chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope. Circulation. 2000;102: Connolly SJ, Sheldon R, Thorpe KE, et al. Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial. JAMA. 2003;289: Linzer M, Yang E, Estes M III, et al. Diagnosing syncope, part 2: unexplained syncope. Clinical Efficacy Assessment Project of the American College of Physicians. Ann Intern Med. 1997;127: Source URL: Links: [1] [2] Page 8 of 8
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